Cheap flights from Panama City to Mexico City from £163

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MEX
12 Jul — 19 Jul1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Mexico City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Mexico City
Explore the most affordable flight options available from Panama City to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 June 2026.

Tue 30/616:05
PTY
-
MEX
Nonstop4h 00m
Copa Airlines
Tue 7/715:30
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Deal found 12/6£303
Mon 13/711:45
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Mon 27/709:50
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Deal found 10/6£308
Thu 9/721:20
PTY
-
MEX
Nonstop3h 55m
Copa Airlines
Wed 15/705:50
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 8/6£310
Thu 10/911:47
PTY
-
MEX
Nonstop3h 43m
Copa Airlines
Thu 17/909:50
MEX
-
PTY
Nonstop3h 48m
Copa Airlines
Deal found 8/6£314
Sat 18/709:25
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Sat 25/715:30
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Deal found 12/6£316
Wed 1/716:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Thu 30/709:50
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Deal found 12/6£320
Sat 1/809:28
PTY
-
MEX
Nonstop3h 42m
Copa Airlines
Fri 7/802:10
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 10/6£321
Sun 26/709:25
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Sun 2/809:50
MEX
-
PTY
Nonstop3h 48m
Copa Airlines
Deal found 11/6£326
Fri 3/709:25
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Sat 25/715:30
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Deal found 11/6£328
Sat 1/809:28
PTY
-
MEX
Nonstop3h 42m
Copa Airlines
Fri 14/802:10
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Deal found 8/6£333
Mon 22/622:13
PTY
-
MEX
Nonstop3h 47m
Copa Airlines
Fri 26/613:10
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Deal found 10/6£342
Mon 22/622:13
PTY
-
MEX
Nonstop3h 47m
Copa Airlines
Tue 28/702:10
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Deal found 10/6£344

Find flight deals from Panama City to Mexico City

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 June 2026.

Round-trip from

£303

One-way from

£163

Popular in

June

Cheapest in

December

Average price

£337

Good one-way deal

£496 or less
Copa Airlines
  • Copa Airlines
  • 3/7-4/7
  • Nonstop
  • 7h 46m total
  • Panama City to Mexico City
Avianca
  • Avianca
  • 8/7
  • 1 total stop
  • 12h 55m total
  • Panama City to Mexico City
Highest demand for flights based on searches. 7% potential increase in price (£17 potential increase over avg. return price).
Cheapest flight prices on average. 2% potential price decrease (£5 potential savings vs. average return price).
Average for round-trip flights in June 2026
Price to beat on a one-way flight from Panama City Tocumen Intl to Mexico City Benito Juarez.

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama City to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 June 2026.
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 7/7

11:45-14:30

Nonstop3h 45m

Mexico City Benito Juarez

Fri 10/7

15:30-20:16

Nonstop3h 46m

£303

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Tue 30/6

16:05-19:05

Nonstop4h 00m

Mexico City Benito Juarez

Mon 6/7

05:50-10:33

Nonstop3h 43m

£303

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 1/7

09:25-12:10

Nonstop3h 45m

Mexico City Benito Juarez

Wed 1/7

15:30-20:16

Nonstop3h 46m

£303

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Fri 10/7

16:02-19:05

Nonstop4h 03m

Mexico City Benito Juarez

Tue 14/7

05:50-10:33

Nonstop3h 43m

£303

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sun 5/7

21:20-00:15

Nonstop3h 55m

Mexico City Benito Juarez

Fri 10/7

13:10-17:56

Nonstop3h 46m

£303

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 9/7

16:02-19:05

Nonstop4h 03m

Mexico City Benito Juarez

Wed 15/7

15:30-20:16

Nonstop3h 46m

£310

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sat 11/7

21:20-00:15

Nonstop3h 55m

Mexico City Benito Juarez

Fri 17/7

15:30-20:16

Nonstop3h 46m

£310

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 15/7

09:25-12:10

Nonstop3h 45m

Mexico City Benito Juarez

Sun 19/7

13:10-17:56

Nonstop3h 46m

£310

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Sun 12/7

19:02-22:05

Nonstop4h 03m

Mexico City Benito Juarez

Thu 16/7

15:30-20:16

Nonstop3h 46m

£310
Fastest return journey

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Wed 22/7

11:45-14:30

Nonstop3h 45m

Mexico City Benito Juarez

Tue 28/7

02:10-06:53

Nonstop3h 43m

£314

Flights are sorted by cheapest return flights first.

Deals found on 10/6

Showing 1-10 of 22 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 74 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, December is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £254). Flying from Panama City to Mexico City in June is currently the most expensive (average of £337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

Find hourly flight availability from Panama City to Mexico City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 12 June 2026.

It’s optimal to fly from Panama City to Mexico City in the morning. By choosing this option you can save up to 67% on the cost of your flight, compared to a flight in the afternoon.

How much does it cost for a return flight from Panama City to Mexico City?

Related info for your journey

Find useful and relevant information for your journey from Panama City to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How popular is this Panama City to Mexico City flight route?

  • How long is the flight from Panama City to Mexico City?

    For as low as £303, Copa Airlines can have you in Mexico City from Panama City in 3h 46m. Airlines will cover a distance of 1497 mi. All flights are typically direct.

  • What are the most reliable airlines from Panama City to Mexico City?

    No one likes to see their flight delayed. When booking a flight from Panama City to Mexico City consider choosing Emirates (97%), Copa Airlines (89%) or Aeromexico (88%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama City to Mexico City?

    On average you can expect to pay £496 for a flight from Panama City to Mexico City. The cheapest flight overall is £496 while the most popular route, (Panama City Tocumen Intl - Mexico City Benito Juarez) is currently priced at £262.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, December is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £254). Flying from Panama City to Mexico City in June is currently the most expensive (average of £337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Yes! Cheapflights helps users easily find flights from Panama City to Mexico City with no change fees.

Can Cheapflights notify me if prices for flights from Panama City to Mexico City become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Mexico City from Panama City today and book when prices fit your budget.

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