Cheap flights from Madrid, Spain to Panama City from £324
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — PTY
27 Jan — 3 Feb1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in March or May, booked 71 days in advance, depart on a Friday or Wednesday and return on a Tuesday
Cheap flight deals from Madrid to Panama City
Enter your travel dates to find the best prices.
Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 December 2025.
Mon 29/1211:15MAD - PTY
1 stop32h 42mDelta
Wed 21/115:20PTY - MAD
2 stops34h 40mDelta
Deal found 27/12£632
Sun 28/1207:30MAD - PTY
2 stops36h 27mDelta
Thu 22/115:20PTY - MAD
2 stops34h 40mDelta
Deal found 27/12£654
Mon 29/1210:00MAD - PTY
2 stops33h 57mDelta
Tue 20/115:20PTY - MAD
2 stops58h 40mDelta
Deal found 27/12£670
Mon 29/1211:15MAD - PTY
1 stop32h 42mDelta
Tue 13/115:20PTY - MAD
2 stops42h 45mDelta
Deal found 27/12£683
Wed 31/1216:20MAD - PTY
1 stop14h 20mAvianca
Wed 21/114:55PTY - MAD
1 stop26h 25mAvianca
Deal found 27/12£693
Wed 31/1213:05MAD - PTY
1 stop33h 25mMultiple Airlines
Thu 22/115:20PTY - MAD
1 stop35h 55mMultiple Airlines
Deal found 27/12£702
Sun 28/1207:30MAD - PTY
2 stops36h 27mDelta
Tue 13/115:20PTY - MAD
2 stops36h 55mDelta
Deal found 27/12£703
Mon 29/1210:00MAD - PTY
2 stops40h 00mDelta
Sat 24/115:20PTY - MAD
2 stops34h 40mDelta
Deal found 27/12£720
Best flights from Madrid to Panama City
Discover carefully curated flight deals from Madrid to Panama City that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 28 December 2025.
Sat 14/315:10MAD - PTY
Nonstop10h 35mAir Europa
Mon 23/321:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 28/12£532
Mon 16/206:35MAD - PTY
1 stop24h 05mAvianca
Tue 3/314:55PTY - MAD
1 stop16h 30mAvianca
Deal found 27/12£534
Sat 6/613:05MAD - PTY
1 stop34h 45mKLM
Sat 13/618:50PTY - MAD
1 stop31h 40mKLM
Deal found 28/12£555
Mon 9/210:00MAD - PTY
2 stops33h 55mDelta
Sat 28/215:15PTY - MAD
1 stop36h 00mDelta
Deal found 26/12£568
Sun 15/315:10MAD - PTY
Nonstop10h 35mAir Europa
Mon 23/321:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 27/12£533
Tue 27/106:35MAD - PTY
1 stop16h 20mAvianca
Tue 3/217:50PTY - MAD
1 stop23h 30mAvianca
Deal found 28/12£551
Thu 16/415:05MAD - PTY
Nonstop10h 35mAir Europa
Sun 19/420:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 25/12£533
Sat 28/206:40MAD - PTY
1 stop16h 15mAvianca
Mon 16/317:50PTY - MAD
1 stop13h 35mAvianca
Deal found 28/12£555
Thu 21/515:05MAD - PTY
Nonstop10h 35mAir Europa
Mon 25/520:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 27/12£558
Wed 25/315:10MAD - PTY
Nonstop10h 35mAir Europa
Wed 15/420:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 26/12£559
Fri 13/215:10MAD - PTY
Nonstop10h 35mAir Europa
Mon 2/321:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 26/12£585
Direct flights from Madrid to Panama City
Explore direct flight options from Madrid to Panama City based on user searches, and compare prices and availability for your desired travel dates. Data last updated 28 December 2025.
Sat 14/315:10MAD - PTY
Nonstop10h 35mAir Europa
Mon 23/321:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 26/12£532
Wed 25/315:10MAD - PTY
Nonstop10h 35mAir Europa
Sun 19/420:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 26/12£533
Thu 21/515:05MAD - PTY
Nonstop10h 35mAir Europa
Mon 25/520:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 27/12£558
Wed 25/315:10MAD - PTY
Nonstop10h 35mAir Europa
Wed 15/420:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 26/12£559
Fri 27/215:10MAD - PTY
Nonstop10h 35mAir Europa
Wed 18/321:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 28/12£585
Tue 10/215:10MAD - PTY
Nonstop10h 35mAir Europa
Wed 25/221:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 26/12£611
Wed 28/115:10MAD - PTY
Nonstop10h 35mAir Europa
Tue 10/221:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 26/12£612
Tue 31/315:05MAD - PTY
Nonstop10h 35mAir Europa
Thu 16/420:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 26/12£615
Wed 11/215:10MAD - PTY
Nonstop10h 35mAir Europa
Tue 24/221:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 26/12£637
Tue 31/315:05MAD - PTY
Nonstop10h 35mAir Europa
Fri 17/420:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 26/12£642
Sun 29/315:05MAD - PTY
Nonstop10h 35mAir Europa
Mon 20/420:25PTY - MAD
Nonstop9h 50mAir Europa
Deal found 26/12£646
Thu 12/215:10MAD - PTY
Nonstop10h 35mAir Europa
Sun 1/321:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 26/12£668
Last-minute flights from Madrid to Panama City
Discover last-minute flight deals from Madrid to Panama City. Data last updated 28 December 2025 and is based on user searches.
