Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £368
This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
3 Dec — 10 Dec1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in September or April, booked 43 days in advance, depart on a Wednesday or Friday and return on a Monday
Cheap flight deals from Madrid to Santa Cruz de la Sierra
Enter your travel dates to find the best prices.
Cheapest
Best
Direct
Last-minute
One-way
Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 3 November 2026.
Sat 21/1110:10 -
1 stop21h 30m
Wed 23/1203:45 -
1 stop23h 25m
Deal found 30/10£782
Wed 18/1110:10 -
1 stop21h 30m
Wed 23/1203:45 -
1 stop23h 25m
Deal found 2/11£782
Sat 28/1110:10 -
1 stop21h 30m
Wed 23/1203:45 -
1 stop14h 40m
Deal found 1/11£802
Sun 29/1110:10 -
1 stop21h 30m
Wed 23/1203:45 -
1 stop23h 25m
Deal found 1/11£851
Sat 5/1208:10 -
1 stop23h 30m
Thu 4/303:45 -
1 stop14h 40m
Deal found 2/11£861
Sat 28/1110:10 -
1 stop21h 30m
Sun 20/1203:45 -
1 stop23h 25m
Deal found 1/11£908
Sat 5/1211:00 -
2 stops40h 48m
Mon 25/111:53 -
2 stops40h 37m
Deal found 2/11£933
Thu 26/1106:40 -
2 stops25h 00m
Wed 23/1203:45 -
1 stop28h 40m
Deal found 1/11£940
Sun 29/1110:10 -
1 stop21h 30m
Tue 22/1203:45 -
2 stops34h 40m
Deal found 1/11£943
Best flights from Madrid to Santa Cruz de la Sierra
Discover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 3 November 2026.
Wed 13/106:40 -
2 stops25h 00m
Sat 30/103:45 -
1 stop28h 40m
Deal found 2/11£729
Wed 14/414:45 -
Nonstop11h 00m
Sat 17/419:30 -
Nonstop10h 45m
Deal found 29/10£796
Sun 22/1111:00 -
2 stops40h 38m
Sat 5/1211:34 -
2 stops39h 11m
Deal found 3/11£1,165
Fri 5/208:10 -
1 stop23h 30m
Thu 1/403:35 -
2 stops26h 25m
Deal found 31/10£732
Thu 4/208:10 -
1 stop23h 30m
Sat 3/403:35 -
2 stops25h 35m
Deal found 31/10£732
Mon 1/211:55 -
3 stops44h 48m
Wed 31/309:56 -
2 stops42h 34m
Deal found 1/11£1,736
Sat 6/208:10 -
1 stop23h 30m
Sat 3/403:35 -
2 stops25h 35m
Deal found 31/10£769
Tue 23/306:40 -
2 stops25h 00m
Tue 30/303:35 -
2 stops26h 25m
Deal found 30/10£771
Tue 12/120:00 -
2 stops35h 40m
Mon 25/103:45 -
2 stops37h 55m
Deal found 2/11£865
Sun 13/1211:00 -
2 stops40h 48m
Wed 20/111:53 -
2 stops40h 37m
Deal found 2/11£1,536
Wed 18/1106:40 -
2 stops25h 00m
Wed 23/1203:45 -
1 stop23h 25m
Deal found 31/10£1,115
Tue 22/1201:25 -
1 stop30h 15m
Fri 8/103:45 -
1 stop21h 25m
Deal found 30/10£1,726
Direct flights from Madrid to Santa Cruz de la Sierra
Explore direct flight options from Madrid to Santa Cruz de la Sierra based on user searches, and compare prices and availability for your desired travel dates. Data last updated 3 November 2026.
Wed 14/414:45 -
Nonstop11h 00m
Sat 17/419:30 -
Nonstop10h 45m
Deal found 29/10£796
Fri 29/103:05 -
Nonstop11h 20m
Thu 25/213:30 -
Nonstop10h 40m
Deal found 3/11£902
Wed 6/123:35 -
Nonstop11h 20m
Thu 21/113:30 -
Nonstop10h 40m
Deal found 30/10£1,148
Last-minute flights from Madrid to Santa Cruz de la Sierra
Discover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated 3 November 2026 and is based on user searches.
