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£80+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — LHR
10 Apr — 17 Apr1
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 11 March 2026.

Good round-trip deal

£106 or less

Good one-way deal

£117 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

Enter your travel dates to find the best prices.

Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 11 March 2026.

Tue 26/503:25
PTY
-
MAD
1 stop13h 55m
Avianca
Tue 2/602:20
MAD
-
PTY
1 stop18h 55m
Avianca
Deal found 7/3£507
Wed 3/618:50
PTY
-
MAD
1 stop31h 40m
KLM
Tue 16/607:05
MAD
-
PTY
1 stop16h 45m
KLM
Deal found 10/3£525
Wed 27/518:50
PTY
-
MAD
1 stop35h 50m
Multiple Airlines
Wed 17/616:40
MAD
-
PTY
1 stop34h 05m
Multiple Airlines
Deal found 9/3£535
Wed 27/518:50
PTY
-
MAD
1 stop35h 50m
KLM
Sun 31/520:30
MAD
-
PTY
1 stop27h 20m
KLM
Deal found 9/3£538
Tue 28/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 16/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 7/3£542
Sun 19/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Mon 27/415:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 6/3£544
Mon 20/422:20
PTY
-
BRU
1 stop33h 55m
Turkish Airlines
Mon 27/407:20
BRU
-
PTY
1 stop20h 05m
Turkish Airlines
Deal found 6/3£547
Mon 13/422:20
PTY
-
MAD
1 stop32h 15m
Turkish Airlines
Fri 24/418:25
MAD
-
PTY
1 stop33h 00m
Turkish Airlines
Deal found 9/3£547
Sun 10/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 16/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 7/3£552
Sun 17/520:05
PTY
-
STN
1 stop20h 05m
Turkish Airlines
Sun 31/517:35
STN
-
PTY
1 stop32h 50m
Turkish Airlines
Deal found 6/3£594
Sun 10/520:25
PTY
-
BRU
1 stop14h 15m
Air Europa
Mon 18/510:45
BRU
-
PTY
1 stop14h 55m
Air Europa
Deal found 7/3£597
Sun 17/520:05
PTY
-
LGW
1 stop20h 20m
Turkish Airlines
Sun 31/514:05
LGW
-
PTY
1 stop36h 20m
Turkish Airlines
Deal found 8/3£602

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 11 March 2026. In the last 7 days, Cheapflights users made a total of 858,174 searches

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 27/5

22:20-22:35

1 stop41h 15m

Madrid Barajas

Wed 3/6

12:00-18:30

2 stops37h 30m

£556
Fastest return journey

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 27/5

21:30-14:20

Nonstop9h 50m

Madrid Barajas

Wed 3/6

15:55-20:00

Nonstop11h 05m

£566

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Thu 14/5

20:25-17:40

1 stop14h 15m

Brussels Bruxelles-National

Wed 20/5

10:45-18:40

1 stop14h 55m

£597

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sun 10/5

20:25-17:40

1 stop14h 15m

Brussels Bruxelles-National

Fri 22/5

10:45-18:40

1 stop14h 55m

£597

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 13/4

22:20-21:25

1 stop40h 05m

Brussels Bruxelles-National

Sat 25/4

07:20-18:25

2 stops42h 05m

£603

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Wed 3/6

20:25-17:40

1 stop14h 15m

Brussels Bruxelles-National

Sun 7/6

10:45-18:40

1 stop14h 55m

£617

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 25/5

20:25-17:40

1 stop14h 15m

Brussels Bruxelles-National

Fri 29/5

18:55-18:40

1 stop30h 45m

£617

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Fri 15/5

20:25-17:40

1 stop14h 15m

Brussels Bruxelles-National

Mon 18/5

10:45-18:40

1 stop14h 55m

£621

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 11/5

20:25-17:40

1 stop14h 15m

Brussels Bruxelles-National

Fri 22/5

10:45-18:40

1 stop14h 55m

£621

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Wed 13/5

20:25-17:40

1 stop14h 15m

Brussels Bruxelles-National

Wed 20/5

10:45-18:40

1 stop14h 55m

£621

Flights are sorted by cheapest return flights first.

Deals found on 7/3

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama?

Currently, February is the cheapest month in which you can book a flight from Panama (average of £586). Flying from Panama in January will prove the most costly (average of £789). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

Which airlines fly from Panama?

Many airlines operate round-trip flights from Panama: Turkish Airlines, KLM, Air France, United Airlines. These airlines fly to the following popular destinations: London.

Copa Airlines
Copa Airlines
From £141
Turkish Airlines
Turkish Airlines
From £638
Air Panama
Air Panama
From £114
Air Europa
Air Europa
From £523

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is San José Juan Santamaria Intl, with prices starting at £96. Explore other affordable destinations below.

San José Juan Santamaria Intl
San José Juan Santamaria Intl
From £96
Medellín Jose Maria Cordova Intl
Medellín Jose Maria Cordova Intl
From £106
Cartagena Rafael Nunez
Cartagena Rafael Nunez
From £117
Bogotá El Dorado
Bogotá El Dorado
From £129

Airline reviews for flights from Panama

Get insights into the airlines that provide service from Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Panama. In the last 7 days, Cheapflights users made a total of 858,174 searches.
Read through reviews of airlines serving Panama, such as KLM,Air France, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,470 reviews
Check prices

Crew

8.4

Boarding

7.8

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
KLM
7.8
Good
1,470 reviews
KLM
7.8
Good
1,470 reviews
Check prices

Crew

8.4

Boarding

7.8

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Air France
7.4
Good
1,543 reviews
KLM
7.8
Good
1,470 reviews
Check prices

Crew

8.4

Boarding

7.8

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
United Airlines
7.4
Good
9,415 reviews
KLM
7.8
Good
1,470 reviews
Check prices

Crew

8.4

Boarding

7.8

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Turkish Airlines
7.3
Good
4,252 reviews
KLM
7.8
Good
1,470 reviews
Check prices

Crew

8.4

Boarding

7.8

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas

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Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 11 March 2026.

  • What is the cheapest month to fly from Panama?

    At the present moment the cheapest month to fly from Panama is currently February; with January being the most expensive. Prices will vary depending on multiple factors such as booking in advance, airline and departure airports and times.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Certainly. Search results for flights from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Not ready to book yet? You can track prices for flights from Panama on Cheapflights with our Price Alerts feature and get notified when better prices are available.

See more FAQs

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Panama?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Certainly. Search results for flights from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Not ready to book yet? You can track prices for flights from Panama on Cheapflights with our Price Alerts feature and get notified when better prices are available.

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