Cheap flights from Madrid, Spain to Panama City from £241
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — PTY
24 Sep — 1 Oct1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in April or May, booked 47 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday
Cheap flight deals from Madrid to Panama City
Enter your travel dates to find the best prices.
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One-way
Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 25 August 2026.
Fri 11/915:55 -
Nonstop10h 40m
Sun 27/921:05 -
Nonstop10h 05m
Deal found 21/8£585
Wed 21/1015:05 -
Nonstop10h 35m
Sun 25/1021:30 -
Nonstop9h 35m
Deal found 20/8£588
Thu 8/1015:05 -
Nonstop10h 35m
Mon 12/1020:25 -
Nonstop9h 50m
Deal found 21/8£590
Thu 10/906:00 -
1 stop17h 50m
Thu 12/1118:45 -
1 stop15h 20m
Deal found 20/8£603
Wed 2/915:05 -
Nonstop10h 35m
Tue 29/920:25 -
Nonstop9h 50m
Deal found 20/8£609
Wed 23/915:05 -
Nonstop10h 35m
Mon 9/1121:30 -
Nonstop9h 35m
Deal found 20/8£612
Sat 7/1108:10 -
1 stop15h 05m
Sat 14/1118:10 -
1 stop23h 10m
Deal found 21/8£612
Fri 20/1115:10 -
Nonstop10h 35m
Wed 2/1221:30 -
Nonstop9h 35m
Deal found 24/8£614
Wed 16/915:05 -
Nonstop10h 35m
Tue 29/920:25 -
Nonstop9h 50m
Deal found 22/8£614
Tue 6/1015:05 -
Nonstop10h 35m
Mon 12/1020:25 -
Nonstop9h 50m
Deal found 21/8£616
Fri 23/1015:55 -
Nonstop10h 40m
Sun 25/1018:35 -
Nonstop10h 05m
Deal found 20/8£618
Best flights from Madrid to Panama City
Discover carefully curated flight deals from Madrid to Panama City that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 25 August 2026.
Fri 25/914:35 -
2 stops29h 23m
Sun 11/1014:24 -
1 stop14h 51m
Deal found 24/8£661
Sun 22/1108:10 -
1 stop31h 00m
Sat 28/1102:30 -
1 stop14h 55m
Deal found 24/8£682
Wed 23/905:55 -
2 stops20h 36m
Sun 8/1108:55 -
2 stops18h 20m
Deal found 20/8£731
Wed 9/914:35 -
2 stops53h 23m
Sun 13/914:23 -
2 stops32h 57m
Deal found 24/8£678
Fri 23/1006:00 -
2 stops20h 31m
Sun 25/1009:30 -
2 stops40h 15m
Deal found 20/8£731
Sat 10/1014:35 -
2 stops29h 24m
Tue 13/1014:24 -
1 stop14h 51m
Deal found 21/8£679
Sat 26/905:55 -
2 stops20h 36m
Tue 6/1009:45 -
1 stop16h 15m
Deal found 24/8£733
Tue 6/1014:35 -
2 stops29h 24m
Tue 13/1014:24 -
2 stops19h 21m
Deal found 22/8£696
Fri 15/106:05 -
2 stops38h 40m
Fri 29/116:41 -
2 stops34h 34m
Deal found 23/8£733
Sat 26/914:35 -
2 stops29h 23m
Tue 6/1014:24 -
2 stops22h 11m
Deal found 24/8£709
Direct flights from Madrid to Panama City
Explore direct flight options from Madrid to Panama City based on user searches, and compare prices and availability for your desired travel dates. Data last updated 25 August 2026.
Fri 11/915:55 -
Nonstop10h 40m
Sun 27/921:05 -
Nonstop10h 05m
Deal found 21/8£585
Wed 21/1015:05 -
Nonstop10h 35m
Sun 25/1021:30 -
Nonstop9h 35m
Deal found 20/8£588
Thu 8/1015:05 -
Nonstop10h 35m
Mon 12/1020:25 -
Nonstop9h 50m
Deal found 21/8£590
Fri 5/212:00 -
Nonstop11h 05m
Sun 14/218:35 -
Nonstop10h 05m
Deal found 20/8£605
Fri 4/915:05 -
Nonstop10h 35m
Tue 29/920:25 -
Nonstop9h 50m
Deal found 20/8£609
Wed 23/915:05 -
Nonstop10h 35m
Mon 9/1121:30 -
Nonstop9h 35m
Deal found 20/8£612
Fri 20/1115:10 -
Nonstop10h 35m
Sun 29/1121:30 -
Nonstop9h 35m
Deal found 24/8£614
Wed 16/915:05 -
Nonstop10h 35m
Tue 29/920:25 -
Nonstop9h 50m
Deal found 22/8£614
Tue 6/1015:05 -
Nonstop10h 35m
Mon 12/1020:25 -
Nonstop9h 50m
Deal found 21/8£616
Last-minute flights from Madrid to Panama City
Discover last-minute flight deals from Madrid to Panama City. Data last updated 25 August 2026 and is based on user searches.
