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Cheap flights from Madrid, Spain to Santiago from £328

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — SCL
15 Jun — 22 Jun1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Santiago Arturo Merino Benitez are usually found in March or May, booked 72 days in advance, depart on a Monday or Sunday and return on a Tuesday

Cheap flight deals from Madrid to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Madrid to Santiago
Explore the most affordable flight options available from Madrid to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 16 May 2026.

Thu 17/910:25
MAD
-
SCL
2 stops26h 50m
Delta
Tue 29/920:40
SCL
-
MAD
2 stops28h 40m
Delta
Deal found 14/5£641
Tue 10/1112:35
MAD
-
SCL
2 stops47h 05m
Delta
Wed 25/1123:10
SCL
-
MAD
1 stop30h 45m
Delta
Deal found 14/5£644
Thu 12/1106:00
MAD
-
SCL
2 stops29h 40m
Delta
Sat 21/1123:10
SCL
-
MAD
2 stops40h 00m
Delta
Deal found 16/5£644
Tue 2/609:50
MAD
-
SCL
1 stop27h 25m
Delta
Tue 9/620:40
SCL
-
MAD
2 stops30h 50m
Delta
Deal found 15/5£645
Sun 31/512:20
MAD
-
SCL
2 stops48h 55m
Delta
Sun 7/620:40
SCL
-
MAD
2 stops55h 15m
Delta
Deal found 12/5£646
Mon 1/606:00
MAD
-
SCL
2 stops31h 15m
Delta
Sun 7/620:40
SCL
-
MAD
2 stops32h 40m
Delta
Deal found 15/5£647
Fri 15/509:50
MAD
-
SCL
1 stop27h 25m
Delta
Wed 27/520:40
SCL
-
MAD
2 stops33h 30m
Delta
Deal found 13/5£648
Thu 5/1111:55
MAD
-
SCL
1 stop23h 45m
Delta
Mon 23/1123:10
SCL
-
MAD
2 stops40h 25m
Delta
Deal found 12/5£649
Mon 18/512:45
MAD
-
SCL
2 stops24h 30m
Delta
Tue 2/620:40
SCL
-
MAD
2 stops33h 30m
Delta
Deal found 11/5£649
Wed 16/906:00
MAD
-
SCL
2 stops31h 15m
Delta
Wed 4/1123:10
SCL
-
MAD
2 stops32h 20m
Delta
Deal found 11/5£651
Thu 4/623:59
MAD
-
SCL
Nonstop13h 26m
Iberia
Mon 15/610:40
SCL
-
MAD
Nonstop12h 40m
Iberia
Deal found 15/5£652
Thu 5/1111:55
MAD
-
SCL
1 stop23h 45m
Delta
Thu 26/1123:10
SCL
-
MAD
1 stop30h 45m
Delta
Deal found 12/5£654

Find flight deals from Madrid to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 16 May 2026.

Round-trip from

£641

One-way from

£328

Popular in

July

Cheapest in

March

Average price

£724

Good round-trip deal

£969 or less

Good one-way deal

£436 or less
Delta
  • Delta
  • 17/9-29/9
  • 4 total stops
  • 55h 30m total
  • Madrid to Santiago
Search Deals
LATAM Airlines
  • LATAM Airlines
  • 12/9
  • Nonstop
  • 12h 20m total
  • Madrid to Santiago
Search Deals
Highest demand for flights based on searches. 11% potential increase in price (£83 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£16 potential savings vs. average return price).
Search Deals
Average for round-trip flights in May 2026
Search Deals
Price to beat on a round-trip flight from Madrid Barajas to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Madrid Barajas to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Madrid to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 16 May 2026.
Use the filters below to find and compare flights from Madrid to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Thu 5/11

11:55-07:40

1 stop23h 45m

Santiago Arturo Merino Benitez

Thu 3/12

21:50-09:55

1 stop32h 05m

£649

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Wed 4/11

12:35-07:40

2 stops47h 05m

Santiago Arturo Merino Benitez

Thu 3/12

21:50-09:55

1 stop32h 05m

£685

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Wed 10/6

07:40-19:23

2 stops41h 43m

Santiago Arturo Merino Benitez

Wed 17/6

11:17-16:55

2 stops47h 38m

£688

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Tue 2/6

18:25-23:26

2 stops59h 01m

Santiago Arturo Merino Benitez

Sun 14/6

10:15-10:25

2 stops42h 10m

£701

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Sun 1/11

14:25-06:00

3 stops43h 35m

Santiago Arturo Merino Benitez

Sun 29/11

11:40-10:25

2 stops42h 45m

£721

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Tue 2/6

12:00-05:03

3 stops47h 03m

Santiago Arturo Merino Benitez

Sun 14/6

10:15-10:25

2 stops42h 10m

£726

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Thu 4/6

12:00-05:03

3 stops47h 03m

Santiago Arturo Merino Benitez

Mon 15/6

10:15-10:25

2 stops42h 10m

£748

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Fri 18/9

14:40-05:59

3 stops44h 19m

Santiago Arturo Merino Benitez

Thu 5/11

11:40-16:25

2 stops24h 45m

£876

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Thu 11/6

07:40-08:25

3 stops54h 45m

Santiago Arturo Merino Benitez

Thu 18/6

09:15-16:55

3 stops49h 40m

£925
Cheapest one-way

MadridSantiago

MAD - SCL

MADSCL

Madrid Barajas

Wed 2/9

08:10-23:20

1 stop21h 10m

£417

Flights are sorted by cheapest return flights first.

