Cheap flights from Panama City to Guayaquil from £173

PTY — GYE
5 Dec — 12 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Guayaquil

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Guayaquil

Tue 17/1111:27 -
Nonstop2h 15m
Sat 21/1112:25 -
Nonstop2h 15m
Deal found 4/11£257
Fri 25/1202:30 -
1 stop6h 30m
Thu 7/119:35 -
1 stop5h 45m
Deal found 1/11£266
Thu 24/1210:05 -
1 stop22h 55m
Wed 6/103:30 -
1 stop21h 50m
Deal found 1/11£296
Thu 24/1202:30 -
2 stops12h 10m
Wed 6/119:35 -
1 stop5h 45m
Deal found 1/11£321
Sun 20/1215:19 -
Nonstop2h 17m
Sun 27/1218:34 -
Nonstop2h 16m
Deal found 4/11£332
Thu 24/1202:30 -
2 stops8h 55m
Fri 1/106:30 -
2 stops8h 45m
Deal found 1/11£529

Find flight deals from Panama City to Guayaquil

Round-trip from

£257

One-way from

£173

Popular in

October

Cheapest in

February

Average price

£306
Copa Airlines
  • Copa Airlines
  • 17/3-27/3
  • Nonstop
  • 4h 35m total
  • Panama City to Guayaquil
Copa Airlines
  • Copa Airlines
  • 21/2-31/12
  • Nonstop
  • 2h 18m total
  • Panama City to Guayaquil
Highest demand for flights based on searches. 7% potential increase in price (£17 potential increase over avg. return price).
Cheapest flight prices on average. 1% potential price decrease (£3 potential savings vs. average return price).
Average for round-trip flights in November 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

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Price

Cheapest return flight

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Sun 21/2

18:40-20:58

Nonstop2h 18m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-00:00

Nonstop0h 00m

£173

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Sat 5/12

21:40-23:59

Nonstop2h 19m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-00:00

Nonstop0h 00m

£173

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Sat 6/2

18:40-20:58

Nonstop2h 18m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-00:00

Nonstop0h 00m

£173
Fastest return journey

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Mon 26/4

11:39-13:53

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-00:00

Nonstop0h 00m

£173

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Sun 7/3

07:57-10:14

Nonstop2h 17m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-00:00

Nonstop0h 00m

£173

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Sun 22/11

21:39-23:55

Nonstop2h 16m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-00:00

Nonstop0h 00m

£173

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Thu 29/4

07:57-10:14

Nonstop2h 17m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-00:00

Nonstop0h 00m

£173

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Tue 17/11

21:24-23:40

Nonstop2h 16m

Guayaquil Jose Joaquin de Olmedo

Sun 22/11

14:47-17:01

Nonstop2h 14m

£257

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Fri 4/12

09:02-11:22

Nonstop2h 20m

Guayaquil Jose Joaquin de Olmedo

Thu 10/12

04:22-06:34

Nonstop2h 12m

£257

Panama CityGuayaquil

PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo

PTYGYE

Panama City Tocumen Intl

Tue 17/11

09:02-11:18

Nonstop2h 16m

Guayaquil Jose Joaquin de Olmedo

Tue 24/11

14:47-17:01

Nonstop2h 14m

£257

Flights are sorted by cheapest return flights first.

Deals found on 1/11

Showing 1-10 of 15 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Panama City to Guayaquil

How far ahead should I book a flight from Panama City to Guayaquil?

Booking 32 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Guayaquil. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Guayaquil?

Currently, February is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of £225). Flying from Panama City to Guayaquil in October is currently the most expensive (average of £321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to GYE?

When flying from Panama City to Guayaquil, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Panama City to Guayaquil?

Airfare is below average for this route at the moment.

Panama City to Guayaquil flights typically cost between £274 and £428 in November.
The cheapest return price found within the last 5 days was £257 on Copa Airlines (17 Nov–21 Nov).

Related info for your journey

  • How popular is this Panama City to Guayaquil flight route?

  • How long is the flight from Panama City to Guayaquil?

    Departing from Panama City to Guayaquil will take you 2h 16m. There are 776 mi between Panama City and Guayaquil. Most flights are nonstop.

  • What are the most reliable airlines from Panama City to Guayaquil?

    Consider Copa Airlines (87%), KLM (85%) or Turkish Airlines (85%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Guayaquil.

  • Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.

  • Can I find deals for business class flights from Panama City to Guayaquil?

    Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Guayaquil?

    Currently, February is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of £225). Flying from Panama City to Guayaquil in October is currently the most expensive (average of £321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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