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Cheap flights from Mexico City to Santiago from £252

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 29/5. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
28 May — 4 Jun1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 April 2026.

Sat 2/500:25
MEX
-
SCL
1 stop21h 01m
Copa Airlines
Tue 12/504:41
SCL
-
MEX
1 stop19h 24m
Copa Airlines
Deal found 24/4£505
Tue 28/405:50
MEX
-
SCL
1 stop19h 10m
Copa Airlines
Thu 14/502:22
SCL
-
MEX
1 stop18h 43m
Copa Airlines
Deal found 24/4£520
Mon 4/505:50
MEX
-
SCL
1 stop15h 36m
Copa Airlines
Mon 3/811:22
SCL
-
MEX
1 stop12h 43m
Copa Airlines
Deal found 27/4£528
Fri 1/505:50
MEX
-
SCL
1 stop21h 20m
Copa Airlines
Fri 15/511:17
SCL
-
MEX
1 stop15h 43m
Copa Airlines
Deal found 27/4£539
Sun 11/1001:20
MEX
-
SCL
1 stop20h 02m
Copa Airlines
Mon 19/1001:07
SCL
-
MEX
1 stop20h 58m
Copa Airlines
Deal found 28/4£551
Fri 1/505:50
MEX
-
SCL
1 stop15h 36m
Copa Airlines
Fri 8/502:22
SCL
-
MEX
1 stop21h 43m
Copa Airlines
Deal found 26/4£562
Mon 20/709:50
MEX
-
SCL
1 stop14h 00m
Copa Airlines
Sun 13/903:27
SCL
-
MEX
1 stop18h 38m
Copa Airlines
Deal found 27/4£566
Tue 19/520:05
MEX
-
SCL
Nonstop8h 50m
Multiple Airlines
Sun 31/509:30
SCL
-
MEX
1 stop24h 00m
Multiple Airlines
Deal found 24/4£568
Thu 9/705:50
MEX
-
SCL
1 stop15h 36m
Copa Airlines
Thu 16/711:22
SCL
-
MEX
1 stop15h 38m
Copa Airlines
Deal found 28/4£579

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 28 April 2026.

Round-trip from

£505

One-way from

£252

Popular in

April

Cheapest in

May

Average price

£506
Copa Airlines
  • Copa Airlines
  • 7/5-15/5
  • 2 total stops
  • 31h 46m total
  • Mexico City to Santiago
Search Deals
Copa Airlines
  • Copa Airlines
  • 29/5
  • 1 total stop
  • 16h 03m total
  • Mexico City to Santiago
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£4 potential savings vs. average return price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 28 April 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 12/10

09:50-03:16

1 stop14h 26m

Santiago Arturo Merino Benitez

Fri 16/10

05:15-22:05

1 stop19h 50m

£551

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 29/7

05:50-22:43

1 stop14h 53m

Santiago Arturo Merino Benitez

Wed 5/8

02:27-14:30

1 stop14h 03m

£551

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 11/10

02:10-00:22

1 stop19h 12m

Santiago Arturo Merino Benitez

Thu 15/10

12:23-00:15

1 stop14h 52m

£551

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 9/8

05:50-19:23

1 stop11h 33m

Santiago Arturo Merino Benitez

Wed 9/12

03:50-19:20

1 stop18h 30m

£551

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 14/7

09:50-03:00

1 stop15h 10m

Santiago Arturo Merino Benitez

Wed 29/7

11:22-01:00

1 stop15h 38m

£551

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 28/7

05:50-22:43

1 stop14h 53m

Santiago Arturo Merino Benitez

Wed 5/8

04:14-14:30

1 stop12h 16m

£551

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 15/7

02:10-19:23

1 stop15h 13m

Santiago Arturo Merino Benitez

Wed 29/7

11:22-01:00

1 stop15h 38m

£551
Fastest return journey

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 11/10

05:50-00:22

1 stop15h 32m

Santiago Arturo Merino Benitez

Wed 14/10

03:57-12:10

1 stop11h 13m

£551

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 26/5

01:20-23:26

1 stop20h 06m

Santiago Arturo Merino Benitez

Sun 31/5

11:17-01:00

1 stop15h 43m

£551

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 11/10

01:20-00:22

1 stop20h 02m

Santiago Arturo Merino Benitez

Mon 19/10

01:07-19:05

1 stop20h 58m

£551

Flights are sorted by cheapest return flights first.

Deals found on 24/4

Showing 1-10 of 19 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Booking 89 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £411). Flying from Mexico City to Santiago in April is currently the most expensive (average of £506). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 28 April 2026.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Mexico City to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 1 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • How long is the flight from Mexico City to Santiago?

    Airlines like Copa Airlines fly from Mexico City to Santiago in about 14h 30m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 4096 mi.

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider LATAM Airlines (100%), Wamos Air (100%) or WestJet (77%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £411). Flying from Mexico City to Santiago in April is currently the most expensive (average of £506). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Balmaceda car hire
Lastarria car hire

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Mexico City to Santiago?

Cheapflights helps you search for flights from Mexico City to Santiago via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights helps you find that perfect flight to Santiago from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Need flexible booking options for your flight to Santiago from Mexico City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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