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Cheap flights from Manchester to Knoxville from £335

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/1. Fares are subject to change and may not be available on all flights or dates of travel.
MAN — TYS
15 Feb — 22 Feb1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Manchester to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MAN) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 16 January 2026.

Round-trip from

£621

One-way from

£335

Popular in

August

Cheapest in

March

Average price

£661
United Airlines
  • United Airlines
  • 26/2-2/3
  • 4 total stops
  • 41h 17m total
  • Manchester to Knoxville
Search Deals
22/1
  • 22/1
  • 3 total stops
  • 32h 35m total
  • Manchester to Knoxville
Search Deals
Highest demand for flights based on searches. 12% potential increase in price (£81 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£14 potential savings vs. average return price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Find flight deals from Manchester to Knoxville

Enter your travel dates to find the best prices.

Cheapest flights from Manchester to Knoxville
Explore the most affordable flight options available from Manchester to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 16 January 2026.

Thu 26/206:00
MAN
-
TYS
2 stops19h 37m
United Airlines
Mon 2/309:40
TYS
-
MAN
2 stops21h 40m
United Airlines
Deal found 15/1£621
Fri 30/106:05
MAN
-
TYS
2 stops19h 47m
United Airlines
Fri 6/211:07
TYS
-
MAN
2 stops24h 53m
United Airlines
Deal found 15/1£623
Sat 25/406:45
MAN
-
TYS
2 stops18h 16m
Iberia
Sun 3/511:43
TYS
-
MAN
2 stops17h 12m
Iberia
Deal found 14/1£663
Sat 11/407:00
MAN
-
TYS
2 stops17h 42m
Multiple Airlines
Wed 15/413:53
TYS
-
MAN
2 stops15h 32m
Multiple Airlines
Deal found 14/1£679
Fri 30/113:25
MAN
-
TYS
1 stop26h 43m
Delta
Fri 6/207:00
TYS
-
MAN
1 stop22h 30m
Delta
Deal found 15/1£691
Sat 25/413:15
MAN
-
TYS
1 stop27h 00m
Delta
Sun 3/505:30
TYS
-
MAN
1 stop20h 45m
Delta
Deal found 15/1£703

Cheapflights Fare Finder

 
Customise your flight search to find flights from Manchester to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 16 January 2026.
Use the filters below to find and compare flights from Manchester to Knoxville that are best for you.

Fly from

Manchester

Fly to

Knoxville

Route

Depart

Return

Price

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Thu 26/2

06:00-20:37

2 stops19h 37m

Knoxville McGhee Tyson

Mon 2/3

09:40-12:20

2 stops21h 40m

£621

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Sat 25/4

06:45-20:01

2 stops18h 16m

Knoxville McGhee Tyson

Sun 3/5

11:43-09:55

2 stops17h 12m

£663

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Sat 11/4

07:00-19:42

2 stops17h 42m

Knoxville McGhee Tyson

Wed 15/4

13:53-10:25

2 stops15h 32m

£679

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Fri 30/1

13:25-11:08

1 stop26h 43m

Knoxville McGhee Tyson

Fri 6/2

07:00-10:30

1 stop22h 30m

£691

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Sat 25/4

13:15-09:22

1 stop25h 07m

Knoxville McGhee Tyson

Sun 3/5

08:50-07:15

1 stop17h 25m

£704

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Thu 22/1

08:30-12:05

3 stops32h 35m

£335

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Wed 21/1

16:50-12:05

3 stops48h 15m

£338

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Tue 20/1

14:50-17:53

2 stops56h 03m

£477

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Thu 22/1

13:30-17:52

1 stop33h 22m

£852

ManchesterKnoxville

MAN - TYS

MANTYS

Manchester

Tue 20/1

13:30-17:56

1 stop33h 26m

£1,213

Flights are sorted by cheapest return flights first.

Deals found on 15/1

Showing 1-10 of 14 results
1
2

Best time to book a flight from Manchester to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Manchester with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Manchester to Knoxville

How far ahead should I book a flight from Manchester to Knoxville?

Use this chart to determine the optimal time to book a return flight from Manchester to Knoxville. Price data was last updated on 9 January 2026.

