Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £281
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
23 Apr — 30 Apr1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in March or September, booked 56 days in advance, depart on a Tuesday or Thursday and return on a Tuesday
Cheap flight deals from Madrid to Santa Cruz de la Sierra
Enter your travel dates to find the best prices.
Cheapest
Best
Direct
Last-minute
One-way
Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 24 March 2026.
Mon 1/611:05
MAD
-
VVI
1 stop21h 25m
Avianca
Tue 30/603:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£509
Tue 6/1011:05
MAD
-
VVI
1 stop21h 25m
Avianca
Mon 26/1003:40
VVI
-
MAD
1 stop24h 10m
Avianca
Deal found 21/3£511
Tue 14/411:05
MAD
-
VVI
1 stop21h 25m
Avianca
Fri 24/403:35
VVI
-
MAD
1 stop28h 30m
Avianca
Deal found 19/3£524
Fri 8/517:20
MAD
-
VVI
1 stop15h 10m
Avianca
Sun 19/703:35
VVI
-
MAD
2 stops56h 30m
Avianca
Deal found 21/3£525
Sun 3/508:10
MAD
-
VVI
1 stop24h 20m
Avianca
Sat 30/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£532
Fri 1/511:05
MAD
-
VVI
1 stop21h 25m
Avianca
Sun 31/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 19/3£558
Thu 2/411:05
MAD
-
VVI
1 stop21h 25m
Avianca
Sun 3/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 23/3£559
Sun 3/508:10
MAD
-
VVI
1 stop24h 20m
Avianca
Mon 1/603:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£560
Sat 26/908:10
MAD
-
VVI
1 stop24h 20m
Avianca
Fri 27/1103:40
VVI
-
MAD
1 stop28h 45m
Avianca
Deal found 20/3£561
Fri 17/417:20
MAD
-
VVI
1 stop15h 10m
Avianca
Fri 1/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£563
Fri 8/508:10
MAD
-
VVI
1 stop24h 20m
Avianca
Wed 20/503:35
VVI
-
MAD
1 stop23h 30m
Avianca
Deal found 23/3£566
Best flights from Madrid to Santa Cruz de la Sierra
Discover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 24 March 2026.
Mon 4/511:05
MAD
-
VVI
1 stop21h 25m
Avianca
Sat 30/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£532
Sun 19/407:05
MAD
-
VVI
2 stops25h 25m
Avianca
Tue 19/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 22/3£615
Sun 19/407:05
MAD
-
VVI
2 stops25h 25m
Avianca
Sat 23/503:35
VVI
-
MAD
1 stop20h 35m
Avianca
Deal found 22/3£615
Fri 1/511:05
MAD
-
VVI
1 stop21h 25m
Avianca
Sun 31/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 22/3£622
Sun 12/408:10
MAD
-
VVI
1 stop24h 20m
Avianca
Thu 23/403:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 19/3£634
Sat 2/511:05
MAD
-
VVI
1 stop21h 25m
Avianca
Mon 1/603:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£637
Sun 26/407:05
MAD
-
VVI
2 stops25h 25m
Avianca
Wed 13/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 21/3£663
Tue 14/417:20
MAD
-
VVI
1 stop15h 10m
Avianca
Sun 26/403:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 19/3£682
Mon 13/408:10
MAD
-
VVI
1 stop24h 20m
Avianca
Mon 27/403:35
VVI
-
MAD
1 stop28h 30m
Avianca
Deal found 19/3£761
Wed 10/608:10
MAD
-
VVI
1 stop24h 20m
Avianca
Sat 5/903:35
VVI
-
MAD
2 stops38h 35m
Avianca
Deal found 21/3£788
Fri 29/511:05
MAD
-
VVI
1 stop21h 25m
Avianca
Mon 29/603:35
VVI
-
MAD
2 stops32h 30m
Avianca
Deal found 21/3£809
Direct flights from Madrid to Santa Cruz de la Sierra
Explore direct flight options from Madrid to Santa Cruz de la Sierra based on user searches, and compare prices and availability for your desired travel dates. Data last updated 24 March 2026.
Fri 8/521:00
MAD
-
VVI
Nonstop11h 30m
Iberia
Mon 20/721:15
VVI
-
MAD
Nonstop10h 40m
Iberia
Deal found 21/3£758
Fri 3/421:00
MAD
-
VVI
Nonstop11h 30m
BoA
Mon 20/421:15
VVI
-
MAD
Nonstop10h 40m
BoA
Deal found 23/3£1,428
Fri 3/421:00
MAD
-
VVI
Nonstop11h 30m
BoA
Sat 18/420:05
VVI
-
MAD
Nonstop10h 40m
BoA
Deal found 23/3£1,468
Last-minute flights from Madrid to Santa Cruz de la Sierra
Discover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated 24 March 2026 and is based on user searches.
