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Cheap flights from Guayaquil to Santiago from £183

GYE — SCL
10 Oct — 17 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Guayaquil to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Guayaquil to Santiago

Thu 19/1118:38 -
1 stop27h 41m
Tue 24/1103:19 -
1 stop9h 59m
Deal found 8/9£351
Mon 5/1017:38 -
Nonstop4h 51m
Sun 11/1001:45 -
Nonstop5h 18m
Deal found 5/9£368
Tue 22/918:28 -
1 stop27h 54m
Thu 24/901:43 -
1 stop11h 38m
Deal found 7/9£377
Mon 5/1010:05 -
1 stop12h 15m
Sun 11/1001:30 -
1 stop15h 05m
Deal found 5/9£384
Mon 5/1017:38 -
Nonstop4h 51m
Sun 11/1001:30 -
1 stop9h 25m
Deal found 5/9£402
Tue 8/918:28 -
1 stop9h 42m
Fri 25/903:14 -
1 stop10h 07m
Deal found 8/9£413
Mon 7/918:28 -
1 stop9h 42m
Sat 26/903:14 -
1 stop10h 07m
Deal found 7/9£440
Thu 10/906:00 -
1 stop16h 22m
Wed 16/903:14 -
1 stop10h 07m
Deal found 8/9£454
Mon 7/918:28 -
1 stop27h 54m
Wed 9/903:14 -
1 stop10h 07m
Deal found 6/9£460
Wed 9/906:00 -
1 stop12h 32m
Wed 9/903:14 -
1 stop10h 07m
Deal found 7/9£475
Thu 10/904:13 -
1 stop21h 43m
Tue 15/903:14 -
1 stop10h 07m
Deal found 8/9£480

Find flight deals from Guayaquil to Santiago

Round-trip from

£324

One-way from

£183

Popular in

February

Cheapest in

November

Average price

£303
LATAM Airlines
  • LATAM Airlines
  • 15/2-21/2
  • 2 total stops
  • 16h 15m total
  • Guayaquil to Santiago
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Copa Airlines
  • Copa Airlines
  • 22/9-31/12
  • 1 total stop
  • 27h 54m total
  • Guayaquil to Santiago
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£12 potential increase over avg. return price).
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Cheapest flight prices on average. 0% potential price decrease (£2 potential savings vs. average return price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Guayaquil to Santiago that are best for you.

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Route

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Price

Cheapest return flight

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Tue 22/9

18:28-00:22

1 stop27h 54m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-22:00

Nonstop0h 00m

£183

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 11/10

06:01-00:22

1 stop16h 21m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-22:00

Nonstop0h 00m

£319

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Tue 13/10

08:24-02:46

1 stop16h 22m

Santiago Arturo Merino Benitez

Wed 31/12

00:00-22:00

Nonstop0h 00m

£319

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 15/2

09:05-21:50

1 stop10h 45m

Santiago Arturo Merino Benitez

Sat 20/2

01:45-05:03

Nonstop5h 18m

£325

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 15/2

09:05-21:50

1 stop10h 45m

Santiago Arturo Merino Benitez

Sun 21/2

06:07-18:50

2 stops14h 43m

£369
Fastest return journey

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 5/10

17:38-00:29

Nonstop4h 51m

Santiago Arturo Merino Benitez

Sun 11/10

01:30-08:55

1 stop9h 25m

£402

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 21/9

08:28-02:46

1 stop16h 18m

Santiago Arturo Merino Benitez

Wed 23/9

03:14-11:21

1 stop10h 07m

£486

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 12/10

06:01-02:46

1 stop18h 45m

Santiago Arturo Merino Benitez

Thu 15/10

03:15-11:21

1 stop10h 06m

£571

GuayaquilSantiago

GYE Guayaquil Jose Joaquin de Olmedo - SCL Santiago Arturo Merino Benitez

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 11/10

04:14-00:22

1 stop18h 08m

Santiago Arturo Merino Benitez

Wed 14/10

03:15-11:21

1 stop10h 06m

£588

Flights are sorted by cheapest return flights first.

Deals found on 8/9

Sorted by cheapest first

Best time to book a flight from Guayaquil to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guayaquil with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Santiago

How far ahead should I book a flight from Guayaquil to Santiago?

The price you pay for your flight from Guayaquil to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 58 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Guayaquil to Santiago?

Currently, November is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of £295). Flying from Guayaquil to Santiago in February is currently the most expensive (average of £362). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to SCL?

When flying from Guayaquil to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Guayaquil to Santiago?

Airfare is typical for this route at the moment.

Guayaquil to Santiago flights typically cost between £275 and £358 in February.
The cheapest return price found within the last 5 days was £324 on LATAM Airlines (15 Feb–21 Feb).

Related info for your journey

  • How popular is this Guayaquil to Santiago flight route?

    Within the past month, 2 users have taken a look at flights from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.

  • How long is the flight from Guayaquil to Santiago?

    There are many flights that can get you from Guayaquil to Santiago in 10h 45m. Fly via LATAM Airlines or Copa Airlines to get the fastest option. The distance between Guayaquil and Santiago is about 2235 mi. Both multi-stop and direct flights can be found to your destination and back.

  • Can I find deals for flights from Guayaquil to Santiago that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Santiago.

  • Can I find deals for business class flights from Guayaquil to Santiago?

    Yes. Cheapflights offers flight deals from Guayaquil to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of £295). Flying from Guayaquil to Santiago in February is currently the most expensive (average of £362). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

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Viña del Mar

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Alternative routes for Guayaquil to Santiago

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