The best time to book flights from Manchester to Knoxville is 79 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Manchester to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Manchester to Knoxville (average of £525). Flying from Manchester to Knoxville in July is currently the most expensive (average of £713). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated 16 January 2026.
Read reviews from past customers who have flown with KLM, Finnair, andVirgin Atlantic from Manchester to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.7
Good
1,440 reviews
Check prices

Comfort

7.6

Overall

7.7

Entertainment

7.1

Food

7.2

Boarding

7.8

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
KLM
7.7
Good
1,440 reviews
KLM
7.7
Good
1,440 reviews
Check prices

Comfort

7.6

Overall

7.7

Entertainment

7.1

Food

7.2

Boarding

7.8

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
Finnair
7.6
Good
1,349 reviews
KLM
7.7
Good
1,440 reviews
Check prices

Comfort

7.6

Overall

7.7

Entertainment

7.1

Food

7.2

Boarding

7.8

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
Virgin Atlantic
7.5
Good
678 reviews
KLM
7.7
Good
1,440 reviews
Check prices

Comfort

7.6

Overall

7.7

Entertainment

7.1

Food

7.2

Boarding

7.8

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
United Airlines
7.4
Good
9,164 reviews
KLM
7.7
Good
1,440 reviews
Check prices

Comfort

7.6

Overall

7.7

Entertainment

7.1

Food

7.2

Boarding

7.8

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
British Airways
6.7
Okay
7,678 reviews
KLM
7.7
Good
1,440 reviews
Check prices

Comfort

7.6

Overall

7.7

Entertainment

7.1

Food

7.2

Boarding

7.8

Crew

8.4

Reviews

1 / 20
10.0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.

Related info for your journey

Find useful and relevant information for your journey from Manchester to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Manchester to Knoxville?

    Airlines like United Airlines and Iberia fly from Manchester to Knoxville in about 18h 16m. The time it takes to get you to your destination can typically vary by up to 1h 21m. There are 3961 mi between Manchester and Knoxville. Both multi-stop and direct flights can be found to your destination and back.

  • What are the cheapest airlines flying from Manchester to Knoxville round-trip?

    Currently priced at £547, United Airlines will fly you from Manchester to Knoxville and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Finnair and British Airways - these airlines can fly you to your destination from £552 and £571, respectively. You may be able to fly from Manchester to Knoxville for 27% less than the average price by searching for these airlines.

  • Can I find deals for flights from Manchester to Knoxville that include hotel bookings?

    Yes. In addition to deals on Manchester to Knoxville flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Manchester to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to Knoxville.

  • Can I find deals for business class flights from Manchester to Knoxville?

    Yes. Cheapflights offers flight deals from Manchester to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Manchester to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Manchester to Knoxville (average of £525). Flying from Manchester to Knoxville in July is currently the most expensive (average of £713). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee

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Alternative routes for Manchester to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Manchester to Knoxville

Discover the top 5 airlines that operate flights from Manchester to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 16 January 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest£547Average£644FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
FinnairCheapest£552Average£656FlexibilityNo cancel feeOn-time76%
Search Finnair flights
British AirwaysCheapest£571Average£655FlexibilityNo cancel feeOn-time70%
Search British Airways flights
Virgin AtlanticCheapest£578Average£725FlexibilityNo cancel feeOn-time72%
Search Virgin Atlantic flights
KLMCheapest£591Average£723FlexibilityNo cancel feeOn-time75%
Search KLM flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Manchester to Knoxville?

When you search for this flight from Manchester to Knoxville, Cheapflights searches on 900+ travel sites to save you time finding great flight deals online. Additionally, we offer filter features so you can choose a preferred cabin class or airline, see different price ranges, and much more so you can book the flight for you.

Why should you use Cheapflights to find cheap flight tickets from Manchester to Knoxville?

Cheapflights helps you find that perfect flight to Knoxville from Manchester by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Manchester to Knoxville with no change fees?

Yes, we can. To see specific flights from Manchester to Knoxville with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Manchester to Knoxville become cheaper?

Yes, Cheapflights offers price alerts on Manchester to Knoxville flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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