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Cheap flights from Mexico City to Santiago from £281

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
15 Jul — 22 Jul1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 15 June 2026.

Wed 8/705:50
MEX
-
SCL
1 stop15h 36m
Copa Airlines
Tue 14/711:22
SCL
-
MEX
1 stop12h 43m
Copa Airlines
Deal found 14/6£545
Wed 8/704:55
MEX
-
SCL
1 stop16h 25m
Multiple Airlines
Tue 14/705:00
SCL
-
MEX
2 stops20h 00m
Multiple Airlines
Deal found 14/6£562
Mon 22/602:10
MEX
-
SCL
1 stop19h 16m
Copa Airlines
Thu 23/711:22
SCL
-
MEX
1 stop14h 53m
Copa Airlines
Deal found 11/6£564
Tue 30/600:25
MEX
-
SCL
1 stop24h 35m
Copa Airlines
Wed 8/700:43
SCL
-
MEX
1 stop15h 47m
Copa Airlines
Deal found 11/6£579
Thu 9/701:20
MEX
-
SCL
1 stop20h 06m
Copa Airlines
Fri 24/704:21
SCL
-
MEX
1 stop19h 44m
Copa Airlines
Deal found 10/6£592
Thu 10/902:10
MEX
-
SCL
1 stop15h 22m
Copa Airlines
Fri 18/901:43
SCL
-
MEX
1 stop13h 27m
Copa Airlines
Deal found 11/6£595
Sun 21/602:10
MEX
-
SCL
1 stop19h 16m
Copa Airlines
Thu 25/602:22
SCL
-
MEX
1 stop18h 43m
Copa Airlines
Deal found 12/6£608
Sat 13/619:00
MEX
-
SCL
1 stop24h 10m
Multiple Airlines
Sat 20/621:30
SCL
-
MEX
1 stop18h 20m
Multiple Airlines
Deal found 11/6£610
Tue 30/600:25
MEX
-
SCL
1 stop17h 11m
Copa Airlines
Tue 28/700:06
SCL
-
MEX
1 stop14h 04m
Copa Airlines
Deal found 11/6£622
Sat 15/819:55
MEX
-
SCL
1 stop23h 15m
Multiple Airlines
Sat 29/808:30
SCL
-
MEX
Nonstop9h 05m
Multiple Airlines
Deal found 12/6£623
Sat 1/819:00
MEX
-
SCL
1 stop24h 10m
Multiple Airlines
Sat 15/808:30
SCL
-
MEX
Nonstop9h 05m
Multiple Airlines
Deal found 14/6£636

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 15 June 2026.

Round-trip from

£545

One-way from

£281

Popular in

June

Cheapest in

November

Average price

£578
Copa Airlines
  • Copa Airlines
  • 8/7-14/7
  • 2 total stops
  • 28h 19m total
  • Mexico City to Santiago
Search Deals
Copa Airlines
  • Copa Airlines
  • 21/10
  • 1 total stop
  • 16h 12m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 10% potential increase in price (£41 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
Search Deals
Average for round-trip flights in June 2026
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Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 15 June 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 7/7

01:20-19:36

1 stop16h 16m

Santiago Arturo Merino Benitez

Wed 15/7

11:22-00:15

1 stop14h 53m

£564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 31/10

01:10-20:15

1 stop16h 05m

Santiago Arturo Merino Benitez

Wed 4/11

03:19-22:05

1 stop21h 46m

£564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 29/7

09:50-23:26

1 stop11h 36m

Santiago Arturo Merino Benitez

Wed 5/8

04:14-01:00

1 stop22h 46m

£564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 7/7

01:20-03:00

1 stop23h 40m

Santiago Arturo Merino Benitez

Thu 16/7

04:21-00:15

1 stop21h 54m

£564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 13/7

01:20-03:00

1 stop23h 40m

Santiago Arturo Merino Benitez

Wed 15/7

11:22-01:00

1 stop15h 38m

£564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 12/7

01:20-01:50

1 stop22h 30m

Santiago Arturo Merino Benitez

Mon 20/7

11:22-00:15

1 stop14h 53m

£564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 3/8

09:50-03:00

1 stop15h 10m

Santiago Arturo Merino Benitez

Thu 27/8

04:14-01:00

1 stop22h 46m

£564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 11/7

00:25-22:43

1 stop20h 18m

Santiago Arturo Merino Benitez

Fri 17/7

04:21-14:30

1 stop12h 09m

£564

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 30/6

00:25-03:00

1 stop24h 35m

Santiago Arturo Merino Benitez

Wed 8/7

00:43-14:30

1 stop15h 47m

£579

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 1/12

02:00-20:11

1 stop15h 11m

Santiago Arturo Merino Benitez

Fri 11/12

01:27-22:00

1 stop23h 33m

£579

Flights are sorted by cheapest return flights first.

Deals found on 13/6

Showing 1-10 of 22 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Booking 89 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £430). Flying from Mexico City to Santiago in June is currently the most expensive (average of £578). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 15 June 2026.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Mexico City to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 1 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • How long is the flight from Mexico City to Santiago?

    Airlines like Copa Airlines fly from Mexico City to Santiago in about 16h 05m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 4096 mi.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £430). Flying from Mexico City to Santiago in June is currently the most expensive (average of £578). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Balmaceda car hire
Lastarria car hire

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Santiago?

Cheapflights helps you search for flights from Mexico City to Santiago via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights helps you find that perfect flight to Santiago from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Need flexible booking options for your flight to Santiago from Mexico City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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