Wed 2/915:05 -
Nonstop10h 35m
Tue 29/920:25 -
Nonstop9h 50m
Deal found 20/8£609
Thu 10/906:00 -
1 stop17h 50m
Thu 12/1118:45 -
1 stop15h 20m
Deal found 20/8£603
Fri 11/915:55 -
Nonstop10h 40m
Sun 27/921:05 -
Nonstop10h 05m
Deal found 21/8£585
Wed 16/915:05 -
Nonstop10h 35m
Tue 29/920:25 -
Nonstop9h 50m
Deal found 22/8£614
Sat 19/914:35 -
2 stops29h 23m
Mon 5/1014:23 -
2 stops32h 57m
Deal found 21/8£628
Tue 22/915:05 -
Nonstop10h 35m
Mon 19/1020:25 -
Nonstop9h 50m
Deal found 24/8£614
Wed 23/915:05 -
Nonstop10h 35m
Mon 9/1121:30 -
Nonstop9h 35m
Deal found 20/8£612
Wed 23/906:00 -
1 stop17h 50m
Thu 8/1021:55 -
1 stop14h 20m
Deal found 23/8£624
Thu 24/914:35 -
2 stops53h 23m
Sat 7/1115:24 -
2 stops33h 56m
Deal found 20/8£625
Thu 24/909:50 -
1 stop34h 08m
Wed 21/1014:24 -
2 stops36h 31m
Deal found 24/8£627
Fri 25/915:05 -
Nonstop10h 35m
Sun 11/1020:25 -
Nonstop9h 50m
Deal found 24/8£619
One-way flights from Madrid to Panama City
Search for one-way flight options from Madrid to Panama City. Find affordable one-way fares based on user searches. Data last updated 25 August 2026.
Wed 11/1108:10 -
1 stop23h 10m
Deal found 24/8£241
Mon 25/110:10 -
1 stop21h 10m
Deal found 23/8£270
Sun 24/110:10 -
1 stop35h 05m
Deal found 23/8£276
Wed 27/111:25 -
2 stops19h 55m
Deal found 23/8£320
Sat 6/216:20 -
1 stop28h 55m
Deal found 23/8£338
Mon 1/211:25 -
2 stops19h 55m
Deal found 24/8£341
Thu 3/908:10 -
1 stop13h 05m
Deal found 22/8£364
Mon 1/201:25 -
1 stop13h 45m
Deal found 23/8£370
Thu 4/214:55 -
2 stops40h 25m
Deal found 23/8£371
Mon 8/219:50 -
3 stops35h 30m
Deal found 23/8£372
Find flight deals from Madrid to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 25 August 2026.
Customise your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 25 August 2026.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Fri 25/9
14:35-12:58
2 stops29h 23m
Panama City Tocumen Intl
Sun 11/10
14:24-12:15
1 stop14h 51m
£661
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Wed 9/9
14:35-12:58
2 stops53h 23m
Panama City Tocumen Intl
Sun 13/9
14:23-06:20
2 stops32h 57m
£678
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Sat 10/10
14:35-12:59
2 stops29h 24m
Panama City Tocumen Intl
Tue 13/10
14:24-12:15
1 stop14h 51m
£679
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Sun 22/11
08:10-09:10
1 stop31h 00m
Panama City Tocumen Intl
Sat 28/11
02:30-23:25
1 stop14h 55m
£682
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Tue 6/10
14:35-12:59
2 stops29h 24m
Panama City Tocumen Intl
Tue 13/10
14:24-16:45
2 stops19h 21m
£696
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Sat 26/9
14:35-12:58
2 stops29h 23m
Panama City Tocumen Intl
Tue 6/10
14:24-19:35
2 stops22h 11m
£709
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Wed 23/9
05:55-19:31
2 stops20h 36m
Panama City Tocumen Intl
Sun 8/11
08:55-09:15
2 stops18h 20m
£731
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Fri 23/10
06:00-19:31
2 stops20h 31m
Panama City Tocumen Intl
Sun 25/10
09:30-07:45
2 stops40h 15m
£731
Fastest return journey
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Sat 26/9
05:55-19:31
2 stops20h 36m
Panama City Tocumen Intl
Tue 6/10
09:45-09:00
1 stop16h 15m
£733
MadridPanama City
MAD Madrid Barajas - PTY Panama City Tocumen Intl
MADPTY
Madrid Barajas
Fri 15/1
06:05-14:45
2 stops38h 40m
Panama City Tocumen Intl
Fri 29/1
16:41-09:15
2 stops34h 34m
£733
Flights are sorted by cheapest return flights first.
