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Cheap flights from Quito to Santiago from £129

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
UIO — SCL
3 Jan — 10 Jan1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Quito to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Quito to Santiago
Explore the most affordable flight options available from Quito to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 4 December 2025.

Fri 26/1216:49UIO - SCL
1 stop10h 25mJetSMART
Wed 31/1205:59SCL - UIO
1 stop12h 01mJetSMART
Deal found 1/12£307
Sun 28/1216:49UIO - SCL
1 stop15h 50mJetSMART
Wed 31/1205:59SCL - UIO
1 stop12h 01mJetSMART
Deal found 1/12£311
Tue 2/1218:34UIO - SCL
1 stop9h 27mCopa Airlines
Wed 25/305:21SCL - UIO
1 stop9h 30mCopa Airlines
Deal found 2/12£320
Wed 24/1216:49UIO - SCL
1 stop10h 25mJetSMART
Sat 10/121:29SCL - UIO
1 stop20h 26mJetSMART
Deal found 2/12£336
Fri 26/1216:49UIO - SCL
1 stop10h 25mJetSMART
Sat 10/121:29SCL - UIO
1 stop20h 26mJetSMART
Deal found 2/12£353
Mon 8/1203:10UIO - SCL
1 stop18h 31mCopa Airlines
Sun 21/1212:20SCL - UIO
1 stop14h 15mCopa Airlines
Deal found 2/12£495

Find flight deals from Quito to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Quito (UIO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 4 December 2025.

Round-trip from

£232

One-way from

£129

Popular in

February

Cheapest in

April

Average price

£320
JetSMART
  • JetSMART
  • 12/4-19/4
  • 2 total stops
  • 22h 23m total
  • Quito to Santiago
Search Deals
JetSMART
  • JetSMART
  • 12/12
  • 1 total stop
  • 19h 45m total
  • Quito to Santiago
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (£18 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£5 potential savings vs. average return price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 4 December 2025.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Quito

Fly to

Santiago

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 12/4

16:56-04:01

1 stop10h 05m

Santiago Arturo Merino Benitez

Sun 19/4

04:51-16:09

1 stop12h 18m

£232

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 17/4

16:41-04:01

1 stop10h 20m

Santiago Arturo Merino Benitez

Sun 19/4

04:51-16:09

1 stop12h 18m

£241

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 3/4

16:41-05:01

1 stop10h 20m

Santiago Arturo Merino Benitez

Sun 12/4

04:51-16:09

1 stop12h 18m

£250

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 17/4

16:41-04:01

1 stop10h 20m

Santiago Arturo Merino Benitez

Wed 22/4

04:51-15:54

1 stop12h 03m

£263

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 22/2

16:49-20:44

1 stop25h 55m

Santiago Arturo Merino Benitez

Sun 8/3

05:59-16:00

1 stop12h 01m

£293

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 11/3

16:49-10:39

1 stop15h 50m

Santiago Arturo Merino Benitez

Fri 13/3

05:59-16:00

1 stop12h 01m

£294

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Thu 15/1

16:16-20:44

1 stop26h 28m

Santiago Arturo Merino Benitez

Thu 22/1

21:29-16:00

1 stop20h 31m

£296

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 6/3

16:49-10:39

1 stop15h 50m

Santiago Arturo Merino Benitez

Wed 11/3

05:59-16:00

1 stop12h 01m

£303

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 28/12

16:49-10:39

1 stop15h 50m

Santiago Arturo Merino Benitez

Wed 31/12

05:59-16:00

1 stop12h 01m

£311

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 15/3

16:49-05:14

1 stop10h 25m

Santiago Arturo Merino Benitez

Wed 18/3

05:59-16:00

1 stop12h 01m

£317

Flights are sorted by cheapest return flights first.

Deals found on 2/12

Showing 1-10 of 23 results
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Best time to book a flight from Quito to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Quito with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Quito to Santiago

How far ahead should I book a flight from Quito to Santiago?

Use this chart to determine the optimal time to book a return flight from Quito to Santiago. Price data was last updated on 28 November 2025.

The best time to book flights from Quito to Santiago is 68 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Quito to Santiago?

Currently, March is the cheapest month in which you can book a flight from Quito to Santiago (average of £90). Flying from Quito to Santiago in December is currently the most expensive (average of £129). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from UIO to SCL?

Find hourly flight availability from Quito to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 4 December 2025.

It’s optimal to fly from Quito to Santiago in the afternoon. By choosing this option you can save up to 33% on the cost of your flight, compared to a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Quito to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Quito to Santiago?

    A quick flight from Quito to Santiago can take about 10h 05m. JetSMART provides one of the quickest options available for as low as £232. Quito and Santiago are separated by a distance of 2349 mi.

  • Can I find deals for flights from Quito to Santiago that include hotel bookings?

    Yes. In addition to deals on Quito to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Quito to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Quito to Santiago.

  • Can I find deals for business class flights from Quito to Santiago?

    Yes. Cheapflights offers flight deals from Quito to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Quito to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Quito to Santiago (average of £90). Flying from Quito to Santiago in December is currently the most expensive (average of £129). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Balmaceda car hire
Puerto Montt car hire
Lastarria car hire

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Users can book flights with no change fees policies with our dedicated filters. Book flights from Quito to Santiago flexibly with Cheapflights today.

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