Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £348
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
25 Feb — 4 Mar1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in March or May, booked 75 days in advance, depart on a Wednesday or Monday and return on a Tuesday
Cheap flight deals from Madrid to Santa Cruz de la Sierra
Enter your travel dates to find the best prices.
Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 26 January 2026.
Sun 10/517:30
MAD
-
VVI
1 stop38h 20m
Avianca
Sat 23/502:55
VVI
-
MAD
1 stop26h 15m
Avianca
Deal found 24/1£588
Thu 1/1009:40
MAD
-
VVI
1 stop22h 10m
Avianca
Sat 17/1002:55
VVI
-
MAD
1 stop22h 45m
Avianca
Deal found 25/1£593
Mon 13/409:40
MAD
-
VVI
1 stop22h 10m
Avianca
Sat 9/502:55
VVI
-
MAD
1 stop26h 15m
Avianca
Deal found 24/1£596
Fri 20/310:50
MAD
-
VVI
1 stop20h 45m
Avianca
Mon 20/402:55
VVI
-
MAD
1 stop29h 10m
Avianca
Deal found 25/1£609
Sun 4/1001:30
MAD
-
VVI
1 stop30h 20m
Avianca
Thu 22/1002:55
VVI
-
MAD
1 stop29h 10m
Avianca
Deal found 25/1£611
Sat 9/509:40
MAD
-
VVI
1 stop22h 10m
Avianca
Sat 23/502:55
VVI
-
MAD
1 stop26h 15m
Avianca
Deal found 24/1£616
Mon 17/802:10
MAD
-
VVI
2 stops29h 40m
Avianca
Tue 15/902:55
VVI
-
MAD
1 stop29h 10m
Avianca
Deal found 25/1£620
Sun 12/421:00
MAD
-
VVI
Nonstop11h 30m
Iberia
Sat 2/521:15
VVI
-
MAD
Nonstop10h 40m
Iberia
Deal found 24/1£621
Sat 3/1017:30
MAD
-
VVI
1 stop38h 20m
Avianca
Tue 20/1002:55
VVI
-
MAD
1 stop26h 15m
Avianca
Deal found 25/1£637
Thu 30/413:10
MAD
-
VVI
1 stop18h 40m
Avianca
Mon 11/502:55
VVI
-
MAD
1 stop14h 35m
Avianca
Deal found 24/1£642
Best flights from Madrid to Santa Cruz de la Sierra
Discover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 26 January 2026.
Mon 13/409:40
MAD
-
VVI
1 stop22h 10m
Avianca
Sat 9/502:55
VVI
-
MAD
1 stop26h 15m
Avianca
Deal found 24/1£596
Thu 9/401:30
MAD
-
VVI
1 stop30h 20m
Avianca
Sun 19/402:55
VVI
-
MAD
1 stop22h 45m
Avianca
Deal found 26/1£610
Fri 20/310:50
MAD
-
VVI
1 stop20h 45m
Avianca
Mon 20/402:55
VVI
-
MAD
1 stop14h 35m
Avianca
Deal found 26/1£610
Sat 25/401:30
MAD
-
VVI
1 stop30h 20m
Avianca
Wed 13/502:55
VVI
-
MAD
1 stop14h 35m
Avianca
Deal found 25/1£650
Mon 13/409:40
MAD
-
VVI
1 stop22h 10m
Avianca
Sat 2/502:55
VVI
-
MAD
1 stop29h 10m
Avianca
Deal found 25/1£650
Sun 12/409:40
MAD
-
VVI
1 stop22h 10m
Avianca
Thu 16/402:55
VVI
-
MAD
1 stop26h 15m
Avianca
Deal found 26/1£675
Fri 10/401:30
MAD
-
VVI
1 stop30h 20m
Avianca
Wed 22/402:55
VVI
-
MAD
1 stop22h 45m
Avianca
Deal found 26/1£675
Thu 9/401:30
MAD
-
VVI
1 stop30h 20m
Avianca
Wed 22/402:55
VVI
-
MAD
1 stop14h 35m
Avianca
Deal found 26/1£675
Thu 9/401:30
MAD
-
VVI
1 stop30h 20m
Avianca
Thu 16/402:55
VVI
-
MAD
1 stop14h 35m
Avianca
Deal found 26/1£675
Direct flights from Madrid to Santa Cruz de la Sierra
Explore direct flight options from Madrid to Santa Cruz de la Sierra based on user searches, and compare prices and availability for your desired travel dates. Data last updated 26 January 2026.
