Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £422
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 31/12. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
7 Dec — 14 Dec1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or March, booked 68 days in advance, depart on a Thursday or Tuesday and return on a Monday
Find flight deals from Madrid to Santa Cruz de la Sierra
Enter your travel dates to find the best prices.
Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 7 November 2025.
Sun 23/1111:05MAD - VVI
2 stops40h 41mUnited Airlines
Sat 6/1211:40VVI - MAD
2 stops39h 25mUnited Airlines
Deal found 5/11£816
Sun 23/1106:35MAD - VVI
1 stop25h 00mAvianca
Thu 4/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£876
Tue 25/1106:35MAD - VVI
1 stop25h 00mAvianca
Wed 3/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£890
Wed 26/1111:05MAD - VVI
2 stops40h 41mUnited Airlines
Sat 6/1211:40VVI - MAD
2 stops39h 25mUnited Airlines
Deal found 5/11£904
Sat 22/1110:50MAD - VVI
1 stop20h 45mAvianca
Thu 4/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£920
Sun 23/1106:35MAD - VVI
1 stop25h 00mAvianca
Tue 2/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£932
Thu 25/1206:35MAD - VVI
1 stop25h 00mAvianca
Sat 24/103:40VVI - MAD
1 stop28h 45mAvianca
Deal found 5/11£957
Wed 26/1110:50MAD - VVI
1 stop20h 45mAvianca
Thu 4/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£965
Sat 22/1110:50MAD - VVI
1 stop20h 45mAvianca
Sun 30/1103:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£977
Best flights from Madrid to Santa Cruz de la Sierra
Discover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 7 November 2025.
Mon 24/1111:05MAD - VVI
2 stops40h 41mUnited Airlines
Sat 6/1211:40VVI - MAD
2 stops39h 25mUnited Airlines
Deal found 5/11£816
Mon 9/201:20MAD - VVI
1 stop30h 15mAvianca
Mon 9/303:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/11£838
Tue 10/301:20MAD - VVI
1 stop30h 15mAvianca
Sun 10/502:55VVI - MAD
1 stop29h 10mAvianca
Deal found 6/11£838
Sun 23/1111:05MAD - VVI
2 stops40h 41mUnited Airlines
Sat 6/1211:40VVI - MAD
2 stops39h 25mUnited Airlines
Deal found 6/11£858
Sat 7/206:40MAD - VVI
1 stop24h 55mAvianca
Mon 16/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/11£838
Sun 26/409:40MAD - VVI
1 stop22h 10mAvianca
Wed 13/502:55VVI - MAD
1 stop29h 10mAvianca
Deal found 6/11£838
Sun 12/409:40MAD - VVI
1 stop22h 10mAvianca
Tue 21/402:55VVI - MAD
1 stop29h 10mAvianca
Deal found 5/11£870
Last-minute flights from Madrid to Santa Cruz de la Sierra
Discover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated 7 November 2025 and is based on user searches.
Sat 22/1110:50MAD - VVI
1 stop20h 45mAvianca
Thu 4/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£920
Sat 22/1110:50MAD - VVI
1 stop20h 45mAvianca
Sun 30/1103:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£977
Sun 23/1111:05MAD - VVI
2 stops40h 41mUnited Airlines
Sat 6/1211:40VVI - MAD
2 stops39h 25mUnited Airlines
Deal found 5/11£816
Sun 23/1106:35MAD - VVI
1 stop25h 00mAvianca
Fri 5/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£876
Sun 23/1106:35MAD - VVI
1 stop25h 00mAvianca
Mon 1/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£932
Tue 25/1106:35MAD - VVI
1 stop25h 00mAvianca
Wed 3/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£890
Wed 26/1111:05MAD - VVI
2 stops40h 41mUnited Airlines
Sat 6/1211:40VVI - MAD
2 stops39h 25mUnited Airlines
Deal found 5/11£904
Wed 26/1110:50MAD - VVI
1 stop20h 45mAvianca
Thu 4/1203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 5/11£965
Thu 25/1206:35MAD - VVI
1 stop25h 00mAvianca
Sat 24/103:40VVI - MAD
1 stop28h 45mAvianca
Deal found 5/11£957
One-way flights from Madrid to Santa Cruz de la Sierra
Search for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated 7 November 2025.
Wed 31/1223:35MAD - VVI
Nonstop11h 20mAir Europa
Deal found 5/11£422
Wed 31/1210:50MAD - VVI
1 stop20h 45mAvianca
Deal found 6/11£427
Sat 14/210:50MAD - VVI
1 stop20h 45mAvianca
Deal found 6/11£428
Sat 18/401:30MAD - VVI
1 stop30h 20mAvianca
Deal found 6/11£444
Sun 15/206:35MAD - VVI
1 stop25h 00mAvianca
Deal found 6/11£459
Mon 24/1120:25MAD - VVI
2 stops37h 25mMultiple Airlines
Deal found 5/11£483
Wed 28/110:25MAD - VVI
2 stops21h 10mAvianca
Deal found 5/11£498
Cheap flight deals from Madrid to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 7 November 2025.
Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 7 November 2025.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.
