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Cheap flights from Panama City to Mexico City from £167

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/12. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
28 Nov — 5 Dec1
1 adult
1 adult, Economy, 0 bags

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in July or August, booked 83 days in advance, depart on a Monday or Tuesday and return on a Monday

Cheap flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 29 October 2025.

Round-trip from

£191

One-way from

£167

Popular in

January

Cheapest in

July

Average price

£307
Copa Airlines
  • Copa Airlines
  • 1/1-14/1
  • Nonstop
  • 7h 29m total
  • Panama City to Mexico City
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Aeromexico
  • Aeromexico
  • 17/12
  • Nonstop
  • 3h 59m total
  • Panama City to Mexico City
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£11 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£3 potential savings vs. average return price).
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Average for round-trip flights in October 2025
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Find flight deals from Panama City to Mexico City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 29 October 2025.

Sun 21/1222:14PTY - MEX
Nonstop3h 46mCopa Airlines
Thu 1/101:20MEX - PTY
Nonstop3h 40mCopa Airlines
Deal found 28/10£191
Tue 30/1222:14PTY - MEX
Nonstop3h 46mCopa Airlines
Thu 8/102:00MEX - PTY
Nonstop3h 41mCopa Airlines
Deal found 28/10£207
Fri 21/1122:13PTY - MEX
Nonstop3h 47mCopa Airlines
Fri 28/1102:00MEX - PTY
Nonstop3h 41mCopa Airlines
Deal found 28/10£231
Thu 11/1222:14PTY - MEX
Nonstop3h 46mCopa Airlines
Thu 18/1215:30MEX - PTY
Nonstop3h 45mCopa Airlines
Deal found 27/10£258
Wed 10/1222:14PTY - MEX
Nonstop3h 46mCopa Airlines
Mon 15/1213:10MEX - PTY
Nonstop3h 46mCopa Airlines
Deal found 27/10£274
Tue 30/1211:38PTY - MEX
Nonstop3h 52mCopa Airlines
Fri 9/101:20MEX - PTY
Nonstop3h 40mCopa Airlines
Deal found 28/10£301
Thu 11/1214:55PTY - MEX
1 stop9h 00mAvianca
Wed 17/1204:00MEX - PTY
1 stop5h 30mAvianca
Deal found 27/10£321
Mon 22/1222:14PTY - MEX
Nonstop3h 46mCopa Airlines
Sun 28/1202:00MEX - PTY
Nonstop3h 41mCopa Airlines
Deal found 27/10£327
Wed 17/1222:14PTY - MEX
Nonstop3h 46mCopa Airlines
Sun 21/1201:20MEX - PTY
Nonstop3h 40mCopa Airlines
Deal found 28/10£334
Fri 7/1111:44PTY - MEX
Nonstop3h 46mCopa Airlines
Wed 26/1101:20MEX - PTY
Nonstop3h 39mCopa Airlines
Deal found 28/10£337
Thu 27/1122:13PTY - MEX
Nonstop3h 47mCopa Airlines
Sat 29/1102:00MEX - PTY
Nonstop3h 41mCopa Airlines
Deal found 28/10£341

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 29 October 2025.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sun 21/12

22:14-01:00

Nonstop3h 46m

Mexico City Benito Juarez

Fri 2/1

15:30-20:07

Nonstop3h 37m

£191

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 30/12

22:14-01:00

Nonstop3h 46m

Mexico City Benito Juarez

Thu 8/1

01:20-06:00

Nonstop3h 40m

£207

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 31/1

16:13-19:20

Nonstop4h 07m

Mexico City Benito Juarez

Fri 6/2

01:20-06:00

Nonstop3h 40m

£258

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mon 15/12

22:14-01:00

Nonstop3h 46m

Mexico City Benito Juarez

Sat 31/1

01:20-06:00

Nonstop3h 40m

£258

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 6/2

16:17-19:20

Nonstop4h 03m

Mexico City Benito Juarez

Sat 14/2

05:55-10:35

Nonstop3h 40m

£258

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 19/12

22:14-01:00

Nonstop3h 46m

Mexico City Benito Juarez

Mon 5/1

05:55-10:35

Nonstop3h 40m

£258

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 11/12

22:14-01:00

Nonstop3h 46m

Mexico City Benito Juarez

Thu 18/12

15:30-20:15

Nonstop3h 45m

£258

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Mon 22/12

22:14-01:00

Nonstop3h 46m

Mexico City Benito Juarez

Mon 5/1

15:30-20:07

Nonstop3h 37m

£258

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 17/12

14:36-17:35

Nonstop3h 59m

£167

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 12/12

14:55-01:55

2 stops12h 00m

£180

Flights are sorted by cheapest return flights first.

Deals found on 27/10

Showing 1-10 of 14 results
1
2

Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

Use this chart to determine the optimal time to book a return flight from Panama City to Mexico City. Price data was last updated on 24 October 2025.

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 83 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, September is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £161). Flying from Panama City to Mexico City in March is currently the most expensive (average of £279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 29 October 2025.

It’s optimal to fly from Panama City to Mexico City at midday. By choosing this option you can save up to 60% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated 29 October 2025.
Read reviews from past customers who have flown with Copa Airlines from Panama City to Mexico City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,562 reviews
Check prices

Entertainment

6.8

Boarding

7.8

Crew

8.1

Food

6.8

Comfort

7.4

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sept 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,562 reviews
Copa Airlines
7.6
Good
1,562 reviews
Check prices

Entertainment

6.8

Boarding

7.8

Crew

8.1

Food

6.8

Comfort

7.4

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sept 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Mexico City?

    You will need to book a flight from Panama City Tocumen Intl to Mexico City Benito Juarez if you want to fly from Panama City to Mexico City. At least 1 airline has flights from Tocumen Intl (PTY) to Benito Juarez (MEX) on a regular basis. There are 6 flights to Mexico City from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to MEX to be around 3h 49m.

  • How popular is this Panama City to Mexico City flight route?

    The Panama City Tocumen Intl to Mexico City Benito Juarez flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Mexico City?

    For as low as £191, Copa Airlines can have you in Mexico City from Panama City in 3h 46m. Airlines will cover a distance of 1497 mi. All flights are typically direct.

  • What is the cheapest airline to fly from Panama City to Mexico City round-trip?

    Flying on Copa Airlines is currently your cheapest option to Mexico City, with prices starting at £255. You may be able to fly from Panama City to Mexico City for 14% less than the average price by searching for this airline.

  • What are the most reliable airlines from Panama City to Mexico City?

    No one likes to see their flight delayed. When booking a flight from Panama City to Mexico City consider choosing Emirates (95%), AeroMexico Connect (93%) or Aeromexico (90%) as they are the most reliable in getting you off to your destination on time.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, September is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £161). Flying from Panama City to Mexico City in March is currently the most expensive (average of £279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Panama City to Mexico City

Discover the top airline that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 29 October 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest£255Average£302FlexibilityNo cancel feeOn-time70%
Search Copa Airlines flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City to Mexico City?

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Why should you use Cheapflights to find cheap flight tickets from Panama City to Mexico City?

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Can Cheapflights find flights from Panama City to Mexico City with no change fees?

Yes! Cheapflights helps users easily find flights from Panama City to Mexico City with no change fees.

Can Cheapflights notify me if prices for flights from Panama City to Mexico City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Mexico City from Panama City today and book when prices fit your budget.

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