Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £394
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 31/12. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
7 Jan — 14 Jan1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or March, booked 55 days in advance, depart on a Tuesday or Saturday and return on a Tuesday
Cheap flight deals from Madrid to Santa Cruz de la Sierra
Enter your travel dates to find the best prices.
Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 8 December 2025.
Fri 26/1210:50MAD - VVI
1 stop20h 45mAvianca
Tue 27/103:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£1,076
Fri 26/1210:50MAD - VVI
1 stop20h 45mAvianca
Sun 25/103:40VVI - MAD
1 stop28h 45mAvianca
Deal found 6/12£1,139
Wed 24/1210:50MAD - VVI
1 stop20h 45mAvianca
Wed 28/103:40VVI - MAD
1 stop28h 45mAvianca
Deal found 6/12£1,149
Fri 26/1210:50MAD - VVI
1 stop20h 45mAvianca
Sat 24/103:40VVI - MAD
1 stop28h 45mAvianca
Deal found 6/12£1,169
Wed 24/1210:50MAD - VVI
1 stop20h 45mAvianca
Sun 25/103:40VVI - MAD
1 stop28h 45mAvianca
Deal found 6/12£1,212
Mon 8/1215:25MAD - VVI
2 stops36h 21mMultiple Airlines
Thu 18/1222:05VVI - MAD
Nonstop10h 50mMultiple Airlines
Deal found 7/12£1,224
Wed 24/1210:50MAD - VVI
1 stop20h 45mAvianca
Tue 27/103:40VVI - MAD
2 stops27h 20mAvianca
Deal found 6/12£1,229
Wed 24/1210:50MAD - VVI
1 stop20h 45mAvianca
Sat 24/103:40VVI - MAD
1 stop24h 10mAvianca
Deal found 6/12£1,242
Best flights from Madrid to Santa Cruz de la Sierra
Discover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 8 December 2025.
Mon 16/206:35MAD - VVI
1 stop25h 00mAvianca
Thu 19/303:40VVI - MAD
1 stop14h 40mAvianca
Deal found 8/12£713
Thu 19/301:20MAD - VVI
1 stop30h 15mAvianca
Mon 20/402:55VVI - MAD
1 stop22h 45mAvianca
Deal found 7/12£718
Sat 21/307:05MAD - VVI
2 stops24h 30mAvianca
Wed 15/402:55VVI - MAD
1 stop29h 10mAvianca
Deal found 7/12£787
Sun 10/507:05MAD - VVI
2 stops24h 45mAvianca
Sat 23/502:55VVI - MAD
1 stop29h 10mAvianca
Deal found 7/12£787
Sun 12/401:30MAD - VVI
1 stop30h 20mAvianca
Sat 2/502:55VVI - MAD
2 stops29h 00mAvianca
Deal found 7/12£790
Tue 10/206:35MAD - VVI
1 stop25h 00mAvianca
Mon 9/303:40VVI - MAD
2 stops26h 00mAvianca
Deal found 7/12£790
Direct flights from Madrid to Santa Cruz de la Sierra
Explore direct flight options from Madrid to Santa Cruz de la Sierra based on user searches, and compare prices and availability for your desired travel dates. Data last updated 8 December 2025.
Fri 30/121:00MAD - VVI
Nonstop11h 00mIberia
Mon 23/222:05VVI - MAD
Nonstop10h 50mIberia
Deal found 8/12£1,188
Mon 2/223:35MAD - VVI
Nonstop11h 20mAir Europa
Tue 24/213:30VVI - MAD
Nonstop10h 40mAir Europa
Deal found 8/12£1,246
Fri 30/103:05MAD - VVI
Nonstop11h 20mAir Europa
Tue 24/213:30VVI - MAD
Nonstop10h 40mAir Europa
Deal found 8/12£1,356
Sun 1/221:00MAD - VVI
Nonstop11h 00mIberia
Thu 26/222:05VVI - MAD
Nonstop10h 50mIberia
Deal found 8/12£1,365
Fri 30/103:05MAD - VVI
Nonstop11h 20mMultiple Airlines
Mon 23/222:05VVI - MAD
Nonstop10h 50mMultiple Airlines
Deal found 8/12£1,774
Last-minute flights from Madrid to Santa Cruz de la Sierra
Discover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated 8 December 2025 and is based on user searches.