Thu 2/411:05
MAD
-
VVI
1 stop21h 25m
Avianca
Sun 3/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 23/3£559
Sun 12/402:20
MAD
-
VVI
1 stop30h 10m
Avianca
Sat 23/503:35
VVI
-
MAD
1 stop20h 35m
Avianca
Deal found 22/3£571
Sun 12/408:10
MAD
-
VVI
1 stop24h 20m
Avianca
Fri 24/403:35
VVI
-
MAD
1 stop28h 30m
Avianca
Deal found 19/3£593
Tue 14/411:05
MAD
-
VVI
1 stop21h 25m
Avianca
Fri 24/403:35
VVI
-
MAD
1 stop28h 30m
Avianca
Deal found 19/3£524
Thu 16/411:05
MAD
-
VVI
1 stop21h 25m
Avianca
Fri 24/403:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£613
Fri 17/417:20
MAD
-
VVI
1 stop15h 10m
Avianca
Fri 1/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£563
Sun 19/407:05
MAD
-
VVI
2 stops25h 25m
Avianca
Tue 19/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 22/3£615
Sun 26/407:05
MAD
-
VVI
2 stops25h 25m
Avianca
Wed 13/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 20/3£611
Mon 27/408:10
MAD
-
VVI
1 stop24h 20m
Avianca
Sat 16/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 21/3£532
Mon 27/411:05
MAD
-
VVI
1 stop21h 25m
Avianca
Thu 14/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 21/3£592
Wed 29/411:05
MAD
-
VVI
1 stop21h 25m
Avianca
Sun 10/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 21/3£561
Wed 29/411:05
MAD
-
VVI
1 stop21h 25m
Avianca
Sat 16/503:35
VVI
-
MAD
1 stop14h 45m
Avianca
Deal found 21/3£610
One-way flights from Madrid to Santa Cruz de la Sierra
Search for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated 24 March 2026.
Fri 10/402:20
MAD
-
VVI
1 stop30h 10m
Avianca
Deal found 20/3£281
Fri 11/902:10
MAD
-
VVI
2 stops30h 20m
Avianca
Deal found 22/3£325
Sat 16/511:05
MAD
-
VVI
1 stop21h 25m
Avianca
Deal found 20/3£331
Fri 29/511:05
MAD
-
VVI
1 stop21h 25m
Avianca
Deal found 19/3£357
Sun 10/507:05
MAD
-
VVI
2 stops25h 25m
Avianca
Deal found 20/3£410
Sat 9/520:00
MAD
-
VVI
2 stops36h 30m
Avianca
Deal found 19/3£423
Wed 19/811:25
MAD
-
VVI
2 stops21h 05m
Avianca
Deal found 22/3£479
Mon 30/319:05
MAD
-
VVI
2 stops37h 25m
Avianca
Deal found 21/3£496
Sun 12/720:20
MAD
-
VVI
2 stops36h 10m
Avianca
Deal found 20/3£498
Mon 13/711:05
MAD
-
VVI
1 stop21h 25m
Avianca
Deal found 21/3£508
Mon 14/911:25
MAD
-
VVI
2 stops21h 05m
Avianca
Deal found 22/3£520
Find flight deals from Madrid to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 24 March 2026.
Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 24 March 2026.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 4/5
11:05-02:30
1 stop21h 25m
Santa Cruz de la Sierra Viru Viru Intl
Sat 30/5
03:35-00:20
1 stop14h 45m
£532
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 19/4
07:05-02:30
2 stops25h 25m
Santa Cruz de la Sierra Viru Viru Intl
Tue 19/5
03:35-00:20
1 stop14h 45m
£615
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 19/4
07:05-02:30
2 stops25h 25m
Santa Cruz de la Sierra Viru Viru Intl
Sat 23/5
03:35-06:10
1 stop20h 35m
£615
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Fri 1/5
11:05-02:30
1 stop21h 25m
Santa Cruz de la Sierra Viru Viru Intl
Sun 31/5
03:35-00:20
1 stop14h 45m
£622
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 12/4
08:10-02:30
1 stop24h 20m
Santa Cruz de la Sierra Viru Viru Intl
Thu 23/4
03:35-00:20
1 stop14h 45m
£634
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sat 2/5
11:05-02:30
1 stop21h 25m
Santa Cruz de la Sierra Viru Viru Intl
Mon 1/6
03:35-00:20
1 stop14h 45m
£637
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 26/4
07:05-02:30
2 stops25h 25m
Santa Cruz de la Sierra Viru Viru Intl
Wed 13/5
03:35-00:20
1 stop14h 45m
£663
Fastest return journey
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Tue 14/4
17:20-02:30
1 stop15h 10m
Santa Cruz de la Sierra Viru Viru Intl
Sun 26/4
03:35-00:20
1 stop14h 45m
£682
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 13/4
08:10-02:30
1 stop24h 20m
Santa Cruz de la Sierra Viru Viru Intl
Mon 27/4
03:35-14:05
1 stop28h 30m
£761
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Wed 10/6
08:10-02:30
1 stop24h 20m
Santa Cruz de la Sierra Viru Viru Intl
Sat 5/9
03:35-00:10
2 stops38h 35m
£788
Flights are sorted by cheapest return flights first.
