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£107+ Direct flights from St. Louis

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
STL — LHR
22 May — 29 May1
1 adult
1 adult, Economy, 0 bags

Find direct flights from St. Louis within your budget

 
Use the slider to find direct flights from St. Louis within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 858,174 searches. This data was last updated on 22 April 2026.

Fly to

Route

Depart

Return

Price

Cheapest return flight

St. LouisOrlando

STL - MCO

STLMCO

Lambert-St Louis

Tue 19/5

18:50-22:10

Nonstop2h 20m

Orlando

Tue 26/5

20:55-22:35

Nonstop2h 40m

£212

St. LouisOrlando

STL - MCO

STLMCO

Lambert-St Louis

Tue 1/9

18:45-22:05

Nonstop2h 20m

Orlando

Wed 9/9

06:05-07:40

Nonstop2h 35m

£212

St. LouisSan Antonio

STL - SAT

STLSAT

Lambert-St Louis

Sat 30/5

08:45-11:00

Nonstop2h 15m

San Antonio

Mon 1/6

16:45-18:55

Nonstop2h 10m

£227

St. LouisSan Antonio

STL - SAT

STLSAT

Lambert-St Louis

Mon 11/5

21:45-00:05

Nonstop2h 20m

San Antonio

Wed 13/5

07:25-09:35

Nonstop2h 10m

£248

St. LouisOrlando

STL - MCO

STLMCO

Lambert-St Louis

Wed 20/5

18:50-22:10

Nonstop2h 20m

Orlando

Sat 23/5

09:45-11:25

Nonstop2h 40m

£254

St. LouisSan Antonio

STL - SAT

STLSAT

Lambert-St Louis

Fri 22/5

21:45-00:05

Nonstop2h 20m

San Antonio

Tue 26/5

07:25-09:35

Nonstop2h 10m

£264

St. LouisOrlando

STL - MCO

STLMCO

Lambert-St Louis

Mon 11/5

19:40-23:00

Nonstop2h 20m

Orlando

Tue 19/5

06:50-08:30

Nonstop2h 40m

£268

St. LouisOrlando

STL - MCO

STLMCO

Lambert-St Louis

Sat 5/9

13:20-16:45

Nonstop2h 25m

Orlando

Sat 12/9

06:05-07:40

Nonstop2h 35m

£278

St. LouisSan Antonio

STL - SAT

STLSAT

Lambert-St Louis

Thu 14/5

21:45-00:05

Nonstop2h 20m

San Antonio

Sat 16/5

07:40-09:50

Nonstop2h 10m

£285

St. LouisOrlando

STL - MCO

STLMCO

Lambert-St Louis

Wed 10/6

20:15-23:40

Nonstop2h 25m

Orlando

Mon 15/6

08:50-10:20

Nonstop2h 30m

£287

Flights are sorted by cheapest return flights first.

Deals found on 20/4

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from St. Louis

Have a flexible travel schedule? Discover the best time to fly from St. Louis with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines flying non-stop to St. Louis

Get insights into the airlines that provide direct flights from St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight from St. Louis. Reviews last updated Cheapflights.
Read through reviews of airlines serving St. Louis, such as Virgin Atlantic and British Airways. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Virgin Atlantic
7.5
Good
687 reviews
Check prices

Comfort

7.3

Overall

7.5

Boarding

7.7

Food

6.9

Entertainment

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
Virgin Atlantic
7.5
Good
687 reviews
Virgin Atlantic
7.5
Good
687 reviews
Check prices

Comfort

7.3

Overall

7.5

Boarding

7.7

Food

6.9

Entertainment

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
British Airways
6.7
Okay
7,905 reviews
Virgin Atlantic
7.5
Good
687 reviews
Check prices

Comfort

7.3

Overall

7.5

Boarding

7.7

Food

6.9

Entertainment

7.5

Crew

8.1

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!

Related info for your journey

Access useful and relevant information related to your journey from St. Louis. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 22 April 2026.

  • Where can you fly direct from St. Louis?

    Currently, the most popular direct flight destination from St. Louis is Dallas/Fort Worth Airport.

  • What is the best time of year to fly direct from St. Louis?

    If you're seeking the lowest price on a direct flight from St. Louis, August is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, January offers travelers the most options.

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