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Cheap flights from Madrid, Spain to Panama City from £369

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — PTY
14 Dec — 21 Dec1
1 adult
1 adult, Economy, 0 bags

Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in March or February, booked 54 days in advance, depart on a Thursday or Wednesday and return on a Tuesday

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Enter your travel dates to find the best prices.

Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 14 November 2025.

Mon 24/1106:00MAD - PTY
2 stops38h 12mDelta
Wed 3/1215:46PTY - MAD
2 stops58h 14mDelta
Deal found 11/11£607
Sun 23/1110:00MAD - PTY
2 stops58h 12mDelta
Wed 3/1215:46PTY - MAD
2 stops58h 14mDelta
Deal found 11/11£609
Thu 27/1113:05MAD - PTY
2 stops31h 07mDelta
Wed 3/1215:46PTY - MAD
2 stops34h 14mDelta
Deal found 11/11£613
Wed 26/1107:30MAD - PTY
2 stops36h 42mDelta
Wed 3/1215:46PTY - MAD
1 stop35h 29mDelta
Deal found 11/11£627
Tue 25/1115:10MAD - PTY
2 stops53h 02mDelta
Tue 2/1215:46PTY - MAD
2 stops58h 14mDelta
Deal found 11/11£634
Tue 18/1110:00MAD - PTY
2 stops34h 12mDelta
Wed 26/1115:37PTY - MAD
2 stops34h 23mDelta
Deal found 13/11£640
Sun 7/1206:00MAD - PTY
2 stops38h 21mDelta
Thu 19/215:27PTY - MAD
2 stops34h 33mDelta
Deal found 12/11£642
Thu 27/1106:00MAD - PTY
2 stops43h 59mDelta
Tue 2/1215:46PTY - MAD
2 stops58h 14mDelta
Deal found 11/11£648
Wed 19/1110:00MAD - PTY
2 stops34h 12mDelta
Sat 6/1208:05PTY - MAD
2 stops29h 05mDelta
Deal found 13/11£674
Thu 4/1206:00MAD - PTY
2 stops43h 59mDelta
Fri 16/115:20PTY - MAD
2 stops45h 50mDelta
Deal found 13/11£676

Cheap flight deals from Madrid to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 14 November 2025.

Round-trip from

£607

One-way from

£369

Popular in

December

Cheapest in

March

Average price

£660
Delta
  • Delta
  • 24/11-3/12
  • 4 total stops
  • 96h 26m total
  • Madrid to Panama City
Search Deals
KLM
  • KLM
  • 9/3
  • 1 total stop
  • 16h 30m total
  • Madrid to Panama City
Search Deals
Highest demand for flights based on searches. 12% potential increase in price (£64 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease (£15 potential savings vs. average return price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 14 November 2025.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Madrid

Fly to

Panama City

Route

Depart

Return

Price

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sun 8/3

15:10-19:45

Nonstop10h 35m

Panama City Tocumen Intl

Fri 27/3

21:30-13:05

Nonstop9h 35m

£648

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 4/12

06:00-19:59

2 stops43h 59m

Panama City Tocumen Intl

Fri 16/1

15:20-19:10

2 stops45h 50m

£676

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 5/12

06:00-19:59

2 stops43h 59m

Panama City Tocumen Intl

Mon 19/1

15:20-09:10

2 stops59h 50m

£678

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 15/4

20:25-16:50

1 stop27h 25m

Panama City Tocumen Intl

Fri 15/5

18:50-23:25

1 stop21h 35m

£687

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 3/12

11:00-19:59

2 stops62h 59m

Panama City Tocumen Intl

Wed 14/1

15:20-10:15

2 stops36h 55m

£698

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 15/4

10:50-19:31

1 stop15h 41m

Panama City Tocumen Intl

Fri 15/5

10:00-08:05

2 stops39h 05m

£708

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 11/3

11:05-16:07

2 stops35h 02m

Panama City Tocumen Intl

Wed 25/3

07:55-09:15

2 stops19h 20m

£710

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 6/12

11:15-14:45

2 stops33h 30m

Panama City Tocumen Intl

Tue 13/1

10:00-16:40

2 stops24h 40m

£716

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 14/3

11:40-16:45

Nonstop11h 05m

Panama City Tocumen Intl

Sat 28/3

15:50-18:45

2 stops20h 55m

£737

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 25/3

11:40-16:45

Nonstop11h 05m

Panama City Tocumen Intl

Sat 11/4

13:55-18:05

2 stops21h 10m

£747

Flights are sorted by cheapest return flights first.

