£101+ Direct flights from Santo Domingo

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
SDQ — LHR
4 Mar — 11 Mar1
1 adult
1 adult, Economy, 0 bags

Direct flights from Santo Domingo

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo
Explore the most affordable flight options available from Santo Domingo. Find the lowest fares based on data from user searches, with prices last updated on 2 February 2026.

Fri 13/310:19
SDQ
-
MIA
Nonstop2h 20m
WorldTicket
Tue 24/319:25
MIA
-
SDQ
Nonstop2h 20m
WorldTicket
Deal found 2/2£270
Fri 13/310:19
SDQ
-
MIA
Nonstop2h 20m
WorldTicket
Mon 30/314:09
MIA
-
SDQ
Nonstop2h 20m
WorldTicket
Deal found 2/2£275
Mon 2/310:19
SDQ
-
MIA
Nonstop2h 20m
WorldTicket
Tue 10/319:25
MIA
-
SDQ
Nonstop2h 20m
WorldTicket
Deal found 1/2£280
Tue 17/215:54
SDQ
-
GUA
Nonstop3h 36m
WorldTicket
Thu 19/208:25
GUA
-
SDQ
Nonstop3h 35m
WorldTicket
Deal found 1/2£307
Fri 6/318:00
SDQ
-
CTG
Nonstop2h 02m
WorldTicket
Fri 13/319:47
CTG
-
SDQ
Nonstop2h 00m
WorldTicket
Deal found 1/2£309
Mon 22/610:19
SDQ
-
MIA
Nonstop2h 20m
WorldTicket
Fri 26/614:09
MIA
-
SDQ
Nonstop2h 20m
WorldTicket
Deal found 2/2£336
Mon 22/610:19
SDQ
-
MIA
Nonstop2h 20m
WorldTicket
Thu 25/620:52
MIA
-
SDQ
Nonstop2h 20m
WorldTicket
Deal found 2/2£521
Sat 13/615:35
SDQ
-
MIA
Nonstop2h 20m
WorldTicket
Sat 20/619:25
MIA
-
SDQ
Nonstop2h 20m
WorldTicket
Deal found 2/2£620
Sat 20/615:35
SDQ
-
MIA
Nonstop2h 20m
WorldTicket
Sat 27/619:25
MIA
-
SDQ
Nonstop2h 20m
WorldTicket
Deal found 2/2£770

Find direct flights from Santo Domingo within your budget

 
Use the slider to find direct flights from Santo Domingo within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 858,174 searches. This data was last updated on 2 February 2026.

Fly to

Heathrow

Route

Depart

Return

Price

Santo DomingoMiami

SDQ - MIA

SDQMIA

Santo Domingo Las Americas

Fri 13/3

10:19-12:39

Nonstop2h 20m

Miami

Tue 24/3

19:25-21:45

Nonstop2h 20m

£270

Santo DomingoMiami

SDQ - MIA

SDQMIA

Santo Domingo Las Americas

Fri 13/3

10:19-12:39

Nonstop2h 20m

Miami

Mon 30/3

14:09-16:29

Nonstop2h 20m

£275

Santo DomingoMiami

SDQ - MIA

SDQMIA

Santo Domingo Las Americas

Mon 2/3

10:19-11:39

Nonstop2h 20m

Miami

Tue 10/3

19:25-21:45

Nonstop2h 20m

£280

Santo DomingoMiami

SDQ - MIA

SDQMIA

Santo Domingo Las Americas

Mon 2/3

10:19-11:39

Nonstop2h 20m

Miami

Mon 9/3

14:09-16:29

Nonstop2h 20m

£280

Santo DomingoGuatemala City

SDQ - GUA

SDQGUA

Santo Domingo Las Americas

Tue 17/2

15:54-17:30

Nonstop3h 36m

Guatemala City La Aurora

Thu 19/2

08:25-14:00

Nonstop3h 35m

£307

Santo DomingoCartagena

SDQ - CTG

SDQCTG

Santo Domingo Las Americas

Fri 6/3

18:00-19:02

Nonstop2h 02m

Cartagena Rafael Nunez

Fri 13/3

19:47-22:47

Nonstop2h 00m

£309

Santo DomingoMiami

SDQ - MIA

SDQMIA

Santo Domingo Las Americas

Mon 22/6

10:19-12:39

Nonstop2h 20m

Miami

Fri 26/6

14:09-16:29

Nonstop2h 20m

£336

Santo DomingoMiami

SDQ - MIA

SDQMIA

Santo Domingo Las Americas

Mon 22/6

10:19-12:39

Nonstop2h 20m

Miami

Thu 25/6

20:52-23:12

Nonstop2h 20m

£521

Santo DomingoMiami

SDQ - MIA

SDQMIA

Santo Domingo Las Americas

Mon 22/6

10:19-12:39

Nonstop2h 20m

Miami

Mon 29/6

14:09-16:29

Nonstop2h 20m

£521

Santo DomingoMiami

SDQ - MIA

SDQMIA

Santo Domingo Las Americas

Mon 22/6

10:19-12:39

Nonstop2h 20m

Miami

Sun 28/6

19:25-21:45

Nonstop2h 20m

£521

Flights are sorted by cheapest return flights first.

Deals found on 1/2

Showing 1-10 of 24 results
1
2
3

Best time to book a flight from Santo Domingo

Have a flexible travel schedule? Discover the best time to fly from Santo Domingo with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Santo Domingo. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 2 February 2026.

  • Where can you fly direct from Santo Domingo?

    Currently, the most popular direct flight destination from Santo Domingo is Madrid.

  • What is the best time of year to fly direct from Santo Domingo?

    If you're seeking the lowest price on a direct flight from Santo Domingo, March is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, November offers travelers the most options.

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.