Mon 29/1211:15MAD - PTY
1 stop32h 42mDelta
Thu 22/115:20PTY - MAD
2 stops34h 40mDelta
Deal found 27/12£632
Sat 17/111:15MAD - PTY
1 stop32h 40mDelta
Fri 23/115:20PTY - MAD
2 stops34h 40mDelta
Deal found 27/12£568
Sat 17/110:00MAD - PTY
2 stops33h 55mDelta
Sun 8/215:20PTY - MAD
2 stops34h 40mDelta
Deal found 27/12£602
Sun 18/106:00MAD - PTY
2 stops37h 55mDelta
Sat 7/215:20PTY - MAD
2 stops34h 40mDelta
Deal found 27/12£607
Tue 20/106:00MAD - PTY
2 stops37h 55mDelta
Tue 27/115:20PTY - MAD
2 stops58h 40mDelta
Deal found 27/12£600
Tue 20/106:00MAD - PTY
2 stops37h 55mDelta
Sun 8/215:20PTY - MAD
2 stops34h 40mDelta
Deal found 27/12£635
Wed 21/106:00MAD - PTY
1 stop16h 30mKLM
Wed 4/222:05PTY - MAD
1 stop30h 10mKLM
Deal found 28/12£559
Wed 21/110:00MAD - PTY
2 stops33h 55mDelta
Wed 4/215:20PTY - MAD
2 stops21h 50mDelta
Deal found 28/12£631
Wed 21/110:00MAD - PTY
2 stops33h 55mDelta
Thu 29/115:20PTY - MAD
2 stops34h 40mDelta
Deal found 28/12£635
Fri 23/110:50MAD - PTY
1 stop19h 50mAvianca
Sat 31/102:55PTY - MAD
1 stop14h 25mAvianca
Deal found 27/12£613
Tue 27/106:35MAD - PTY
1 stop16h 20mAvianca
Tue 3/217:50PTY - MAD
1 stop23h 30mAvianca
Deal found 28/12£551
Wed 28/115:10MAD - PTY
Nonstop10h 35mAir Europa
Tue 10/221:30PTY - MAD
Nonstop9h 35mAir Europa
Deal found 26/12£612
One-way flights from Madrid to Panama City
Search for one-way flight options from Madrid to Panama City. Find affordable one-way fares based on user searches. Data last updated 28 December 2025.
Fri 3/407:10MAD - PTY
3 stops21h 00mMultiple Airlines
Deal found 27/12£324
Thu 2/418:55MAD - PTY
3 stops33h 15mMultiple Airlines
Deal found 26/12£325
Sat 4/420:30MAD - PTY
1 stop27h 20mKLM
Deal found 27/12£366
Thu 5/210:50MAD - PTY
2 stops34h 05mAvianca
Deal found 26/12£415
Sat 7/215:25MAD - PTY
2 stops23h 25mAvianca
Deal found 26/12£418
Fri 3/415:05MAD - PTY
Nonstop10h 35mAir Europa
Deal found 27/12£427
Sat 14/315:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 28/12£451
Mon 23/215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 26/12£453
Sat 28/211:40MAD - PTY
Nonstop11h 05mIberia
Deal found 26/12£466
Fri 3/415:55MAD - PTY
Nonstop11h 05mIberia
Deal found 26/12£469
Find flight deals from Madrid to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 28 December 2025.
Customise your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 28 December 2025.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.
Fly from
Madrid
Fly to
Panama City
Route
Depart
Return
Price
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Sat 14/3
15:10-19:45
Nonstop10h 35m
Panama City Tocumen Intl
Mon 23/3
21:30-13:05
Nonstop9h 35m
£532
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Sun 15/3
15:10-19:45
Nonstop10h 35m
Panama City Tocumen Intl
Mon 23/3
21:30-13:05
Nonstop9h 35m
£533
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Thu 16/4
15:05-18:40
Nonstop10h 35m
Panama City Tocumen Intl
Sun 19/4
20:25-13:15
Nonstop9h 50m
£533
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Mon 16/2
06:35-00:40
1 stop24h 05m
Panama City Tocumen Intl
Tue 3/3
14:55-13:25
1 stop16h 30m
£534
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Tue 27/1
06:35-16:55
1 stop16h 20m
Panama City Tocumen Intl
Tue 3/2
17:50-23:20
1 stop23h 30m
£551
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Sat 28/2
06:40-16:55
1 stop16h 15m
Panama City Tocumen Intl
Mon 16/3
17:50-13:25
1 stop13h 35m
£555
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Sat 6/6
13:05-16:50
1 stop34h 45m
Panama City Tocumen Intl
Sat 13/6
18:50-09:30
1 stop31h 40m
£555
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Thu 21/5
15:05-18:40
Nonstop10h 35m
Panama City Tocumen Intl
Mon 25/5
20:25-13:15
Nonstop9h 50m
£558
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Wed 25/3
15:10-19:45
Nonstop10h 35m
Panama City Tocumen Intl
Wed 15/4
20:25-13:15
Nonstop9h 50m
£559
MadridPanama City
MAD - PTY
MADPTY
Madrid Barajas
Mon 9/2
10:00-13:55
2 stops33h 55m
Panama City Tocumen Intl
Sat 28/2
15:15-09:15
1 stop36h 00m
£568
Flights are sorted by cheapest return flights first.