Tue 20/106:35MAD - VVI
1 stop25h 00mAvianca
Sun 22/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£811
Wed 21/110:50MAD - VVI
1 stop20h 45mAvianca
Tue 17/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£748
Wed 21/110:50MAD - VVI
1 stop20h 45mAvianca
Sun 15/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£865
Thu 22/101:20MAD - VVI
1 stop30h 15mAvianca
Sat 21/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£841
Fri 23/110:50MAD - VVI
1 stop20h 45mAvianca
Wed 18/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£841
Sat 24/110:50MAD - VVI
1 stop20h 45mAvianca
Sat 21/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£773
Sat 24/101:20MAD - VVI
1 stop30h 15mAvianca
Thu 19/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£871
Sat 24/106:40MAD - VVI
1 stop24h 55mAvianca
Sun 15/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£889
Sun 25/120:00MAD - VVI
2 stops35h 35mAvianca
Tue 17/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£895
Mon 26/107:40MAD - VVI
2 stops23h 55mAvianca
Tue 17/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 6/12£889
Thu 29/110:25MAD - VVI
2 stops21h 10mAvianca
Sat 21/203:40VVI - MAD
1 stop14h 40mAvianca
Deal found 8/12£850
Sat 31/116:25MAD - VVI
2 stops59h 25mMultiple Airlines
Tue 24/210:00VVI - MAD
2 stops28h 10mMultiple Airlines
Deal found 8/12£830
One-way flights from Madrid to Santa Cruz de la Sierra
Search for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated 8 December 2025.
Wed 31/1223:35MAD - VVI
Nonstop11h 20mAir Europa
Deal found 8/12£394
Mon 26/110:50MAD - VVI
1 stop20h 45mAvianca
Deal found 7/12£442
Wed 28/110:50MAD - VVI
1 stop20h 45mAvianca
Deal found 7/12£496
Thu 29/106:35MAD - VVI
1 stop25h 00mAvianca
Deal found 7/12£525
Sun 25/120:00MAD - VVI
2 stops35h 35mAvianca
Deal found 7/12£578
Wed 31/1207:05MAD - VVI
2 stops24h 30mAvianca
Deal found 8/12£771
Sat 24/120:00MAD - VVI
2 stops35h 35mAvianca
Deal found 7/12£874
Sun 31/501:30MAD - VVI
1 stop30h 20mAvianca
Deal found 7/12£996
Find flight deals from Madrid to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 8 December 2025.
Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 8 December 2025.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.
Fly from
Madrid
Fly to
Santa Cruz de la Sierra
Route
Depart
Return
Price
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 16/2
06:35-02:35
1 stop25h 00m
Santa Cruz de la Sierra Viru Viru Intl
Thu 19/3
03:40-23:20
1 stop14h 40m
£713
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Thu 19/3
01:20-02:35
1 stop30h 15m
Santa Cruz de la Sierra Viru Viru Intl
Mon 20/4
02:55-07:40
1 stop22h 45m
£718
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sat 21/3
07:05-02:35
2 stops24h 30m
Santa Cruz de la Sierra Viru Viru Intl
Wed 15/4
02:55-14:05
1 stop29h 10m
£787
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 10/5
07:05-01:50
2 stops24h 45m
Santa Cruz de la Sierra Viru Viru Intl
Sat 23/5
02:55-14:05
1 stop29h 10m
£787
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 12/4
01:30-01:50
1 stop30h 20m
Santa Cruz de la Sierra Viru Viru Intl
Sat 2/5
02:55-13:55
2 stops29h 00m
£790
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Tue 10/2
06:35-02:35
1 stop25h 00m
Santa Cruz de la Sierra Viru Viru Intl
Mon 9/3
03:40-10:40
2 stops26h 00m
£790
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Wed 31/12
23:35-05:55
Nonstop11h 20m
£394
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 26/1
10:50-02:35
1 stop20h 45m
£442
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Wed 28/1
10:50-02:35
1 stop20h 45m
£496
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Thu 29/1
06:35-02:35
1 stop25h 00m
£525
Flights are sorted by cheapest return flights first.
