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Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £353

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 23/9. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
17 Oct — 24 Oct1
1 adult
1 adult, Economy

Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or March, booked 55 days in advance, depart on a Friday or Wednesday and return on a Monday

Cheap flight deals from Madrid to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 17 September 2025.

Round-trip from

£661

One-way from

£353

Popular in

December

Cheapest in

May

Average price

£669
Avianca
  • Avianca
  • 27/9-25/10
  • 2 total stops
  • 59h 05m total
  • Madrid to Santa Cruz de la Sierra
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Avianca
  • Avianca
  • 23/9
  • 1 total stop
  • 30h 20m total
  • Madrid to Santa Cruz de la Sierra
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (£48 potential increase over avg. return price).
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Cheapest flight prices on average. 3% potential price decrease (£20 potential savings vs. average return price).
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Average for round-trip flights in September 2025
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Find flight deals from Madrid to Santa Cruz de la Sierra

Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 17 September 2025.

Sun 21/909:40MAD - VVI
1 stop22h 10mAvianca
Thu 9/1002:50VVI - MAD
1 stop26h 20mAvianca
Deal found 15/9£647
Sat 27/901:30MAD - VVI
1 stop30h 20mAvianca
Sat 25/1003:40VVI - MAD
1 stop28h 45mAvianca
Deal found 15/9£661
Sun 9/1106:35MAD - VVI
1 stop25h 00mAvianca
Fri 21/1103:40VVI - MAD
1 stop19h 55mAvianca
Deal found 16/9£662
Mon 22/909:40MAD - VVI
1 stop22h 10mAvianca
Thu 9/1002:50VVI - MAD
1 stop26h 20mAvianca
Deal found 15/9£690
Tue 14/1001:30MAD - VVI
1 stop30h 20mAvianca
Tue 21/1002:50VVI - MAD
1 stop29h 15mAvianca
Deal found 15/9£720
Sun 12/1001:30MAD - VVI
1 stop30h 20mAvianca
Sun 19/1002:50VVI - MAD
1 stop29h 15mAvianca
Deal found 15/9£744
Sun 28/1206:35MAD - VVI
1 stop25h 00mAvianca
Wed 11/303:40VVI - MAD
1 stop28h 45mAvianca
Deal found 16/9£745
Thu 25/917:30MAD - VVI
1 stop38h 20mAvianca
Wed 8/1002:50VVI - MAD
1 stop29h 15mAvianca
Deal found 15/9£749
Mon 29/1206:35MAD - VVI
1 stop25h 00mAvianca
Sat 14/303:40VVI - MAD
1 stop28h 45mAvianca
Deal found 16/9£749
Sat 27/1206:35MAD - VVI
1 stop25h 00mAvianca
Mon 9/303:40VVI - MAD
1 stop28h 45mAvianca
Deal found 16/9£774
Mon 22/917:30MAD - VVI
1 stop38h 20mAvianca
Tue 7/1002:50VVI - MAD
1 stop29h 15mAvianca
Deal found 15/9£791
Mon 22/911:15MAD - VVI
2 stops41h 10mUnited Airlines
Sat 4/1001:09VVI - MAD
2 stops24h 56mUnited Airlines
Deal found 15/9£798

Cheapflights Fare Finder

 
Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 17 September 2025.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.

Fly from

Madrid

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Sat 27/9

01:30-01:50

1 stop30h 20m

Santa Cruz de la Sierra Viru Viru Intl

Sat 25/10

03:40-13:25

1 stop28h 45m

£661

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Tue 10/2

10:50-02:35

1 stop20h 45m

Santa Cruz de la Sierra Viru Viru Intl

Mon 9/3

03:40-13:25

1 stop28h 45m

£661

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Sat 27/9

13:10-01:50

1 stop18h 40m

Santa Cruz de la Sierra Viru Viru Intl

Thu 9/10

02:50-11:10

1 stop26h 20m

£690

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Thu 25/12

06:35-02:35

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Sat 24/1

03:40-13:25

1 stop28h 45m

£744

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Sun 28/12

01:20-02:35

1 stop30h 15m

Santa Cruz de la Sierra Viru Viru Intl

Sat 31/1

03:40-04:35

1 stop19h 55m

£745

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Mon 29/12

10:50-02:35

1 stop20h 45m

Santa Cruz de la Sierra Viru Viru Intl

Fri 13/3

03:40-04:35

1 stop19h 55m

£749

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Tue 23/9

01:30-01:50

1 stop30h 20m

£353

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Tue 10/2

10:50-02:35

1 stop20h 45m

£353

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Tue 21/10

01:30-01:50

1 stop30h 20m

£419

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Sat 1/11

06:35-02:35

1 stop25h 00m

£419

Flights are sorted by cheapest return flights first.

Deals found on 16/9

Showing 1-10 of 17 results
1
2

Best time to book a flight from Madrid to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra

How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a return flight from Madrid to Santa Cruz de la Sierra. Price data was last updated on 12 September 2025.

