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Cheap flights from Panama City to Madrid, Spain from £317

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
6 Jul — 13 Jul1
1 adult

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in March or February, booked 58 days in advance, depart on a Saturday or Tuesday and return on a Wednesday

Cheap flight deals from Panama City to Madrid

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 1 July 2025.

Round-trip from

£541

One-way from

£317

Popular in

July

Cheapest in

March

Average price

£650

Good round-trip deal

£631 or less

Good one-way deal

£390 or less
Turkish Airlines
  • Turkish Airlines
  • 22/11-29/11
  • 2 total stops
  • 56h 10m total
  • Panama City to Madrid
Turkish Airlines
  • Turkish Airlines
  • 21/9
  • 1 total stop
  • 35h 55m total
  • Panama City to Madrid
Highest demand for flights based on searches. 9% potential increase in price (£42 potential increase over avg. return price).
Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
Average for round-trip flights in July 2025
Price to beat on a round-trip flight from Panama City Tocumen Intl to Madrid Barajas.
Price to beat on a one-way flight from Panama City Tocumen Intl to Madrid Barajas.

Find flight deals from Panama City to Madrid

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 1 July 2025.

Sat 22/1121:45PTY - MAD
1 stop36h 40mTurkish Airlines
Sat 29/1106:20MAD - PTY
1 stop19h 30mTurkish Airlines
Deal found 30/6£541
Sun 29/618:50PTY - MAD
1 stop17h 40mKLM
Thu 3/720:25MAD - PTY
1 stop27h 25mKLM
Deal found 29/6£551
Tue 5/820:25PTY - MAD
Nonstop9h 50mAir Europa
Fri 19/915:05MAD - PTY
Nonstop10h 35mAir Europa
Deal found 30/6£552
Tue 8/718:50PTY - MAD
1 stop14h 35mMultiple Airlines
Sat 12/710:05MAD - PTY
1 stop15h 58mMultiple Airlines
Deal found 30/6£572
Fri 31/1021:55PTY - MAD
1 stop18h 40mAvianca
Sat 8/1100:35MAD - PTY
1 stop15h 05mAvianca
Deal found 29/6£586
Sun 5/1009:45PTY - MAD
1 stop16h 15mUnited Airlines
Wed 15/1011:15MAD - PTY
2 stops33h 59mUnited Airlines
Deal found 30/6£615

Cheapflights Fare Finder

Customise your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 1 July 2025.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Panama City

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 22/11

21:45-16:25

1 stop36h 40m

Madrid Barajas

Sat 29/11

06:20-19:50

1 stop19h 30m

£541

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 15/7

18:50-19:30

1 stop17h 40m

Madrid Barajas

Tue 30/9

10:05-17:45

1 stop14h 40m

£551

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 5/8

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Fri 19/9

15:05-18:40

Nonstop10h 35m

£552

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 7/10

18:50-09:35

1 stop31h 45m

Madrid Barajas

Tue 28/10

07:05-16:25

1 stop15h 20m

£576

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 31/10

21:55-22:35

1 stop18h 40m

Madrid Barajas

Sat 8/11

00:35-09:40

1 stop15h 05m

£586

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 5/10

15:30-09:00

2 stops34h 30m

Madrid Barajas

Wed 15/10

11:15-18:37

2 stops38h 22m

£615

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 21/9

21:55-16:50

1 stop35h 55m

£317

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 15/7

18:50-09:35

1 stop31h 45m

£372

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 15/7

20:25-13:15

Nonstop9h 50m

£384

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 28/7

11:05-13:40

1 stop19h 35m

£394

Flights are sorted by cheapest return flights first.

Deals found on 1/7

Showing 1-10 of 13 results
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Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

Use this chart to determine the optimal time to book a return flight from Panama City to Madrid. Price data was last updated on 27 June 2025.

To ensure you get the cheapest price possible for a flight from Panama City to Madrid, you should look to book at least 58 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, January is the cheapest month in which you can book a flight from Panama City to Madrid (average of £94). Flying from Panama City to Madrid in July is currently the most expensive (average of £262). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 1 July 2025.

It’s optimal to fly from Panama City to Madrid in the morning. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight at midday.

Weekly flight availability from Panama City to Madrid

Explore weekly flight availability from Panama City to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 1 July 2025.

The most flights from PTY to MAD are scheduled on a Monday (9 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).

How much does it cost for a return flight from Panama City to Madrid?

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated 1 July 2025.
See what other customers who have flown with KLM, Copa Airlines, andUnited Airlines from Panama City to Madrid have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Overall

7.8

Food

7.2

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Crew

8.4

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Overall

7.8

Food

7.2

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Crew

8.4

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Overall

7.8

Food

7.2

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Crew

8.4

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Overall

7.8

Food

7.2

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Crew

8.4

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Overall

7.8

Food

7.2

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Crew

8.4

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Overall

7.8

Food

7.2

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Crew

8.4

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airports do I use to fly from Panama City to Madrid?

    If you book a flight from Panama City to Madrid, you will be flying from Tocumen Intl to Barajas. Flights to Madrid Barajas (MAD) from Panama City Tocumen Intl (PTY) take 9h 50m for a nonstop flight. There are 5 flights from Tocumen Intl to Madrid per day from 2 airlines.

  • How popular is this Panama City to Madrid flight route?

  • What are the cheapest airlines flying from Panama City to Madrid round-trip?

    According to our current data, Turkish Airlines (£541), Air Europa (£552), and KLM (£576) offers the cheapest pricing from Panama City to Madrid. Turkish Airlines is 4% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City to Madrid one-way?

    £317 is the cheapest one-way deal found within the past few days, from Turkish Airlines. You may also be able to find cheap deals on KLM and Air Europa, with prices starting from £372 and £384, respectively.

  • What are the most reliable airlines from Panama City to Madrid?

    The top 3 most reliable airlines when flying from Panama City to Madrid are Air Europa (82%), Etihad Airways (82%) and China Eastern (82%).

  • What are the cheapest flights from Panama City to Madrid?

    Looking at all options, your cheapest flight can be booked for £379. While the most popular route (Panama City Tocumen Intl - Madrid Barajas) can be booked for £916 on average our data indicates £600 when flying from Panama City to Madrid.

  • Can I find deals for flights from Panama City to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

  • Can I find deals for business class flights from Panama City to Madrid?

    Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Madrid?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Madrid (average of £94). Flying from Panama City to Madrid in July is currently the most expensive (average of £262). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Guadalajara
Getafe

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Top 2 airlines flying from Panama City to Madrid

Discover the top 2 airlines that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 1 July 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest£474Average£579FlexibilityNo cancel feeOn-time83%
Search Air Europa flights
IberiaCheapest£484Average£637FlexibilityNo cancel feeOn-time77%
Search Iberia flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama City to Madrid?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama City to Madrid. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Panama City to Madrid?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City to Madrid for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Panama City to Madrid with no change fees?

Certainly. Search results for flights to Madrid from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?

Of course! You can now track prices for flights from Panama City to Madrid and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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