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Cheap flights from Mexico City to Panama City from £293

This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/5. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
27 May — 3 Jun1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in August or September, booked 88 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from Mexico City to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 27 April 2026.

Fri 22/513:10
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Sun 31/519:13
PTY
-
MEX
Nonstop3h 52m
Copa Airlines
Deal found 23/4£293
Sat 4/709:50
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Sun 19/721:20
PTY
-
MEX
Nonstop3h 55m
Copa Airlines
Deal found 23/4£301
Fri 4/913:10
MEX
-
PTY
Nonstop3h 44m
Copa Airlines
Sun 13/921:27
PTY
-
MEX
Nonstop3h 48m
Copa Airlines
Deal found 22/4£309
Fri 24/715:30
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Sun 2/809:28
PTY
-
MEX
Nonstop3h 42m
Copa Airlines
Deal found 23/4£316
Mon 11/501:20
MEX
-
PTY
Nonstop3h 36m
Copa Airlines
Sat 16/519:08
PTY
-
MEX
Nonstop3h 52m
Copa Airlines
Deal found 23/4£324
Thu 30/402:10
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Tue 5/516:13
PTY
-
MEX
Nonstop3h 52m
Copa Airlines
Deal found 22/4£332
Sun 26/405:00
MEX
-
PTY
2 stops11h 00m
Avianca
Tue 12/504:25
PTY
-
MEX
1 stop8h 45m
Avianca
Deal found 24/4£346
Fri 1/505:50
MEX
-
PTY
Nonstop3h 36m
Copa Airlines
Mon 4/522:14
PTY
-
MEX
Nonstop3h 46m
Copa Airlines
Deal found 23/4£351
Tue 21/702:10
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Tue 28/716:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Deal found 23/4£355
Thu 10/902:10
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Wed 16/909:26
PTY
-
MEX
Nonstop3h 44m
Copa Airlines
Deal found 23/4£363
Mon 31/802:10
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Thu 1/1021:28
PTY
-
MEX
Nonstop3h 47m
Copa Airlines
Deal found 25/4£374

Find flight deals from Mexico City to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 27 April 2026.

Round-trip from

£293

Popular in

April

Cheapest in

August

Average price

£324

Good one-way deal

£94 or less
Copa Airlines
  • Copa Airlines
  • 22/5-31/5
  • Nonstop
  • 7h 32m total
  • Mexico City to Panama City
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (£17 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£4 potential savings vs. average return price).
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Average for round-trip flights in April 2026
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Price to beat on a one-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
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Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 27 April 2026.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 7/7

02:10-06:53

Nonstop3h 43m

Panama City Tocumen Intl

Wed 15/7

09:25-12:10

Nonstop3h 45m

£293
Fastest return journey

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 17/5

15:30-20:10

Nonstop3h 40m

Panama City Tocumen Intl

Wed 8/7

11:45-14:30

Nonstop3h 45m

£293

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 22/5

15:30-20:10

Nonstop3h 40m

Panama City Tocumen Intl

Sun 31/5

21:29-00:15

Nonstop3h 46m

£293

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 29/6

02:10-06:53

Nonstop3h 43m

Panama City Tocumen Intl

Tue 21/7

09:25-12:10

Nonstop3h 45m

£301

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 3/7

13:10-17:56

Nonstop3h 46m

Panama City Tocumen Intl

Sun 19/7

21:20-00:15

Nonstop3h 55m

£301

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 20/6

00:25-05:08

Nonstop3h 43m

Panama City Tocumen Intl

Sun 28/6

19:05-22:05

Nonstop4h 00m

£301

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 4/7

05:50-10:33

Nonstop3h 43m

Panama City Tocumen Intl

Tue 4/8

09:28-12:10

Nonstop3h 42m

£301

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 20/7

09:50-14:36

Nonstop3h 46m

Panama City Tocumen Intl

Tue 28/7

22:05-01:00

Nonstop3h 55m

£309

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 4/9

05:50-10:41

Nonstop3h 51m

Panama City Tocumen Intl

Sun 13/9

21:27-00:15

Nonstop3h 48m

£309

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 20/7

09:50-14:36

Nonstop3h 46m

Panama City Tocumen Intl

Mon 27/7

11:45-14:30

Nonstop3h 45m

£309

Flights are sorted by cheapest return flights first.

Deals found on 23/4

Showing 1-10 of 13 resultsSorted by cheapest first
1
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Best time to book a flight from Mexico City to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama City

How far ahead should I book a flight from Mexico City to Panama City?

The best time to book flights from Mexico City to Panama City is 87 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Panama City?

Currently, August is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £259). Flying from Mexico City to Panama City in April is currently the most expensive (average of £324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PTY?

Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 27 April 2026.

One of the essential ways to save on airfare from Mexico City to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at midday could potentially save you up to 41% on airfare.

How much does it cost for a return flight from Mexico City to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Panama City flight route?

    The Mexico City Benito Juarez to Panama City Tocumen Intl flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Panama City?

    For as low as £293, Copa Airlines can have you in Panama City from Mexico City in 3h 43m. The distance between Mexico City and Panama City is about 1497 mi. All flights are typically direct.

  • What are the most reliable airlines from Mexico City to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: Copa Airlines (96%), Emirates (95%), Aeromexico (93%).

  • What are the cheapest flights from Mexico City to Panama City?

    Looking for the cheapest flight from Mexico City to Panama City? While on average our users pay £285, our data indicates the cheapest price to be £94. The most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl), is priced around £284.

  • Can I find deals for flights from Mexico City to Panama City that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.

  • Can I find deals for business class flights from Mexico City to Panama City?

    Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama City?

    Currently, August is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £259). Flying from Mexico City to Panama City in April is currently the most expensive (average of £324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Panama City?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Panama City from Mexico City.

Can Cheapflights find flights from Mexico City to Panama City with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Mexico City to Panama City flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Mexico City to Panama City become cheaper?

Yes! Start tracking prices for Mexico City to Panama City flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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