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Cheap flights from Panama City to Madrid, Spain from £353

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/6. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
5 May — 12 May1
1 adult

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in March or February, booked 58 days in advance, depart on a Saturday or Monday and return on a Tuesday

Cheap flight deals from Panama City to Madrid

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 30 April 2025.

Round-trip from

£521

One-way from

£353

Popular in

December

Cheapest in

March

Average price

£541
KLM
  • KLM
  • 3/7-21/8
  • 2 total stops
  • 61h 40m total
  • Panama City to Madrid
Search Deals
Turkish Airlines
  • Turkish Airlines
  • 6/6
  • 1 total stop
  • 29h 30m total
  • Panama City to Madrid
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£18 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
Search Deals
Average for round-trip flights in April 2025
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Find flight deals from Panama City to Madrid

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 April 2025.

Thu 3/718:50PTY - MAD
1 stop34h 15mKLM
Thu 21/820:25MAD - PTY
1 stop27h 25mKLM
Deal found 30/4£521
Fri 16/521:55PTY - MAD
1 stop29h 30mTurkish Airlines
Thu 12/618:20MAD - PTY
1 stop32h 40mTurkish Airlines
Deal found 29/4£535
Wed 9/718:50PTY - MAD
1 stop21h 35mMultiple Airlines
Sat 19/710:05MAD - PTY
1 stop16h 03mMultiple Airlines
Deal found 30/4£538
Wed 24/920:25PTY - MAD
Nonstop9h 50mAir Europa
Sat 18/1015:05MAD - PTY
Nonstop10h 35mAir Europa
Deal found 30/4£540
Mon 26/517:35PTY - MAD
Nonstop9h 50mIberia
Thu 5/612:00MAD - PTY
Nonstop11h 05mIberia
Deal found 30/4£553
Tue 3/603:20PTY - MAD
1 stop13h 10mAvianca
Thu 9/1009:40MAD - PTY
1 stop13h 50mAvianca
Deal found 29/4£592
Wed 1/1015:30PTY - MAD
2 stops32h 10mUnited Airlines
Thu 16/1011:15MAD - PTY
2 stops33h 35mUnited Airlines
Deal found 28/4£630
Mon 26/515:57PTY - MAD
2 stops20h 23mAir France
Thu 5/606:00MAD - PTY
2 stops17h 50mAir France
Deal found 30/4£685

Cheapflights Fare Finder

Customise your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 30 April 2025.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Panama City

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 3/7

18:50-12:05

1 stop34h 15m

Madrid Barajas

Thu 21/8

20:25-16:50

1 stop27h 25m

£521

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 16/5

21:55-10:25

1 stop29h 30m

Madrid Barajas

Thu 12/6

18:20-20:00

1 stop32h 40m

£535

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 9/7

18:50-23:25

1 stop21h 35m

Madrid Barajas

Sat 19/7

10:05-19:08

1 stop16h 03m

£538

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 24/9

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Sat 18/10

15:05-18:40

Nonstop10h 35m

£540

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 26/5

17:35-10:25

Nonstop9h 50m

Madrid Barajas

Thu 5/6

12:00-16:05

Nonstop11h 05m

£553

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 3/6

03:20-23:30

1 stop13h 10m

Madrid Barajas

Thu 9/10

09:40-16:30

1 stop13h 50m

£592

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 1/10

15:30-06:40

2 stops32h 10m

Madrid Barajas

Thu 16/10

11:15-13:50

2 stops33h 35m

£630

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 26/5

15:57-19:20

2 stops20h 23m

Madrid Barajas

Thu 5/6

06:00-16:50

2 stops17h 50m

£685

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 6/6

21:55-10:25

1 stop29h 30m

£353

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 25/5

20:25-13:15

Nonstop9h 50m

£393

Flights are sorted by cheapest return flights first.

Deals found on 29/4

Showing 1-10 of 13 results
1
2

Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

Use this chart to determine the optimal time to book a return flight from Panama City to Madrid. Price data was last updated on 25 April 2025.

To ensure you get the cheapest price possible for a flight from Panama City to Madrid, you should look to book at least 58 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, January is the cheapest month in which you can book a flight from Panama City to Madrid (average of £94). Flying from Panama City to Madrid in August is currently the most expensive (average of £267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 30 April 2025.

It’s optimal to fly from Panama City to Madrid in the morning. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight at midday.

Rainfall in Madrid by month

Plan your trip to Madrid by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Madrid ranges from 10.0 - 60.0 inches per month. November is typically the wettest month, when rainfall can reach 60.0 mm. July is typically the driest time to visit Madrid when rainfall is around 10.0 mm.

Temperature in Madrid by month

Plan your trip to Madrid by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Madrid, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 25.0 C. Travellers hoping to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 5.0 C).

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated 30 April 2025.
See what other customers who have flown with KLM, Air France and United Airlines from Panama City to Madrid have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,334 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
KLM
7.8
Good
1,334 reviews
KLM
7.8
Good
1,334 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
Air France
7.4
Good
1,446 reviews
KLM
7.8
Good
1,334 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
United Airlines
7.4
Good
8,696 reviews
KLM
7.8
Good
1,334 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
Turkish Airlines
7.3
Good
3,790 reviews
KLM
7.8
Good
1,334 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.
Iberia
7.0
Good
2,701 reviews
KLM
7.8
Good
1,334 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Boarding

7.8

Overall

7.8

Food

7.2

Crew

8.4

Reviews

1 / 20
8.0
Excellent

Anonymous,Mar 2025

LBA - AMS

Overall, the flight from Leeds Bradford to Amsterdam was at expected. The crew were efficient at boarding and professional on board. The only issue was extremely slow check in at Leeds Bradford which was very frustrating.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Madrid?

    If you book a flight from Panama City to Madrid, you will be flying from Tocumen Intl to Barajas. Flights to Madrid Barajas (MAD) from Panama City Tocumen Intl (PTY) take 9h 50m for a nonstop flight. There are 4 flights from Tocumen Intl to Madrid per day from 2 airlines.

  • How popular is this Panama City to Madrid flight route?

    Flights from Panama City Tocumen Intl to Madrid Barajas have been viewed 18 times in the past calendar month.

  • What are the cheapest airlines flying from Panama City to Madrid round-trip?

    According to our current data, KLM (£521), Turkish Airlines (£535), and Air Europa (£540) offers the cheapest pricing from Panama City to Madrid. KLM is 8% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City to Madrid one-way?

    £353 is the cheapest one-way deal found within the past few days, from Turkish Airlines. You may also be able to find cheap deals on Air Europa and Avianca, with prices starting from £393 and £403, respectively.

  • What are the most reliable airlines from Panama City to Madrid?

    The top 3 most reliable airlines when flying from Panama City to Madrid are Air Europa (81%), Etihad Airways (81%) and China Eastern (81%).

  • Can I find deals for flights from Panama City to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

  • Can I find deals for business class flights from Panama City to Madrid?

    Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Madrid?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Madrid (average of £94). Flying from Panama City to Madrid in August is currently the most expensive (average of £267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Guadalajara
Getafe

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Top 2 airlines flying from Panama City to Madrid

Discover the top 2 airlines that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 30 April 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest£483Average£612FlexibilityNo cancel feeOn-time83%
Search Air Europa flights
IberiaCheapest£495Average£658FlexibilityNo cancel feeOn-time77%
Search Iberia flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City to Madrid?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama City to Madrid. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Panama City to Madrid?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City to Madrid for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Panama City to Madrid with no change fees?

Certainly. Search results for flights to Madrid from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?

Of course! You can now track prices for flights from Panama City to Madrid and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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