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£107+ Cheap flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — LHR
16 Aug — 23 Aug1
1 adult
1 adult, Economy, 0 bags

Find flights from Panama City within your budget

 
Find flights departing from Panama City that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 17 July 2026. In the last 7 days, Cheapflights users made a total of 858,174 searches

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 27/7

06:49-08:15

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Thu 30/7

11:45-13:12

Nonstop1h 27m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 24/8

12:49-14:15

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Sat 29/8

09:15-10:42

Nonstop1h 27m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 7/9

13:20-14:45

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Sun 13/9

12:40-14:09

Nonstop1h 29m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sun 20/9

09:30-10:55

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Fri 25/9

18:20-19:49

Nonstop1h 29m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sun 16/8

06:49-08:15

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Sat 22/8

10:35-12:02

Nonstop1h 27m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 5/10

09:30-10:55

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Fri 9/10

12:40-14:09

Nonstop1h 29m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 3/10

09:30-10:55

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Tue 20/10

15:10-16:39

Nonstop1h 29m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 7/8

06:49-08:15

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Fri 14/8

18:20-19:47

Nonstop1h 27m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 3/10

09:30-10:55

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Tue 6/10

15:10-16:39

Nonstop1h 29m

£204

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sun 13/9

09:30-10:55

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Sun 20/9

09:15-10:44

Nonstop1h 29m

£204

Flights are sorted by cheapest return flights first.

Deals found on 15/7

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City

Get recent, data-driven insights about flights from Panama City including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama City?

Currently, March is the cheapest month in which you can book a flight from Panama City (average of £718). Flying from Panama City in January will prove the most costly (average of £948). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

Which airlines fly from Panama City?

Many airlines operate round-trip flights from Panama City: Turkish Airlines, KLM. These airlines fly to the following popular destinations: London.

Copa Airlines
Copa Airlines
From £71
Turkish Airlines
Turkish Airlines
From £635
Air Europa
Air Europa
From £518
Air Panama
Air Panama
From £115

What are popular destinations to fly to from Panama City?

If you’re flying from Panama City, these routes are more frequently taken by airlines Sao Paulo (270 flights per day), San José (147 flights per day) and Guatemala City (121 flights per day).

Bogotá El Dorado
Bogotá El Dorado
From £152
David Enrique Malek
David Enrique Malek
From £111
Bocas Del Toro
Bocas Del Toro
From £116
New York
New York
From £619

What is the cheapest place to fly to from Panama City?

The cheapest city to fly to from Panama City is David Enrique Malek, with prices starting at £111. Explore other affordable destinations below.

David Enrique Malek
David Enrique Malek
From £111
Bocas Del Toro
Bocas Del Toro
From £116
San Salvador El Salvador Intl
San Salvador El Salvador Intl
From £120
Cali Alfonso B. Aragon Intl
Cali Alfonso B. Aragon Intl
From £138

When is the best time to book a flight from Panama City?

Booking 77 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

Airline reviews for flights from Panama City

Get insights into the airlines that provide service from Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Panama City. In the last 7 days, Cheapflights users made a total of 858,174 searches.
Read through reviews of airlines serving Panama City, such as KLM and Turkish Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,539 reviews
Check prices

Comfort

7.7

Food

7.3

Entertainment

7.2

Overall

7.8

Boarding

7.8

Crew

8.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
KLM
7.8
Good
1,539 reviews
KLM
7.8
Good
1,539 reviews
Check prices

Comfort

7.7

Food

7.3

Entertainment

7.2

Overall

7.8

Boarding

7.8

Crew

8.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Turkish Airlines
7.4
Good
4,447 reviews
KLM
7.8
Good
1,539 reviews
Check prices

Comfort

7.7

Food

7.3

Entertainment

7.2

Overall

7.8

Boarding

7.8

Crew

8.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas

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Direct flights from Panama

Book a direct flight from one of these other cities located in Panama.
Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 17 July 2026.

  • What are the most popular destinations to fly to from Panama City?

    This month, the top selected destinations from Panama City are Bogotá, Cartagena, Bocas del Toro. Throughout the year, Bogotá, Cancún, Bocas del Toro are some of the top choices made by users flying from Panama City.

  • What is the cheapest flight from Panama City to anywhere?

    Users have flown out of Panama City for as low as £111 to David (prices may vary depending on the airline and departure time). On average, users have booked flights for £469 to fly from Panama City.

  • What are the cheapest airlines flying from Panama City to anywhere?

    Over the past few days, we've found that Wingo, Copa Airlines, and Air Panama have the cheapest prices from Panama City. Wingo flights from Panama City to Medellín Jose Maria Cordova Intl (£52), Copa Airlines flights from Panama City to David Enrique Malek (£71), and Air Panama flights from Panama City to Bocas Del Toro (£115).

  • What is the cheapest premium economy flight from Panama City?

    Here are some of the cheapest offers we have found for the cheapest premium economy flights from Panama City.
    Panama City Tocumen Intl to Paris Charles de Gaulle Airport from £967
    Panama City Tocumen Intl to Houston George Bush Intcntl Airport from £1,366
    Panama City Tocumen Intl to Amsterdam from £1,782

  • What is the cheapest month to fly from Panama City?

    At the present moment the cheapest month to fly from Panama City is currently March; with January being the most expensive. Prices will vary depending on multiple factors such as booking in advance, airline and departure airports and times.

  • Where are the cheapest places to fly to from Panama City?

    Check out the cheapest flights from Panama City to embark to:
    Travel from Panama City to London from £634 round trip

  • How does Cheapflights help users find flights from Panama City?

    Cheapflights makes it easy to find flights from Panama City by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

  • Why should you use Cheapflights to find cheap flight tickets from Panama City?

    Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City for you. Better yet — we are completely free to use.

  • Can Cheapflights find flights from Panama City with no change fees?

    Users can book flights with no change fees policies with our dedicated filters. Book flights from Panama City flexibly with Cheapflights today.

  • Can Cheapflights notify me if prices for flights from Panama City become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama City today and book when you’re ready!

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How does Cheapflights help users find flights from Panama City?

Cheapflights makes it easy to find flights from Panama City by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Panama City?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Panama City with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Panama City flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Panama City become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama City today and book when you’re ready!

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