Sun 12/421:00
MAD
-
VVI
Nonstop11h 30m
Iberia
Sat 2/521:15
VVI
-
MAD
Nonstop10h 40m
Iberia
Deal found 24/1£621
Sun 15/221:00
MAD
-
VVI
Nonstop11h 00m
BoA
Mon 23/222:05
VVI
-
MAD
Nonstop10h 50m
BoA
Deal found 24/1£1,666
Mon 9/223:35
MAD
-
VVI
Nonstop11h 20m
Air Europa
Tue 10/213:30
VVI
-
MAD
Nonstop10h 40m
Air Europa
Deal found 24/1£1,806
Last-minute flights from Madrid to Santa Cruz de la Sierra
Discover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated 26 January 2026 and is based on user searches.
Wed 4/200:40
MAD
-
VVI
1 stop32h 55m
LATAM Airlines
Sun 15/205:20
VVI
-
MAD
1 stop30h 05m
LATAM Airlines
Deal found 24/1£1,159
Thu 5/213:05
MAD
-
VVI
2 stops44h 40m
Multiple Airlines
Sun 15/221:30
VVI
-
MAD
2 stops54h 40m
Multiple Airlines
Deal found 24/1£1,110
Sat 14/200:40
MAD
-
VVI
1 stop32h 55m
LATAM Airlines
Mon 23/205:20
VVI
-
MAD
2 stops27h 50m
LATAM Airlines
Deal found 24/1£1,039
Sun 15/206:00
MAD
-
VVI
2 stops27h 45m
Multiple Airlines
Mon 23/218:55
VVI
-
MAD
2 stops41h 45m
Multiple Airlines
Deal found 24/1£1,091
Sun 15/206:35
MAD
-
VVI
1 stop25h 00m
Avianca
Fri 27/203:40
VVI
-
MAD
1 stop28h 45m
Avianca
Deal found 24/1£1,111
Wed 25/210:50
MAD
-
VVI
1 stop20h 45m
Avianca
Sun 15/303:40
VVI
-
MAD
1 stop28h 45m
Avianca
Deal found 24/1£647
One-way flights from Madrid to Santa Cruz de la Sierra
Search for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated 26 January 2026.
Sun 10/517:30
MAD
-
VVI
1 stop38h 20m
Avianca
Deal found 25/1£348
Mon 1/617:30
MAD
-
VVI
1 stop38h 20m
Avianca
Deal found 24/1£351
Sat 9/509:40
MAD
-
VVI
1 stop22h 10m
Avianca
Deal found 25/1£379
Fri 27/210:50
MAD
-
VVI
1 stop20h 45m
Avianca
Deal found 24/1£404
Fri 29/509:40
MAD
-
VVI
1 stop22h 10m
Avianca
Deal found 25/1£407
Tue 17/210:50
MAD
-
VVI
1 stop20h 45m
Avianca
Deal found 24/1£460
Tue 17/210:50
MAD
-
VVI
2 stops43h 00m
Multiple Airlines
Deal found 24/1£480
Tue 10/214:55
MAD
-
VVI
3 stops49h 20m
Multiple Airlines
Deal found 25/1£519
Sat 14/213:30
MAD
-
VVI
1 stop31h 20m
Multiple Airlines
Deal found 24/1£546
Mon 9/223:45
MAD
-
VVI
1 stop20h 55m
Multiple Airlines
Deal found 25/1£552
Find flight deals from Madrid to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 26 January 2026.
Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 26 January 2026.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.
