Cheap flights from Mexico City to Santiago from £461

MEX — SCL
13 Oct — 20 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago

Tue 3/1102:00 -
1 stop18h 36m
Wed 11/1103:19 -
1 stop21h 46m
Deal found 10/9£514
Tue 3/1102:00 -
1 stop22h 38m
Thu 12/1103:48 -
1 stop21h 37m
Deal found 10/9£544
Wed 23/913:10 -
1 stop11h 46m
Wed 14/1005:22 -
1 stop22h 38m
Deal found 10/9£568
Thu 8/1002:10 -
1 stop22h 46m
Fri 23/1012:23 -
1 stop15h 37m
Deal found 9/9£579
Sat 3/1022:00 -
1 stop21h 10m
Sat 10/1009:30 -
Nonstop9h 15m
Deal found 9/9£582
Sat 19/909:50 -
1 stop11h 32m
Sun 4/1012:23 -
1 stop15h 37m
Deal found 12/9£587
Mon 5/1002:10 -
1 stop22h 46m
Fri 23/1012:23 -
1 stop15h 37m
Deal found 9/9£591
Sat 31/1001:20 -
1 stop23h 18m
Wed 4/1103:19 -
1 stop21h 46m
Deal found 10/9£598
Sat 3/1022:00 -
1 stop21h 10m
Sun 11/1009:30 -
Nonstop9h 15m
Deal found 10/9£599
Sat 3/1022:00 -
1 stop21h 10m
Mon 12/1009:30 -
Nonstop9h 15m
Deal found 13/9£600
Sat 19/909:50 -
1 stop11h 32m
Fri 25/901:43 -
1 stop13h 27m
Deal found 12/9£606
Thu 1/1002:10 -
1 stop18h 29m
Sat 10/1001:44 -
1 stop26h 16m
Deal found 9/9£610

Find flight deals from Mexico City to Santiago

Round-trip from

£514

One-way from

£461

Popular in

July

Cheapest in

January

Average price

£536
Copa Airlines
  • Copa Airlines
  • 3/11-11/11
  • 2 total stops
  • 40h 22m total
  • Mexico City to Santiago
Copa Airlines
  • Copa Airlines
  • 26/9-31/12
  • 1 total stop
  • 23h 36m total
  • Mexico City to Santiago
Highest demand for flights based on searches. 7% potential increase in price (£30 potential increase over avg. return price).
Cheapest flight prices on average. 0% potential price decrease (£4 potential savings vs. average return price).
Average for round-trip flights in September 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Sat 26/9

00:25-23:39

1 stop20h 14m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-21:00

Nonstop0h 00m

£461

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Fri 25/9

01:20-00:22

1 stop20h 02m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-21:00

Nonstop0h 00m

£461

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Sun 18/10

02:10-03:56

1 stop22h 46m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-21:00

Nonstop0h 00m

£461

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Thu 15/10

02:10-02:46

1 stop21h 36m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-21:00

Nonstop0h 00m

£461
Fastest return journey

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Fri 9/10

01:20-20:32

1 stop16h 12m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-21:00

Nonstop0h 00m

£461

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Wed 23/9

13:10-03:56

1 stop11h 46m

Santiago Arturo Merino Benitez

Wed 14/10

05:22-01:00

1 stop22h 38m

£568

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Tue 22/9

01:20-00:22

1 stop20h 02m

Santiago Arturo Merino Benitez

Tue 6/10

03:57-19:05

1 stop18h 08m

£568

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Sat 31/10

01:20-03:38

1 stop23h 18m

Santiago Arturo Merino Benitez

Wed 4/11

03:19-22:05

1 stop21h 46m

£598

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Sat 3/10

22:00-22:10

1 stop21h 10m

Santiago Arturo Merino Benitez

Mon 12/10

09:30-15:45

Nonstop9h 15m

£600

Mexico CitySantiago

MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez

MEXSCL

Mexico City Benito Juarez

Thu 1/10

02:10-23:39

1 stop18h 29m

Santiago Arturo Merino Benitez

Sat 10/10

01:44-01:00

1 stop26h 16m

£610

Flights are sorted by cheapest return flights first.

Deals found on 9/9

Showing 1-10 of 13 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Booking 87 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, January is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £446). Flying from Mexico City to Santiago in July is currently the most expensive (average of £571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Mexico City to Santiago?

Airfare is typical for this route at the moment.

Mexico City to Santiago flights typically cost between £470 and £587 in November.
The cheapest return price found within the last 5 days was £514 on Copa Airlines (3 Nov–11 Nov).

Related info for your journey

  • How popular is this Mexico City to Santiago flight route?

  • How long is the flight from Mexico City to Santiago?

    Airlines like Copa Airlines fly from Mexico City to Santiago in about 11h 46m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 4096 mi.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, January is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £446). Flying from Mexico City to Santiago in July is currently the most expensive (average of £571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

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Need flexible booking options for your flight to Santiago from Mexico City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

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Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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