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Cheap flights from Santo Domingo to Cali from £166

SDQ — CLO
7 Oct — 14 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santo Domingo to Cali

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Cali

Sun 20/906:06 -
1 stop6h 02m
Sun 20/915:12 -
1 stop18h 43m
Deal found 6/9£344
Mon 28/912:42 -
1 stop11h 51m
Sun 4/1018:36 -
1 stop16h 05m
Deal found 6/9£375

Find flight deals from Santo Domingo to Cali

Round-trip from

£344

One-way from

£166

Popular in

December

Cheapest in

February

Average price

£288
Copa Airlines
  • Copa Airlines
  • 18/1-24/1
  • 2 total stops
  • 22h 55m total
  • Santo Domingo to Cali
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Copa Airlines
  • Copa Airlines
  • 24/2-31/12
  • 1 total stop
  • 9h 39m total
  • Santo Domingo to Cali
Search Deals
Highest demand for flights based on searches. 1% potential increase in price (£3 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£5 potential savings vs. average return price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to Cali that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Wed 24/2

08:54-17:33

1 stop9h 39m

Cali Alfonso B. Aragon Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£166
Fastest return journey

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Mon 18/1

12:42-17:34

1 stop5h 52m

Cali Alfonso B. Aragon Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£166

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Mon 11/1

19:05-11:00

1 stop16h 55m

Cali Alfonso B. Aragon Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£183

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Mon 18/1

08:52-17:34

1 stop9h 42m

Cali Alfonso B. Aragon Intl

Sun 24/1

08:41-22:54

1 stop13h 13m

£344

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Thu 19/11

19:06-14:06

1 stop20h 00m

Cali Alfonso B. Aragon Intl

Thu 26/11

12:05-22:58

1 stop9h 53m

£344

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Thu 24/9

12:42-17:33

1 stop5h 51m

Cali Alfonso B. Aragon Intl

Sun 27/9

15:12-13:13

1 stop21h 01m

£344

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Sun 20/9

06:06-11:08

1 stop6h 02m

Cali Alfonso B. Aragon Intl

Sun 20/9

15:12-10:55

1 stop18h 43m

£344

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Mon 2/11

08:55-17:32

1 stop9h 37m

Cali Alfonso B. Aragon Intl

Thu 12/11

18:08-11:45

1 stop16h 37m

£344

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Wed 20/1

12:42-23:34

1 stop11h 52m

Cali Alfonso B. Aragon Intl

Mon 25/1

04:38-22:54

1 stop17h 16m

£344

Santo DomingoCali

SDQ Santo Domingo Las Americas - CLO Cali Alfonso B. Aragon Intl

SDQCLO

Santo Domingo Las Americas

Wed 24/2

14:53-23:35

3 stops33h 42m

Cali Alfonso B. Aragon Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£1,128

Flights are sorted by cheapest return flights first.

Deals found on 4/9

Sorted by cheapest first

Best time to book a flight from Santo Domingo to Cali

Have a flexible travel schedule? Discover the best time to fly to Cali from Santo Domingo with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Cali

How far ahead should I book a flight from Santo Domingo to Cali?

To ensure you get the cheapest price possible for a flight from Santo Domingo to Cali, you should look to book at least 49 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Santo Domingo to Cali?

Currently, February is the cheapest month in which you can book a flight from Santo Domingo to Cali (average of £260). Flying from Santo Domingo to Cali in December is currently the most expensive (average of £373). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Santo Domingo to Cali?

Airfare is above average for this route at the moment.

Santo Domingo to Cali flights typically cost between £278 and £306 in September.
The cheapest return price found within the last 5 days was £344 on Copa Airlines (20 Sept–20 Sept).

Related info for your journey

  • How long is the flight from Santo Domingo to Cali?

    A quick flight from Santo Domingo to Cali can take about 9h 42m. Copa Airlines provides one of the quickest options available for as low as £344. The distance between Santo Domingo and Cali is about 1123 mi.

  • Can I find deals for flights from Santo Domingo to Cali that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Cali flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Cali?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Cali.

  • Can I find deals for business class flights from Santo Domingo to Cali?

    Yes. Cheapflights offers flight deals from Santo Domingo to Cali by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Cali?

    Currently, February is the cheapest month in which you can book a flight from Santo Domingo to Cali (average of £260). Flying from Santo Domingo to Cali in December is currently the most expensive (average of £373). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Santo Domingo to Cali

Santo Domingo to Cartagena flights

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Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Cali from Santo Domingo today and book when prices fit your budget.

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