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Cheap flights from Santa Ana, California to Des Moines from £166

SNA — DSM
24 Oct — 31 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santa Ana to Des Moines

Enter your travel dates to find the best prices.

Cheapest flights from Santa Ana to Des Moines

Wed 21/1009:00 -
1 stop5h 20m
Wed 28/1017:12 -
1 stop6h 07m
Deal found 21/9£267
Tue 10/1118:55 -
2 stops13h 24m
Wed 18/1114:48 -
1 stop8h 07m
Deal found 23/9£271
Tue 10/1118:55 -
2 stops13h 24m
Thu 12/1111:00 -
2 stops13h 30m
Deal found 23/9£276
Fri 13/1112:47 -
1 stop6h 26m
Wed 18/1114:48 -
1 stop8h 07m
Deal found 23/9£280
Fri 13/1118:55 -
2 stops13h 24m
Tue 17/1114:48 -
1 stop8h 07m
Deal found 23/9£284
Fri 13/1118:55 -
2 stops13h 24m
Sat 14/1116:00 -
2 stops8h 02m
Deal found 23/9£288
Thu 15/1018:02 -
2 stops14h 09m
Sat 17/1016:01 -
1 stop6h 55m
Deal found 21/9£303
Wed 11/1107:00 -
2 stops12h 13m
Mon 16/1114:48 -
1 stop8h 07m
Deal found 23/9£325
Wed 21/1011:20 -
2 stops7h 20m
Wed 28/1007:05 -
2 stops7h 50m
Deal found 21/9£333
Wed 30/1207:20 -
2 stops7h 40m
Fri 8/106:55 -
2 stops8h 30m
Deal found 21/9£334
Thu 15/1016:15 -
1 stop5h 33m
Sun 18/1005:45 -
2 stops8h 18m
Deal found 19/9£340

Find flight deals from Santa Ana to Des Moines

Round-trip from

£267

One-way from

£166

Popular in

November

Cheapest in

January

Average price

£164
United Airlines
  • United Airlines
  • 21/10-28/10
  • 2 total stops
  • 11h 27m total
  • Santa Ana to Des Moines
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Delta
  • Delta
  • 29/10-31/12
  • 1 total stop
  • 9h 01m total
  • Santa Ana to Des Moines
Search Deals
Highest demand for flights based on searches. 16% potential increase in price (£33 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease (£9 potential savings vs. average return price).
Search Deals
Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santa Ana to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 29/10

11:32-22:33

1 stop9h 01m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£166

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Tue 24/11

18:55-10:19

2 stops13h 24m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£176

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 29/10

06:50-17:27

2 stops8h 37m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£179

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Fri 16/10

18:22-10:31

2 stops14h 09m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£192

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Tue 13/10

10:37-21:23

1 stop8h 46m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£201

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Wed 25/11

07:20-17:00

2 stops7h 40m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£206

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Thu 18/3

08:30-18:30

2 stops8h 00m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£229
Fastest return journey

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Wed 7/10

07:00-16:20

1 stop7h 20m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£248

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Wed 21/10

09:00-16:20

1 stop5h 20m

Des Moines

Wed 28/10

17:12-21:19

1 stop6h 07m

£267

Santa AnaDes Moines

SNA Santa Ana J. Wayne/Orange Cnty - DSM Des Moines

SNADSM

Santa Ana J. Wayne/Orange Cnty

Sun 3/1

08:00-18:30

2 stops8h 30m

Des Moines

Wed 31/12

00:00-22:00

Nonstop0h 00m

£288

Flights are sorted by cheapest return flights first.

Deals found on 20/9

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Santa Ana to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Santa Ana with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Des Moines

What is the cheapest month to book a flight from Santa Ana, California to Des Moines?

Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Des Moines (average of £132). Flying from Santa Ana, California to Des Moines in November is currently the most expensive (average of £348). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Santa Ana, California to Des Moines?

Airfare is above average for this route at the moment.

Santa Ana, California to Des Moines flights typically cost between £139 and £258 in October.
The cheapest return price found within the last 5 days was £267 on United Airlines (21 Oct–28 Oct).

Related info for your journey

  • How long is the flight from Santa Ana, California to Des Moines?

    For as low as £340, United Airlines can have you in Des Moines from Santa Ana, California in 5h 33m. There are 1425 mi between Santa Ana, California and Des Moines.

  • Can I find deals for flights from Santa Ana to Des Moines that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Des Moines flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Des Moines.

  • Can I find deals for business class flights from Santa Ana to Des Moines?

    Yes. Cheapflights offers flight deals from Santa Ana to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Des Moines?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Des Moines (average of £132). Flying from Santa Ana, California to Des Moines in November is currently the most expensive (average of £348). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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How does Cheapflights help users find flights from Santa Ana to Des Moines?

When you search for this flight from Santa Ana to Des Moines, Cheapflights searches on 900+ travel sites to save you time finding great flight deals online. Additionally, we offer filter features so you can choose a preferred cabin class or airline, see different price ranges, and much more so you can book the flight for you.

Why should you use Cheapflights to find cheap flight tickets from Santa Ana to Des Moines?

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Can Cheapflights find flights from Santa Ana to Des Moines with no change fees?

Yes, we can. To see specific flights from Santa Ana to Des Moines with no change fees, users can toggle flexible booking options after using the search form above to find flights.

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