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Cheap flights from Santiago to Panama City from £206

SCL — PTY
11 Oct — 18 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santiago to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santiago to Panama City

Wed 28/1012:23 -
Nonstop6h 48m
Sun 1/1115:08 -
Nonstop6h 28m
Deal found 9/9£432
Sat 5/1205:07 -
Nonstop6h 56m
Sun 13/1211:48 -
Nonstop6h 23m
Deal found 6/9£432
Fri 30/1005:22 -
Nonstop6h 48m
Sun 15/1115:08 -
Nonstop6h 28m
Deal found 10/9£452
Sat 24/1016:20 -
1 stop10h 15m
Sat 31/1010:05 -
1 stop17h 40m
Deal found 9/9£458
Wed 28/1002:10 -
1 stop15h 05m
Wed 4/1110:05 -
1 stop17h 40m
Deal found 8/9£459
Tue 29/903:14 -
Nonstop6h 49m
Fri 30/1011:48 -
Nonstop6h 31m
Deal found 8/9£470
Fri 13/1105:07 -
Nonstop6h 56m
Sat 21/1111:48 -
Nonstop6h 27m
Deal found 11/9£473
Thu 17/912:22 -
Nonstop6h 49m
Tue 22/915:08 -
Nonstop6h 31m
Deal found 6/9£477
Wed 23/905:14 -
Nonstop6h 49m
Sat 31/1015:08 -
Nonstop6h 31m
Deal found 7/9£482
Mon 14/1201:27 -
Nonstop6h 52m
Tue 22/1215:51 -
Nonstop6h 27m
Deal found 11/9£484
Thu 8/1003:15 -
Nonstop6h 48m
Sun 11/1015:51 -
Nonstop6h 31m
Deal found 10/9£491
Sat 26/1201:27 -
Nonstop6h 52m
Sun 3/121:24 -
Nonstop6h 33m
Deal found 10/9£495

Find flight deals from Santiago to Panama City

Round-trip from

£432

One-way from

£206

Popular in

September

Cheapest in

November

Average price

£492

Good one-way deal

£272 or less
Copa Airlines
  • Copa Airlines
  • 29/10-4/11
  • Nonstop
  • 13h 16m total
  • Santiago to Panama City
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Copa Airlines
  • Copa Airlines
  • 2/11-31/12
  • Nonstop
  • 6h 56m total
  • Santiago to Panama City
Search Deals
Highest demand for flights based on searches. 8% potential increase in price (£28 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
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Average for round-trip flights in September 2026
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Price to beat on a one-way flight from Santiago Arturo Merino Benitez to Panama City Tocumen Intl.
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santiago to Panama City that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Mon 2/11

05:07-10:03

Nonstop6h 56m

Panama City Tocumen Intl

Wed 31/12

00:00-02:00

Nonstop0h 00m

£206

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Sun 1/11

05:07-10:03

Nonstop6h 56m

Panama City Tocumen Intl

Wed 31/12

00:00-02:00

Nonstop0h 00m

£206

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Wed 28/10

12:23-17:11

Nonstop6h 48m

Panama City Tocumen Intl

Sun 8/11

15:08-23:36

Nonstop6h 28m

£452

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Fri 23/10

12:23-17:11

Nonstop6h 48m

Panama City Tocumen Intl

Wed 28/10

15:51-00:22

Nonstop6h 31m

£452

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Tue 13/10

05:22-10:10

Nonstop6h 48m

Panama City Tocumen Intl

Wed 21/10

15:51-00:22

Nonstop6h 31m

£473

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Mon 7/12

12:20-17:11

Nonstop6h 51m

Panama City Tocumen Intl

Wed 16/12

11:48-20:11

Nonstop6h 23m

£473

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Wed 14/10

12:23-17:11

Nonstop6h 48m

Panama City Tocumen Intl

Sat 24/10

15:08-23:39

Nonstop6h 31m

£473

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Wed 14/10

03:15-08:03

Nonstop6h 48m

Panama City Tocumen Intl

Tue 20/10

15:51-00:22

Nonstop6h 31m

£473

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Tue 20/10

01:44-06:32

Nonstop6h 48m

Panama City Tocumen Intl

Sun 25/10

15:51-00:22

Nonstop6h 31m

£473

SantiagoPanama City

SCL Santiago Arturo Merino Benitez - PTY Panama City Tocumen Intl

SCLPTY

Santiago Arturo Merino Benitez

Mon 14/12

01:27-06:19

Nonstop6h 52m

Panama City Tocumen Intl

Tue 22/12

15:51-00:18

Nonstop6h 27m

£484

Flights are sorted by cheapest return flights first.

Deals found on 11/9

Showing 1-10 of 19 resultsSorted by cheapest first
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Best time to book a flight from Santiago to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santiago with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santiago to Panama City

How far ahead should I book a flight from Santiago to Panama City?

The best time to book flights from Santiago to Panama City is 10 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santiago to Panama City?

Currently, November is the cheapest month in which you can book a flight from Santiago to Panama City (average of £349). Flying from Santiago to Panama City in September is currently the most expensive (average of £492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santiago to Panama City as you normally would.

How much does it cost for a return flight from Santiago to Panama City?

Airfare is below average for this route at the moment.

Santiago to Panama City flights typically cost between £456 and £541 in October.
The cheapest return price found within the last 5 days was £432 on Copa Airlines (28 Oct–1 Nov).

Related info for your journey

  • How popular is this Santiago to Panama City flight route?

    The Santiago Arturo Merino Benitez to Panama City Tocumen Intl flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santiago to Panama City?

    A quick flight from Santiago to Panama City can take about 6h 56m. Copa Airlines provides one of the quickest options available for as low as £432. Airlines will cover a distance of 2986 mi. Generally, flights for this route are direct.

  • What are the most reliable airlines from Santiago to Panama City?

    The top 3 most reliable airlines when flying from Santiago to Panama City are KLM (90%), Copa Airlines (83%) and United Airlines (82%).

  • Can I find deals for flights from Santiago to Panama City that include hotel bookings?

    Yes. In addition to deals on Santiago to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Panama City.

  • Can I find deals for business class flights from Santiago to Panama City?

    Yes. Cheapflights offers flight deals from Santiago to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Panama City?

    Currently, November is the cheapest month in which you can book a flight from Santiago to Panama City (average of £349). Flying from Santiago to Panama City in September is currently the most expensive (average of £492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

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