Deals found on 12/11

Showing 1-10 of 20 results
1
2

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

How far ahead should I book a flight from Madrid to Panama City?

Use this chart to determine the optimal time to book a return flight from Madrid to Panama City. Price data was last updated on 7 November 2025.

The best time to book flights from Madrid to Panama City is 54 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Madrid to Panama City?

Currently, February is the cheapest month in which you can book a flight from Madrid to Panama City (average of £412). Flying from Madrid to Panama City in December is currently the most expensive (average of £590). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to PTY?

Find hourly flight availability from Madrid to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 14 November 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Madrid to Panama City as you normally would.

How much does it cost for a return flight from Madrid to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated 14 November 2025.
See what other customers who have flown with Air Europa from Madrid to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air Europa
7.0
Good
569 reviews
Check prices

Comfort

7.0

Entertainment

6.6

Boarding

7.1

Overall

7.0

Food

6.3

Crew

7.5

Reviews

1 / 12
6.0
Good

Anonymous,Sept 2025

MAD - JFK

Even though I paid for a ticket that included check in baggage and seat assignment, they did not honor the seat assignment and said it was not included. I paid for 6 tickets, 6 bags so I wanted to ensure we sat together for the long flight. I was given the worst seats possible, very last row, next to the bathroom, and a windowless "window seat". Not what I expected when I made the reservation.
Air Europa
7.0
Good
569 reviews
Air Europa
7.0
Good
569 reviews
Check prices

Comfort

7.0

Entertainment

6.6

Boarding

7.1

Overall

7.0

Food

6.3

Crew

7.5

Reviews

1 / 12
6.0
Good

Anonymous,Sept 2025

MAD - JFK

Even though I paid for a ticket that included check in baggage and seat assignment, they did not honor the seat assignment and said it was not included. I paid for 6 tickets, 6 bags so I wanted to ensure we sat together for the long flight. I was given the worst seats possible, very last row, next to the bathroom, and a windowless "window seat". Not what I expected when I made the reservation.

Related info for your journey

Find useful and relevant information for your journey from Madrid to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Madrid to Panama City?

    You will need to book a flight from Madrid Barajas to Panama City Tocumen Intl if you want to fly from Madrid to Panama City. At least 1 airline has flights from Barajas (MAD) to Tocumen Intl (PTY) on a regular basis. There are 6 flights to Panama City from the Madrid airport per day. If you manage to book one that is nonstop, then you can expect the flight time from MAD to PTY to be around 10h 35m.

  • How popular is this Madrid to Panama City flight route?

    Flights from Madrid Barajas to Panama City Tocumen Intl have been viewed 11 times in the past calendar month.

  • How long is the flight from Madrid to Panama City?

    Departing from Madrid to Panama City will take you 10h 35m. Airlines will cover a distance of 5065 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Madrid to Panama City round-trip?

    Our cheapest airline available from Madrid to Panama City is Air Europa. Our recent data shows that you can find tickets from as low as £445 on this airline. Air Europa is 27% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Madrid to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Panama City on time: Air Europa (86%), Etihad Airways (86%), China Eastern (86%).

  • Can I find deals for flights from Madrid to Panama City that include hotel bookings?

    Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.

  • Can I find deals for business class flights from Madrid to Panama City?

    Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Panama City?

    Currently, February is the cheapest month in which you can book a flight from Madrid to Panama City (average of £412). Flying from Madrid to Panama City in December is currently the most expensive (average of £590). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

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Top airline flying from Madrid to Panama City

Discover the top airline that operate flights from Madrid to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 14 November 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest£445Average£533FlexibilityNo cancel feeOn-time83%
Search Air Europa flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Madrid to Panama City?

Deals for Madrid to Panama City flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Madrid to Panama City?

Cheapflights helps you find that perfect flight to Panama City from Madrid by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Madrid to Panama City with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Madrid to Panama City, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Madrid to Panama City become cheaper?

Not ready to book yet? You can track prices for flights from Madrid to Panama City on Cheapflights with our Price Alert feature and get notified when better prices are available.

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