Cheap flights from Panama City to Mexico City from £133

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/4. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
11 Apr — 18 Apr1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Mexico City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 March 2026.

Mon 6/422:11
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Wed 8/415:30
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 10/3£243
Mon 6/422:11
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Sun 26/415:30
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 8/3£258
Wed 22/410:10
PTY
-
MEX
1 stop8h 55m
Avianca
Wed 29/416:55
MEX
-
PTY
1 stop8h 00m
Avianca
Deal found 8/3£265
Sun 8/315:50
PTY
-
MEX
1 stop10h 25m
Avianca
Fri 10/423:20
MEX
-
PTY
1 stop8h 55m
Avianca
Deal found 7/3£266
Mon 4/505:30
PTY
-
MEX
1 stop6h 25m
Avianca
Thu 4/604:00
MEX
-
PTY
1 stop5h 30m
Avianca
Deal found 8/3£267
Fri 17/411:44
PTY
-
MEX
Nonstop3h 46m
Copa Airlines
Fri 1/502:10
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 10/3£273
Thu 9/411:44
PTY
-
MEX
Nonstop3h 46m
Copa Airlines
Thu 16/409:50
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 10/3£281
Mon 6/422:11
PTY
-
MEX
Nonstop3h 49m
Multiple Airlines
Sat 11/408:40
MEX
-
PTY
Nonstop3h 50m
Multiple Airlines
Deal found 8/3£282
Thu 9/409:19
PTY
-
MEX
Nonstop3h 51m
Copa Airlines
Sat 25/413:10
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 9/3£289
Wed 8/422:11
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Tue 14/409:50
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 10/3£305
Mon 6/411:44
PTY
-
MEX
Nonstop3h 46m
Copa Airlines
Tue 21/415:30
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 10/3£311

Find flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 March 2026.

Round-trip from

£243

One-way from

£133

Popular in

April

Cheapest in

July

Average price

£302

Good one-way deal

£494 or less
Copa Airlines
  • Copa Airlines
  • 6/4-8/4
  • Nonstop
  • 7h 29m total
  • Panama City to Mexico City
Copa Airlines
  • Copa Airlines
  • 4/4
  • Nonstop
  • 3h 49m total
  • Panama City to Mexico City
Highest demand for flights based on searches. 9% potential increase in price (£21 potential increase over avg. return price).
Cheapest flight prices on average. 1% potential price decrease (£3 potential savings vs. average return price).
Average for round-trip flights in March 2026
Price to beat on a one-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez.

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 March 2026.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 19/6

16:05-19:05

Nonstop4h 00m

Mexico City Benito Juarez

Fri 3/7

09:50-14:36

Nonstop3h 46m

£273

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sun 12/4

22:11-01:00

Nonstop3h 49m

Mexico City Benito Juarez

Sun 19/4

13:10-17:53

Nonstop3h 43m

£273

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sun 31/5

11:45-14:30

Nonstop3h 45m

Mexico City Benito Juarez

Sun 7/6

13:10-17:56

Nonstop3h 46m

£273

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 16/6

22:13-01:00

Nonstop3h 47m

Mexico City Benito Juarez

Fri 26/6

13:10-17:56

Nonstop3h 46m

£273
Fastest return journey

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 7/5

11:45-14:30

Nonstop3h 45m

Mexico City Benito Juarez

Mon 18/5

09:50-14:30

Nonstop3h 40m

£281

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 22/4

11:44-14:30

Nonstop3h 46m

Mexico City Benito Juarez

Wed 29/4

15:30-20:10

Nonstop3h 40m

£281

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 7/4

22:11-01:00

Nonstop3h 49m

Mexico City Benito Juarez

Tue 21/4

09:50-14:30

Nonstop3h 40m

£281

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 8/4

22:11-01:00

Nonstop3h 49m

Mexico City Benito Juarez

Tue 14/4

09:50-14:30

Nonstop3h 40m

£305

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mon 6/4

11:44-14:30

Nonstop3h 46m

Mexico City Benito Juarez

Tue 21/4

15:30-20:10

Nonstop3h 40m

£311
Cheapest one-way
Fastest single journey

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 4/4

22:11-01:00

Nonstop3h 49m

£133

Flights are sorted by cheapest return flights first.

Deals found on 12/3

Showing 1-10 of 17 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

Use this chart to determine the optimal time to book a return flight from Panama City to Mexico City. Price data was last updated on 6 March 2026.

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 75 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £124). Flying from Panama City to Mexico City in May is currently the most expensive (average of £235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 12 March 2026.

It’s optimal to fly from Panama City to Mexico City in the afternoon. By choosing this option you can save up to 35% on the cost of your flight, compared to a flight in the evening.

How much does it cost for a return flight from Panama City to Mexico City?

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How popular is this Panama City to Mexico City flight route?

  • How long is the flight from Panama City to Mexico City?

    For as low as £273, Copa Airlines can have you in Mexico City from Panama City in 4h. Airlines will cover a distance of 1497 mi. All flights are typically direct.

  • What are the most reliable airlines from Panama City to Mexico City?

    No one likes to see their flight delayed. When booking a flight from Panama City to Mexico City consider choosing Copa Airlines (94%), Emirates (93%) or AeroMexico Connect (89%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama City to Mexico City?

    On average you can expect to pay £494 for a flight from Panama City to Mexico City. The cheapest flight overall is £494 while the most popular route, (Panama City Tocumen Intl - Mexico City Benito Juarez) is currently priced at £322.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £124). Flying from Panama City to Mexico City in May is currently the most expensive (average of £235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Yes! Cheapflights helps users easily find flights from Panama City to Mexico City with no change fees.

Can Cheapflights notify me if prices for flights from Panama City to Mexico City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Mexico City from Panama City today and book when prices fit your budget.

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