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Cheap flights from Des Moines to Manchester from £385

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 30/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MAN
16 Jul — 23 Jul1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Des Moines to Manchester

Enter your travel dates to find the best prices.

Cheapest flights from Des Moines to Manchester
Explore the most affordable flight options available from Des Moines to Manchester. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 16 June 2026.

Tue 10/1105:00
DSM
-
MAN
2 stops29h 55m
United Airlines
Thu 12/1111:30
MAN
-
DSM
2 stops41h 00m
United Airlines
Deal found 15/6£590
Mon 9/1120:15
DSM
-
MAN
2 stops38h 45m
United Airlines
Thu 12/1111:30
MAN
-
DSM
2 stops39h 47m
United Airlines
Deal found 15/6£594
Mon 9/1106:15
DSM
-
MAN
3 stops22h 05m
United Airlines
Wed 11/1106:10
MAN
-
DSM
2 stops19h 15m
United Airlines
Deal found 15/6£601
Mon 9/1117:03
DSM
-
MAN
2 stops57h 37m
United Airlines
Fri 13/1106:10
MAN
-
DSM
2 stops19h 15m
United Airlines
Deal found 15/6£605
Wed 29/717:52
DSM
-
MAN
2 stops14h 08m
Air France
Wed 5/810:40
MAN
-
DSM
1 stop17h 57m
Air France
Deal found 14/6£763
Tue 28/718:50
DSM
-
MAN
2 stops16h 15m
Lufthansa
Tue 4/810:35
MAN
-
DSM
2 stops42h 21m
Lufthansa
Deal found 13/6£775
Tue 28/717:52
DSM
-
MAN
2 stops14h 08m
Air France
Tue 4/813:00
MAN
-
DSM
1 stop34h 50m
Air France
Deal found 13/6£790
Tue 28/714:25
DSM
-
MAN
1 stop12h 25m
Virgin Atlantic
Tue 4/820:50
MAN
-
DSM
2 stops26h 21m
Virgin Atlantic
Deal found 13/6£792
Tue 28/714:25
DSM
-
MAN
2 stops20h 20m
KLM
Tue 4/820:50
MAN
-
DSM
2 stops29h 49m
KLM
Deal found 13/6£800
Wed 29/717:32
DSM
-
MAN
2 stops14h 28m
Delta
Wed 5/805:55
MAN
-
DSM
2 stops20h 44m
Delta
Deal found 14/6£800
Wed 29/706:00
DSM
-
MAN
3 stops22h 25m
United Airlines
Wed 5/806:05
MAN
-
DSM
2 stops21h 17m
United Airlines
Deal found 14/6£803
Tue 28/711:30
DSM
-
MAN
1 stop15h 20m
Multiple Airlines
Tue 4/813:00
MAN
-
DSM
1 stop15h 37m
Multiple Airlines
Deal found 13/6£804

Find flight deals from Des Moines to Manchester

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Manchester (MAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 16 June 2026.

Round-trip from

£590

One-way from

£385
United Airlines
  • United Airlines
  • 10/11-12/11
  • 4 total stops
  • 70h 55m total
  • Des Moines to Manchester
Search Deals
Air France
  • Air France
  • 30/7
  • 2 total stops
  • 14h 08m total
  • Des Moines to Manchester
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Des Moines to Manchester that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 16 June 2026.
Use the filters below to find and compare flights from Des Moines to Manchester that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Tue 10/11

05:00-16:55

2 stops29h 55m

Manchester

Thu 12/11

11:30-22:30

2 stops41h 00m

£590

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Mon 16/11

08:00-08:40

2 stops18h 40m

Manchester

Wed 18/11

06:10-00:40

2 stops24h 30m

£601

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Wed 11/11

06:15-10:20

3 stops22h 05m

Manchester

Fri 13/11

06:10-17:33

2 stops17h 23m

£601

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Mon 9/11

06:15-08:40

2 stops20h 25m

Manchester

Wed 11/11

06:10-17:33

2 stops17h 23m

£601

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sun 15/11

20:15-08:40

2 stops30h 25m

Manchester

Wed 18/11

06:10-23:01

2 stops22h 51m

£601
Fastest return journey

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Wed 29/7

17:52-14:00

2 stops14h 08m

Manchester

Wed 5/8

10:40-22:37

1 stop17h 57m

£763

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Wed 29/7

16:48-15:30

2 stops16h 42m

Manchester

Wed 5/8

10:55-22:06

2 stops17h 11m

£790

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Wed 29/7

17:32-14:00

2 stops14h 28m

Manchester

Wed 5/8

05:55-20:39

2 stops20h 44m

£800

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Mon 27/7

06:00-10:25

3 stops22h 25m

Manchester

Mon 3/8

10:35-22:56

2 stops42h 21m

£811

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Tue 28/7

15:24-10:25

2 stops13h 01m

Manchester

Tue 4/8

10:35-21:22

2 stops40h 47m

£811

Flights are sorted by cheapest return flights first.

Deals found on 15/6

Showing 1-10 of 12 resultsSorted by cheapest first
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Best time to book a flight from Des Moines to Manchester

Have a flexible travel schedule? Discover the best time to fly to Manchester from Des Moines with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Manchester. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Manchester?

    Airlines like United Airlines fly from Des Moines to Manchester in about 29h 55m. The time it takes to get you to your destination can typically vary by up to . The distance between Des Moines and Manchester is about 4045 mi.

  • Can I find deals for flights from Des Moines to Manchester that include hotel bookings?

    Yes. In addition to deals on Des Moines to Manchester flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Manchester?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Manchester.

  • Can I find deals for business class flights from Des Moines to Manchester?

    Yes. Cheapflights offers flight deals from Des Moines to Manchester by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Travelling to a place near Manchester?

Book flights to Manchester if you plan to visit one of these locations
Windermere
Bradford
Lincoln
Llandudno
Southport
Derby
Harrogate
Stoke-on-Trent
Otley
Warrington
Shrewsbury
Lancaster
Telford
Salford
Preston
Wakefield
Bolton
Burnley
Huddersfield
Macclesfield

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How does Cheapflights help users find flights from Des Moines to Manchester?

Cheapflights helps you search for flights from Des Moines to Manchester via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines to Manchester?

Cheapflights simply makes it quick and affordable to book flights from Des Moines to Manchester by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Des Moines to Manchester with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Des Moines to Manchester, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Des Moines to Manchester become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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