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Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £418

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 31/12. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
23 Nov — 30 Nov1
1 adult
1 adult, Economy, 0 bags

Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or March, booked 74 days in advance, depart on a Thursday or Tuesday and return on a Monday

Find flight deals from Madrid to Santa Cruz de la Sierra

Enter your travel dates to find the best prices.

Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 24 October 2025.

Sun 23/1101:20MAD - VVI
1 stop30h 15mAvianca
Sat 6/1203:40VVI - MAD
1 stop24h 10mAvianca
Deal found 23/10£715
Thu 25/1210:50MAD - VVI
1 stop20h 45mAvianca
Sat 24/103:40VVI - MAD
1 stop14h 40mAvianca
Deal found 23/10£798
Sat 22/1110:50MAD - VVI
1 stop20h 45mAvianca
Fri 28/1103:40VVI - MAD
1 stop14h 40mAvianca
Deal found 23/10£808
Thu 20/1101:20MAD - VVI
1 stop30h 15mAvianca
Mon 15/1203:40VVI - MAD
1 stop28h 45mAvianca
Deal found 22/10£832

Cheap flight deals from Madrid to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 24 October 2025.

Round-trip from

£658

One-way from

£418

Popular in

December

Cheapest in

May

Average price

£768
Avianca
  • Avianca
  • 4/3-18/3
  • 2 total stops
  • 54h 25m total
  • Madrid to Santa Cruz de la Sierra
Search Deals
Air Europa
  • Air Europa
  • 31/12
  • Nonstop
  • 11h 20m total
  • Madrid to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 6% potential increase in price (£41 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease (£20 potential savings vs. average return price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 24 October 2025.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.

Fly from

Madrid

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Thu 5/3

06:35-02:35

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Wed 18/3

03:40-08:50

1 stop24h 10m

£658

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Tue 10/2

06:35-02:35

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Mon 9/3

03:40-13:25

1 stop28h 45m

£715

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Sun 23/11

01:20-02:35

1 stop30h 15m

Santa Cruz de la Sierra Viru Viru Intl

Sat 6/12

03:40-23:20

1 stop14h 40m

£716

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Thu 20/11

01:20-02:35

1 stop30h 15m

Santa Cruz de la Sierra Viru Viru Intl

Thu 27/11

03:40-08:50

1 stop24h 10m

£716

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Thu 2/4

17:30-01:50

1 stop38h 20m

Santa Cruz de la Sierra Viru Viru Intl

Thu 16/4

02:55-23:30

1 stop14h 35m

£746

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Thu 2/4

17:30-01:50

1 stop38h 20m

Santa Cruz de la Sierra Viru Viru Intl

Fri 17/4

02:55-07:40

1 stop22h 45m

£746

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Fri 3/4

09:40-01:50

1 stop22h 10m

Santa Cruz de la Sierra Viru Viru Intl

Sun 19/4

02:55-07:40

1 stop22h 45m

£746

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Fri 3/4

09:40-01:50

1 stop22h 10m

Santa Cruz de la Sierra Viru Viru Intl

Thu 16/4

02:55-23:30

1 stop14h 35m

£746

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Wed 31/12

23:35-05:55

Nonstop11h 20m

£418

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Wed 31/12

10:50-02:35

1 stop20h 45m

£478

Flights are sorted by cheapest return flights first.

Deals found on 22/10

Showing 1-10 of 11 results
1
2

Best time to book a flight from Madrid to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra

How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a return flight from Madrid to Santa Cruz de la Sierra. Price data was last updated on 17 October 2025.

The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 74 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?

Currently, May is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £486). Flying from Madrid to Santa Cruz de la Sierra in December is currently the most expensive (average of £687). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to VVI?

Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 24 October 2025.

