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Cheap flights from Santiago to Guayaquil from £171

SCL — GYE
8 Oct — 15 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santiago to Guayaquil

Enter your travel dates to find the best prices.

Cheapest flights from Santiago to Guayaquil

Thu 17/903:14 -
1 stop10h 07m
Thu 24/918:28 -
1 stop27h 54m
Deal found 3/9£350
Tue 15/903:14 -
1 stop10h 07m
Tue 22/918:28 -
1 stop27h 54m
Deal found 6/9£368
Sun 6/903:14 -
1 stop10h 07m
Mon 14/918:28 -
1 stop27h 54m
Deal found 6/9£389
Sun 6/912:22 -
1 stop24h 59m
Mon 7/918:28 -
1 stop24h 04m
Deal found 6/9£409
Sun 6/912:22 -
1 stop24h 59m
Tue 6/1008:24 -
1 stop16h 22m
Deal found 5/9£432
Thu 10/903:56 -
1 stop22h 05m
Fri 25/908:28 -
1 stop10h 04m
Deal found 5/9£677
Mon 30/1122:45 -
2 stops26h 56m
Thu 10/1208:25 -
2 stops22h 25m
Deal found 6/9£1,932
Thu 3/1222:45 -
2 stops26h 56m
Thu 10/1208:25 -
2 stops22h 25m
Deal found 6/9£1,950
Mon 30/1122:45 -
2 stops44h 51m
Fri 11/1208:25 -
2 stops22h 25m
Deal found 6/9£1,980
Wed 2/1222:45 -
2 stops24h 12m
Thu 10/1208:25 -
2 stops22h 25m
Deal found 6/9£1,987
Thu 3/1222:45 -
2 stops26h 56m
Fri 11/1208:25 -
2 stops22h 25m
Deal found 6/9£1,998
Fri 4/1222:45 -
2 stops24h 12m
Thu 10/1212:22 -
2 stops42h 28m
Deal found 6/9£2,009

Find flight deals from Santiago to Guayaquil

Round-trip from

£350

One-way from

£171

Popular in

January

Cheapest in

August

Average price

£347
Copa Airlines
  • Copa Airlines
  • 24/9-27/9
  • 2 total stops
  • 25h 46m total
  • Santiago to Guayaquil
Search Deals
Copa Airlines
  • Copa Airlines
  • 23/9-31/12
  • 1 total stop
  • 10h 07m total
  • Santiago to Guayaquil
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (£21 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£4 potential savings vs. average return price).
Search Deals
Average for round-trip flights in September 2026
Search Deals

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

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Price

Cheapest return flight

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Wed 23/9

03:14-11:21

1 stop10h 07m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£171

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Thu 24/9

01:43-11:21

1 stop11h 38m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£171

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Wed 30/9

03:15-11:21

1 stop10h 06m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£171

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Wed 30/9

12:22-11:21

1 stop24h 59m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£171
Fastest return journey

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Tue 27/10

03:28-11:15

1 stop9h 47m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£171

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Thu 17/9

03:14-11:21

1 stop10h 07m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£180

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Wed 14/10

03:15-11:21

1 stop10h 06m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£212

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Thu 24/9

01:43-11:21

1 stop11h 38m

Guayaquil Jose Joaquin de Olmedo

Sun 27/9

11:48-03:56

1 stop14h 08m

£350

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Mon 21/9

03:56-13:59

1 stop12h 03m

Guayaquil Jose Joaquin de Olmedo

Mon 28/9

18:28-20:32

1 stop24h 04m

£350

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Thu 17/9

03:14-11:21

1 stop10h 07m

Guayaquil Jose Joaquin de Olmedo

Thu 24/9

18:28-20:32

1 stop24h 04m

£350

Flights are sorted by cheapest return flights first.

Deals found on 7/9

Showing 1-10 of 15 resultsSorted by cheapest first
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Best time to book a flight from Santiago to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santiago with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santiago to Guayaquil

How far ahead should I book a flight from Santiago to Guayaquil?

The price you pay for your flight from Santiago to Guayaquil may vary depending on when you book. For the best chance of a lower fare, look to book 58 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santiago to Guayaquil?

Currently, August is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of £313). Flying from Santiago to Guayaquil in January is currently the most expensive (average of £403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to GYE?

When flying from Santiago to Guayaquil, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Santiago to Guayaquil?

Airfare is typical for this route at the moment.

Santiago to Guayaquil flights typically cost between £313 and £382 in September.
The cheapest return price found within the last 5 days was £350 on Copa Airlines (17 Sept–24 Sept).

Related info for your journey

  • How long is the flight from Santiago to Guayaquil?

    For as low as £350, Copa Airlines can have you in Guayaquil from Santiago in 11h 38m. Airlines will cover a distance of 2235 mi.

  • Can I find deals for flights from Santiago to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santiago to Guayaquil flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Guayaquil.

  • Can I find deals for business class flights from Santiago to Guayaquil?

    Yes. Cheapflights offers flight deals from Santiago to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Guayaquil?

    Currently, August is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of £313). Flying from Santiago to Guayaquil in January is currently the most expensive (average of £403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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