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Cheap flights from Panama City to Mexico City from £150

PTY — MEX
11 Oct — 18 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Mexico City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Mexico City

Thu 24/1211:44 -
Nonstop3h 46m
Wed 30/1215:30 -
Nonstop3h 50m
Deal found 10/9£277
Fri 9/1010:10 -
1 stop13h 50m
Thu 15/1000:40 -
1 stop7h 35m
Deal found 11/9£283
Fri 9/1022:13 -
Nonstop3h 47m
Fri 16/1005:50 -
Nonstop3h 51m
Deal found 11/9£285
Sun 25/1021:28 -
Nonstop3h 47m
Sun 1/1113:10 -
Nonstop3h 49m
Deal found 10/9£293
Sun 25/1021:28 -
Nonstop3h 47m
Mon 9/1113:10 -
Nonstop3h 49m
Deal found 10/9£301
Fri 25/922:12 -
Nonstop3h 48m
Thu 1/1002:10 -
Nonstop3h 41m
Deal found 10/9£314
Thu 5/1111:45 -
Nonstop3h 45m
Mon 9/1105:55 -
Nonstop3h 52m
Deal found 11/9£321
Sun 18/1009:29 -
Nonstop3h 41m
Sun 25/1015:30 -
Nonstop3h 44m
Deal found 10/9£332
Sun 1/1119:18 -
Nonstop4h 07m
Wed 11/1109:10 -
Nonstop3h 53m
Deal found 11/9£343
Sun 27/905:30 -
1 stop6h 25m
Fri 2/1016:55 -
1 stop8h 00m
Deal found 11/9£349
Sat 26/921:27 -
Nonstop3h 48m
Sat 3/1005:50 -
Nonstop3h 51m
Deal found 11/9£350

Find flight deals from Panama City to Mexico City

Round-trip from

£277

One-way from

£150

Popular in

October

Cheapest in

December

Average price

£305

Good round-trip deal

£456 or less
Copa Airlines
  • Copa Airlines
  • 25/12-1/1
  • Nonstop
  • 7h 35m total
  • Panama City to Mexico City
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Copa Airlines
  • Copa Airlines
  • 25/12-31/12
  • Nonstop
  • 3h 46m total
  • Panama City to Mexico City
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (£13 potential increase over avg. return price).
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Cheapest flight prices on average. 2% potential price decrease (£5 potential savings vs. average return price).
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Average for round-trip flights in September 2026
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Mexico City Benito Juarez.
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to Mexico City that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Sat 26/9

16:12-19:05

Nonstop3h 53m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Mon 16/11

09:24-12:10

Nonstop3h 46m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205
Fastest return journey

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Sat 10/10

11:53-14:30

Nonstop3h 37m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Wed 7/10

16:12-19:05

Nonstop3h 53m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Tue 26/1

21:27-00:15

Nonstop3h 48m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Sun 22/11

19:20-22:05

Nonstop3h 45m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Fri 23/10

16:12-19:05

Nonstop3h 53m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Tue 6/10

22:13-01:00

Nonstop3h 47m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Wed 23/9

21:27-00:15

Nonstop3h 48m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£205

Panama CityMexico City

PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez

PTYMEX

Panama City Tocumen Intl

Sun 18/10

09:29-12:10

Nonstop3h 41m

Mexico City Benito Juarez

Wed 31/12

00:00-01:00

Nonstop0h 00m

£213

Flights are sorted by cheapest return flights first.

Deals found on 7/9

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Mexico City

Have a flexible travel schedule? Discover the best time to fly to Mexico City from Panama City with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Panama City to Mexico City

How far ahead should I book a flight from Panama City to Mexico City?

The price you pay for your flight from Panama City to Mexico City may vary depending on when you book. For the best chance of a lower fare, look to book 3 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Mexico City?

Currently, December is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £253). Flying from Panama City to Mexico City in October is currently the most expensive (average of £359). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MEX?

It’s optimal to fly from Panama City to Mexico City at midday. By choosing this option you can save up to 63% on the cost of your flight, compared to a flight in the afternoon.

How much does it cost for a return flight from Panama City to Mexico City?

Airfare is typical for this route at the moment.

Panama City to Mexico City flights typically cost between £271 and £357 in December.
The cheapest return price found within the last 5 days was £277 on Copa Airlines (24 Dec–30 Dec).

Related info for your journey

  • How popular is this Panama City to Mexico City flight route?

    The Panama City Tocumen Intl to Mexico City Benito Juarez flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Mexico City?

    For as low as £277, Copa Airlines can have you in Mexico City from Panama City in 3h 51m. Airlines will cover a distance of 1497 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Panama City to Mexico City?

    No one likes to see their flight delayed. When booking a flight from Panama City to Mexico City consider choosing AeroMexico Connect (88%), Copa Airlines (87%) or Aeromexico (87%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama City to Mexico City?

    On average you can expect to pay £456 for a flight from Panama City to Mexico City. The cheapest flight overall is £456 while the most popular route, (Panama City Tocumen Intl - Mexico City Benito Juarez) is currently priced at £285.

  • Can I find deals for flights from Panama City to Mexico City that include hotel bookings?

    Yes. In addition to deals on Panama City to Mexico City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Mexico City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Mexico City.

  • Can I find deals for business class flights from Panama City to Mexico City?

    Yes. Cheapflights offers flight deals from Panama City to Mexico City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Mexico City?

    Currently, December is the cheapest month in which you can book a flight from Panama City to Mexico City (average of £253). Flying from Panama City to Mexico City in October is currently the most expensive (average of £359). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Mexico City from Panama City today and book when prices fit your budget.

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