Out of all the popular cities in Chile, Santiago is the cheapest city to hire a car in at just £17/day. Renting a car in Santiago is 79% cheaper than renting one in Puerto Natales where the per day rate is around £76. Other fairly inexpensive cities in Chile to get a car hire in are: Puerto Montt (£17/day), Calama (£28/day), and Antofagasta (£32/day). While these cities typically have cheaper prices than the rest of the country, travellers looking to hire a car in Santiago should expect to spend around £17/day on their transportation. The most popular city to rent a car in Chile is Santiago.