Wed 18/1110:10 -
1 stop21h 30m
Wed 23/1203:45 -
1 stop23h 25m
Deal found 2/11£782
Sat 21/1110:10 -
1 stop21h 30m
Wed 23/1203:45 -
1 stop23h 25m
Deal found 30/10£782
Thu 26/1106:40 -
2 stops25h 00m
Wed 23/1203:45 -
1 stop28h 40m
Deal found 1/11£940
Sat 28/1110:10 -
1 stop21h 30m
Wed 23/1203:45 -
1 stop14h 40m
Deal found 1/11£802
Sat 28/1110:10 -
1 stop21h 30m
Sun 20/1203:45 -
1 stop23h 25m
Deal found 1/11£908
Sun 29/1110:10 -
1 stop21h 30m
Wed 23/1203:45 -
1 stop23h 25m
Deal found 1/11£851
Sun 29/1110:10 -
1 stop21h 30m
Tue 22/1203:45 -
2 stops34h 40m
Deal found 1/11£943
Sat 5/1208:10 -
1 stop23h 30m
Thu 4/303:45 -
1 stop14h 40m
Deal found 2/11£861
Sat 5/1211:00 -
2 stops40h 48m
Mon 25/111:53 -
2 stops40h 37m
Deal found 2/11£933
One-way flights from Madrid to Santa Cruz de la Sierra
Search for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated 3 November 2026.
Mon 8/306:40 -
2 stops25h 00m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 1/11£368
Mon 1/306:40 -
2 stops25h 00m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 31/10£368
Tue 16/220:00 -
2 stops35h 40m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 2/11£374
Fri 5/306:40 -
2 stops25h 00m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 31/10£389
Mon 1/208:10 -
1 stop23h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 2/11£393
Tue 26/101:25 -
1 stop30h 15m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 3/11£394
Tue 19/106:40 -
2 stops25h 00m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 3/11£411
Tue 17/1115:50 -
2 stops39h 50m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 3/11£416
Mon 18/119:10 -
2 stops36h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 3/11£418
Thu 21/108:10 -
1 stop23h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 3/11£428
Find flight deals from Madrid to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 3 November 2026.
Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 3 November 2026.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Fri 5/3
06:40-02:40
2 stops25h 00m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£390
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Fri 29/1
07:05-02:40
2 stops24h 35m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£390
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Tue 26/1
01:25-02:40
1 stop30h 15m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£393
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Tue 9/3
06:40-02:40
2 stops25h 00m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£410
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Mon 8/3
06:40-02:40
2 stops25h 00m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£410
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 10/3
06:40-02:40
2 stops25h 00m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£411
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Thu 21/1
08:10-02:40
1 stop23h 30m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£428
Fastest return journey
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Thu 31/12
10:10-02:40
1 stop21h 30m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£480
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Sun 17/1
20:00-02:40
2 stops35h 40m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£609
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 9/12
11:00-22:48
2 stops40h 48m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£653
Flights are sorted by cheapest return flights first.
Deals found on 1/11
Showing 1-10 of 23 resultsSorted by cheapest first
1
2
3
Best time to book a flight from Madrid to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
MAD-VVI
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra
Prices
Delays
More
How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?
The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 42 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, September is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £623). Flying from Madrid to Santa Cruz de la Sierra in December is currently the most expensive (average of £1,068). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to VVI?
Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 3 November 2026.
When flying from Madrid to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost for a return flight from Madrid to Santa Cruz de la Sierra?
Airfare is typical for this route at the moment.
Madrid to Santa Cruz de la Sierra flights typically cost between £661 and £1,028 in February.The cheapest return price found within the last 5 days was £667 on Avianca (13 Feb–26 Feb).
How often are flights from Madrid to Santa Cruz de la Sierra delayed?