Fly from
Madrid
Fly to
Santa Cruz de la Sierra
Route
Depart
Return
Price
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 24/11
11:05-22:46
2 stops40h 41m
Santa Cruz de la Sierra Viru Viru Intl
Sat 6/12
11:40-08:05
2 stops39h 25m
£816
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 9/2
01:20-02:35
1 stop30h 15m
Santa Cruz de la Sierra Viru Viru Intl
Mon 9/3
03:40-23:20
1 stop14h 40m
£838
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Tue 10/3
01:20-02:35
1 stop30h 15m
Santa Cruz de la Sierra Viru Viru Intl
Sun 10/5
02:55-14:05
1 stop29h 10m
£838
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sat 7/2
06:40-02:35
1 stop24h 55m
Santa Cruz de la Sierra Viru Viru Intl
Mon 16/2
03:40-23:20
1 stop14h 40m
£838
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 26/4
09:40-01:50
1 stop22h 10m
Santa Cruz de la Sierra Viru Viru Intl
Wed 13/5
02:55-14:05
1 stop29h 10m
£838
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 23/11
11:05-22:46
2 stops40h 41m
Santa Cruz de la Sierra Viru Viru Intl
Sat 6/12
11:40-08:05
2 stops39h 25m
£858
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 12/4
09:40-01:50
1 stop22h 10m
Santa Cruz de la Sierra Viru Viru Intl
Tue 21/4
02:55-14:05
1 stop29h 10m
£870
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Wed 31/12
23:35-05:55
Nonstop11h 20m
£422
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sat 14/2
10:50-02:35
1 stop20h 45m
£428
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Wed 31/12
10:50-02:35
1 stop20h 45m
£429
Flights are sorted by cheapest return flights first.
Deals found on 5/11
Showing 1-10 of 16 results
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Best time to book a flight from Madrid to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra
Prices
Delays
More
How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?
Use this chart to determine the optimal time to book a return flight from Madrid to Santa Cruz de la Sierra. Price data was last updated on 31 October 2025.
The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 68 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, May is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £496). Flying from Madrid to Santa Cruz de la Sierra in December is currently the most expensive (average of £704). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to VVI?
Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 7 November 2025.
It’s typically best to fly out from Madrid to Santa Cruz de la Sierra in the afternoon. Doing so could potentially save you 31% on the flight price compared to flying in the morning, which is usually more expensive.
How much does it cost for a return flight from Madrid to Santa Cruz de la Sierra?
How often are flights from Madrid to Santa Cruz de la Sierra delayed?
About 45% of weekly flights between Madrid and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 164 minutes.
What is the most punctual flight time for Madrid to Santa Cruz de la Sierra flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Friday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Santa Cruz de la Sierra flights?
Over the past year, Etihad Airways have had the lowest number of delays on this route, with no flights being classified as delayed.
What’s the top stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Share of one-stop return flights from Madrid to Santa Cruz de la Sierra chosen by Cheapflights users in the past 12 months, using the same stopover each way.
Bogotá (BOG) – chosen by Cheapflights users on 83% of one-stop itineraries from Madrid to Santa Cruz de la Sierra on Cheapflights.
What’s the fastest stopover option from Madrid to Santa Cruz de la Sierra?
Shortest average travel time for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for one-stop routes: 19h 22m.
What’s the fastest stopover option from Madrid to Santa Cruz de la Sierra?
Shortest average travel time for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for one-stop routes: 19h 22m.
Which airport typically offers the quickest stopover for flights from Madrid to Santa Cruz de la Sierra?
Average stopover duration for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) offer the fastest connection on this route, with an average stopover time of 2h 58m.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 7 November 2025.
Check out reviews from past customers who have flown with Iberia, BoA, andAvianca from Madrid to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Worst customer service, at a check in lady could not find our reservation at all. End it up as buying brand new ticket to be able to fly with other family members. Very disappointed.
Worst customer service, at a check in lady could not find our reservation at all. End it up as buying brand new ticket to be able to fly with other family members. Very disappointed.
Worst customer service, at a check in lady could not find our reservation at all. End it up as buying brand new ticket to be able to fly with other family members. Very disappointed.
Worst customer service, at a check in lady could not find our reservation at all. End it up as buying brand new ticket to be able to fly with other family members. Very disappointed.
Related info for your journey
Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
How popular is this Madrid to Santa Cruz de la Sierra flight route?
The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 7 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Madrid to Santa Cruz de la Sierra?
For as low as £838, United Airlines can have you in Santa Cruz de la Sierra from Madrid in 30h 15m. Madrid and Santa Cruz de la Sierra are separated by a distance of 5537 mi. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.
What are the cheapest airlines flying from Madrid to Santa Cruz de la Sierra round-trip?
BoA, at £544, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.Alternate airlines flying return to your destination include Iberia and Avianca. Users have found that BoA is 32% cheaper than the other options available to this destination.
What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Santa Cruz de la Sierra on time: BoA (65%), Iberia (65%), Air Europa (57%).
What are the cheapest flights from Madrid to Santa Cruz de la Sierra?
Looking for the cheapest flight from Madrid to Santa Cruz de la Sierra? While on average our users pay £2,025, our data indicates the cheapest price to be £1,853. The most popular route (Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl), is priced around £1,776.
Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Madrid to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.
Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, May is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £496). Flying from Madrid to Santa Cruz de la Sierra in December is currently the most expensive (average of £704). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Top 3 airlines flying from Madrid to Santa Cruz de la Sierra
Discover the top 3 airlines that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 7 November 2025.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?
Cheapflights makes it easy to find Madrid to Santa Cruz de la Sierra flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.
Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Madrid to Santa Cruz de la Sierra for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?
Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.
Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?
Of course! You can now track prices for flights from Madrid to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
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