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Cheap flights from Guayaquil to Panama City from £123

GYE — PTY
8 Oct — 15 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Guayaquil to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Guayaquil to Panama City

Thu 10/918:50 -
1 stop14h 25m
Sat 12/904:25 -
1 stop10h 10m
Deal found 3/9£236
Wed 9/918:50 -
1 stop5h 45m
Sat 12/904:25 -
1 stop10h 10m
Deal found 3/9£245
Wed 28/1006:01 -
Nonstop2h 11m
Sat 31/1009:02 -
Nonstop2h 13m
Deal found 7/9£250
Tue 3/1118:38 -
Nonstop2h 12m
Mon 9/1118:40 -
Nonstop2h 16m
Deal found 6/9£260
Wed 4/1114:47 -
Nonstop2h 14m
Sun 8/1115:19 -
Nonstop2h 16m
Deal found 6/9£269
Mon 21/918:28 -
Nonstop2h 12m
Fri 25/911:21 -
Nonstop2h 13m
Deal found 7/9£270
Mon 14/916:40 -
2 stops7h 55m
Mon 21/910:10 -
1 stop7h 25m
Deal found 3/9£272
Mon 7/915:20 -
2 stops9h 15m
Mon 14/917:55 -
1 stop5h 35m
Deal found 4/9£273
Thu 22/1014:33 -
Nonstop2h 16m
Sun 25/1021:48 -
Nonstop2h 13m
Deal found 3/9£278
Thu 5/1104:22 -
Nonstop2h 12m
Sun 8/1115:19 -
Nonstop2h 16m
Deal found 6/9£279
Mon 7/915:20 -
2 stops9h 15m
Wed 9/910:10 -
1 stop13h 20m
Deal found 3/9£282

Find flight deals from Guayaquil to Panama City

Round-trip from

£236

One-way from

£123

Popular in

December

Cheapest in

May

Average price

£250

Good one-way deal

£254 or less
Avianca
  • Avianca
  • 28/10-9/11
  • 2 total stops
  • 26h 15m total
  • Guayaquil to Panama City
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Copa Airlines
  • Copa Airlines
  • 28/10-31/12
  • Nonstop
  • 2h 11m total
  • Guayaquil to Panama City
Search Deals
Highest demand for flights based on searches. 8% potential increase in price (£16 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£3 potential savings vs. average return price).
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Average for round-trip flights in September 2026
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Price to beat on a one-way flight from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl.
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Guayaquil to Panama City that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Wed 28/10

06:01-08:12

Nonstop2h 11m

Panama City Tocumen Intl

Wed 31/12

00:00-00:00

Nonstop0h 00m

£123

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Mon 21/9

14:37-16:49

Nonstop2h 12m

Panama City Tocumen Intl

Wed 31/12

00:00-00:00

Nonstop0h 00m

£139
Fastest return journey

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Fri 9/10

18:30-20:40

Nonstop2h 10m

Panama City Tocumen Intl

Wed 31/12

00:00-00:00

Nonstop0h 00m

£139

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Mon 11/1

12:22-14:39

Nonstop2h 17m

Panama City Tocumen Intl

Wed 31/12

00:00-00:00

Nonstop0h 00m

£139

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Wed 10/2

08:26-10:41

Nonstop2h 15m

Panama City Tocumen Intl

Wed 31/12

00:00-00:00

Nonstop0h 00m

£139

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Mon 26/10

18:40-20:50

Nonstop2h 10m

Panama City Tocumen Intl

Wed 31/12

00:00-00:00

Nonstop0h 00m

£139

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Mon 19/10

14:33-16:49

Nonstop2h 16m

Panama City Tocumen Intl

Wed 31/12

00:00-00:00

Nonstop0h 00m

£139

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Thu 22/10

06:01-08:12

Nonstop2h 11m

Panama City Tocumen Intl

Tue 27/10

11:27-13:40

Nonstop2h 13m

£260

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Thu 24/9

04:13-06:25

Nonstop2h 12m

Panama City Tocumen Intl

Mon 28/9

11:21-13:34

Nonstop2h 13m

£270

GuayaquilPanama City

GYE Guayaquil Jose Joaquin de Olmedo - PTY Panama City Tocumen Intl

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Tue 29/9

06:00-08:12

Nonstop2h 12m

Panama City Tocumen Intl

Fri 2/10

21:48-00:01

Nonstop2h 13m

£270

Flights are sorted by cheapest return flights first.

Deals found on 6/9

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Guayaquil to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Guayaquil with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Panama City

How far ahead should I book a flight from Guayaquil to Panama City?

To ensure you get the cheapest price possible for a flight from Guayaquil to Panama City, you should look to book at least 83 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Guayaquil to Panama City?

Currently, May is the cheapest month in which you can book a flight from Guayaquil to Panama City (average of £209). Flying from Guayaquil to Panama City in December is currently the most expensive (average of £281). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to PTY?

It’s optimal to fly from Guayaquil to Panama City in the evening. By choosing this option you can save up to 73% on the cost of your flight, compared to a flight in the afternoon.

How much does it cost for a return flight from Guayaquil to Panama City?

Airfare is typical for this route at the moment.

Guayaquil to Panama City flights typically cost between £231 and £273 in October.
The cheapest return price found within the last 5 days was £236 on Avianca (28 Oct–9 Nov).

Related info for your journey

  • How popular is this Guayaquil to Panama City flight route?

    This flight path from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Guayaquil to Panama City?

    Departing from Guayaquil to Panama City will take you 2h 12m. The distance from Guayaquil to Panama City is about 776 mi. Generally, flights for this route are direct.

  • What are the most reliable airlines from Guayaquil to Panama City?

    No one likes to see their flight delayed. When booking a flight from Guayaquil to Panama City consider choosing Copa Airlines (88%), Air France (87%) or KLM (86%) as they are the most reliable in getting you off to your destination on time.

  • Can I find deals for flights from Guayaquil to Panama City that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Panama City.

  • Can I find deals for business class flights from Guayaquil to Panama City?

    Yes. Cheapflights offers flight deals from Guayaquil to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Panama City?

    Currently, May is the cheapest month in which you can book a flight from Guayaquil to Panama City (average of £209). Flying from Guayaquil to Panama City in December is currently the most expensive (average of £281). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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