Deals found on 20/3
Showing 1-10 of 22 resultsSorted by cheapest first
1
2
3
Best time to book a flight from Madrid to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
MAD-VVI
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra
Prices
Delays
More
How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?
Use this chart to determine the optimal time to book a return flight from Madrid to Santa Cruz de la Sierra. Price data was last updated on 13 March 2026.
The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 56 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, March is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £456). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of £810). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to VVI?
Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 24 March 2026.
When flying from Madrid to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost for a return flight from Madrid to Santa Cruz de la Sierra?
How often are flights from Madrid to Santa Cruz de la Sierra delayed?
About 45% of weekly flights between Madrid and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 130 minutes.
What is the most punctual flight time for Madrid to Santa Cruz de la Sierra flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Santa Cruz de la Sierra flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 41% of flights being delayed.
What’s the top stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Share of one-stop return flights from Madrid to Santa Cruz de la Sierra chosen by Cheapflights users in the past 12 months, using the same stopover each way.
Lima (LIM) – chosen by Cheapflights users on 57% of one-stop itineraries from Madrid to Santa Cruz de la Sierra on Cheapflights.
What’s the cheapest stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Average return fare for one-stop flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the past 12 months, with the same stopover each way.
Lima (LIM) is the most affordable one-stop option, with an average return flight price of £758.
What’s the fastest stopover option from Madrid to Santa Cruz de la Sierra?
Shortest average travel time for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for one-stop routes: 19h 50m.
Which airport typically offers the quickest stopover for flights from Madrid to Santa Cruz de la Sierra?
Average stopover duration for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) offer the fastest connection on this route, with an average stopover time of 3h 12m.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 24 March 2026.
Check out reviews from past customers who have flown with Avianca from Madrid to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Customer service was great from the counter to the light crew. It would be nice if the airplanes were equipped with in-flight entertainment system for such a longhaul flight.
Customer service was great from the counter to the light crew. It would be nice if the airplanes were equipped with in-flight entertainment system for such a longhaul flight.
Related info for your journey
Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
How popular is this Madrid to Santa Cruz de la Sierra flight route?
The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Madrid to Santa Cruz de la Sierra?
For as low as £532, Avianca can have you in Santa Cruz de la Sierra from Madrid in 21h 25m. Madrid and Santa Cruz de la Sierra are separated by a distance of 5537 mi.
What is the cheapest airline to fly from Madrid to Santa Cruz de la Sierra round-trip?
Avianca, at £535, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.. Users have found that Avianca is 34% cheaper than the other options available to this destination.
What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Santa Cruz de la Sierra on time: Air Europa (58%), BoA (6%), Iberia (6%).
What are the cheapest flights from Madrid to Santa Cruz de la Sierra?
Looking for the cheapest flight from Madrid to Santa Cruz de la Sierra? While on average our users pay £387, our data indicates the cheapest price to be £341. The most popular route (Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl), is priced around £1,055.
Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Madrid to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.
Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, March is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £456). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of £810). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Top airline flying from Madrid to Santa Cruz de la Sierra
Discover the top airline that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 24 March 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?
Cheapflights makes it easy to find Madrid to Santa Cruz de la Sierra flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.
Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Madrid to Santa Cruz de la Sierra for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?
Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.
Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?
Of course! You can now track prices for flights from Madrid to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
We value your privacy
Cheapflights and its partners wish to use cookies or similar technologies to store and/or access information on and about your device and process personal data such as your IP address, device identifiers etc., in order to improve your experience on the site, to analyse navigation, to offer and measure personalised advertising, and to facilitate sharing on social networks. We also allow the use of third-party cookies (including those from our advertising partners) on our sites.
By clicking 'Accept', you consent to your data being processed by 0 vendors on this web site for the purposes described in this notice. You can review the vendors and their individual processing purposes on the .
To review individual processing purposes and cookie categories, please click ’Select individual purposes’. You can review your choices and withdraw your consent at any time by clicking the ’Privacy Preferences’ link in the page side navigation.