Cheap flights from Madrid, Spain to Santa Cruz de la Sierra from £349
This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/2. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
31 Oct — 7 Nov1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or September, booked 43 days in advance, depart on a Wednesday or Thursday and return on a Monday
Cheap flight deals from Madrid to Santa Cruz de la Sierra
Enter your travel dates to find the best prices.
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Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 1 October 2026.
Tue 17/1108:10 -
1 stop23h 30m
Sun 29/1103:45 -
1 stop14h 40m
Deal found 26/9£658
Wed 18/1110:10 -
1 stop21h 30m
Sat 28/1103:45 -
1 stop14h 40m
Deal found 29/9£659
Tue 10/1108:10 -
1 stop23h 30m
Tue 8/1203:45 -
1 stop14h 40m
Deal found 30/9£661
Mon 16/1110:10 -
1 stop21h 30m
Tue 1/1203:45 -
1 stop14h 40m
Deal found 26/9£663
Sun 15/1110:10 -
1 stop21h 30m
Fri 27/1103:45 -
1 stop14h 40m
Deal found 28/9£664
Thu 19/1108:10 -
1 stop23h 30m
Sun 29/1103:45 -
1 stop14h 40m
Deal found 29/9£664
Mon 9/1110:10 -
1 stop21h 30m
Mon 23/1103:45 -
1 stop23h 25m
Deal found 29/9£665
Wed 11/1110:10 -
1 stop21h 30m
Tue 24/1103:45 -
1 stop14h 40m
Deal found 28/9£676
Wed 18/1110:10 -
1 stop21h 30m
Mon 30/1103:45 -
1 stop14h 40m
Deal found 26/9£678
Tue 10/1108:10 -
1 stop23h 30m
Sat 5/1203:45 -
1 stop23h 25m
Deal found 30/9£681
Sun 15/1110:10 -
1 stop21h 30m
Wed 25/1103:45 -
1 stop14h 40m
Deal found 28/9£683
Sun 15/1110:10 -
1 stop21h 30m
Wed 2/1203:45 -
1 stop14h 40m
Deal found 26/9£684
Best flights from Madrid to Santa Cruz de la Sierra
Discover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 1 October 2026.
Sun 31/107:05 -
2 stops24h 35m
Thu 4/303:45 -
1 stop21h 25m
Deal found 30/9£753
Thu 12/1111:00 -
2 stops45h 37m
Thu 26/1111:41 -
2 stops40h 49m
Deal found 29/9£955
Mon 18/110:10 -
1 stop21h 30m
Tue 2/303:45 -
1 stop14h 40m
Deal found 30/9£860
Tue 17/1111:00 -
2 stops40h 38m
Mon 30/1111:41 -
2 stops40h 49m
Deal found 26/9£956
Mon 19/1006:40 -
2 stops25h 50m
Fri 13/1103:45 -
1 stop14h 40m
Deal found 27/9£954
Thu 12/1111:00 -
2 stops40h 38m
Tue 24/1111:41 -
2 stops39h 04m
Deal found 28/9£956
Wed 11/1111:00 -
2 stops40h 38m
Tue 24/1111:41 -
2 stops39h 04m
Deal found 28/9£956
Sat 14/1111:00 -
2 stops40h 38m
Tue 1/1211:34 -
2 stops40h 56m
Deal found 26/9£956
Mon 19/1010:25 -
2 stops22h 05m
Tue 10/1103:45 -
2 stops30h 15m
Deal found 27/9£1,068
Tue 17/1111:00 -
2 stops40h 38m
Wed 2/1211:34 -
2 stops40h 56m
Deal found 29/9£1,041
Sat 14/1111:00 -
2 stops40h 38m
Sat 28/1111:41 -
2 stops40h 49m
Deal found 26/9£1,105
Sun 7/311:15 -
2 stops45h 40m
Thu 1/409:56 -
2 stops41h 04m
Deal found 30/9£1,123
Direct flights from Madrid to Santa Cruz de la Sierra
Explore direct flight options from Madrid to Santa Cruz de la Sierra based on user searches, and compare prices and availability for your desired travel dates. Data last updated 1 October 2026.