Deals found on 6/12
Showing 1-10 of 13 results
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Best time to book a flight from Madrid to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra
Prices
Delays
More
How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?
Use this chart to determine the optimal time to book a return flight from Madrid to Santa Cruz de la Sierra. Price data was last updated on 5 December 2025.
The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 55 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, May is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £460). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of £718). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to VVI?
Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 8 December 2025.
It’s typically best to fly out from Madrid to Santa Cruz de la Sierra in the afternoon. Doing so could potentially save you 31% on the flight price compared to flying in the morning, which is usually more expensive.
How much does it cost for a return flight from Madrid to Santa Cruz de la Sierra?
How often are flights from Madrid to Santa Cruz de la Sierra delayed?
About 42% of weekly flights between Madrid and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 170 minutes.
What is the most punctual flight time for Madrid to Santa Cruz de la Sierra flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Friday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Santa Cruz de la Sierra flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 34% of flights being delayed.
What’s the top stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Share of one-stop return flights from Madrid to Santa Cruz de la Sierra chosen by Cheapflights users in the past 12 months, using the same stopover each way.
Bogotá (BOG) – chosen by Cheapflights users on 56% of one-stop itineraries from Madrid to Santa Cruz de la Sierra on Cheapflights.
What’s the cheapest stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Average return fare for one-stop flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the past 12 months, with the same stopover each way.
Lima (LIM) is the most affordable one-stop option, with an average return flight price of £760.
What’s the fastest stopover option from Madrid to Santa Cruz de la Sierra?
Shortest average travel time for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for one-stop routes: 19h 22m.
Which airport typically offers the quickest stopover for flights from Madrid to Santa Cruz de la Sierra?
Average stopover duration for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) offer the fastest connection on this route, with an average stopover time of 2h 58m.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 8 December 2025.
Check out reviews from past customers who have flown with Avianca from Madrid to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
no meals provided. Staff was nice. no entertainment behind seats
Related info for your journey
Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Madrid to Santa Cruz de la Sierra?
If you book a flight from Madrid to Santa Cruz de la Sierra, you will be flying from Barajas to Viru Viru Intl. Flights to Santa Cruz de la Sierra Viru Viru Intl (VVI) from Madrid Barajas (MAD) take 30h 15m for a nonstop flight. There is 1 flight from Barajas to Santa Cruz de la Sierra per day from 1 airline.
How popular is this Madrid to Santa Cruz de la Sierra flight route?
The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Madrid to Santa Cruz de la Sierra?
For as low as £713, Avianca can have you in Santa Cruz de la Sierra from Madrid in 25h. Madrid and Santa Cruz de la Sierra are separated by a distance of 5537 mi.
What is the cheapest airline to fly from Madrid to Santa Cruz de la Sierra round-trip?
Avianca, at £567, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.. Users have found that Avianca is 29% cheaper than the other options available to this destination.
What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Santa Cruz de la Sierra on time: Air Europa (56%), BoA (33%), Iberia (33%).
What are the cheapest flights from Madrid to Santa Cruz de la Sierra?
Looking for the cheapest flight from Madrid to Santa Cruz de la Sierra? While on average our users pay £1,988, our data indicates the cheapest price to be £1,819. The most popular route (Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl), is priced around £1,155.
Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Madrid to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.
Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, May is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £460). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of £718). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Top airline flying from Madrid to Santa Cruz de la Sierra
Discover the top airline that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 8 December 2025.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?
Cheapflights makes it easy to find Madrid to Santa Cruz de la Sierra flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.
Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Madrid to Santa Cruz de la Sierra for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?
Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.
Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?
Of course! You can now track prices for flights from Madrid to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
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