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£127+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 31/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — LHR
22 Mar — 29 Mar1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 20 February 2026.

Fri 1/509:44
PTY
-
CTG
Nonstop1h 16m
Copa Airlines
Wed 6/512:05
CTG
-
PTY
Nonstop1h 19m
Copa Airlines
Deal found 19/2£206
Sun 10/507:24
PTY
-
CTG
Nonstop1h 16m
Copa Airlines
Sun 10/515:05
CTG
-
PTY
Nonstop1h 19m
Copa Airlines
Deal found 19/2£214
Thu 9/406:55
PTY
-
CTG
Nonstop1h 10m
Copa Airlines
Sun 12/409:45
CTG
-
PTY
Nonstop1h 18m
Copa Airlines
Deal found 18/2£220
Tue 7/721:45
PTY
-
CTG
Nonstop1h 14m
Copa Airlines
Sat 11/706:19
CTG
-
PTY
Nonstop1h 20m
Copa Airlines
Deal found 18/2£229
Wed 15/721:45
PTY
-
CTG
Nonstop1h 14m
Copa Airlines
Sat 25/715:04
CTG
-
PTY
Nonstop1h 20m
Copa Airlines
Deal found 18/2£237
Thu 19/307:30
PTY
-
CTG
Nonstop1h 11m
Copa Airlines
Mon 23/309:42
CTG
-
PTY
Nonstop1h 22m
Copa Airlines
Deal found 19/2£239
Thu 12/307:30
PTY
-
CTG
Nonstop1h 11m
Copa Airlines
Sun 15/309:42
CTG
-
PTY
Nonstop1h 22m
Copa Airlines
Deal found 19/2£244
Thu 2/412:52
PTY
-
CTG
Nonstop1h 13m
Copa Airlines
Mon 6/406:20
CTG
-
PTY
Nonstop1h 18m
Copa Airlines
Deal found 19/2£247
Sun 7/607:24
PTY
-
CTG
Nonstop1h 16m
Copa Airlines
Thu 11/615:05
CTG
-
PTY
Nonstop1h 19m
Copa Airlines
Deal found 19/2£252
Thu 2/406:55
PTY
-
CTG
Nonstop1h 10m
Copa Airlines
Sun 5/409:45
CTG
-
PTY
Nonstop1h 18m
Copa Airlines
Deal found 18/2£253
Thu 5/306:55
PTY
-
CTG
Nonstop1h 11m
Copa Airlines
Sun 8/309:42
CTG
-
PTY
Nonstop1h 22m
Copa Airlines
Deal found 19/2£266

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 858,174 searches. This data was last updated on 20 February 2026.

Fly to

Heathrow

Route

Depart

Return

Price

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Fri 1/5

09:44-11:00

Nonstop1h 16m

Cartagena Rafael Nunez

Tue 5/5

12:00-13:19

Nonstop1h 19m

£206

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Tue 5/5

07:24-08:40

Nonstop1h 16m

Cartagena Rafael Nunez

Mon 11/5

09:45-11:04

Nonstop1h 19m

£206

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Thu 7/5

07:24-08:40

Nonstop1h 16m

Cartagena Rafael Nunez

Sun 10/5

06:20-07:39

Nonstop1h 19m

£206

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Tue 19/5

07:24-08:40

Nonstop1h 16m

Cartagena Rafael Nunez

Sat 23/5

09:45-11:04

Nonstop1h 19m

£206

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Thu 14/5

06:54-08:10

Nonstop1h 16m

Cartagena Rafael Nunez

Mon 18/5

09:45-11:04

Nonstop1h 19m

£206

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Fri 1/5

09:44-11:00

Nonstop1h 16m

Cartagena Rafael Nunez

Wed 6/5

06:20-07:39

Nonstop1h 19m

£206

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Fri 15/5

07:24-08:40

Nonstop1h 16m

Cartagena Rafael Nunez

Sun 17/5

06:20-07:39

Nonstop1h 19m

£206

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Sun 19/4

07:29-08:40

Nonstop1h 11m

£127

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Sun 22/3

07:30-08:41

Nonstop1h 11m

£127

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Fri 3/4

09:47-11:00

Nonstop1h 13m

£127

Flights are sorted by cheapest return flights first.

Deals found on 19/2

Showing 1-10 of 19 results
1
2

Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines flying non-stop to Panama City

Get insights into the airlines that provide direct flights from Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight from Panama City. Reviews last updated Cheapflights.
Read through reviews of airlines serving Panama City, such as KLM, Air France, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.7
Good
1,457 reviews
Check prices

Boarding

7.8

Overall

7.7

Comfort

7.6

Crew

8.4

Entertainment

7.1

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
KLM
7.7
Good
1,457 reviews
KLM
7.7
Good
1,457 reviews
Check prices

Boarding

7.8

Overall

7.7

Comfort

7.6

Crew

8.4

Entertainment

7.1

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Air France
7.4
Good
1,533 reviews
KLM
7.7
Good
1,457 reviews
Check prices

Boarding

7.8

Overall

7.7

Comfort

7.6

Crew

8.4

Entertainment

7.1

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
United Airlines
7.4
Good
9,332 reviews
KLM
7.7
Good
1,457 reviews
Check prices

Boarding

7.8

Overall

7.7

Comfort

7.6

Crew

8.4

Entertainment

7.1

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Turkish Airlines
7.3
Good
4,224 reviews
KLM
7.7
Good
1,457 reviews
Check prices

Boarding

7.8

Overall

7.7

Comfort

7.6

Crew

8.4

Entertainment

7.1

Food

7.3

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 20 February 2026.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Madrid.

  • How much are direct flights from Panama City?

    On average, a one-way direct flight from Panama City will cost users approximately £431. If you're looking for a direct round-trip flight from Panama City, you can expect to pay around £580.

  • How long is a direct flight from Panama City?

    While the flight duration depends heavily on the destination, on average, travelers can expect non-stop flights from Panama City to last approximately 3h 47m on average. The quickest direct flight from Panama City at this time departs from Panama City (1h 11m), while the longest leaves from Panama City (9h 35m).

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, May is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, July offers travelers the most options.

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