Find flights
Airlines

£78+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — LHR
26 Feb — 5 Mar1
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 27 January 2026.

Good round-trip deal

£148 or less

Good one-way deal

£89 or less
Price to beat on a round-trip flight from Panama.
Search Deals
Price to beat on a one-way flight from Panama.
Search Deals

Find flights from Panama

Enter your travel dates to find the best prices.

Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 27 January 2026.

Wed 1/417:25
PTY
-
MEX
1 stop10h 40m
Avianca
Sun 12/404:55
MEX
-
PTY
1 stop18h 15m
Avianca
Deal found 26/1£245
Tue 10/311:41
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Fri 20/315:30
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 26/1£257
Mon 9/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Sat 14/215:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 26/1£289
Wed 1/411:05
PTY
-
MEX
1 stop12h 55m
Avianca
Tue 21/400:40
MEX
-
PTY
1 stop14h 50m
Avianca
Deal found 26/1£306
Sat 28/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Mon 16/315:30
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£335
Mon 18/516:13
PTY
-
MEX
Nonstop3h 52m
Copa Airlines
Fri 22/513:10
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 26/1£340
Thu 26/311:41
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Mon 30/315:30
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 24/1£362
Sat 30/522:14
PTY
-
MEX
Nonstop3h 46m
Copa Airlines
Fri 5/601:20
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 26/1£365
Wed 24/615:50
PTY
-
MEX
1 stop10h 20m
Avianca
Thu 2/704:00
MEX
-
PTY
1 stop5h 30m
Avianca
Deal found 25/1£375
Mon 20/709:25
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Sun 26/715:30
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Deal found 25/1£399
Fri 13/216:17
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Mon 16/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 25/1£401
Sat 13/616:05
PTY
-
MEX
Nonstop4h 00m
Copa Airlines
Sat 20/600:25
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 25/1£414

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 27 January 2026. In the last 7 days, Cheapflights users made a total of 858,174 searches

Fly to

Heathrow

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 1/4

17:25-03:05

1 stop10h 40m

Mexico City Benito Juarez

Sun 12/4

04:55-00:10

1 stop18h 15m

£245

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 7/2

19:02-22:05

Nonstop4h 03m

Mexico City Benito Juarez

Sun 15/3

09:25-14:04

Nonstop3h 39m

£257

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 29/4

09:19-12:10

Nonstop3h 51m

Mexico City Benito Juarez

Sun 10/5

13:10-17:50

Nonstop3h 40m

£257

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 10/3

09:22-12:10

Nonstop3h 48m

Mexico City Benito Juarez

Tue 17/3

09:25-14:04

Nonstop3h 39m

£257

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 17/2

22:10-01:00

Nonstop3h 50m

Mexico City Benito Juarez

Tue 24/2

15:30-20:07

Nonstop3h 37m

£257

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 11/3

09:22-12:10

Nonstop3h 48m

Mexico City Benito Juarez

Wed 18/3

09:25-14:04

Nonstop3h 39m

£257

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 16/4

11:44-14:30

Nonstop3h 46m

Mexico City Benito Juarez

Thu 30/4

13:10-17:50

Nonstop3h 40m

£257

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 20/3

09:22-12:10

Nonstop3h 48m

Mexico City Benito Juarez

Wed 15/4

13:10-17:50

Nonstop3h 40m

£257

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 14/2

21:25-00:15

Nonstop3h 50m

Mexico City Benito Juarez

Wed 25/2

01:20-06:00

Nonstop3h 40m

£257

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 27/2

09:21-12:10

Nonstop3h 49m

Mexico City Benito Juarez

Tue 10/3

15:30-20:13

Nonstop3h 43m

£257

Flights are sorted by cheapest return flights first.

Deals found on 25/1

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama?

Currently, February is the cheapest month in which you can book a flight from Panama (average of £493). Flying from Panama in August will prove the most costly (average of £755). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

Which airlines fly from Panama?

Many airlines operate round-trip flights from Panama: Turkish Airlines, KLM, Air France, United Airlines. These airlines fly to the following popular destinations: London.

Copa Airlines
Copa Airlines
From £121
Turkish Airlines
Turkish Airlines
From £627
Air Panama
Air Panama
From £112
Air France
Air France
From £658

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Cartagena Rafael Nunez, with prices starting at £89. Explore other affordable destinations below.

Cartagena Rafael Nunez
Cartagena Rafael Nunez
From £89
Bocas Del Toro
Bocas Del Toro
From £96
Panama City Tocumen Intl
Panama City Tocumen Intl
From £96
San José Juan Santamaria Intl
San José Juan Santamaria Intl
From £98

Airline reviews for flights from Panama

Get insights into the airlines that provide service from Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Panama. In the last 7 days, Cheapflights users made a total of 858,174 searches.
Read through reviews of airlines serving Panama, such as KLM, Air France, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.7
Good
1,443 reviews
Check prices

Boarding

7.8

Overall

7.7

Entertainment

7.1

Food

7.3

Comfort

7.6

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
KLM
7.7
Good
1,443 reviews
KLM
7.7
Good
1,443 reviews
Check prices

Boarding

7.8

Overall

7.7

Entertainment

7.1

Food

7.3

Comfort

7.6

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
Air France
7.4
Good
1,526 reviews
KLM
7.7
Good
1,443 reviews
Check prices

Boarding

7.8

Overall

7.7

Entertainment

7.1

Food

7.3

Comfort

7.6

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
United Airlines
7.4
Good
9,203 reviews
KLM
7.7
Good
1,443 reviews
Check prices

Boarding

7.8

Overall

7.7

Entertainment

7.1

Food

7.3

Comfort

7.6

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
Turkish Airlines
7.3
Good
4,208 reviews
KLM
7.7
Good
1,443 reviews
Check prices

Boarding

7.8

Overall

7.7

Entertainment

7.1

Food

7.3

Comfort

7.6

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Direct flights from Central America

Book a direct flight from one of these other cities located in Central America.
Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 27 January 2026.

  • What is the cheapest month to fly from Panama?

    At the present moment the cheapest month to fly from Panama is currently February; with August being the most expensive. Prices will vary depending on multiple factors such as booking in advance, airline and departure airports and times.

  • Where are the cheapest places to fly to from Panama?

    Check out the cheapest flights from Panama to embark to:
    Travel from Panama City to London from £566 round trip

  • How does Cheapflights help users find flights from Panama?

    Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Certainly. Search results for flights from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Not ready to book yet? You can track prices for flights from Panama on Cheapflights with our Price Alerts feature and get notified when better prices are available.

See more FAQs

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Panama?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Certainly. Search results for flights from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Not ready to book yet? You can track prices for flights from Panama on Cheapflights with our Price Alerts feature and get notified when better prices are available.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.