Out of all the popular cities in Chile, Santiago is the cheapest city to hire a car in at just £18/day. Renting a car in Santiago is 79% cheaper than renting one in Puerto Natales where the per day rate is around £80. Other fairly inexpensive cities in Chile to get a car hire in are: Puerto Montt (£18/day), Calama (£29/day), and Antofagasta (£33/day). While these cities typically have cheaper prices than the rest of the country, travellers looking to hire a car in Santiago should expect to spend around £18/day on their transportation. The most popular city to rent a car in Chile is Santiago.