Deals found on 24/8
Showing 1-10 of 20 resultsSorted by cheapest first
1
2
Best time to book a flight from Madrid to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.
MAD-PTY
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Panama City
Prices
Airlines
Delays
How far ahead should I book a flight from Madrid to Panama City?
The best time to book flights from Madrid to Panama City is 46 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Madrid to Panama City?
Currently, April is the cheapest month in which you can book a flight from Madrid to Panama City (average of £534). Flying from Madrid to Panama City in December is currently the most expensive (average of £815). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to PTY?
Find hourly flight availability from Madrid to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 25 August 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Madrid to Panama City as you normally would.
How much does it cost for a return flight from Madrid to Panama City?
Airfare is below average for this route at the moment.
Madrid to Panama City flights typically cost between £595 and £789 in September.The cheapest return price found within the last 5 days was £585 on Iberia (11 Sept–27 Sept).
Weekly flight availability from Madrid to Panama City
Explore weekly flight availability from Madrid to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 25 August 2026.
The most flights from MAD to PTY are scheduled on a Monday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).
How often are flights from Madrid to Panama City delayed?
About 25% of weekly flights between Madrid and Panama City have experienced delays in the past year, with the average delay time being 127 minutes.
What is the most punctual flight time for Madrid to Panama City flights?
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the morning tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Tuesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Panama City flights?
Over the past year, Iberia have had the lowest number of delays on this route, with just 26% of flights being delayed.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated 25 August 2026.
See what other customers who have flown with Air Europa and Iberia from Madrid to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
The food was below average for a business class flight
Related info for your journey
Find useful and relevant information for your journey from Madrid to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Madrid to Panama City?
You will need to book a flight from Madrid Barajas to Panama City Tocumen Intl if you want to fly from Madrid to Panama City. At least 2 different airlines have flights from Barajas (MAD) to Tocumen Intl (PTY) on a regular basis. There are 7 flights to Panama City from the Madrid airport per day. If you manage to book one that is nonstop, then you can expect the flight time from MAD to PTY to be around 10h 35m.
How popular is this Madrid to Panama City flight route?
Flights from Madrid Barajas to Panama City Tocumen Intl have been viewed 1 times in the past calendar month.
How long is the flight from Madrid to Panama City?
Departing from Madrid to Panama City will take you 29h 23m. Airlines will cover a distance of 5065 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Madrid to Panama City round-trip?
Our cheapest airline available from Madrid to Panama City is Air Europa. Our recent data shows that you can find tickets from as low as £481 on this airline. An additional option worth looking into is Iberia, starting at £508. Air Europa is 24% cheaper than the average price of flights available within the next 90 days to this destination.
What are the most reliable airlines from Madrid to Panama City?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Panama City on time: Air Europa (67%), Etihad Airways (67%), China Eastern (67%).
Can I find deals for flights from Madrid to Panama City that include hotel bookings?
Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Madrid to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.
Can I find deals for business class flights from Madrid to Panama City?
Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Panama City?
Currently, April is the cheapest month in which you can book a flight from Madrid to Panama City (average of £534). Flying from Madrid to Panama City in December is currently the most expensive (average of £815). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 25 August 2026.
Discover the top 2 airlines that operate flights from Madrid to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 25 August 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Madrid to Panama City?
Deals for Madrid to Panama City flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.
Why should you use Cheapflights to find cheap flight tickets from Madrid to Panama City?
Cheapflights helps you find that perfect flight to Panama City from Madrid by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!
Can Cheapflights find flights from Madrid to Panama City with no change fees?
Cheapflights does show flights with no change fees to all users. To see these options for flights from Madrid to Panama City, users can toggle the no change fees filter when performing a flight search.
Can Cheapflights notify me if prices for flights from Madrid to Panama City become cheaper?
Not ready to book yet? You can track prices for flights from Madrid to Panama City on Cheapflights with our Price Alert feature and get notified when better prices are available.
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