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Cheap flights from Santo Domingo to Cali from £197

SDQ — CLO
21 Oct — 28 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santo Domingo to Cali

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Cali

Thu 29/1008:57 -
1 stop15h 40m
Sun 1/1115:01 -
1 stop21h 09m
Deal found 17/9£365
Tue 22/908:47 -
1 stop6h 25m
Sat 26/915:12 -
1 stop10h 13m
Deal found 21/9£365
Mon 30/1112:45 -
1 stop5h 47m
Sat 5/1215:01 -
1 stop10h 07m
Deal found 17/9£383
Sun 20/906:06 -
1 stop6h 02m
Sun 20/915:12 -
1 stop24h 03m
Deal found 19/9£383
Wed 16/1212:45 -
1 stop10h 00m
Mon 4/108:50 -
1 stop8h 00m
Deal found 19/9£453
Sun 20/1215:58 -
1 stop15h 11m
Mon 4/122:21 -
1 stop15h 58m
Deal found 19/9£491
Mon 28/912:42 -
1 stop5h 39m
Sun 4/1005:00 -
1 stop5h 41m
Deal found 19/9£551
Wed 16/1212:45 -
1 stop9h 10m
Mon 4/108:58 -
2 stops16h 06m
Deal found 19/9£560
Sun 27/914:53 -
2 stops28h 12m
Tue 6/1010:40 -
2 stops25h 52m
Deal found 21/9£6,367

Find flight deals from Santo Domingo to Cali

Round-trip from

£365

One-way from

£197

Popular in

December

Cheapest in

February

Average price

£291
Copa Airlines
  • Copa Airlines
  • 29/10-1/11
  • 2 total stops
  • 36h 49m total
  • Santo Domingo to Cali
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Copa Airlines
  • Copa Airlines
  • 24/2-31/12
  • 1 total stop
  • 9h 39m total
  • Santo Domingo to Cali
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (£12 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£5 potential savings vs. average return price).
Search Deals
Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to Cali that are best for you.

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Price

Cheapest return flight
Fastest return journey

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Wed 24/2

08:54-17:33

1 stop9h 39m

Cali Alfonso B. Aragon Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£197

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Thu 29/10

08:57-23:37

1 stop15h 40m

Cali Alfonso B. Aragon Intl

Sun 1/11

15:01-13:10

1 stop21h 09m

£365

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Thu 19/11

19:06-14:06

1 stop20h 00m

Cali Alfonso B. Aragon Intl

Thu 26/11

12:05-22:58

1 stop9h 53m

£365

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Mon 5/10

18:41-14:10

1 stop20h 29m

Cali Alfonso B. Aragon Intl

Fri 9/10

12:06-11:41

1 stop22h 35m

£365

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Thu 29/10

12:48-17:51

1 stop6h 03m

Cali Alfonso B. Aragon Intl

Wed 4/11

15:01-11:07

1 stop19h 06m

£365

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Wed 20/1

08:52-17:06

1 stop9h 14m

Cali Alfonso B. Aragon Intl

Tue 26/1

15:12-16:08

1 stop23h 56m

£365

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Wed 16/12

12:45-21:45

1 stop10h 00m

Cali Alfonso B. Aragon Intl

Mon 4/1

08:50-17:50

1 stop8h 00m

£453

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Wed 24/2

14:53-23:35

3 stops33h 42m

Cali Alfonso B. Aragon Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£1,158

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Fri 8/1

14:53-17:34

3 stops27h 41m

Cali Alfonso B. Aragon Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£1,343

Flights are sorted by cheapest return flights first.

Deals found on 21/9

Sorted by cheapest first

Best time to book a flight from Santo Domingo to Cali

Have a flexible travel schedule? Discover the best time to fly to Cali from Santo Domingo with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Cali

How far ahead should I book a flight from Santo Domingo to Cali?

To ensure you get the cheapest price possible for a flight from Santo Domingo to Cali, you should look to book at least 49 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Santo Domingo to Cali?

Currently, February is the cheapest month in which you can book a flight from Santo Domingo to Cali (average of £262). Flying from Santo Domingo to Cali in December is currently the most expensive (average of £377). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Santo Domingo to Cali?

Airfare is typical for this route at the moment.

Santo Domingo to Cali flights typically cost between £285 and £367 in October.
The cheapest return price found within the last 5 days was £365 on Copa Airlines (29 Oct–1 Nov).

Related info for your journey

  • How long is the flight from Santo Domingo to Cali?

    A quick flight from Santo Domingo to Cali can take about 15h 40m. Copa Airlines provides one of the quickest options available for as low as £365. The distance between Santo Domingo and Cali is about 1123 mi.

  • Can I find deals for flights from Santo Domingo to Cali that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Cali flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Cali?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Cali.

  • Can I find deals for business class flights from Santo Domingo to Cali?

    Yes. Cheapflights offers flight deals from Santo Domingo to Cali by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Cali?

    Currently, February is the cheapest month in which you can book a flight from Santo Domingo to Cali (average of £262). Flying from Santo Domingo to Cali in December is currently the most expensive (average of £377). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Santo Domingo to Cali

Santo Domingo to Cartagena flights

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Users can book flights with no change fees policies with our dedicated filters. Book flights from Santo Domingo to Cali flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Santo Domingo to Cali become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Cali from Santo Domingo today and book when prices fit your budget.

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