Wed 11/1123:35 -
Nonstop11h 20m
Tue 24/1113:30 -
Nonstop10h 40m
Deal found 28/9£744
Mon 9/1123:35 -
Nonstop11h 20m
Tue 24/1113:30 -
Nonstop10h 40m
Deal found 29/9£763
Fri 22/103:05 -
Nonstop11h 20m
Sat 20/213:30 -
Nonstop10h 40m
Deal found 27/9£765
Wed 11/1123:35 -
Nonstop11h 20m
Thu 26/1113:30 -
Nonstop10h 40m
Deal found 28/9£774
Mon 16/1123:35 -
Nonstop11h 20m
Thu 3/1213:30 -
Nonstop10h 40m
Deal found 26/9£777
Mon 9/1123:35 -
Nonstop11h 20m
Thu 26/1113:30 -
Nonstop10h 40m
Deal found 29/9£827
Mon 16/1123:35 -
Nonstop11h 20m
Sat 28/1113:30 -
Nonstop10h 40m
Deal found 29/9£859
Mon 16/1123:35 -
Nonstop11h 20m
Tue 1/1213:30 -
Nonstop10h 40m
Deal found 29/9£860
Wed 18/1123:35 -
Nonstop11h 20m
Sat 28/1113:30 -
Nonstop10h 40m
Deal found 26/9£869
Last-minute flights from Madrid to Santa Cruz de la Sierra
Discover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated 1 October 2026 and is based on user searches.
Wed 14/1008:10 -
1 stop24h 20m
Tue 3/1103:45 -
1 stop23h 25m
Deal found 26/9£713
Wed 14/1011:05 -
1 stop21h 25m
Mon 7/1203:45 -
1 stop23h 25m
Deal found 28/9£792
Wed 14/1011:05 -
1 stop21h 25m
Tue 16/203:45 -
1 stop23h 25m
Deal found 28/9£821
Mon 19/1008:10 -
1 stop24h 20m
Sun 8/1103:45 -
1 stop21h 25m
Deal found 27/9£783
Sun 25/1008:10 -
1 stop23h 30m
Sat 21/1103:45 -
1 stop21h 25m
Deal found 30/9£710
Thu 29/1010:10 -
1 stop21h 30m
Wed 4/1103:45 -
1 stop21h 25m
Deal found 29/9£792
One-way flights from Madrid to Santa Cruz de la Sierra
Search for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated 1 October 2026.
Mon 1/210:10 -
1 stop21h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 30/9£349
Wed 27/108:10 -
1 stop23h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 27/9£351
Thu 29/1008:10 -
1 stop23h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 26/9£374
Mon 16/1108:10 -
1 stop23h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 27/9£385
Thu 5/1108:10 -
1 stop23h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 29/9£400
Wed 27/111:25 -
2 stops20h 15m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 27/9£449
Sun 8/1111:15 -
3 stops57h 35m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 29/9£453
Sun 8/1114:45 -
Nonstop11h 00m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 29/9£469
Wed 4/1114:45 -
Nonstop10h 00m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 29/9£481
Wed 14/1008:10 -
1 stop24h 20m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 26/9£494
Find flight deals from Madrid to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 1 October 2026.
Customise your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 1 October 2026.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 18/11
10:10-02:40
1 stop21h 30m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£385
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Mon 16/11
08:10-02:40
1 stop23h 30m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£385
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Sat 24/10
11:05-02:30
1 stop21h 25m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£494
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Sun 1/11
08:10-02:40
1 stop23h 30m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£529
Fastest return journey
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 21/10
17:20-02:30
1 stop15h 10m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£529
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 21/10
10:50-22:44
2 stops41h 54m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£581
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Thu 8/10
11:15-22:44
2 stops41h 29m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£581
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 7/10
11:15-03:38
2 stops22h 23m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£581
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 14/10
11:15-22:44
2 stops41h 29m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£582
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Thu 15/10
11:15-22:44
2 stops41h 29m
Santa Cruz de la Sierra Viru Viru Intl
Wed 31/12
00:00-05:00
Nonstop0h 00m
£582
Flights are sorted by cheapest return flights first.
Deals found on 27/9
Showing 1-10 of 23 resultsSorted by cheapest first
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Best time to book a flight from Madrid to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
MAD-VVI
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra
Prices
Delays
More
How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?
