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Cheap flights from Quito to Santiago from £141

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/12. Fares are subject to change and may not be available on all flights or dates of travel.
UIO — SCL
16 Nov — 23 Nov1
1 adult
1 adult, Economy

Find flight deals from Quito to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Quito to Santiago
Explore the most affordable flight options available from Quito to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 17 October 2025.

Wed 24/1216:49UIO - SCL
1 stop10h 25mJetSMART
Wed 31/1205:59SCL - UIO
1 stop12h 01mJetSMART
Deal found 17/10£287
Fri 7/1116:49UIO - SCL
1 stop10h 25mMultiple Airlines
Wed 12/1108:15SCL - UIO
1 stop8h 04mMultiple Airlines
Deal found 16/10£303
Wed 24/1216:49UIO - SCL
1 stop10h 25mJetSMART
Tue 6/121:29SCL - UIO
1 stop20h 31mJetSMART
Deal found 17/10£306
Fri 26/1216:49UIO - SCL
1 stop10h 25mJetSMART
Sat 10/121:29SCL - UIO
1 stop20h 31mJetSMART
Deal found 16/10£317
Fri 26/1216:49UIO - SCL
1 stop10h 25mJetSMART
Wed 31/1205:59SCL - UIO
1 stop12h 01mJetSMART
Deal found 17/10£319
Wed 10/1216:49UIO - SCL
1 stop10h 25mJetSMART
Wed 17/1205:59SCL - UIO
1 stop12h 01mJetSMART
Deal found 15/10£324
Sun 30/1116:40UIO - SCL
2 stops20h 40mMultiple Airlines
Sat 6/1204:35SCL - UIO
1 stop8h 30mMultiple Airlines
Deal found 16/10£337
Fri 26/1216:49UIO - SCL
1 stop10h 25mJetSMART
Tue 6/121:29SCL - UIO
1 stop20h 31mJetSMART
Deal found 17/10£337

Cheap flight deals from Quito to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Quito (UIO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 17 October 2025.

Round-trip from

£274

One-way from

£141

Popular in

February

Cheapest in

April

Average price

£287
JetSMART
  • JetSMART
  • 3/4-12/4
  • 2 total stops
  • 22h 38m total
  • Quito to Santiago
Search Deals
JetSMART
  • JetSMART
  • 10/12
  • 1 total stop
  • 10h 25m total
  • Quito to Santiago
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (£16 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£5 potential savings vs. average return price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 17 October 2025.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.

Fly from

Quito

Fly to

Santiago

Route

Depart

Return

Price

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 11/3

16:36-20:31

1 stop25h 55m

Santiago Arturo Merino Benitez

Sat 21/3

21:36-15:49

1 stop20h 13m

£281

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 24/12

16:49-05:14

1 stop10h 25m

Santiago Arturo Merino Benitez

Tue 6/1

21:29-16:00

1 stop20h 31m

£306

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 26/12

16:49-05:14

1 stop10h 25m

Santiago Arturo Merino Benitez

Wed 31/12

05:59-16:00

1 stop12h 01m

£319

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 10/12

16:49-05:14

1 stop10h 25m

Santiago Arturo Merino Benitez

Wed 17/12

05:59-16:00

1 stop12h 01m

£324

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 21/12

16:49-10:54

1 stop16h 05m

Santiago Arturo Merino Benitez

Tue 6/1

21:29-16:00

1 stop20h 31m

£343

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Thu 6/11

03:11-20:21

1 stop15h 10m

Santiago Arturo Merino Benitez

Wed 12/11

05:24-12:51

1 stop9h 27m

£363

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Fri 7/11

12:27-03:24

1 stop12h 57m

Santiago Arturo Merino Benitez

Thu 13/11

01:12-12:51

1 stop13h 39m

£363

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Sun 9/11

12:27-03:43

1 stop13h 16m

Santiago Arturo Merino Benitez

Thu 13/11

05:12-12:51

1 stop9h 39m

£363

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Thu 12/3

12:27-00:34

1 stop10h 07m

Santiago Arturo Merino Benitez

Thu 19/3

03:32-12:51

1 stop11h 19m

£363

QuitoSantiago

UIO - SCL

UIOSCL

Quito Mariscal Sucr

Wed 12/11

12:27-23:41

1 stop9h 14m

Santiago Arturo Merino Benitez

Fri 21/11

03:23-11:13

1 stop9h 50m

£363

Flights are sorted by cheapest return flights first.

Deals found on 17/10

Showing 1-10 of 19 results
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Best time to book a flight from Quito to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Quito with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Quito to Santiago

How far ahead should I book a flight from Quito to Santiago?

Use this chart to determine the optimal time to book a return flight from Quito to Santiago. Price data was last updated on 10 October 2025.

The best time to book flights from Quito to Santiago is 32 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Quito to Santiago?

Currently, March is the cheapest month in which you can book a flight from Quito to Santiago (average of £86). Flying from Quito to Santiago in December is currently the most expensive (average of £127). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from UIO to SCL?

Find hourly flight availability from Quito to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 17 October 2025.

It’s optimal to fly from Quito to Santiago in the afternoon. By choosing this option you can save up to 33% on the cost of your flight, compared to a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Quito to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Quito to Santiago?

    A quick flight from Quito to Santiago can take about 25h 55m. JetSMART provides one of the quickest options available for as low as £281. Quito and Santiago are separated by a distance of 2349 mi.

  • Can I find deals for flights from Quito to Santiago that include hotel bookings?

    Yes. In addition to deals on Quito to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Quito to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Quito to Santiago.

  • Can I find deals for business class flights from Quito to Santiago?

    Yes. Cheapflights offers flight deals from Quito to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Quito to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Quito to Santiago (average of £86). Flying from Quito to Santiago in December is currently the most expensive (average of £127). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Balmaceda car hire
Puerto Montt car hire
Lastarria car hire

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How does Cheapflights help users find flights from Quito to Santiago?

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It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Quito to Santiago.

Can Cheapflights find flights from Quito to Santiago with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Quito to Santiago flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Quito to Santiago become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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