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Cheap flights from Santo Domingo to Panama City from £422

SDQ — PTY
10 Oct — 17 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santo Domingo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Panama City

Tue 29/912:45 -
1 stop12h 50m
Thu 1/1004:25 -
1 stop6h 25m
Deal found 5/9£422
Wed 16/912:45 -
1 stop12h 50m
Fri 18/904:25 -
1 stop6h 25m
Deal found 8/9£423
Tue 27/1019:07 -
Nonstop2h 33m
Sun 1/1108:15 -
Nonstop2h 30m
Deal found 6/9£448
Sun 1/1105:55 -
Nonstop2h 33m
Sun 8/1112:44 -
Nonstop2h 28m
Deal found 7/9£465
Thu 1/1014:16 -
Nonstop2h 33m
Thu 15/1007:24 -
Nonstop2h 30m
Deal found 6/9£483
Sat 21/1108:55 -
Nonstop2h 35m
Sat 12/1208:15 -
Nonstop2h 27m
Deal found 8/9£491
Wed 28/1018:45 -
1 stop21h 30m
Fri 6/1102:30 -
1 stop14h 20m
Deal found 9/9£525
Sun 1/1118:45 -
1 stop7h 35m
Mon 9/1118:10 -
1 stop22h 40m
Deal found 9/9£574
Wed 16/918:41 -
Nonstop2h 33m
Sat 26/922:55 -
Nonstop2h 30m
Deal found 6/9£582
Tue 29/914:10 -
1 stop6h 39m
Thu 1/1016:10 -
2 stops19h 01m
Deal found 9/9£586
Tue 15/1212:45 -
1 stop13h 35m
Wed 30/1202:30 -
1 stop8h 20m
Deal found 7/9£593

Find flight deals from Santo Domingo to Panama City

Round-trip from

£422

Popular in

August

Cheapest in

January

Average price

£422
Avianca
  • Avianca
  • 29/10-1/11
  • 2 total stops
  • 24h 15m total
  • Santo Domingo to Panama City
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£14 potential increase over avg. return price).
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Cheapest flight prices on average. 0% potential price decrease (£3 potential savings vs. average return price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Tue 20/10

12:45-00:35

1 stop12h 50m

Panama City Tocumen Intl

Tue 27/10

18:10-11:50

1 stop16h 40m

£423

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Thu 29/10

08:57-10:30

Nonstop2h 33m

Panama City Tocumen Intl

Sat 31/10

09:42-13:12

Nonstop2h 30m

£448
Fastest return journey

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Sun 20/9

18:41-20:14

Nonstop2h 33m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£457

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Mon 1/2

14:19-15:58

Nonstop2h 39m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£457

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Fri 20/11

14:24-15:58

Nonstop2h 34m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£457

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Thu 1/10

14:16-15:49

Nonstop2h 33m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£457

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Wed 30/9

08:47-10:20

Nonstop2h 33m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£457

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Tue 29/12

14:14-15:58

Nonstop2h 44m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£457

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Sun 22/11

14:24-15:58

Nonstop2h 34m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£457

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Tue 24/11

14:24-15:58

Nonstop2h 34m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£457

Flights are sorted by cheapest return flights first.

Deals found on 5/9

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

To ensure you get the cheapest price possible for a flight from Santo Domingo to Panama City, you should look to book at least 89 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of £387). Flying from Santo Domingo to Panama City in August is currently the most expensive (average of £458). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santo Domingo to Panama City as you normally would.

How much does it cost for a return flight from Santo Domingo to Panama City?

Airfare is typical for this route at the moment.

Santo Domingo to Panama City flights typically cost between £394 and £469 in September.
The cheapest return price found within the last 5 days was £422 on Avianca (29 Sept–1 Oct).

Related info for your journey

  • How popular is this Santo Domingo to Panama City flight route?

    Within the past month, 1 users have taken a look at flights from Santo Domingo Las Americas to Panama City Tocumen Intl.

  • How long is the flight from Santo Domingo to Panama City?

    Departing from Santo Domingo to Panama City will take you 2h 33m. The distance from Santo Domingo to Panama City is about 917 mi. Both multi-stop and direct flights can be found to your destination and back.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    The top 3 most reliable airlines when flying from Santo Domingo to Panama City are Air France (92%), Copa Airlines (88%) and KLM (85%).

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of £387). Flying from Santo Domingo to Panama City in August is currently the most expensive (average of £458). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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