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Cheap flights from Missouri to Manchester from £331

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAN
14 Nov — 21 Nov1
1 adult
1 adult, Economy

Cheap flight deals from Missouri to Manchester

Keep the following information in mind while searching for Missouri to Manchester flight deals. Data was last updated 15 October 2025.

Round-trip from

£481

Popular in

June

Cheapest in

February

Average price

£564
Virgin Atlantic
  • Virgin Atlantic
  • 28/11-5/12
  • 2 total stops
  • 37h 40m total
  • Missouri to Manchester
Search Deals
Highest demand for flights based on searches. 25% potential increase in price (£175 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease (£27 potential savings vs. average return price).
Search Deals
Average for round-trip flights in October 2025
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Find flight deals from Missouri to Manchester

Enter your travel dates to find the best prices.

Cheapest flights from Missouri to Manchester
Explore the most affordable flight options available from Missouri to Manchester. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 15 October 2025.

Fri 28/1107:05STL - MAN
1 stop21h 25mVirgin Atlantic
Fri 5/1213:25MAN - STL
1 stop16h 15mVirgin Atlantic
Deal found 14/10£481
Mon 24/1116:05STL - MAN
2 stops25h 50mMultiple Airlines
Tue 2/1217:30MAN - STL
2 stops26h 25mMultiple Airlines
Deal found 12/10£484
Fri 28/1119:20STL - MAN
2 stops13h 30mBritish Airways
Fri 5/1207:50MAN - STL
2 stops17h 16mBritish Airways
Deal found 14/10£488
Thu 13/1112:18MCI - MAN
1 stop16h 12mVirgin Atlantic
Sun 16/1109:05MAN - MCI
1 stop19h 30mVirgin Atlantic
Deal found 14/10£498
Tue 11/1109:04STL - MAN
2 stops15h 36mVirgin Atlantic
Sat 22/1113:30MAN - STL
1 stop14h 28mVirgin Atlantic
Deal found 13/10£501
Thu 13/1112:10MCI - MAN
2 stops16h 50mAmerican Airlines
Sun 16/1108:55MAN - MCI
2 stops18h 28mAmerican Airlines
Deal found 14/10£504
Thu 27/1108:25STL - MAN
2 stops19h 55mUnited Airlines
Thu 4/1206:10MAN - STL
2 stops15h 30mUnited Airlines
Deal found 13/10£511
Mon 24/1118:43STL - MAN
2 stops16h 12mLufthansa
Tue 2/1217:40MAN - STL
2 stops26h 15mLufthansa
Deal found 14/10£515
Fri 28/1111:36MCI - MAN
2 stops16h 44mUnited Airlines
Fri 5/1209:25MAN - MCI
2 stops38h 04mUnited Airlines
Deal found 14/10£523
Mon 24/1113:10STL - MAN
2 stops15h 10mUnited Airlines
Tue 2/1209:25MAN - STL
1 stop34h 30mUnited Airlines
Deal found 14/10£526
Sun 7/1212:47MCI - MAN
1 stop11h 43mVirgin Atlantic
Wed 7/113:30MAN - MCI
1 stop16h 31mVirgin Atlantic
Deal found 14/10£533
Mon 15/1215:27MCI - MAN
2 stops15h 18mVirgin Atlantic
Thu 15/113:30MAN - MCI
1 stop16h 31mVirgin Atlantic
Deal found 13/10£541

Cheapflights Fare Finder

 
Customise your flight search to find flights from Missouri to Manchester that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 15 October 2025.
Use the filters below to find and compare flights from Missouri to Manchester that are best for you.

