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£146+ Direct flights from St. Louis

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
STL — LHR
13 Feb — 20 Feb1
1 adult
1 adult, Economy, 0 bags

Direct flights from St. Louis

Enter your travel dates to find the best prices.

Cheapest flights from St. Louis
Explore the most affordable flight options available from St. Louis. Find the lowest fares based on data from user searches, with prices last updated on 14 January 2026.

Tue 10/306:51
STL
-
SFO
Nonstop4h 54m
United Airlines
Tue 10/316:17
SFO
-
STL
Nonstop4h 08m
United Airlines
Deal found 13/1£291
Tue 3/310:50
STL
-
SFO
Nonstop4h 45m
Southwest
Thu 5/310:10
SFO
-
STL
Nonstop3h 45m
Southwest
Deal found 13/1£302
Mon 9/209:40
STL
-
SFO
Nonstop4h 35m
Southwest
Tue 17/211:55
SFO
-
STL
Nonstop3h 45m
Southwest
Deal found 12/1£313
Wed 4/217:00
STL
-
SFO
Nonstop5h 01m
United Airlines
Sun 8/223:00
SFO
-
STL
Nonstop4h 11m
United Airlines
Deal found 13/1£324
Wed 20/508:35
STL
-
SFO
Nonstop4h 25m
Southwest
Tue 26/511:55
SFO
-
STL
Nonstop3h 55m
Southwest
Deal found 12/1£325
Wed 18/210:50
STL
-
SFO
Nonstop4h 45m
Southwest
Wed 25/211:45
SFO
-
STL
Nonstop3h 50m
Southwest
Deal found 13/1£334
Sun 15/209:40
STL
-
SFO
Nonstop4h 35m
Southwest
Wed 18/211:45
SFO
-
STL
Nonstop3h 50m
Southwest
Deal found 12/1£336
Fri 13/209:50
STL
-
SFO
Nonstop4h 30m
Southwest
Tue 17/211:55
SFO
-
STL
Nonstop3h 45m
Southwest
Deal found 13/1£353
Wed 27/519:06
STL
-
SFO
Nonstop4h 35m
United Airlines
Sat 30/512:00
SFO
-
STL
Nonstop3h 53m
United Airlines
Deal found 13/1£357
Fri 6/308:30
STL
-
SFO
Nonstop4h 25m
Southwest
Fri 13/310:10
SFO
-
STL
Nonstop3h 45m
Southwest
Deal found 13/1£359
Wed 11/217:00
STL
-
SFO
Nonstop5h 01m
United Airlines
Sat 14/210:35
SFO
-
STL
Nonstop3h 52m
United Airlines
Deal found 14/1£363
Wed 28/110:50
STL
-
SFO
Nonstop4h 45m
Southwest
Wed 4/211:45
SFO
-
STL
Nonstop3h 50m
Southwest
Deal found 13/1£364

Find direct flights from St. Louis within your budget

 
Use the slider to find direct flights from St. Louis within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 858,174 searches. This data was last updated on 14 January 2026.

Fly to

Heathrow

Route

Depart

Return

Price

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Tue 10/3

06:51-09:45

Nonstop4h 54m

San Francisco

Tue 10/3

16:17-22:25

Nonstop4h 08m

£291

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Mon 9/2

09:40-12:15

Nonstop4h 35m

San Francisco

Tue 17/2

11:55-17:40

Nonstop3h 45m

£313

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Mon 2/3

09:40-12:15

Nonstop4h 35m

San Francisco

Thu 5/3

10:10-15:55

Nonstop3h 45m

£313

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Thu 16/4

08:25-10:45

Nonstop4h 20m

San Francisco

Tue 28/4

11:55-17:50

Nonstop3h 55m

£334

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Wed 18/2

10:50-13:35

Nonstop4h 45m

San Francisco

Tue 24/2

11:45-17:35

Nonstop3h 50m

£334

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Sun 15/2

09:40-12:15

Nonstop4h 35m

San Francisco

Wed 18/2

11:45-17:35

Nonstop3h 50m

£336

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Fri 27/3

08:30-10:55

Nonstop4h 25m

San Francisco

Mon 30/3

10:10-15:55

Nonstop3h 45m

£359

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Tue 2/6

08:35-11:00

Nonstop4h 25m

San Francisco

Tue 9/6

12:20-18:10

Nonstop3h 50m

£359

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Sun 24/5

09:05-11:25

Nonstop4h 20m

San Francisco

Sat 6/6

10:25-16:10

Nonstop3h 45m

£366

St. LouisLondon

STL - LHR

STLLHR

Lambert-St Louis

Tue 5/5

21:35-11:35

Nonstop8h 00m

London Heathrow

Tue 19/5

16:25-19:30

Nonstop9h 05m

£482

Flights are sorted by cheapest return flights first.

Deals found on 13/1

Showing 1-10 of 42 results
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Best time to book a flight from St. Louis

Have a flexible travel schedule? Discover the best time to fly from St. Louis with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines flying non-stop to St. Louis

Get insights into the airlines that provide direct flights from St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight from St. Louis. Reviews last updated Cheapflights.
Read through reviews of airlines serving St. Louis, such as Virgin Atlantic, Air Canada, andBritish Airways. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Virgin Atlantic
7.5
Good
678 reviews
Check prices

Entertainment

7.6

Crew

8.2

Overall

7.5

Comfort

7.3

Food

6.9

Boarding

7.7

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
Virgin Atlantic
7.5
Good
678 reviews
Virgin Atlantic
7.5
Good
678 reviews
Check prices

Entertainment

7.6

Crew

8.2

Overall

7.5

Comfort

7.3

Food

6.9

Boarding

7.7

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
Air Canada
7.1
Good
10,620 reviews
Virgin Atlantic
7.5
Good
678 reviews
Check prices

Entertainment

7.6

Crew

8.2

Overall

7.5

Comfort

7.3

Food

6.9

Boarding

7.7

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
British Airways
6.7
Okay
7,671 reviews
Virgin Atlantic
7.5
Good
678 reviews
Check prices

Entertainment

7.6

Crew

8.2

Overall

7.5

Comfort

7.3

Food

6.9

Boarding

7.7

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!

Related info for your journey

Access useful and relevant information related to your journey from St. Louis. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 14 January 2026.

  • Where can you fly direct from St. Louis?

    Currently, the most popular direct flight destination from St. Louis is Tampa.

  • What is the best time of year to fly direct from St. Louis?

    If you're seeking the lowest price on a direct flight from St. Louis, October is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, September offers travelers the most options.

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