Cheap flights from Panama City to Mexico City from £197

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
27 Feb — 6 Mar1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Panama City Tocumen Intl to Mexico City Benito Juarez are usually found in July or December, booked 75 days in advance, depart on a Monday or Tuesday and return on a Wednesday

Cheap flight deals from Panama City to Mexico City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 January 2026.

Wed 1/417:25
PTY
-
MEX
1 stop10h 40m
Avianca
Sun 12/404:55
MEX
-
PTY
1 stop18h 15m
Avianca
Deal found 26/1£244
Tue 10/309:22
PTY
-
MEX
Nonstop3h 48m
Copa Airlines
Tue 17/313:10
MEX
-
PTY
Nonstop3h 39m
Copa Airlines
Deal found 26/1£256
Fri 13/314:48
PTY
-
MEX
Nonstop3h 57m
Aeromexico
Fri 20/308:55
MEX
-
PTY
Nonstop3h 50m
Aeromexico
Deal found 27/1£258
Sat 31/109:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Sat 7/215:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 28/1£272
Fri 30/109:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Sun 1/209:25
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 26/1£288
Thu 5/214:55
PTY
-
MEX
2 stops12h 00m
Avianca
Wed 11/200:40
MEX
-
PTY
1 stop12h 20m
Avianca
Deal found 27/1£289
Wed 1/411:05
PTY
-
MEX
1 stop12h 55m
Avianca
Tue 21/400:40
MEX
-
PTY
1 stop14h 50m
Avianca
Deal found 26/1£305
Tue 24/211:45
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Thu 29/1015:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Deal found 27/1£329
Sat 28/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Mon 16/315:30
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£333
Sat 14/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Wed 18/201:20
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Deal found 28/1£339
Sat 30/519:08
PTY
-
MEX
Nonstop3h 52m
Copa Airlines
Thu 4/601:20
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 27/1£363
Sat 3/1009:55
PTY
-
MEX
1 stop9h 10m
Avianca
Thu 29/1004:00
MEX
-
PTY
1 stop13h 55m
Avianca
Deal found 26/1£371

Find flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 28 January 2026.

Round-trip from

£244

One-way from

£197

Popular in

June

Cheapest in

July

Average price

£267

Good one-way deal

£483 or less
Avianca
  • Avianca
  • 1/4-12/4
  • 2 total stops
  • 28h 55m total
  • Panama City to Mexico City
Avianca
  • Avianca
  • 2/2
  • 1 total stop
  • 6h 25m total
  • Panama City to Mexico City
Highest demand for flights based on searches. 3% potential increase in price (£6 potential increase over avg. return price).
Cheapest flight prices on average. 1% potential price decrease (£3 potential savings vs. average return price).
Average for round-trip flights in January 2026
Price to beat on a one-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez.

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 28 January 2026.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Panama City

Fly to

Mexico City

Route

Depart

Return

Price

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 1/4

17:25-03:05

1 stop10h 40m

Mexico City Benito Juarez

Sun 12/4

04:55-00:10

1 stop18h 15m

£244

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 7/2

19:02-22:05

Nonstop4h 03m

Mexico City Benito Juarez

Sun 15/3

09:25-14:04

Nonstop3h 39m

£256

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 29/4

09:19-12:10

Nonstop3h 51m

Mexico City Benito Juarez

Sun 10/5

13:10-17:50

Nonstop3h 40m

£256

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 10/3

09:22-12:10

Nonstop3h 48m

Mexico City Benito Juarez

Tue 17/3

09:25-14:04

Nonstop3h 39m

£256

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 7/2

16:17-19:20

Nonstop4h 03m

Mexico City Benito Juarez

Thu 19/2

15:30-20:07

Nonstop3h 37m

£256

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 18/2

11:45-14:30

Nonstop3h 45m

Mexico City Benito Juarez

Tue 24/2

01:20-06:00

Nonstop3h 40m

£256

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 14/2

19:02-22:05

Nonstop4h 03m

Mexico City Benito Juarez

Sat 21/2

13:10-17:48

Nonstop3h 38m

£256

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 14/2

21:25-00:15

Nonstop3h 50m

Mexico City Benito Juarez

Wed 25/2

01:20-06:00

Nonstop3h 40m

£256

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 25/2

21:25-00:15

Nonstop3h 50m

Mexico City Benito Juarez

Tue 3/3

01:20-05:54

Nonstop3h 34m

£256

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 17/2

09:21-12:10

Nonstop3h 49m

Mexico City Benito Juarez

Wed 25/2

01:20-06:00

Nonstop3h 40m

£256

Flights are sorted by cheapest return flights first.

Deals found on 27/1

Showing 1-10 of 20 results
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Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

Use this chart to determine the optimal time to book a return flight from Panama City to Mexico City. Price data was last updated on 23 January 2026.

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 75 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £124). Flying from Panama City to Mexico City in March is currently the most expensive (average of £234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 28 January 2026.

It’s optimal to fly from Panama City to Mexico City in the afternoon. By choosing this option you can save up to 18% on the cost of your flight, compared to a flight in the evening.

How much does it cost for a return flight from Panama City to Mexico City?

Reviews of airlines servicing Mexico City

Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated 28 January 2026.
Read reviews from past customers who have flown with Copa Airlines from Panama City to Mexico City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Crew

8.1

Food

6.8

Entertainment

6.8

Overall

7.5

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Crew

8.1

Food

6.8

Entertainment

6.8

Overall

7.5

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airports do I use to fly from Panama City to Mexico City?

    You will need to book a flight from Panama City Tocumen Intl to Mexico City Benito Juarez if you want to fly from Panama City to Mexico City. At least 1 airline has flights from Tocumen Intl (PTY) to Benito Juarez (MEX) on a regular basis. There are 7 flights to Mexico City from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to MEX to be around 27h 14m.

  • How popular is this Panama City to Mexico City flight route?

  • How long is the flight from Panama City to Mexico City?

    For as low as £256, Avianca can have you in Mexico City from Panama City in 4h 03m. Airlines will cover a distance of 1497 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Panama City to Mexico City round-trip?

    Flying on Copa Airlines is currently your cheapest option to Mexico City, with prices starting at £247. You may be able to fly from Panama City to Mexico City for 11% less than the average price by searching for this airline.

  • What are the most reliable airlines from Panama City to Mexico City?

    No one likes to see their flight delayed. When booking a flight from Panama City to Mexico City consider choosing AeroMexico Connect (97%), Copa Airlines (94%) or Aeromexico (93%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama City to Mexico City?

    On average you can expect to pay £483 for a flight from Panama City to Mexico City. The cheapest flight overall is £383 while the most popular route, (Panama City Tocumen Intl - Mexico City Benito Juarez) is currently priced at £868.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £124). Flying from Panama City to Mexico City in March is currently the most expensive (average of £234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Panama City to Mexico City

Discover the top airline that operate flights from Panama City to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 28 January 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest£247Average£292FlexibilityNo cancel feeOn-time70%
Search Copa Airlines flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City to Mexico City?

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Millions of users choose and trust Cheapflights to book the best flight deals from Panama City to Mexico City for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

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Yes! Cheapflights helps users easily find flights from Panama City to Mexico City with no change fees.

Can Cheapflights notify me if prices for flights from Panama City to Mexico City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Mexico City from Panama City today and book when prices fit your budget.

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