The price you pay for your flight from Madrid to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 42 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, April is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £642). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of £1,096). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to VVI?
Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 1 October 2026.
When flying from Madrid to Santa Cruz de la Sierra, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost for a return flight from Madrid to Santa Cruz de la Sierra?
Airfare is typical for this route at the moment.
Madrid to Santa Cruz de la Sierra flights typically cost between £656 and £935 in November.The cheapest return price found within the last 5 days was £658 on Avianca (17 Nov–29 Nov).
How often are flights from Madrid to Santa Cruz de la Sierra delayed?
About 47% of weekly flights between Madrid and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 141 minutes.
What is the most punctual flight time for Madrid to Santa Cruz de la Sierra flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Santa Cruz de la Sierra flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 35% of flights being delayed.
What’s the top stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Share of one-stop return flights from Madrid to Santa Cruz de la Sierra chosen by Cheapflights users in the past 12 months, using the same stopover each way.
Lima (LIM) – chosen by Cheapflights users on 60% of one-stop itineraries from Madrid to Santa Cruz de la Sierra on Cheapflights.
What’s the cheapest stopover airport for flights from Madrid to Santa Cruz de la Sierra?
Average return fare for one-stop flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the past 12 months, with the same stopover each way.
Lima (LIM) is the most affordable one-stop option, with an average return flight price of £657.
What’s the fastest stopover option from Madrid to Santa Cruz de la Sierra?
Shortest average travel time for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for one-stop routes: 18h 18m.
Which airport typically offers the quickest stopover for flights from Madrid to Santa Cruz de la Sierra?
Average stopover duration for one-stop one-way flights from Madrid to Santa Cruz de la Sierra, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) offer the fastest connection on this route, with an average stopover time of 2h 39m.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated 1 October 2026.
Check out reviews from past customers who have flown with Avianca from Madrid to Santa Cruz de la Sierra to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
On time, quite confortable. The food was good (and necessary).
Related info for your journey
Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Madrid to Santa Cruz de la Sierra?
If you book a flight from Madrid to Santa Cruz de la Sierra, you will be flying from Barajas to Viru Viru Intl. Flights to Santa Cruz de la Sierra Viru Viru Intl (VVI) from Madrid Barajas (MAD) take 24h 00m for a nonstop flight. There is 1 flight from Barajas to Santa Cruz de la Sierra per day from 1 airline.
How popular is this Madrid to Santa Cruz de la Sierra flight route?
The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Madrid to Santa Cruz de la Sierra?
For as low as £661, Avianca can have you in Santa Cruz de la Sierra from Madrid in 23h 30m. Madrid and Santa Cruz de la Sierra are separated by a distance of 5537 mi.
What is the cheapest airline to fly from Madrid to Santa Cruz de la Sierra round-trip?
Avianca, at £539, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.. Users have found that Avianca is 33% cheaper than the other options available to this destination.
What are the cheapest airlines to fly from Madrid to Santa Cruz de la Sierra one-way?
£267 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on BoA and Iberia, with prices starting from £349 and £390, respectively.
What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Santa Cruz de la Sierra on time: Air Europa (63%), BoA (22%), Iberia (22%).
What are the cheapest flights from Madrid to Santa Cruz de la Sierra?
Looking for the cheapest flight from Madrid to Santa Cruz de la Sierra? While on average our users pay £747, our data indicates the cheapest price to be £351. The most popular route (Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl), is priced around £1,322.
Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?
Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Madrid to Santa Cruz de la Sierra?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.
Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?
Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, April is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of £642). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of £1,096). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Top airline flying from Madrid to Santa Cruz de la Sierra
Discover the top airline that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 1 October 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Madrid to Santa Cruz de la Sierra?
Cheapflights makes it easy to find Madrid to Santa Cruz de la Sierra flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.
Why should you use Cheapflights to find cheap flight tickets from Madrid to Santa Cruz de la Sierra?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Madrid to Santa Cruz de la Sierra for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Madrid to Santa Cruz de la Sierra with no change fees?
Need flexible booking options for your flight to Santa Cruz de la Sierra from Madrid? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.
Can Cheapflights notify me if prices for flights from Madrid to Santa Cruz de la Sierra become cheaper?
Of course! You can now track prices for flights from Madrid to Santa Cruz de la Sierra and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
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