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£112+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — LHR
30 Nov — 7 Dec1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 31 October 2025.

Thu 4/1211:34PTY - SAP
Nonstop2h 14mCopa Airlines
Fri 2/104:25SAP - PTY
Nonstop2h 14mCopa Airlines
Deal found 29/10£222
Tue 25/1122:19PTY - SAP
Nonstop2h 14mCopa Airlines
Mon 2/204:28SAP - PTY
Nonstop2h 11mCopa Airlines
Deal found 30/10£238
Sun 11/111:34PTY - SAP
Nonstop2h 06mCopa Airlines
Fri 30/113:52SAP - PTY
Nonstop2h 09mCopa Airlines
Deal found 28/10£246
Fri 23/122:19PTY - SAP
Nonstop2h 10mCopa Airlines
Sat 7/213:55SAP - PTY
Nonstop2h 06mCopa Airlines
Deal found 28/10£254
Mon 17/1111:34PTY - SAP
Nonstop2h 14mCopa Airlines
Tue 25/1113:53SAP - PTY
Nonstop2h 08mCopa Airlines
Deal found 29/10£260
Sat 13/1222:19PTY - SAP
Nonstop2h 14mCopa Airlines
Fri 9/113:52SAP - PTY
Nonstop2h 09mCopa Airlines
Deal found 29/10£284
Wed 19/1111:34PTY - SAP
Nonstop2h 14mCopa Airlines
Wed 26/1113:53SAP - PTY
Nonstop2h 08mCopa Airlines
Deal found 29/10£338
Tue 23/1222:19PTY - SAP
Nonstop2h 14mCopa Airlines
Tue 6/104:25SAP - PTY
Nonstop2h 14mCopa Airlines
Deal found 29/10£647

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 858,174 searches. This data was last updated on 31 October 2025.

Fly to

Heathrow

Route

Depart

Return

Price

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Tue 30/12

11:34-12:48

Nonstop2h 14m

San Pedro Sula Ramon Villeda

Thu 8/1

04:25-07:39

Nonstop2h 14m

£222

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Thu 4/12

22:19-23:33

Nonstop2h 14m

San Pedro Sula Ramon Villeda

Sat 3/1

13:52-17:01

Nonstop2h 09m

£222

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Thu 4/12

11:34-12:48

Nonstop2h 14m

San Pedro Sula Ramon Villeda

Tue 9/12

13:53-17:01

Nonstop2h 08m

£222

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Tue 18/11

22:19-23:33

Nonstop2h 14m

San Pedro Sula Ramon Villeda

Thu 27/11

04:26-07:39

Nonstop2h 13m

£222

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Mon 15/12

11:34-12:48

Nonstop2h 14m

San Pedro Sula Ramon Villeda

Fri 16/1

13:52-17:01

Nonstop2h 09m

£238

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Tue 25/11

11:34-12:48

Nonstop2h 14m

San Pedro Sula Ramon Villeda

Tue 3/2

13:55-17:01

Nonstop2h 06m

£238

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Thu 8/1

11:34-12:40

Nonstop2h 06m

San Pedro Sula Ramon Villeda

Thu 22/1

04:25-07:39

Nonstop2h 14m

£238

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Fri 9/1

11:34-12:40

Nonstop2h 06m

San Pedro Sula Ramon Villeda

Thu 22/1

04:25-07:39

Nonstop2h 14m

£238

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Sun 11/1

11:34-12:40

Nonstop2h 06m

San Pedro Sula Ramon Villeda

Fri 30/1

13:52-17:01

Nonstop2h 09m

£246

Panama CitySan Pedro Sula

PTY - SAP

PTYSAP

Panama City Tocumen Intl

Mon 1/12

11:34-12:48

Nonstop2h 14m

£112

Flights are sorted by cheapest return flights first.

Deals found on 29/10

Showing 1-10 of 13 results
1
2

Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines flying non-stop to Panama City

Get insights into the airlines that provide direct flights from Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight from Panama City. Reviews last updated Cheapflights.
Read through reviews of airlines serving Panama City, such as KLM, Air France, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.7
Good
1,406 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Overall

7.7

Boarding

7.8

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
KLM
7.7
Good
1,406 reviews
KLM
7.7
Good
1,406 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Overall

7.7

Boarding

7.8

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
Air France
7.4
Good
1,482 reviews
KLM
7.7
Good
1,406 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Overall

7.7

Boarding

7.8

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.
United Airlines
7.4
Good
8,996 reviews
KLM
7.7
Good
1,406 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Overall

7.7

Boarding

7.8

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Abisola,Oct 2025

LOS - CDG

The food option was finished and what wa left was vegan pasta so I had to go without food for an 8 hour flight without any sort of empathy from crew that was mean.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 31 October 2025.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Miami.

  • How much are direct flights from Panama City?

    On average, a one-way direct flight from Panama City will cost users approximately £583. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around £448.

  • How long is a direct flight from Panama City?

    While the flight duration depends heavily on the destination, on average, travelers can expect non-stop flights from Panama City to last approximately 3h 14m on average. The quickest direct flight from Panama City at this time departs from Panama City (1h 15m), while the longest leaves from Panama City (5h 13m).

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, August offers travelers the most options.

See more FAQs

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