Cheap flights from Panama City to Guayaquil from £173
This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GYE
5 Dec — 12 Dec1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheap flight deals from Panama City to Guayaquil
Enter your travel dates to find the best prices.
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Cheapest flights from Panama City to Guayaquil
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 5 November 2026.
Tue 17/1111:27 -
Nonstop2h 15m
Sat 21/1112:25 -
Nonstop2h 15m
Deal found 4/11£257
Fri 25/1202:30 -
1 stop6h 30m
Thu 7/119:35 -
1 stop5h 45m
Deal found 1/11£266
Thu 24/1210:05 -
1 stop22h 55m
Wed 6/103:30 -
1 stop21h 50m
Deal found 1/11£296
Thu 24/1202:30 -
2 stops12h 10m
Wed 6/119:35 -
1 stop5h 45m
Deal found 1/11£321
Sun 20/1215:19 -
Nonstop2h 17m
Sun 27/1218:34 -
Nonstop2h 16m
Deal found 4/11£332
Thu 24/1202:30 -
2 stops8h 55m
Fri 1/106:30 -
2 stops8h 45m
Deal found 1/11£529
Best flights from Panama City to Guayaquil
Discover carefully curated flight deals from Panama City to Guayaquil that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 5 November 2026.
Tue 17/1121:24 -
Nonstop2h 16m
Sun 22/1114:47 -
Nonstop2h 14m
Deal found 1/11£257
Fri 4/1209:02 -
Nonstop2h 20m
Thu 10/1204:22 -
Nonstop2h 12m
Deal found 4/11£257
Tue 17/1109:02 -
Nonstop2h 16m
Tue 24/1114:47 -
Nonstop2h 14m
Deal found 5/11£257
Thu 26/1115:19 -
Nonstop2h 16m
Thu 3/1214:45 -
Nonstop2h 16m
Deal found 1/11£257
Sun 13/1218:40 -
Nonstop2h 17m
Sat 16/108:25 -
Nonstop2h 16m
Deal found 4/11£257
Wed 2/1211:27 -
Nonstop2h 15m
Wed 9/1212:23 -
Nonstop2h 17m
Deal found 2/11£257
Sat 6/209:02 -
Nonstop2h 18m
Mon 8/204:22 -
Nonstop2h 12m
Deal found 1/11£257
Thu 21/109:02 -
Nonstop2h 20m
Thu 21/118:34 -
Nonstop2h 16m
Deal found 5/11£257
Direct flights from Panama City to Guayaquil
Explore direct flight options from Panama City to Guayaquil based on user searches, and compare prices and availability for your desired travel dates. Data last updated 5 November 2026.
Tue 17/1111:27 -
Nonstop2h 15m
Sat 21/1112:25 -
Nonstop2h 15m
Deal found 4/11£257
Sun 3/109:02 -
Nonstop2h 20m
Sun 4/405:19 -
Nonstop2h 20m
Deal found 1/11£295
Sun 20/1215:19 -
Nonstop2h 17m
Sun 27/1218:34 -
Nonstop2h 16m
Deal found 4/11£332
Sat 3/411:39 -
Nonstop2h 14m
Sat 10/418:32 -
Nonstop2h 19m
Deal found 4/11£335
Last-minute flights from Panama City to Guayaquil
Discover last-minute flight deals from Panama City to Guayaquil. Data last updated 5 November 2026 and is based on user searches.
Tue 17/1109:02 -
Nonstop2h 16m
Tue 24/1114:47 -
Nonstop2h 14m
Deal found 3/11£257
Sun 20/1215:19 -
Nonstop2h 17m
Sun 27/1218:34 -
Nonstop2h 16m
Deal found 4/11£332
Thu 24/1210:05 -
1 stop22h 55m
Wed 6/119:35 -
1 stop5h 45m
Deal found 1/11£296
Thu 24/1202:30 -
2 stops8h 55m
Fri 8/119:35 -
1 stop5h 45m
Deal found 1/11£321
Thu 24/1202:30 -
2 stops8h 55m
Fri 1/106:30 -
2 stops8h 45m
Deal found 1/11£529
Fri 25/1202:30 -
1 stop6h 30m
Thu 7/119:35 -
1 stop5h 45m
Deal found 1/11£266
One-way flights from Panama City to Guayaquil
Search for one-way flight options from Panama City to Guayaquil. Find affordable one-way fares based on user searches. Data last updated 5 November 2026.
Sun 22/1121:39 -
Nonstop2h 16m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 3/11£173
Mon 8/218:40 -
Nonstop2h 18m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 5/11£197
Wed 30/1211:27 -
Nonstop2h 15m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 5/11£208
Sun 3/102:30 -
2 stops42h 00m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 2/11£238
Find flight deals from Panama City to Guayaquil
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 5 November 2026.
Customise your flight search to find flights from Panama City to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 5 November 2026.
Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sun 21/2
18:40-20:58
Nonstop2h 18m
Guayaquil Jose Joaquin de Olmedo
Wed 31/12
00:00-00:00
Nonstop0h 00m
£173
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sat 5/12
21:40-23:59
Nonstop2h 19m
Guayaquil Jose Joaquin de Olmedo
Wed 31/12
00:00-00:00
Nonstop0h 00m
£173
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sat 6/2
18:40-20:58
Nonstop2h 18m
Guayaquil Jose Joaquin de Olmedo
Wed 31/12
00:00-00:00
Nonstop0h 00m
£173
Fastest return journey
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Mon 26/4
11:39-13:53
Nonstop2h 14m
Guayaquil Jose Joaquin de Olmedo
Wed 31/12
00:00-00:00
Nonstop0h 00m
£173
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sun 7/3
07:57-10:14
Nonstop2h 17m
Guayaquil Jose Joaquin de Olmedo
Wed 31/12
00:00-00:00
Nonstop0h 00m
£173
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sun 22/11
21:39-23:55
Nonstop2h 16m
Guayaquil Jose Joaquin de Olmedo
Wed 31/12
00:00-00:00
Nonstop0h 00m
£173
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Thu 29/4
07:57-10:14
Nonstop2h 17m
Guayaquil Jose Joaquin de Olmedo
Wed 31/12
00:00-00:00
Nonstop0h 00m
£173
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Tue 17/11
21:24-23:40
Nonstop2h 16m
Guayaquil Jose Joaquin de Olmedo
Sun 22/11
14:47-17:01
Nonstop2h 14m
£257
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Fri 4/12
09:02-11:22
Nonstop2h 20m
Guayaquil Jose Joaquin de Olmedo
Thu 10/12
04:22-06:34
Nonstop2h 12m
£257
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Tue 17/11
09:02-11:18
Nonstop2h 16m
Guayaquil Jose Joaquin de Olmedo
Tue 24/11
14:47-17:01
Nonstop2h 14m
£257
Flights are sorted by cheapest return flights first.
Deals found on 1/11
Showing 1-10 of 15 resultsSorted by cheapest first
1
2
Best time to book a flight from Panama City to Guayaquil
Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.
PTY-GYE
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Guayaquil
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Guayaquil?
Booking 32 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Guayaquil. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Panama City to Guayaquil?
Currently, February is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of £225). Flying from Panama City to Guayaquil in October is currently the most expensive (average of £321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to GYE?
Find hourly flight availability from Panama City to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 5 November 2026.
When flying from Panama City to Guayaquil, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost for a return flight from Panama City to Guayaquil?
Airfare is below average for this route at the moment.
Panama City to Guayaquil flights typically cost between £274 and £428 in November.The cheapest return price found within the last 5 days was £257 on Copa Airlines (17 Nov–21 Nov).
Weekly flight availability from Panama City to Guayaquil
Explore weekly flight availability from Panama City to Guayaquil. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 5 November 2026.
The most flights from PTY to GYE are scheduled on a Wednesday (12 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (10 on average).
How often are flights from Panama City to Guayaquil delayed?
About 7% of weekly flights between Panama City and Guayaquil have experienced delays in the past year, with the average delay time being 101 minutes.
What is the most punctual flight time for Panama City to Guayaquil flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Wednesday tends to have the lowest number of delays on this route, whereas Monday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Guayaquil flights?
Over the past year, Copa Airlines have had the lowest number of delays on this route, with just 7% of flights being delayed.
Related info for your journey
Find useful and relevant information for your journey from Panama City to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
How popular is this Panama City to Guayaquil flight route?
This flight path from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Panama City to Guayaquil?
Departing from Panama City to Guayaquil will take you 2h 16m. There are 776 mi between Panama City and Guayaquil. Most flights are nonstop.
What are the most reliable airlines from Panama City to Guayaquil?
Consider Copa Airlines (87%), KLM (85%) or Turkish Airlines (85%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Guayaquil.
Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?
Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Panama City to Guayaquil?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.
Can I find deals for business class flights from Panama City to Guayaquil?
Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Guayaquil?
Currently, February is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of £225). Flying from Panama City to Guayaquil in October is currently the most expensive (average of £321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Explore flights to Guayaquil departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 5 November 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Panama City to Guayaquil?
Cheapflights helps you search for flights from Panama City to Guayaquil via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.
Why should you use Cheapflights to find cheap flight tickets from Panama City to Guayaquil?
It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama City to Guayaquil.
Can Cheapflights find flights from Panama City to Guayaquil with no change fees?
Yes, we can. To see specific flights from Panama City to Guayaquil with no change fees, users can toggle flexible booking options after using the search form above to find flights.
Can Cheapflights notify me if prices for flights from Panama City to Guayaquil become cheaper?
Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Guayaquil from Panama City today and book when prices fit your budget.
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