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Cheap flights from Santiago to Mexico City from £204

SCL — MEX
15 Oct — 22 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santiago to Mexico City

Enter your travel dates to find the best prices.

Cheapest flights from Santiago to Mexico City

Wed 30/901:44 -
1 stop26h 16m
Wed 7/1009:50 -
1 stop13h 56m
Deal found 14/9£376
Fri 25/1205:07 -
1 stop20h 18m
Thu 7/103:25 -
1 stop23h 32m
Deal found 14/9£391
Sun 27/901:06 -
1 stop20h 59m
Wed 21/1002:10 -
1 stop15h 22m
Deal found 10/9£395
Sat 19/916:20 -
1 stop13h 45m
Thu 24/904:55 -
1 stop16h 25m
Deal found 13/9£401
Tue 22/916:20 -
1 stop13h 45m
Fri 25/904:55 -
1 stop16h 25m
Deal found 14/9£408
Mon 14/905:14 -
1 stop12h 16m
Fri 18/905:50 -
1 stop11h 42m
Deal found 12/9£413
Thu 22/1012:23 -
1 stop15h 37m
Sat 21/1103:25 -
1 stop17h 54m
Deal found 14/9£446
Tue 15/912:22 -
1 stop15h 38m
Tue 22/915:30 -
1 stop29h 09m
Deal found 14/9£453
Thu 31/1212:20 -
1 stop13h 05m
Wed 31/315:30 -
1 stop25h 37m
Deal found 10/9£465
Tue 10/1105:07 -
1 stop22h 08m
Sun 15/1103:25 -
1 stop17h 11m
Deal found 15/9£465
Sun 27/912:22 -
1 stop14h 53m
Thu 1/1002:10 -
1 stop19h 12m
Deal found 11/9£466

Find flight deals from Santiago to Mexico City

Round-trip from

£376

One-way from

£204

Popular in

June

Cheapest in

March

Average price

£501
Copa Airlines
  • Copa Airlines
  • 27/9-27/10
  • 2 total stops
  • 33h 33m total
  • Santiago to Mexico City
Search Deals
Copa Airlines
  • Copa Airlines
  • 23/12-31/12
  • 1 total stop
  • 21h 17m total
  • Santiago to Mexico City
Search Deals
Highest demand for flights based on searches. 8% potential increase in price (£36 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£5 potential savings vs. average return price).
Search Deals
Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santiago to Mexico City that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Fri 25/12

05:07-22:25

1 stop20h 18m

Mexico City Benito Juarez

Wed 31/12

00:00-03:00

Nonstop0h 00m

£204
Fastest return journey

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Mon 16/11

03:19-12:10

1 stop11h 51m

Mexico City Benito Juarez

Wed 31/12

00:00-03:00

Nonstop0h 00m

£239

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Mon 23/11

05:07-00:15

1 stop22h 08m

Mexico City Benito Juarez

Wed 31/12

00:00-03:00

Nonstop0h 00m

£239

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Tue 17/11

03:48-22:05

1 stop21h 17m

Mexico City Benito Juarez

Wed 31/12

00:00-03:00

Nonstop0h 00m

£239

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Fri 23/10

12:23-01:00

1 stop15h 37m

Mexico City Benito Juarez

Wed 31/12

00:00-03:00

Nonstop0h 00m

£279

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Sun 27/9

03:14-01:00

1 stop24h 46m

Mexico City Benito Juarez

Wed 31/12

00:00-03:00

Nonstop0h 00m

£279

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Sun 15/11

05:07-22:25

1 stop20h 18m

Mexico City Benito Juarez

Mon 23/11

13:10-03:38

1 stop11h 28m

£376

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Sun 8/11

05:07-00:15

1 stop22h 08m

Mexico City Benito Juarez

Sun 15/11

05:55-00:19

1 stop15h 24m

£395

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Sun 27/9

01:06-19:05

1 stop20h 59m

Mexico City Benito Juarez

Wed 21/10

02:10-20:32

1 stop15h 22m

£395

SantiagoMexico City

SCL Santiago Arturo Merino Benitez - MEX Mexico City Benito Juarez

SCLMEX

Santiago Arturo Merino Benitez

Thu 22/10

12:23-01:00

1 stop15h 37m

Mexico City Benito Juarez

Wed 28/10

09:10-05:55

1 stop17h 45m

£446

Flights are sorted by cheapest return flights first.

Deals found on 14/9

Showing 1-10 of 16 resultsSorted by cheapest first
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Best time to book a flight from Santiago to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Santiago with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santiago to Mexico City

How far ahead should I book a flight from Santiago to Mexico City?

Booking 82 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santiago to Mexico City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santiago to Mexico City?

Currently, March is the cheapest month in which you can book a flight from Santiago to Mexico City (average of £425). Flying from Santiago to Mexico City in June is currently the most expensive (average of £567). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to MEX?

When flying from Santiago to Mexico City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Santiago to Mexico City?

Airfare is below average for this route at the moment.

Santiago to Mexico City flights typically cost between £412 and £556 in September.
The cheapest return price found within the last 5 days was £376 on Copa Airlines (27 Sept–27 Oct).

Related info for your journey

  • How popular is this Santiago to Mexico City flight route?

    This flight path from Santiago Arturo Merino Benitez to Mexico City Benito Juarez was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santiago to Mexico City?

    There are many flights that can get you from Santiago to Mexico City in 20h 18m. Fly via Copa Airlines to get the fastest option. There are 4096 mi between Santiago and Mexico City.

  • Can I find deals for flights from Santiago to Mexico City that include hotel bookings?

    Yes. In addition to deals on Santiago to Mexico City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Mexico City.

  • Can I find deals for business class flights from Santiago to Mexico City?

    Yes. Cheapflights offers flight deals from Santiago to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Mexico City?

    Currently, March is the cheapest month in which you can book a flight from Santiago to Mexico City (average of £425). Flying from Santiago to Mexico City in June is currently the most expensive (average of £567). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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