Cheap flights from Panama City to Mexico City from £197
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
27 Feb — 6 Mar1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in July or December, booked 75 days in advance, depart on a Monday or Tuesday and return on a Wednesday
Cheap flight deals from Panama City to Mexico City
Enter your travel dates to find the best prices.
Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 January 2026.
Wed 1/417:25
PTY
-
MEX
1 stop10h 40m
Avianca
Sun 12/404:55
MEX
-
PTY
1 stop18h 15m
Avianca
Deal found 26/1£244
Tue 10/309:22
PTY
-
MEX
Nonstop3h 48m
Copa Airlines
Tue 17/313:10
MEX
-
PTY
Nonstop3h 39m
Copa Airlines
Deal found 26/1£256
Fri 13/314:48
PTY
-
MEX
Nonstop3h 57m
Aeromexico
Fri 20/308:55
MEX
-
PTY
Nonstop3h 50m
Aeromexico
Deal found 27/1£258
Sat 31/109:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Sat 7/215:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 28/1£272
Fri 30/109:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Sun 1/209:25
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 26/1£288
Thu 5/214:55
PTY
-
MEX
2 stops12h 00m
Avianca
Wed 11/200:40
MEX
-
PTY
1 stop12h 20m
Avianca
Deal found 27/1£289
Wed 1/411:05
PTY
-
MEX
1 stop12h 55m
Avianca
Tue 21/400:40
MEX
-
PTY
1 stop14h 50m
Avianca
Deal found 26/1£305
Tue 24/211:45
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Thu 29/1015:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 27/1£329
Sat 28/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Mon 16/315:30
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£333
Sat 14/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Wed 18/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 28/1£339
Sat 30/519:08
PTY
-
MEX
Nonstop3h 52m
Copa Airlines
Thu 4/601:20
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£363
Sat 3/1009:55
PTY
-
MEX
1 stop9h 10m
Avianca
Thu 29/1004:00
MEX
-
PTY
1 stop13h 55m
Avianca
Deal found 26/1£371
Best flights from Panama City to Mexico City
Discover carefully curated flight deals from Panama City to Mexico City that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 28 January 2026.
Wed 1/417:25
PTY
-
MEX
1 stop10h 40m
Avianca
Sun 12/404:55
MEX
-
PTY
1 stop18h 15m
Avianca
Deal found 26/1£244
Sat 7/219:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Sun 15/309:25
MEX
-
PTY
Nonstop3h 39m
Copa Airlines
Deal found 26/1£256
Wed 29/409:19
PTY
-
MEX
Nonstop3h 51m
Copa Airlines
Sun 10/513:10
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 26/1£256
Tue 10/309:22
PTY
-
MEX
Nonstop3h 48m
Copa Airlines
Tue 17/309:25
MEX
-
PTY
Nonstop3h 39m
Copa Airlines
Deal found 26/1£256
Sat 7/216:17
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Thu 19/215:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 27/1£256
Wed 18/211:45
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Tue 24/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 27/1£256
Sat 14/219:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Sat 21/213:10
MEX
-
PTY
Nonstop3h 38m
Copa Airlines
Deal found 27/1£256
Sat 14/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Wed 25/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 26/1£256
Wed 25/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Tue 3/301:20
MEX
-
PTY
Nonstop3h 34m
Copa Airlines
Deal found 27/1£256
Tue 17/209:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Wed 25/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 27/1£256
Mon 16/219:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Mon 23/209:25
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 26/1£256
Direct flights from Panama City to Mexico City
Explore direct flight options from Panama City to Mexico City based on user searches, and compare prices and availability for your desired travel dates. Data last updated 28 January 2026.