Deals found on 16/5

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Best time to book a flight from Madrid to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Santiago

How far ahead should I book a flight from Madrid to Santiago?

The price you pay for your flight from Madrid to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 71 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Madrid to Santiago?

Currently, March is the cheapest month in which you can book a flight from Madrid to Santiago (average of £705). Flying from Madrid to Santiago in July is currently the most expensive (average of £1,067). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to SCL?

Find hourly flight availability from Madrid to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 16 May 2026.

When flying from Madrid to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Madrid to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated 16 May 2026.
Read through reviews of airlines operating flights from Madrid to Santiago, such as LATAM Airlines and Iberia. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.4
Good
1,923 reviews
Check prices

Food

6.7

Boarding

7.5

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.4

Reviews

1 / 20
6.0
Good

Juan,Apr 2026

BOG - CLO

Very old aircraft and it was very dirty in the seats and floor
LATAM Airlines
7.4
Good
1,923 reviews
LATAM Airlines
7.4
Good
1,923 reviews
Check prices

Food

6.7

Boarding

7.5

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.4

Reviews

1 / 20
6.0
Good

Juan,Apr 2026

BOG - CLO

Very old aircraft and it was very dirty in the seats and floor
Iberia
7.0
Good
3,217 reviews
LATAM Airlines
7.4
Good
1,923 reviews
Check prices

Food

6.7

Boarding

7.5

Entertainment

7.0

Crew

8.0

Comfort

7.3

Overall

7.4

Reviews

1 / 20
6.0
Good

Juan,Apr 2026

BOG - CLO

Very old aircraft and it was very dirty in the seats and floor

Related info for your journey

Find useful and relevant information for your journey from Madrid to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Madrid to Santiago?

    To fly from Madrid to Santiago, you need to book a flight from Barajas (MAD) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Madrid Barajas take 12h 20m on average. When it comes time to book airfare, you have a few options: there are 13 outbound flights from Barajas to Arturo Merino Benitez offered by 2 different airlines.

  • How popular is this Madrid to Santiago flight route?

    This flight path from Madrid Barajas to Santiago Arturo Merino Benitez was viewed by 18 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Madrid to Santiago?

    A quick flight from Madrid to Santiago can take about 23h 45m. Delta provides one of the quickest options available for as low as £649. Airlines will cover a distance of 6656 mi.

  • What are the cheapest airlines flying from Madrid to Santiago round-trip?

    Cheapflights users have booked flights from Madrid to Santiago round-trip from £608. Another airline that can offer you cheap pricing is LATAM Airlines. Users have found that Iberia is 27% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Madrid to Santiago?

    No one likes to see their flight delayed. When booking a flight from Madrid to Santiago consider choosing Japan Airlines (83%), EL AL (83%) or Qatar Airways (74%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Madrid to Santiago?

    Looking at all options, your cheapest flight can be booked for £436. While the most popular route (Madrid Barajas - Santiago Arturo Merino Benitez) can be booked for £713 on average, our data indicates £831 when flying from Madrid to Santiago.

  • Can I find deals for flights from Madrid to Santiago that include hotel bookings?

    Yes. In addition to deals on Madrid to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santiago.

  • Can I find deals for business class flights from Madrid to Santiago?

    Yes. Cheapflights offers flight deals from Madrid to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Madrid to Santiago (average of £705). Flying from Madrid to Santiago in July is currently the most expensive (average of £1,067). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Balmaceda car hire
Lastarria car hire

Top 2 airlines flying from Madrid to Santiago

Discover the top 2 airlines that operate flights from Madrid to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 16 May 2026.
AirlineCheapestAverageFlexibilityOn-time
IberiaCheapest£608Average£931FlexibilityNo cancel feeOn-time77%
Search Iberia flights
LATAM AirlinesCheapest£754Average£1,109FlexibilityNo cancel feeOn-time81%
Search LATAM Airlines flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Madrid to Santiago?

Cheapflights makes it easy to find Madrid to Santiago flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Madrid to Santiago?

Millions of users choose and trust Cheapflights to book the best flight deals from Madrid to Santiago for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Madrid to Santiago with no change fees?

Certainly. Search results for flights to Santiago from Madrid shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Madrid to Santiago become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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