Fly from
Madrid
Fly to
Santa Cruz de la Sierra
Route
Depart
Return
Price
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 13/4
09:40-01:50
1 stop22h 10m
Santa Cruz de la Sierra Viru Viru Intl
Sat 9/5
02:55-11:10
1 stop26h 15m
£596
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Thu 9/4
01:30-01:50
1 stop30h 20m
Santa Cruz de la Sierra Viru Viru Intl
Sun 19/4
02:55-07:40
1 stop22h 45m
£610
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Fri 20/3
10:50-02:35
1 stop20h 45m
Santa Cruz de la Sierra Viru Viru Intl
Mon 20/4
02:55-23:30
1 stop14h 35m
£610
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sat 25/4
01:30-01:50
1 stop30h 20m
Santa Cruz de la Sierra Viru Viru Intl
Wed 13/5
02:55-23:30
1 stop14h 35m
£650
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 13/4
09:40-01:50
1 stop22h 10m
Santa Cruz de la Sierra Viru Viru Intl
Sat 2/5
02:55-14:05
1 stop29h 10m
£650
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 12/4
09:40-01:50
1 stop22h 10m
Santa Cruz de la Sierra Viru Viru Intl
Thu 16/4
02:55-11:10
1 stop26h 15m
£675
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Fri 10/4
01:30-01:50
1 stop30h 20m
Santa Cruz de la Sierra Viru Viru Intl
Wed 22/4
02:55-07:40
1 stop22h 45m
£675
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Thu 9/4
01:30-01:50
1 stop30h 20m
Santa Cruz de la Sierra Viru Viru Intl
Wed 22/4
02:55-23:30
1 stop14h 35m
£675
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Thu 9/4
01:30-01:50
1 stop30h 20m
Santa Cruz de la Sierra Viru Viru Intl
Thu 16/4
02:55-23:30
1 stop14h 35m
£675
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 10/5
17:30-01:50
1 stop38h 20m
£348
Flights are sorted by cheapest return flights first.
Deals found on 25/1
Showing 1-10 of 19 results
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Best time to book a flight from Madrid to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra
Prices
Delays
More
How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?
Use this chart to determine the optimal time to book a return flight from Madrid to Santa Cruz de la Sierra. Price data was last updated on 23 January 2026.
The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 75 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, May is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £445). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of £726). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to VVI?
Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 26 January 2026.
When flying from Madrid to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How often are flights from Madrid to Santa Cruz de la Sierra delayed?
About 42% of weekly flights between Madrid and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 139 minutes.
What is the most punctual flight time for Madrid to Santa Cruz de la Sierra flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Friday tends to have the lowest number of delays on this route, whereas Wednesday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Santa Cruz de la Sierra flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 36% of flights being delayed.
What’s the top stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Share of one-stop return flights from Madrid to Santa Cruz de la Sierra chosen by Cheapflights users in the past 12 months, using the same stopover each way.
Lima (LIM) – chosen by Cheapflights users on 50% of one-stop itineraries from Madrid to Santa Cruz de la Sierra on Cheapflights.
What’s the cheapest stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Average return fare for one-stop flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the past 12 months, with the same stopover each way.
Lima (LIM) is the most affordable one-stop option, with an average return flight price of £742.
What’s the fastest stopover option from Madrid to Santa Cruz de la Sierra?
Shortest average travel time for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for one-stop routes: 19h 33m.
Which airport typically offers the quickest stopover for flights from Madrid to Santa Cruz de la Sierra?
Average stopover duration for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) offer the fastest connection on this route, with an average stopover time of 3h 03m.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 26 January 2026.
Check out reviews from past customers who have flown with Avianca from Madrid to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Horrible experience and I will never use the airline again I also will make sure I post a video to my 400k followers about this experience
Related info for your journey
Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
How popular is this Madrid to Santa Cruz de la Sierra flight route?
The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Madrid to Santa Cruz de la Sierra?
For as low as £596, Avianca can have you in Santa Cruz de la Sierra from Madrid in 22h 10m. Madrid and Santa Cruz de la Sierra are separated by a distance of 5537 mi.
What is the cheapest airline to fly from Madrid to Santa Cruz de la Sierra round-trip?
Avianca, at £554, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.. Users have found that Avianca is 29% cheaper than the other options available to this destination.
What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Santa Cruz de la Sierra on time: Air Europa (62%), BoA (9%), Iberia (9%).
Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Madrid to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.
Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, May is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £445). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of £726). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Top airline flying from Madrid to Santa Cruz de la Sierra
Discover the top airline that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 26 January 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?
Cheapflights makes it easy to find Madrid to Santa Cruz de la Sierra flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.
Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Madrid to Santa Cruz de la Sierra for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?
Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.
Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?
Of course! You can now track prices for flights from Madrid to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
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