Tue 10/311:41
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Fri 20/315:30
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£256
Fri 13/314:48
PTY
-
MEX
Nonstop3h 57m
Aeromexico
Fri 20/308:55
MEX
-
PTY
Nonstop3h 50m
Aeromexico
Deal found 27/1£258
Mon 9/209:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Fri 13/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 27/1£288
Tue 24/211:45
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Thu 29/1015:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 27/1£329
Sat 28/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Mon 16/315:30
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£333
Sat 14/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Wed 18/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 28/1£339
Sat 30/522:14
PTY
-
MEX
Nonstop3h 46m
Copa Airlines
Sat 6/605:50
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£363
Mon 20/709:25
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Sun 26/715:30
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Deal found 25/1£397
Fri 13/219:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Wed 18/209:25
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 28/1£399
Sat 13/622:13
PTY
-
MEX
Nonstop3h 47m
Copa Airlines
Sat 20/600:25
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£411
Sat 13/619:00
PTY
-
MEX
Nonstop4h 00m
Copa Airlines
Thu 18/605:50
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 26/1£412
Mon 15/622:13
PTY
-
MEX
Nonstop3h 47m
Copa Airlines
Fri 19/605:50
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 26/1£430
Last-minute flights from Panama City to Mexico City
Discover last-minute flight deals from Panama City to Mexico City. Data last updated 28 January 2026 and is based on user searches.
Tue 27/118:58
PTY
-
MEX
Nonstop4h 07m
Copa Airlines
Tue 3/209:25
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 26/1£659
Fri 30/109:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Sun 1/209:25
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 26/1£288
Sat 31/109:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Sat 7/215:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 28/1£272
Sat 31/111:47
PTY
-
MEX
Nonstop3h 43m
Copa Airlines
Tue 3/215:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 28/1£596
Thu 5/214:55
PTY
-
MEX
2 stops12h 00m
Avianca
Wed 11/200:40
MEX
-
PTY
1 stop12h 20m
Avianca
Deal found 27/1£289
Thu 5/208:25
PTY
-
MEX
2 stops16h 45m
United Airlines
Fri 27/207:50
MEX
-
PTY
1 stop8h 17m
United Airlines
Deal found 27/1£1,297
Fri 13/219:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Wed 18/209:25
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 28/1£399
Sat 14/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Wed 25/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 26/1£256
Sat 14/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Wed 18/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 28/1£339
Tue 24/211:45
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Thu 29/1015:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 27/1£329
Sat 28/216:17
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Mon 16/313:10
MEX
-
PTY
Nonstop3h 39m
Copa Airlines
Deal found 28/1£333
One-way flights from Panama City to Mexico City
Search for one-way flight options from Panama City to Mexico City. Find affordable one-way fares based on user searches. Data last updated 28 January 2026.
Mon 2/219:50
PTY
-
MEX
1 stop6h 25m
Avianca
Deal found 27/1£197
Sat 14/214:51
PTY
-
MEX
Nonstop3h 54m
Aeromexico
Deal found 26/1£281
Wed 8/409:19
PTY
-
MEX
Nonstop3h 51m
Copa Airlines
Deal found 26/1£384
Mon 2/209:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 26/1£407
Mon 27/710:00
PTY
-
MEX
3 stops19h 00m
United Airlines
Deal found 26/1£859
Find flight deals from Panama City to Mexico City
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 28 January 2026.
Customise your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 28 January 2026.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.
Fly from
Panama City
Fly to
Mexico City
Route
Depart
Return
Price
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Wed 1/4
17:25-03:05
1 stop10h 40m
Mexico City Benito Juarez
Sun 12/4
04:55-00:10
1 stop18h 15m
£244
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Sat 7/2
19:02-22:05
Nonstop4h 03m
Mexico City Benito Juarez
Sun 15/3
09:25-14:04
Nonstop3h 39m
£256
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Wed 29/4
09:19-12:10
Nonstop3h 51m
Mexico City Benito Juarez
Sun 10/5
13:10-17:50
Nonstop3h 40m
£256
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Tue 10/3
09:22-12:10
Nonstop3h 48m
Mexico City Benito Juarez
Tue 17/3
09:25-14:04
Nonstop3h 39m
£256
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Sat 7/2
16:17-19:20
Nonstop4h 03m
Mexico City Benito Juarez
Thu 19/2
15:30-20:07
Nonstop3h 37m
£256
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Wed 18/2
11:45-14:30
Nonstop3h 45m
Mexico City Benito Juarez
Tue 24/2
01:20-06:00
Nonstop3h 40m
£256
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Sat 14/2
19:02-22:05
Nonstop4h 03m
Mexico City Benito Juarez
Sat 21/2
13:10-17:48
Nonstop3h 38m
£256
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Sat 14/2
21:25-00:15
Nonstop3h 50m
Mexico City Benito Juarez
Wed 25/2
01:20-06:00
Nonstop3h 40m
£256
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Wed 25/2
21:25-00:15
Nonstop3h 50m
Mexico City Benito Juarez
Tue 3/3
01:20-05:54
Nonstop3h 34m
£256
Panama CityMexico City
PTY - MEX
PTYMEX
Panama City Tocumen Intl
Tue 17/2
09:21-12:10
Nonstop3h 49m
Mexico City Benito Juarez
Wed 25/2
01:20-06:00
Nonstop3h 40m
£256
Flights are sorted by cheapest return flights first.