The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 55 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest time of day to fly from MAD to VVI?

Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 17 September 2025.

It’s typically best to fly out from Madrid to Santa Cruz de la Sierra in the afternoon. Doing so could potentially save you 32% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost for a return flight from Madrid to Santa Cruz de la Sierra?

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 17 September 2025.
Check out reviews from past customers who have flown with Iberia, BoA, andAvianca from Madrid to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Iberia
7.0
Good
2,924 reviews
Check prices

Boarding

7.1

Crew

7.6

Entertainment

6.6

Overall

7.0

Food

6.3

Comfort

6.7

Reviews

1 / 20
2.0
Mediocre

Gaby,Aug 2025

BCN - ORD

Our flight kept getting delayed due to the weather and mechanical issues. Then it was canceled and rescheduled until the following day which was also delayed by a couple hours and the returning flight was also delayed so overall, we wasted a lot of time on the airport. Also, when it happened the first day, they did not want to honor a hotel or rideshare service voucher because it was hard to find an uber at 3-4 in the morning and customer service was closed that late in the day.
Iberia
7.0
Good
2,924 reviews
Iberia
7.0
Good
2,924 reviews
Check prices

Boarding

7.1

Crew

7.6

Entertainment

6.6

Overall

7.0

Food

6.3

Comfort

6.7

Reviews

1 / 20
2.0
Mediocre

Gaby,Aug 2025

BCN - ORD

Our flight kept getting delayed due to the weather and mechanical issues. Then it was canceled and rescheduled until the following day which was also delayed by a couple hours and the returning flight was also delayed so overall, we wasted a lot of time on the airport. Also, when it happened the first day, they did not want to honor a hotel or rideshare service voucher because it was hard to find an uber at 3-4 in the morning and customer service was closed that late in the day.
BoA
6.8
Okay
136 reviews
Iberia
7.0
Good
2,924 reviews
Check prices

Boarding

7.1

Crew

7.6

Entertainment

6.6

Overall

7.0

Food

6.3

Comfort

6.7

Reviews

1 / 20
2.0
Mediocre

Gaby,Aug 2025

BCN - ORD

Our flight kept getting delayed due to the weather and mechanical issues. Then it was canceled and rescheduled until the following day which was also delayed by a couple hours and the returning flight was also delayed so overall, we wasted a lot of time on the airport. Also, when it happened the first day, they did not want to honor a hotel or rideshare service voucher because it was hard to find an uber at 3-4 in the morning and customer service was closed that late in the day.
Avianca
6.7
Okay
2,435 reviews
Iberia
7.0
Good
2,924 reviews
Check prices

Boarding

7.1

Crew

7.6

Entertainment

6.6

Overall

7.0

Food

6.3

Comfort

6.7

Reviews

1 / 20
2.0
Mediocre

Gaby,Aug 2025

BCN - ORD

Our flight kept getting delayed due to the weather and mechanical issues. Then it was canceled and rescheduled until the following day which was also delayed by a couple hours and the returning flight was also delayed so overall, we wasted a lot of time on the airport. Also, when it happened the first day, they did not want to honor a hotel or rideshare service voucher because it was hard to find an uber at 3-4 in the morning and customer service was closed that late in the day.

Related info for your journey

Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Madrid to Santa Cruz de la Sierra flight route?

    The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 11 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Madrid to Santa Cruz de la Sierra?

    For as low as £661, Avianca can have you in Santa Cruz de la Sierra from Madrid in 30h 20m. Madrid and Santa Cruz de la Sierra are separated by a distance of 5537 mi.

  • What are the cheapest airlines flying from Madrid to Santa Cruz de la Sierra round-trip?

    BoA, at £544, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.Alternate airlines flying return to your destination include Iberia and Avianca. Users have found that BoA is 28% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Santa Cruz de la Sierra on time: Air Europa (62%), BoA (47%), Iberia (47%).

  • What are the cheapest flights from Madrid to Santa Cruz de la Sierra?

    Looking for the cheapest flight from Madrid to Santa Cruz de la Sierra? While on average our users pay £1,944, our data indicates the cheapest price to be £1,779. The most popular route (Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl), is priced around £785.

  • Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Madrid to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Madrid to La Paz flights

Top 3 airlines flying from Madrid to Santa Cruz de la Sierra

Discover the top 3 airlines that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 17 September 2025.
AirlineCheapestAverageFlexibilityOn-time
BoACheapest£544Average£725FlexibilityNo cancel feeOn-timeN/A
Search BoA flights
IberiaCheapest£545Average£589FlexibilityNo cancel feeOn-time77%
Search Iberia flights
AviancaCheapest£555Average£736FlexibilityNo cancel feeOn-time71%
Search Avianca flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?

Cheapflights makes it easy to find Madrid to Santa Cruz de la Sierra flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?

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Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?

Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?

Of course! You can now track prices for flights from Madrid to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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