Fly from

Missouri

Fly to

Manchester

Route

Depart

Return

Price

St. LouisManchester

STL - MAN

STLMAN

Lambert-St Louis

Fri 28/11

07:05-10:30

1 stop21h 25m

Manchester

Fri 5/12

13:25-23:40

1 stop16h 15m

£481

Kansas CityManchester

MCI - MAN

MCIMAN

Kansas City

Mon 24/11

18:43-12:20

2 stops35h 37m

Manchester

Thu 27/11

06:00-19:54

2 stops19h 54m

£482

St. LouisManchester

STL - MAN

STLMAN

Lambert-St Louis

Fri 28/11

19:20-14:50

2 stops13h 30m

Manchester

Fri 5/12

07:50-19:06

2 stops17h 16m

£488

St. LouisManchester

STL - MAN

STLMAN

Lambert-St Louis

Mon 24/11

16:05-23:55

3 stops25h 50m

Manchester

Tue 2/12

17:30-13:55

2 stops26h 25m

£498

St. LouisManchester

STL - MAN

STLMAN

Lambert-St Louis

Tue 11/11

14:52-11:25

2 stops14h 33m

Manchester

Sat 22/11

08:05-19:38

2 stops17h 33m

£501

St. LouisManchester

STL - MAN

STLMAN

Lambert-St Louis

Tue 11/11

09:04-06:40

2 stops15h 36m

Manchester

Sat 22/11

13:30-21:58

1 stop14h 28m

£501

Kansas CityManchester

MCI - MAN

MCIMAN

Kansas City

Wed 21/1

13:56-13:55

2 stops17h 59m

Manchester

Wed 28/1

18:00-21:27

2 stops33h 27m

£505

Kansas CityManchester

MCI - MAN

MCIMAN

Kansas City

Wed 21/1

10:35-10:10

2 stops17h 35m

Manchester

Wed 28/1

13:30-21:08

1 stop13h 38m

£508

St. LouisManchester

STL - MAN

STLMAN

Lambert-St Louis

Thu 27/11

08:25-10:20

2 stops19h 55m

Manchester

Thu 4/12

06:10-15:40

2 stops15h 30m

£511

Kansas CityManchester

MCI - MAN

MCIMAN

Kansas City

Wed 26/11

11:36-10:20

2 stops16h 44m

Manchester

Wed 3/12

06:10-19:54

2 stops19h 44m

£511

Flights are sorted by cheapest return flights first.

Deals found on 14/10

Showing 1-10 of 23 results
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Best time to book a flight from Missouri to Manchester

Have a flexible travel schedule? Discover the best time to fly to Manchester from Missouri with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Manchester

What is the cheapest month to book a flight from Missouri to Manchester?

Currently, September is the cheapest month in which you can book a flight from Missouri to Manchester (average of £345). Flying from Missouri to Manchester in June is currently the most expensive (average of £577). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to MAN?

Find hourly flight availability from Missouri to Manchester. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 15 October 2025.

It’s optimal to fly from Missouri to Manchester in the morning. By choosing this option you can save up to 31% on the cost of your flight, compared to a flight at midday.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Manchester. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Manchester from Missouri?

    For a flight from Missouri to Manchester, you will be flying into Manchester. Manchester (MAN) is just 8.9 mi from the center of the city.

  • How long is the flight from Missouri to Manchester?

    A quick flight from Missouri to Manchester can take about 13h 30m. Virgin Atlantic provides one of the quickest options available for as low as £488. The distance between Missouri and Manchester is about 4061 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to Manchester?

    While some choose either Lambert-St Louis - Manchester or Springfield-Branson - Manchester, Kansas City - Manchester is the most popular route from Missouri to Manchester.

  • Can I find deals for flights from Missouri to Manchester that include hotel bookings?

    Yes. In addition to deals on Missouri to Manchester flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Manchester?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Manchester.

  • Can I find deals for business class flights from Missouri to Manchester?

    Yes. Cheapflights offers flight deals from Missouri to Manchester by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Manchester?

    Currently, September is the cheapest month in which you can book a flight from Missouri to Manchester (average of £345). Flying from Missouri to Manchester in June is currently the most expensive (average of £577). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Manchester?

Book flights to Manchester if you plan to visit one of these locations
Windermere
Llandudno
Lincoln
Bradford
Derby
Harrogate
Preston
Stoke-on-Trent
Southport
Blackburn
Wakefield
Stockport
Lancaster
Morecambe
Bolton
Telford
Rochdale
Huddersfield
Salford
Warrington

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Top airline flying from Missouri to Manchester

Discover the top airline that operate flights from Missouri to Manchester. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 15 October 2025.
AirlineCheapestAverageFlexibilityOn-time
Virgin AtlanticCheapest£448Average£600FlexibilityNo cancel feeOn-time72%
Search Virgin Atlantic flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Missouri to Manchester?

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Why should you use Cheapflights to find cheap flight tickets from Missouri to Manchester?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Manchester from Missouri.

Can Cheapflights find flights from Missouri to Manchester with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Missouri to Manchester flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Missouri to Manchester become cheaper?

Yes! Start tracking prices for Missouri to Manchester flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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