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Cheap flights from Des Moines to Manchester from £245

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 25/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MAN
11 Jan — 18 Jan1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Des Moines to Manchester

Enter your travel dates to find the best prices.

Best flights from Des Moines to Manchester
Discover carefully curated flight deals from Des Moines to Manchester that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 12 December 2025.

Mon 26/110:21DSM - MAN
2 stops15h 59mVirgin Atlantic
Mon 2/209:00MAN - DSM
2 stops41h 54mVirgin Atlantic
Deal found 12/12£442
Sat 24/113:03DSM - MAN
2 stops15h 07mMultiple Airlines
Sat 31/113:30MAN - DSM
1 stop32h 58mMultiple Airlines
Deal found 10/12£452
Sat 24/112:25DSM - MAN
2 stops13h 55mKLM
Sat 31/105:50MAN - DSM
2 stops17h 18mKLM
Deal found 10/12£464
Sat 24/118:48DSM - MAN
2 stops22h 32mLufthansa
Sat 31/106:45MAN - DSM
2 stops17h 02mLufthansa
Deal found 12/12£465
Sun 25/106:54DSM - MAN
2 stops23h 51mVirgin Atlantic
Sun 1/205:50MAN - DSM
2 stops22h 39mVirgin Atlantic
Deal found 10/12£450
Sat 24/113:03DSM - MAN
1 stop15h 27mVirgin Atlantic
Sat 31/113:30MAN - DSM
1 stop32h 58mVirgin Atlantic
Deal found 10/12£453

Find flight deals from Des Moines to Manchester

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Manchester (MAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 December 2025.

Round-trip from

£435

One-way from

£245

Popular in

June

Cheapest in

September

Average price

£812
Virgin Atlantic
  • Virgin Atlantic
  • 23/1-30/1
  • 2 total stops
  • 26h 18m total
  • Des Moines to Manchester
Search Deals
25/1
  • 25/1
  • 3 total stops
  • 36h 15m total
  • Des Moines to Manchester
Search Deals
Highest demand for flights based on searches. 14% potential increase in price (£92 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease (£21 potential savings vs. average return price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Des Moines to Manchester that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 December 2025.
Use the filters below to find and compare flights from Des Moines to Manchester that are best for you.

Fly from

Des Moines

Fly to

Manchester

Route

Depart

Return

Price

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Mon 26/1

10:21-08:20

2 stops15h 59m

Manchester

Mon 2/2

09:00-20:54

2 stops41h 54m

£442

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sun 25/1

06:54-12:45

2 stops23h 51m

Manchester

Sun 1/2

05:50-22:29

2 stops22h 39m

£450

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 24/1

13:03-10:10

2 stops15h 07m

Manchester

Sat 31/1

13:30-16:28

1 stop32h 58m

£452

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 24/1

13:03-10:30

1 stop15h 27m

Manchester

Sat 31/1

13:30-16:28

1 stop32h 58m

£453

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 24/1

12:25-08:20

2 stops13h 55m

Manchester

Sat 31/1

05:50-17:08

2 stops17h 18m

£464

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 24/1

18:48-23:20

2 stops22h 32m

Manchester

Sat 31/1

06:45-17:47

2 stops17h 02m

£465

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sun 25/1

16:30-10:45

3 stops36h 15m

£245

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sun 25/1

10:59-08:40

2 stops15h 41m

£283

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 24/1

18:48-10:20

3 stops33h 32m

£304

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 24/1

18:48-23:20

2 stops22h 32m

£305

Flights are sorted by cheapest return flights first.

Deals found on 11/12

Showing 1-10 of 13 results
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Best time to book a flight from Des Moines to Manchester

Have a flexible travel schedule? Discover the best time to fly to Manchester from Des Moines with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Manchester. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Manchester?

    Airlines like Virgin Atlantic fly from Des Moines to Manchester in about 15h 59m. The time it takes to get you to your destination can typically vary by up to . The distance between Des Moines and Manchester is about 4045 mi.

  • Can I find deals for flights from Des Moines to Manchester that include hotel bookings?

    Yes. In addition to deals on Des Moines to Manchester flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Manchester?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Manchester.

  • Can I find deals for business class flights from Des Moines to Manchester?

    Yes. Cheapflights offers flight deals from Des Moines to Manchester by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Travelling to a place near Manchester?

Book flights to Manchester if you plan to visit one of these locations
Windermere
Llandudno
Lincoln
Bradford
Derby
Harrogate
Otley
Stoke-on-Trent
Telford
Southport
Bolton
Preston
Morecambe
Lancaster
Wakefield
Stockport
Blackburn
Salford
Warrington
Huddersfield

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How does Cheapflights help users find flights from Des Moines to Manchester?

Cheapflights helps you search for flights from Des Moines to Manchester via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines to Manchester?

Cheapflights simply makes it quick and affordable to book flights from Des Moines to Manchester by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Des Moines to Manchester with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Des Moines to Manchester, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Des Moines to Manchester become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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