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Cheap flights from Knoxville to Manchester from £253

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAN
10 May — 17 May1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Knoxville to Manchester

Enter your travel dates to find the best prices.

Cheapest flights from Knoxville to Manchester
Explore the most affordable flight options available from Knoxville to Manchester. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 10 April 2026.

Sun 9/805:45
TYS
-
MAN
2 stops43h 45m
Air Canada
Tue 18/809:00
MAN
-
TYS
2 stops34h 37m
Air Canada
Deal found 6/4£689
Sat 8/819:19
TYS
-
MAN
2 stops54h 11m
Air Canada
Tue 18/809:00
MAN
-
TYS
2 stops36h 59m
Air Canada
Deal found 6/4£694
Sat 8/819:19
TYS
-
MAN
2 stops54h 11m
Air Canada
Wed 19/809:00
MAN
-
TYS
2 stops19h 57m
Air Canada
Deal found 6/4£698
Mon 10/808:20
TYS
-
MAN
2 stops17h 10m
Multiple Airlines
Tue 18/809:00
MAN
-
TYS
3 stops19h 57m
Multiple Airlines
Deal found 6/4£710
Tue 11/815:01
TYS
-
MAN
2 stops17h 04m
British Airways
Tue 18/808:35
MAN
-
TYS
2 stops16h 46m
British Airways
Deal found 6/4£710
Tue 11/815:01
TYS
-
MAN
2 stops17h 04m
British Airways
Wed 19/809:20
MAN
-
TYS
2 stops17h 03m
British Airways
Deal found 6/4£720
Wed 12/813:35
TYS
-
MAN
2 stops35h 55m
Air Canada
Tue 18/809:00
MAN
-
TYS
2 stops36h 59m
Air Canada
Deal found 6/4£727
Wed 12/810:46
TYS
-
MAN
2 stops18h 39m
United Airlines
Thu 20/806:05
MAN
-
TYS
2 stops19h 43m
United Airlines
Deal found 6/4£731
Fri 6/1116:00
TYS
-
MAN
2 stops36h 30m
Scandinavian Airlines
Sat 14/1110:10
MAN
-
TYS
2 stops40h 35m
Scandinavian Airlines
Deal found 6/4£733
Sun 9/805:45
TYS
-
MAN
2 stops43h 45m
Air Canada
Sun 16/809:00
MAN
-
TYS
2 stops36h 59m
Air Canada
Deal found 6/4£734

Find flight deals from Knoxville to Manchester

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Manchester (MAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 10 April 2026.

Round-trip from

£689

One-way from

£253

Popular in

September

Cheapest in

January

Average price

£586
Air Canada
  • Air Canada
  • 9/8-18/8
  • 4 total stops
  • 78h 22m total
  • Knoxville to Manchester
Search Deals
American Airlines
  • American Airlines
  • 9/8
  • 2 total stops
  • 17h 55m total
  • Knoxville to Manchester
Search Deals
Highest demand for flights based on searches. 12% potential increase in price (£73 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease (£28 potential savings vs. average return price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Knoxville to Manchester that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 10 April 2026.
Use the filters below to find and compare flights from Knoxville to Manchester that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Wed 12/8

10:46-10:25

2 stops18h 39m

Manchester

Thu 20/8

06:05-20:48

2 stops19h 43m

£731

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Mon 4/5

07:00-09:50

3 stops21h 50m

Manchester

Mon 11/5

06:05-20:45

2 stops19h 40m

£776

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Sat 9/5

17:55-10:25

2 stops35h 30m

Manchester

Sun 17/5

10:35-10:49

2 stops29h 14m

£788

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Mon 4/5

08:45-08:50

1 stop19h 05m

Manchester

Mon 11/5

13:00-11:09

1 stop27h 09m

£838
Fastest return journey

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Mon 10/8

11:55-08:15

1 stop15h 20m

Manchester

Wed 19/8

10:40-18:17

1 stop12h 37m

£838

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Sat 8/8

19:19-17:20

2 stops17h 01m

Manchester

Mon 17/8

11:10-23:57

2 stops17h 47m

£843

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Tue 19/5

08:35-08:20

2 stops18h 45m

Manchester

Tue 26/5

13:00-21:48

1 stop13h 48m

£867

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Thu 7/5

07:27-08:50

1 stop20h 23m

Manchester

Sun 17/5

11:15-21:48

1 stop15h 33m

£873

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Thu 7/5

13:59-10:00

2 stops15h 01m

Manchester

Sun 17/5

11:15-21:48

1 stop15h 33m

£877

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Sat 16/5

19:18-09:50

2 stops33h 32m

Manchester

Thu 28/5

06:05-17:12

2 stops16h 07m

£912

Flights are sorted by cheapest return flights first.

Deals found on 6/4

Showing 1-10 of 16 resultsSorted by cheapest first
1
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Best time to book a flight from Knoxville to Manchester

Have a flexible travel schedule? Discover the best time to fly to Manchester from Knoxville with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Manchester

What is the cheapest month to book a flight from Knoxville to Manchester?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Manchester (average of £446). Flying from Knoxville to Manchester in September is currently the most expensive (average of £740). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Knoxville to Manchester?

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Manchester. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Manchester?

    A quick flight from Knoxville to Manchester can take about 18h 39m. United Airlines provides one of the quickest options available for as low as £731. There are 3961 mi between Knoxville and Manchester. This flight may include one or multiple stops.

  • Can I find deals for flights from Knoxville to Manchester that include hotel bookings?

    Yes. In addition to deals on Knoxville to Manchester flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Manchester?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Manchester.

  • Can I find deals for business class flights from Knoxville to Manchester?

    Yes. Cheapflights offers flight deals from Knoxville to Manchester by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Manchester?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Manchester (average of £446). Flying from Knoxville to Manchester in September is currently the most expensive (average of £740). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Manchester?

Book flights to Manchester if you plan to visit one of these locations
Windermere
Llandudno
Lincoln
Bradford
Derby
Southport
Harrogate
Stoke-on-Trent
Otley
Warrington
Salford
Lancaster
Telford
Huddersfield
Shrewsbury
Preston
Bolton
Wakefield
Macclesfield
Wilmslow

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