What day of the week experiences the fewest flight delays on this route?

Tuesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.

What is the most punctual flight time for Panama City to Santiago flights?

Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

Which airline has the best punctuality record on Panama City to Santiago flights?

Over the past year, Copa Airlines have had the lowest number of delays on this route, with just 9% of flights being delayed.

How often are flights from Panama City to Santiago delayed?

About 9% of weekly flights between Panama City and Santiago have experienced delays in the past year, with the average delay time being 116 minutes.

How long is the flight from Panama City to Santiago?

Copa Airlines can get you from Panama City to Santiago in just under 6h 31m. Your travel time will be generally consistent. Airlines will cover a distance of 2986 mi. All flights are typically direct.

Weekly flight availability from Panama City to Santiago

The most flights from PTY to SCL are scheduled on a Monday (13 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (10 on average).

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 70.0 inches per month. June is typically the wettest month, when rainfall can reach 70.0 mm. January is typically the driest time to visit Santiago when rainfall is around 0.0 mm.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 21.0 C. Travellers hoping to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 8.0 C).

What are the most reliable airlines from Panama City to Santiago?

The top 3 most reliable airlines when flying from Panama City to Santiago are KLM (76%), Copa Airlines (71%) and United Airlines (71%).

Can I find deals for flights from Panama City to Santiago that include hotel bookings?

Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

How can I find direct flights from Panama City to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

Can I find deals for business class flights from Panama City to Santiago?

Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

£239+ Cheap Flights from Panama City to Santiago

Cheap flight deals from Panama City to Santiago

Enter your travel dates to find the best prices.

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Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 7 September 2026.

Sun 18/1010:10 -

1 stop12h 10m

Sun 25/1016:15 -

1 stop11h 05m

Deal found 3/9£400

Sun 18/1019:25 -

Nonstop6h 31m

Sun 25/1005:22 -

Nonstop6h 48m

Deal found 3/9£413

Tue 10/1118:25 -

Nonstop6h 23m

Sun 15/1105:07 -

Nonstop6h 56m

Deal found 6/9£416

Sat 5/912:01 -

Nonstop6h 31m

Mon 14/905:14 -

Nonstop6h 49m

Deal found 3/9£428

Sat 31/1015:51 -

Nonstop6h 31m

Fri 6/1103:19 -

Nonstop6h 57m

Deal found 6/9£459

Sun 6/1219:11 -

Nonstop6h 32m

Mon 14/1212:20 -

Nonstop6h 51m

Deal found 6/9£470

Sun 18/1015:51 -

Nonstop6h 31m

Thu 22/1003:15 -

Nonstop6h 48m

Deal found 6/9£473

Sat 31/1015:08 -

Nonstop6h 31m

Wed 4/1101:22 -

Nonstop6h 57m

Deal found 7/9£480

Tue 22/1218:10 -

1 stop9h 35m

Tue 5/102:10 -

1 stop15h 05m

Deal found 5/9£489

Fri 9/1018:15 -

Nonstop6h 31m

Thu 15/1005:22 -

Nonstop6h 48m

Deal found 6/9£493

Tue 22/1219:11 -

Nonstop6h 32m

Mon 1/303:23 -

Nonstop6h 53m

Deal found 6/9£502

Fri 11/921:39 -

Nonstop6h 31m

Sat 10/1012:23 -

Nonstop6h 48m

Deal found 5/9£504

Find flight deals from Panama City to Santiago

Round-trip from	£400
One-way from	£239
Popular in	August
Cheapest in	March
Average price	£453

Avianca
18/10-25/10
2 total stops
23h 15m total
Panama City to Santiago

Search Deals

Copa Airlines
11/11-31/12
Nonstop
6h 27m total
Panama City to Santiago

Search Deals

Highest demand for flights based on searches. 6% potential increase in price (£22 potential increase over avg. return price).

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Cheapest flight prices on average. 1% potential price decrease (£4 potential savings vs. average return price).

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Average for round-trip flights in September 2026

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

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Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Wed 4/11

21:24-05:46

Nonstop6h 22m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-22:00

Nonstop0h 00m

£239

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Mon 19/10

15:08-23:39

Nonstop6h 31m

Santiago Arturo Merino Benitez

Sat 24/10

05:22-10:10

Nonstop6h 48m

£416

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Thu 29/10

18:15-02:46

Nonstop6h 31m

Santiago Arturo Merino Benitez

Fri 6/11

03:19-08:16

Nonstop6h 57m

£416

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Sat 31/10

15:08-23:39

Nonstop6h 31m

Santiago Arturo Merino Benitez

Wed 4/11

01:22-06:19

Nonstop6h 57m

£416

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Sun 18/10

15:51-00:22

Nonstop6h 31m

Santiago Arturo Merino Benitez

Thu 22/10

03:15-08:03

Nonstop6h 48m

£473

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Wed 23/9

18:15-02:46

Nonstop6h 31m

Santiago Arturo Merino Benitez

Mon 19/10

01:07-05:55

Nonstop6h 48m

£513

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Fri 1/1

15:51-00:23

Nonstop6h 32m

Santiago Arturo Merino Benitez

Fri 15/1

03:53-08:45

Nonstop6h 52m

£514

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Wed 20/1

21:24-05:57

Nonstop6h 33m

Santiago Arturo Merino Benitez

Sat 20/2

01:17-05:59

Nonstop6h 42m

£514

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Thu 17/12

11:30-05:45

2 stops16h 15m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-22:00

Nonstop0h 00m

£517

Panama CitySantiago

PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez

PTYSCL

Panama City Tocumen Intl

Fri 18/12

18:10-05:45

1 stop9h 35m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-22:00

Nonstop0h 00m

£533

Flights are sorted by cheapest return flights first.

