Cheap flights from Portland, Maine to Panama City from £478
This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 19/1. Fares are subject to change and may not be available on all flights or dates of travel.
Cheap flight deals from Portland to Panama City
Cheapest flights from Portland to Panama CityExplore the most affordable flight options available from Portland to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 6 October 2026.
Explore the most affordable flight options available from Portland to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 6 October 2026.
Best flights from Portland to Panama CityDiscover carefully curated flight deals from Portland to Panama City that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 6 October 2026.
Discover carefully curated flight deals from Portland to Panama City that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 6 October 2026.
Last-minute flights from Portland to Panama CityDiscover last-minute flight deals from Portland to Panama City. Data last updated 6 October 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Panama City. Data last updated 6 October 2026 and is based on user searches.
Find flight deals from Portland to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 6 October 2026.
Cheapflights Fare Finder
Use the filters below to find and compare flights from Portland to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
PortlandPanama City
PWM Portland - PTY Panama City Tocumen Intl
PWMPTY
Portland
Tue 19/1
19:50-17:12
2 stops21h 22m
Panama City Tocumen Intl
Thu 4/2
08:55-23:32
2 stops14h 37m
PortlandPanama City
PWM Portland - PTY Panama City Tocumen Intl
PWMPTY
Portland
Tue 5/1
09:10-20:02
1 stop10h 52m
Panama City Tocumen Intl
Tue 19/1
16:41-21:03
2 stops28h 22m
PortlandPanama City
PWM Portland - PTY Panama City Tocumen Intl
PWMPTY
Portland
Thu 7/1
09:10-20:02
1 stop10h 52m
Panama City Tocumen Intl
Tue 2/2
16:41-14:33
2 stops21h 52m
PortlandPanama City
PWM Portland - PTY Panama City Tocumen Intl
PWMPTY
Portland
Fri 22/1
19:50-17:12
2 stops21h 22m
Panama City Tocumen Intl
Mon 1/2
08:55-23:32
2 stops14h 37m
PortlandPanama City
PWM Portland - PTY Panama City Tocumen Intl
PWMPTY
Portland
Fri 22/1
06:00-20:02
1 stop14h 02m
Panama City Tocumen Intl
Thu 4/2
08:55-23:32
2 stops14h 37m
PortlandPanama City
PWM Portland - PTY Panama City Tocumen Intl
PWMPTY
Portland
Wed 18/11
08:49-20:02
1 stop11h 13m
Panama City Tocumen Intl
Wed 25/11
16:41-13:26
2 stops20h 45m
PortlandPanama City
PWM Portland - PTY Panama City Tocumen Intl
PWMPTY
Portland
Thu 10/12
06:00-20:02
1 stop14h 02m
Panama City Tocumen Intl
Tue 19/1
16:41-21:03
2 stops28h 22m
Best time to book a flight from Portland to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Portland with our price prediction graph.
Related info for your journey
Find useful and relevant information for your journey from Portland to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Travelling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsBrowse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Complete your trip
Complete your trip to Panama City by adding a car hire and/or hotel booking to your travel itinerary.
Search flights from Portland to Panama City by cabin class
Find flights from Portland to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Portland and Panama City flights
Browse other Portland and Panama City flight options. Last updated on 6 October 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 6 October 2026.
Popular flight searches
Check out other popular destinations found by fellow travellers in 2026
Fly with Cheapflights
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Portland to Panama City?
Deals for Portland to Panama City flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.
Why should you use Cheapflights to find cheap flight tickets from Portland to Panama City?
Cheapflights helps you find that perfect flight to Panama City from Portland by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!
Can Cheapflights find flights from Portland to Panama City with no change fees?
Need flexible booking options for your flight to Panama City from Portland? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.
Can Cheapflights notify me if prices for flights from Portland to Panama City become cheaper?
Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Panama City from Portland today and book when prices fit your budget.