It’s typically best to fly out from Madrid to Santa Cruz de la Sierra in the afternoon. Doing so could potentially save you 31% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 24 October 2025.
Check out reviews from past customers who have flown with Iberia, BoA, andAvianca from Madrid to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Iberia
7.0
Good
2,997 reviews
Check prices

Comfort

6.7

Entertainment

6.6

Boarding

7.1

Crew

7.7

Food

6.3

Overall

7.0

Reviews

1 / 20
2.0
Mediocre

Gaby,Aug 2025

BCN - ORD

Our flight kept getting delayed due to the weather and mechanical issues. Then it was canceled and rescheduled until the following day which was also delayed by a couple hours and the returning flight was also delayed so overall, we wasted a lot of time on the airport. Also, when it happened the first day, they did not want to honor a hotel or rideshare service voucher because it was hard to find an uber at 3-4 in the morning and customer service was closed that late in the day.
Iberia
7.0
Good
2,997 reviews
Iberia
7.0
Good
2,997 reviews
Check prices

Comfort

6.7

Entertainment

6.6

Boarding

7.1

Crew

7.7

Food

6.3

Overall

7.0

Reviews

1 / 20
2.0
Mediocre

Gaby,Aug 2025

BCN - ORD

Our flight kept getting delayed due to the weather and mechanical issues. Then it was canceled and rescheduled until the following day which was also delayed by a couple hours and the returning flight was also delayed so overall, we wasted a lot of time on the airport. Also, when it happened the first day, they did not want to honor a hotel or rideshare service voucher because it was hard to find an uber at 3-4 in the morning and customer service was closed that late in the day.
BoA
6.7
Okay
135 reviews
Iberia
7.0
Good
2,997 reviews
Check prices

Comfort

6.7

Entertainment

6.6

Boarding

7.1

Crew

7.7

Food

6.3

Overall

7.0

Reviews

1 / 20
2.0
Mediocre

Gaby,Aug 2025

BCN - ORD

Our flight kept getting delayed due to the weather and mechanical issues. Then it was canceled and rescheduled until the following day which was also delayed by a couple hours and the returning flight was also delayed so overall, we wasted a lot of time on the airport. Also, when it happened the first day, they did not want to honor a hotel or rideshare service voucher because it was hard to find an uber at 3-4 in the morning and customer service was closed that late in the day.
Avianca
6.7
Okay
2,460 reviews
Iberia
7.0
Good
2,997 reviews
Check prices

Comfort

6.7

Entertainment

6.6

Boarding

7.1

Crew

7.7

Food

6.3

Overall

7.0

Reviews

1 / 20
2.0
Mediocre

Gaby,Aug 2025

BCN - ORD

Our flight kept getting delayed due to the weather and mechanical issues. Then it was canceled and rescheduled until the following day which was also delayed by a couple hours and the returning flight was also delayed so overall, we wasted a lot of time on the airport. Also, when it happened the first day, they did not want to honor a hotel or rideshare service voucher because it was hard to find an uber at 3-4 in the morning and customer service was closed that late in the day.

Related info for your journey

Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Madrid to Santa Cruz de la Sierra flight route?

    The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 8 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Madrid to Santa Cruz de la Sierra?

    For as low as £715, Avianca can have you in Santa Cruz de la Sierra from Madrid in 30h 15m. Madrid and Santa Cruz de la Sierra are separated by a distance of 5537 mi.

  • What are the cheapest airlines flying from Madrid to Santa Cruz de la Sierra round-trip?

    BoA, at £534, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.Alternate airlines flying return to your destination include Iberia and Avianca. Users have found that BoA is 32% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Santa Cruz de la Sierra on time: BoA (72%), Iberia (72%), Air Europa (63%).

  • What are the cheapest flights from Madrid to Santa Cruz de la Sierra?

    Looking for the cheapest flight from Madrid to Santa Cruz de la Sierra? While on average our users pay £1,552, our data indicates the cheapest price to be £1,116. The most popular route (Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl), is priced around £841.

  • Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?

    Currently, May is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £486). Flying from Madrid to Santa Cruz de la Sierra in December is currently the most expensive (average of £687). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Madrid to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Madrid to La Paz flights

Top 3 airlines flying from Madrid to Santa Cruz de la Sierra

Discover the top 3 airlines that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 24 October 2025.
AirlineCheapestAverageFlexibilityOn-time
BoACheapest£534Average£683FlexibilityNo cancel feeOn-timeN/A
Search BoA flights
IberiaCheapest£558Average£607FlexibilityNo cancel feeOn-time77%
Search Iberia flights
AviancaCheapest£567Average£752FlexibilityNo cancel feeOn-time71%
Search Avianca flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?

Cheapflights makes it easy to find Madrid to Santa Cruz de la Sierra flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?

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Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?

Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?

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