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Cheap flights from Panama City to Mexico City from £190

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
12 Okt — 19 Okt1
1 adult
1 adult, Economy

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in July or August, booked 69 days in advance, depart on a Tuesday or Monday and return on a Monday

Cheap flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 September 2025.

Round-trip from

£253

One-way from

£190

Popular in

October

Cheapest in

July

Average price

£313
Copa Airlines
  • Copa Airlines
  • 27/9-4/10
  • Nonstop
  • 7h 22m total
  • Panama City to Mexico City
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Avianca
  • Avianca
  • 7/10
  • 1 total stop
  • 9h 45m total
  • Panama City to Mexico City
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Highest demand for flights based on searches. 4% potential increase in price (£10 potential increase over avg. return price).
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Cheapest flight prices on average. 0% potential price decrease (£2 potential savings vs. average return price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama City to Mexico City

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 September 2025.

Fr 19/922:21PTY - MEX
Nonstop3h 39mCopa Airlines
Fr 26/915:30MEX - PTY
Nonstop3h 44mCopa Airlines
Deal found 11/9£253
Do 25/911:46PTY - MEX
Nonstop3h 44mCopa Airlines
Mo 29/913:05MEX - PTY
Nonstop3h 44mCopa Airlines
Deal found 11/9£269
Mo 1/1219:02PTY - MEX
Nonstop4h 03mCopa Airlines
Sa 10/102:00MEX - PTY
Nonstop3h 41mCopa Airlines
Deal found 10/9£320
Sa 27/919:21PTY - MEX
Nonstop3h 44mCopa Airlines
Mi 1/1002:00MEX - PTY
Nonstop3h 44mCopa Airlines
Deal found 11/9£323
Sa 11/1022:21PTY - MEX
Nonstop3h 39mCopa Airlines
Fr 17/1001:40MEX - PTY
Nonstop3h 40mCopa Airlines
Deal found 12/9£327
Mi 17/1211:28PTY - MEX
Nonstop4h 02mCopa Airlines
Do 1/102:00MEX - PTY
Nonstop3h 41mCopa Airlines
Deal found 10/9£329
Fr 10/1009:26PTY - MEX
Nonstop3h 44mCopa Airlines
Do 23/1009:50MEX - PTY
Nonstop3h 49mCopa Airlines
Deal found 11/9£329
Mi 15/1009:26PTY - MEX
Nonstop3h 44mCopa Airlines
Fr 17/1001:40MEX - PTY
Nonstop3h 40mCopa Airlines
Deal found 10/9£334
Di 16/1222:00PTY - MEX
Nonstop4h 00mCopa Airlines
Mo 22/1215:30MEX - PTY
Nonstop3h 45mCopa Airlines
Deal found 11/9£336
Sa 25/1021:32PTY - MEX
Nonstop3h 43mCopa Airlines
Sa 1/1115:30MEX - PTY
Nonstop3h 44mCopa Airlines
Deal found 9/9£354

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 September 2025.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fr 26/9

09:21-12:10

Nonstop3h 49m

Mexico City Benito Juarez

Fr 3/10

09:50-14:39

Nonstop3h 49m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mo 6/10

09:26-12:10

Nonstop3h 44m

Mexico City Benito Juarez

Di 21/10

13:05-17:50

Nonstop3h 45m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mo 15/12

22:00-01:00

Nonstop4h 00m

Mexico City Benito Juarez

Sa 31/1

01:20-06:00

Nonstop3h 40m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fr 10/10

11:50-14:30

Nonstop3h 40m

Mexico City Benito Juarez

Fr 17/10

15:30-20:13

Nonstop3h 43m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mi 14/1

22:13-01:00

Nonstop3h 47m

Mexico City Benito Juarez

Mi 21/1

15:30-20:07

Nonstop3h 37m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fr 26/9

11:46-14:30

Nonstop3h 44m

Mexico City Benito Juarez

Sa 18/10

13:05-17:50

Nonstop3h 45m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sa 4/10

09:26-12:10

Nonstop3h 44m

Mexico City Benito Juarez

Mi 15/10

09:50-14:39

Nonstop3h 49m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Di 30/9

11:46-14:30

Nonstop3h 44m

Mexico City Benito Juarez

Di 7/10

15:30-20:13

Nonstop3h 43m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Di 13/1

21:28-00:15

Nonstop3h 47m

Mexico City Benito Juarez

Di 27/1

13:10-17:48

Nonstop3h 38m

£253

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Di 13/1

21:28-00:15

Nonstop3h 47m

Mexico City Benito Juarez

Sa 17/1

05:55-10:35

Nonstop3h 40m

£269

Flights are sorted by cheapest return flights first.

Deals found on 11/9

Showing 1-10 of 18 results
1
2

Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

Use this chart to determine the optimal time to book a return flight from Panama City to Mexico City. Price data was last updated on 29 August 2025.

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, April is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £791). Flying from Panama City to Mexico City in July is currently the most expensive (average of £1,261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 12 September 2025.

It’s optimal to fly from Panama City to Mexico City in the morning. By choosing this option you can save up to 22% on the cost of your flight, compared to a flight at midday.

How much does it cost for a return flight from Panama City to Mexico City?

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated 12 September 2025.
Read reviews from past customers who have flown with Copa Airlines from Panama City to Mexico City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews
Check prices

Crew

8.1

Overall

7.6

Entertainment

6.8

Food

6.8

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sept 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews
Check prices

Crew

8.1

Overall

7.6

Entertainment

6.8

Food

6.8

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sept 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Mexico City?

    You will need to book a flight from Panama City Tocumen Intl to Mexico City Benito Juarez if you want to fly from Panama City to Mexico City. At least 1 airline has flights from Tocumen Intl (PTY) to Benito Juarez (MEX) on a regular basis. There are 8 flights to Mexico City from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to MEX to be around 3h 39m.

  • How popular is this Panama City to Mexico City flight route?

    The Panama City Tocumen Intl to Mexico City Benito Juarez flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Mexico City?

    For as low as £253, Copa Airlines can have you in Mexico City from Panama City in 3h 49m. Airlines will cover a distance of 1497 mi. All flights are typically direct.

  • What is the cheapest airline to fly from Panama City to Mexico City round-trip?

    Flying on Copa Airlines is currently your cheapest option to Mexico City, with prices starting at £250. You may be able to fly from Panama City to Mexico City for 17% less than the average price by searching for this airline.

  • What are the most reliable airlines from Panama City to Mexico City?

    No one likes to see their flight delayed. When booking a flight from Panama City to Mexico City consider choosing AeroMexico Connect (100%), Emirates (96%) or Copa Airlines (90%) as they are the most reliable in getting you off to your destination on time.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £791). Flying from Panama City to Mexico City in July is currently the most expensive (average of £1,261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Panama City to Mexico City

Discover the top airline that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 September 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest£250Average£297FlexibilityNo cancel feeOn-time70%
Search Copa Airlines flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City to Mexico City?

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Why should you use Cheapflights to find cheap flight tickets from Panama City to Mexico City?

Millions of users choose and trust Cheapflights to book the best flight deals from Panama City to Mexico City for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Panama City to Mexico City with no change fees?

Yes! Cheapflights helps users easily find flights from Panama City to Mexico City with no change fees.

Can Cheapflights notify me if prices for flights from Panama City to Mexico City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Mexico City from Panama City today and book when prices fit your budget.

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