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Cheap flights from Des Moines to Manchester from £268

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 29/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MAN
1 Jun — 8 Jun1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Des Moines to Manchester

Enter your travel dates to find the best prices.

Cheapest flights from Des Moines to Manchester
Explore the most affordable flight options available from Des Moines to Manchester. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 2 May 2026.

Tue 6/1018:45
DSM
-
MAN
2 stops33h 40m
United Airlines
Fri 9/1009:00
MAN
-
DSM
2 stops37h 16m
United Airlines
Deal found 27/4£662
Sat 12/918:15
DSM
-
MAN
2 stops18h 45m
British Airways
Wed 23/909:20
MAN
-
DSM
2 stops20h 08m
British Airways
Deal found 27/4£729
Fri 31/718:33
DSM
-
MAN
2 stops16h 47m
British Airways
Mon 17/820:15
MAN
-
DSM
2 stops28h 48m
British Airways
Deal found 2/5£751
Sat 12/908:00
DSM
-
MAN
3 stops16h 30m
Multiple Airlines
Wed 23/909:00
MAN
-
DSM
2 stops16h 24m
Multiple Airlines
Deal found 27/4£773
Sat 12/906:20
DSM
-
MAN
2 stops20h 05m
Delta
Wed 23/910:40
MAN
-
DSM
1 stop17h 46m
Delta
Deal found 27/4£794
Fri 31/718:33
DSM
-
MAN
2 stops16h 47m
British Airways
Sat 15/818:10
MAN
-
DSM
2 stops31h 04m
British Airways
Deal found 2/5£795
Wed 10/606:00
DSM
-
MAN
2 stops22h 25m
United Airlines
Wed 17/609:00
MAN
-
DSM
2 stops37h 15m
United Airlines
Deal found 29/4£810
Fri 31/706:00
DSM
-
MAN
3 stops22h 25m
United Airlines
Mon 17/806:05
MAN
-
DSM
2 stops16h 57m
United Airlines
Deal found 2/5£827
Fri 31/717:32
DSM
-
MAN
2 stops13h 53m
Multiple Airlines
Sat 15/813:15
MAN
-
DSM
1 stop15h 22m
Multiple Airlines
Deal found 2/5£848
Thu 4/606:00
DSM
-
MAN
2 stops18h 30m
United Airlines
Wed 17/609:00
MAN
-
DSM
2 stops31h 27m
United Airlines
Deal found 30/4£861

Find flight deals from Des Moines to Manchester

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Manchester (MAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 2 May 2026.

Round-trip from

£662

One-way from

£268
United Airlines
  • United Airlines
  • 6/10-9/10
  • 4 total stops
  • 70h 56m total
  • Des Moines to Manchester
Search Deals
British Airways
  • British Airways
  • 29/9
  • 2 total stops
  • 21h 27m total
  • Des Moines to Manchester
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Des Moines to Manchester that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 2 May 2026.
Use the filters below to find and compare flights from Des Moines to Manchester that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Tue 6/10

18:45-10:25

2 stops33h 40m

Manchester

Fri 9/10

09:00-23:57

2 stops44h 57m

£662

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 12/9

18:15-19:00

2 stops18h 45m

Manchester

Wed 23/9

09:20-23:28

2 stops20h 08m

£729

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 12/9

06:00-06:30

3 stops18h 30m

Manchester

Wed 23/9

09:00-19:24

2 stops16h 24m

£773

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sat 12/9

17:25-16:45

2 stops17h 20m

Manchester

Wed 23/9

10:40-22:26

1 stop17h 46m

£794
Fastest return journey

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Fri 31/7

17:32-13:25

2 stops13h 53m

Manchester

Sat 15/8

13:15-22:37

1 stop15h 22m

£848

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Fri 12/6

06:00-17:20

2 stops29h 20m

Manchester

Fri 19/6

09:00-21:40

2 stops42h 40m

£872

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Sun 14/6

20:15-06:30

2 stops52h 15m

Manchester

Sun 21/6

09:00-22:35

2 stops43h 35m

£934

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Thu 11/6

05:35-08:50

1 stop21h 15m

Manchester

Thu 18/6

13:00-22:31

1 stop15h 31m

£940

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Fri 12/6

14:25-08:50

1 stop12h 25m

Manchester

Fri 19/6

14:55-09:44

2 stops24h 49m

£942
Cheapest one-way
Fastest single journey

Des MoinesManchester

DSM - MAN

DSMMAN

Des Moines

Wed 30/9

14:15-07:15

1 stop11h 00m

£295

Flights are sorted by cheapest return flights first.

Deals found on 29/4

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Des Moines to Manchester

Have a flexible travel schedule? Discover the best time to fly to Manchester from Des Moines with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Manchester. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Manchester?

    Airlines like United Airlines, British Airways, and Delta fly from Des Moines to Manchester in about 17h 20m. The time it takes to get you to your destination can typically vary by up to 16h 20m. The distance between Des Moines and Manchester is about 4045 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Des Moines to Manchester that include hotel bookings?

    Yes. In addition to deals on Des Moines to Manchester flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Manchester?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Manchester.

  • Can I find deals for business class flights from Des Moines to Manchester?

    Yes. Cheapflights offers flight deals from Des Moines to Manchester by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Travelling to a place near Manchester?

Book flights to Manchester if you plan to visit one of these locations
Windermere
Bradford
Lincoln
Llandudno
Derby
Harrogate
Southport
Stoke-on-Trent
Otley
Warrington
Telford
Salford
Lancaster
Shrewsbury
Huddersfield
Preston
Wakefield
Bolton
Wilmslow
Macclesfield

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How does Cheapflights help users find flights from Des Moines to Manchester?

Cheapflights helps you search for flights from Des Moines to Manchester via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines to Manchester?

Cheapflights simply makes it quick and affordable to book flights from Des Moines to Manchester by bringing together all flight options from hundreds of airlines and agencies online — and put it in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Des Moines to Manchester with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Des Moines to Manchester, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Des Moines to Manchester become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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