Deals found on 3/9

Showing 1-10 of 17 resultsSorted by cheapest first

Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.

PTY-SCL

Estimated return price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

Prices

Airlines

Delays

How far ahead should I book a flight from Panama City to Santiago?

To ensure you get the cheapest price possible for a flight from Panama City to Santiago, you should look to book at least 69 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, March is the cheapest month in which you can book a flight from Panama City to Santiago (average of £415). Flying from Panama City to Santiago in August is currently the most expensive (average of £483). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

When flying from Panama City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Panama City to Santiago?

Airfare is below average for this route at the moment.

Panama City to Santiago flights typically cost between £414 and £513 in October.
The cheapest return price found within the last 5 days was £400 on Avianca (18 Oct–25 Oct).

Related info for your journey

How long is the flight from Panama City to Santiago?
Copa Airlines can get you from Panama City to Santiago in just under 6h 31m. Your travel time will be generally consistent. Airlines will cover a distance of 2986 mi. All flights are typically direct.
What are the most reliable airlines from Panama City to Santiago?
The top 3 most reliable airlines when flying from Panama City to Santiago are KLM (76%), Copa Airlines (71%) and United Airlines (71%).
Can I find deals for flights from Panama City to Santiago that include hotel bookings?
Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Panama City to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.
Can I find deals for business class flights from Panama City to Santiago?
Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Santiago?
Currently, March is the cheapest month in which you can book a flight from Panama City to Santiago (average of £415). Flying from Panama City to Santiago in August is currently the most expensive (average of £483). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Millions of users choose and trust Cheapflights to book the best flight deals from Panama City to Santiago for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

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Yes, we can. To see specific flights from Panama City to Santiago with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama City to Santiago become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Santiago from Panama City today and book when prices fit your budget.

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Cheap flights from Panama City to Santiago from £239

This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel.

Cheap flight deals from Panama City to Santiago

Cheapest flights from Panama City to SantiagoExplore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 7 September 2026.

Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 7 September 2026.

Best flights from Panama City to SantiagoDiscover carefully curated flight deals from Panama City to Santiago that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 7 September 2026.

Discover carefully curated flight deals from Panama City to Santiago that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 7 September 2026.

Direct flights from Panama City to SantiagoExplore direct flight options from Panama City to Santiago based on user searches, and compare prices and availability for your desired travel dates. Data last updated 7 September 2026.

Explore direct flight options from Panama City to Santiago based on user searches, and compare prices and availability for your desired travel dates. Data last updated 7 September 2026.

Last-minute flights from Panama City to SantiagoDiscover last-minute flight deals from Panama City to Santiago. Data last updated 7 September 2026 and is based on user searches.

Discover last-minute flight deals from Panama City to Santiago. Data last updated 7 September 2026 and is based on user searches.

One-way flights from Panama City to SantiagoSearch for one-way flight options from Panama City to Santiago. Find affordable one-way fares based on user searches. Data last updated 7 September 2026.

Search for one-way flight options from Panama City to Santiago. Find affordable one-way fares based on user searches. Data last updated 7 September 2026.

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Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.

Cheapflights Insights

How far ahead should I book a flight from Panama City to Santiago?

To ensure you get the cheapest price possible for a flight from Panama City to Santiago, you should look to book at least 69 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Santiago?

What is the cheapest time of day to fly from PTY to SCL?

When flying from Panama City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Panama City to Santiago?

Airfare is below average for this route at the moment.

Panama City to Santiago flights typically cost between £414 and £513 in October.The cheapest return price found within the last 5 days was £400 on Avianca (18 Oct–25 Oct).

Weekly flight availability from Panama City to Santiago

The most flights from PTY to SCL are scheduled on a Monday (13 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (10 on average).

How often are flights from Panama City to Santiago delayed?

About 9% of weekly flights between Panama City and Santiago have experienced delays in the past year, with the average delay time being 116 minutes.

What is the most punctual flight time for Panama City to Santiago flights?

Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Tuesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama City to Santiago flights?

Over the past year, Copa Airlines have had the lowest number of delays on this route, with just 9% of flights being delayed.

Related info for your journey

How long is the flight from Panama City to Santiago?

What are the most reliable airlines from Panama City to Santiago?

Can I find deals for flights from Panama City to Santiago that include hotel bookings?

How can I find direct flights from Panama City to Santiago?

Can I find deals for business class flights from Panama City to Santiago?

What is the cheapest month to book a flight from Panama City to Santiago?

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Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 7 September 2026.

Best flights from Panama City to Santiago
Discover carefully curated flight deals from Panama City to Santiago that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 7 September 2026.

Direct flights from Panama City to Santiago
Explore direct flight options from Panama City to Santiago based on user searches, and compare prices and availability for your desired travel dates. Data last updated 7 September 2026.

Last-minute flights from Panama City to Santiago
Discover last-minute flight deals from Panama City to Santiago. Data last updated 7 September 2026 and is based on user searches.

One-way flights from Panama City to Santiago
Search for one-way flight options from Panama City to Santiago. Find affordable one-way fares based on user searches. Data last updated 7 September 2026.

Panama City to Santiago flights typically cost between £414 and £513 in October.
The cheapest return price found within the last 5 days was £400 on Avianca (18 Oct–25 Oct).