Deals found on 27/12
Showing 1-10 of 22 results
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Best time to book a flight from Madrid to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Panama City
Prices
Airlines
Delays
How far ahead should I book a flight from Madrid to Panama City?
Use this chart to determine the optimal time to book a return flight from Madrid to Panama City. Price data was last updated on 26 December 2025.
The best time to book flights from Madrid to Panama City is 71 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Madrid to Panama City?
Currently, February is the cheapest month in which you can book a flight from Madrid to Panama City (average of £402). Flying from Madrid to Panama City in December is currently the most expensive (average of £582). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to PTY?
Find hourly flight availability from Madrid to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 28 December 2025.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Madrid to Panama City as you normally would.
Weekly flight availability from Madrid to Panama City
Explore weekly flight availability from Madrid to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 28 December 2025.
The most flights from MAD to PTY are scheduled on a Monday (10 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (3 on average).
How often are flights from Madrid to Panama City delayed?
About 23% of weekly flights between Madrid and Panama City have experienced delays in the past year, with the average delay time being 113 minutes.
What is the most punctual flight time for Madrid to Panama City flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Tuesday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Panama City flights?
Over the past year, Pascan have had the lowest number of delays on this route, with just 3% of flights being delayed.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated 28 December 2025.
See what other customers who have flown with Air Europa from Madrid to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
The flight was heavily delayed which put into question my connection. The boarding and unboarding process was horrible. The airline crams as many people as possible on this short flight. A 787 parks in the middle of the airport and a shuttle bus ferries you in. Why? In a major european airport with a huge plane. In addition, the information provided everywhere on the terminal of arrival was simply wrong and this was not the reality.
The flight was heavily delayed which put into question my connection. The boarding and unboarding process was horrible. The airline crams as many people as possible on this short flight. A 787 parks in the middle of the airport and a shuttle bus ferries you in. Why? In a major european airport with a huge plane. In addition, the information provided everywhere on the terminal of arrival was simply wrong and this was not the reality.
Related info for your journey
Find useful and relevant information for your journey from Madrid to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Madrid to Panama City?
You will need to book a flight from Madrid Barajas to Panama City Tocumen Intl if you want to fly from Madrid to Panama City. At least 1 airline has flights from Barajas (MAD) to Tocumen Intl (PTY) on a regular basis. There are 6 flights to Panama City from the Madrid airport per day. If you manage to book one that is nonstop, then you can expect the flight time from MAD to PTY to be around 10h 35m.
How popular is this Madrid to Panama City flight route?
Flights from Madrid Barajas to Panama City Tocumen Intl have been viewed 7 times in the past calendar month.
How long is the flight from Madrid to Panama City?
Departing from Madrid to Panama City will take you 10h 35m. Airlines will cover a distance of 5065 mi. This flight may include one or multiple stops.
What is the cheapest airline to fly from Madrid to Panama City round-trip?
Our cheapest airline available from Madrid to Panama City is Air Europa. Our recent data shows that you can find tickets from as low as £433 on this airline. Air Europa is 28% cheaper than the average price of flights available within the next 90 days to this destination.
What are the most reliable airlines from Madrid to Panama City?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Madrid to Panama City on time: Qatar Airways (69%), Iberia (69%), EL AL (69%).
What are the cheapest flights from Madrid to Panama City?
The cheapest flight price from Madrid to Panama City is £680. On average you can expect to pay £794. The most popular route, (Madrid Barajas - Panama City Tocumen Intl), can usually be booked for £720.
Can I find deals for business class flights from Madrid to Panama City?
Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Panama City?
Currently, February is the cheapest month in which you can book a flight from Madrid to Panama City (average of £402). Flying from Madrid to Panama City in December is currently the most expensive (average of £582). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 28 December 2025.
Discover the top airline that operate flights from Madrid to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 28 December 2025.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Madrid to Panama City?
Deals for Madrid to Panama City flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.
Why should you use Cheapflights to find cheap flight tickets from Madrid to Panama City?
Cheapflights helps you find that perfect flight to Panama City from Madrid by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!
Can Cheapflights find flights from Madrid to Panama City with no change fees?
Cheapflights does show flights with no change fees to all users. To see these options for flights from Madrid to Panama City, users can toggle the no change fees filter when performing a flight search.
Can Cheapflights notify me if prices for flights from Madrid to Panama City become cheaper?
Not ready to book yet? You can track prices for flights from Madrid to Panama City on Cheapflights with our Price Alert feature and get notified when better prices are available.
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