Deals found on 27/1
Showing 1-10 of 20 results
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Best time to book a flight from Panama City to Mexico City
Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Mexico City
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Mexico City?
Use this chart to determine the optimal time to book a return flight from Panama City to Mexico City. Price data was last updated on 23 January 2026.
The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 75 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Panama City to Mexico City?
Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £124). Flying from Panama City to Mexico City in March is currently the most expensive (average of £234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to MEX?
Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 28 January 2026.
It’s optimal to fly from Panama City to Mexico City in the afternoon. By choosing this option you can save up to 18% on the cost of your flight, compared to a flight in the evening.
How much does it cost for a return flight from Panama City to Mexico City?
Weekly flight availability from Panama City to Mexico City
Explore weekly flight availability from Panama City to Mexico City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 28 January 2026.
The most flights from PTY to MEX are scheduled on a Monday (8 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (3 on average).
How often are flights from Panama City to Mexico City delayed?
About 3% of weekly flights between Panama City and Mexico City have experienced delays in the past year, with the average delay time being 128 minutes.
What is the most punctual flight time for Panama City to Mexico City flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Thursday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Mexico City flights?
Over the past year, Copa Airlines have had the lowest number of delays on this route, with just 3% of flights being delayed.
Reviews of airlines servicing Mexico City
Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated 28 January 2026.
Read reviews from past customers who have flown with Copa Airlines
from Panama City to Mexico City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Related info for your journey
Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Panama City to Mexico City?
You will need to book a flight from Panama City Tocumen Intl to Mexico City Benito Juarez if you want to fly from Panama City to Mexico City. At least 1 airline has flights from Tocumen Intl (PTY) to Benito Juarez (MEX) on a regular basis. There are 7 flights to Mexico City from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to MEX to be around 27h 14m.
How popular is this Panama City to Mexico City flight route?
The Panama City Tocumen Intl to Mexico City Benito Juarez flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Panama City to Mexico City?
For as low as £256, Avianca can have you in Mexico City from Panama City in 4h 03m. Airlines will cover a distance of 1497 mi. This flight may include one or multiple stops.
What is the cheapest airline to fly from Panama City to Mexico City round-trip?
Flying on Copa Airlines is currently your cheapest option to Mexico City, with prices starting at £247. You may be able to fly from Panama City to Mexico City for 11% less than the average price by searching for this airline.
What are the most reliable airlines from Panama City to Mexico City?
No one likes to see their flight delayed. When booking a flight from Panama City to Mexico City consider choosing AeroMexico Connect (97%), Copa Airlines (94%) or Aeromexico (93%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Panama City to Mexico City?
On average you can expect to pay £483 for a flight from Panama City to Mexico City. The cheapest flight overall is £383 while the most popular route, (Panama City Tocumen Intl - Mexico City Benito Juarez) is currently priced at £868.
Can I find deals for flights from Panama City to Mexico City that include hotel bookings?
Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Panama City to Mexico City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.
Can I find deals for business class flights from Panama City to Mexico City?
Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Mexico City?
Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £124). Flying from Panama City to Mexico City in March is currently the most expensive (average of £234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Explore flights to Mexico City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 28 January 2026.
Top airline flying from Panama City to Mexico City
Discover the top airline that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 28 January 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Panama City to Mexico City?
Cheapflights helps you search for flights from Panama City to Mexico City via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.
Why should you use Cheapflights to find cheap flight tickets from Panama City to Mexico City?
Millions of users choose and trust Cheapflights to book the best flight deals from Panama City to Mexico City for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.
Can Cheapflights find flights from Panama City to Mexico City with no change fees?
Yes! Cheapflights helps users easily find flights from Panama City to Mexico City with no change fees.
Can Cheapflights notify me if prices for flights from Panama City to Mexico City become cheaper?
Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Mexico City from Panama City today and book when prices fit your budget.
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