About 47% of weekly flights between Madrid and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 141 minutes.
What is the most punctual flight time for Madrid to Santa Cruz de la Sierra flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Santa Cruz de la Sierra flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 35% of flights being delayed.
What’s the top stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Share of one-stop return flights from Madrid to Santa Cruz de la Sierra chosen by Cheapflights users in the past 12 months, using the same stopover each way.
Lima (LIM) – chosen by Cheapflights users on 60% of one-stop itineraries from Madrid to Santa Cruz de la Sierra on Cheapflights.
What’s the cheapest stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Average return fare for one-stop flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the past 12 months, with the same stopover each way.
Lima (LIM) is the most affordable one-stop option, with an average return flight price of £650.
What’s the fastest stopover option from Madrid to Santa Cruz de la Sierra?
Shortest average travel time for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for one-stop routes: 18h 18m.
Which airport typically offers the quickest stopover for flights from Madrid to Santa Cruz de la Sierra?
Average stopover duration for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) offer the fastest connection on this route, with an average stopover time of 2h 39m.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 3 November 2026.
Check out reviews from past customers who have flown with BoA and Avianca from Madrid to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
its hard to comment on crew because now in days there is very or little interaction. food not so good. everything else very good
Related info for your journey
Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Madrid to Santa Cruz de la Sierra?
If you book a flight from Madrid to Santa Cruz de la Sierra, you will be flying from Barajas to Viru Viru Intl. Flights to Santa Cruz de la Sierra Viru Viru Intl (VVI) from Madrid Barajas (MAD) take 40h 48m for a nonstop flight. There is 1 flight from Barajas to Santa Cruz de la Sierra per day from 2 airlines.
How popular is this Madrid to Santa Cruz de la Sierra flight route?
The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Madrid to Santa Cruz de la Sierra?
For as low as £729, Avianca can have you in Santa Cruz de la Sierra from Madrid in 25h. Madrid and Santa Cruz de la Sierra are separated by a distance of 5537 mi.
What are the cheapest airlines flying from Madrid to Santa Cruz de la Sierra round-trip?
Avianca, at £533, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra. An alternate airline flying to your destination would be BoA. Users have found that Avianca is 33% cheaper than the other options available to this destination.
What are the cheapest airlines to fly from Madrid to Santa Cruz de la Sierra one-way?
£264 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on BoA and Iberia, with prices starting from £345 and £386, respectively.
What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Santa Cruz de la Sierra on time: Air Europa (69%), BoA (15%), Iberia (15%).
What are the cheapest flights from Madrid to Santa Cruz de la Sierra?
Looking for the cheapest flight from Madrid to Santa Cruz de la Sierra? While on average our users pay £898, our data indicates the cheapest price to be £417. The most popular route (Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl), is priced around £915.
Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Madrid to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.
Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, September is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £623). Flying from Madrid to Santa Cruz de la Sierra in December is currently the most expensive (average of £1,068). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Top 2 airlines flying from Madrid to Santa Cruz de la Sierra
Discover the top 2 airlines that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 3 November 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?
Cheapflights makes it easy to find Madrid to Santa Cruz de la Sierra flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.
Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Madrid to Santa Cruz de la Sierra for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?
Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.
Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?
Of course! You can now track prices for flights from Madrid to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
We value your privacy
Cheapflights and its partners wish to use cookies or similar technologies to store and/or access information on and about your device and process personal data such as your IP address, device identifiers etc., in order to improve your experience on the site, to analyse navigation, to offer and measure personalised advertising, and to facilitate sharing on social networks. We also allow the use of third-party cookies (including those from our advertising partners) on our sites.
By clicking 'Accept', you consent to your data being processed by 0 vendors on this web site for the purposes described in this notice. You can review the vendors and their individual processing purposes on the .
To review individual processing purposes and cookie categories, please click ’Select individual purposes’. You can review your choices and withdraw your consent at any time by clicking the ’Privacy Preferences’ link in the page side navigation.