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Cheap flights from Santo Domingo to Panama City from £253

SDQ — PTY
29 Nov — 6 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santo Domingo to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Santo Domingo to Panama City

Mon 9/1118:45 -
1 stop15h 25m
Sun 15/1102:30 -
1 stop14h 20m
Deal found 26/10£361
Thu 10/1205:53 -
Nonstop2h 35m
Thu 17/1209:42 -
Nonstop2h 32m
Deal found 26/10£367
Wed 18/1114:20 -
Nonstop2h 34m
Sun 22/1108:15 -
Nonstop2h 30m
Deal found 28/10£370
Fri 27/1108:55 -
Nonstop2h 35m
Tue 1/1209:42 -
Nonstop2h 32m
Deal found 30/10£379
Mon 30/1112:45 -
Nonstop2h 36m
Sat 5/1208:15 -
Nonstop2h 27m
Deal found 30/10£430
Fri 20/1114:20 -
Nonstop2h 34m
Mon 23/1122:41 -
Nonstop2h 27m
Deal found 29/10£438
Sun 1/1118:45 -
1 stop7h 35m
Tue 3/1102:30 -
1 stop14h 20m
Deal found 26/10£441
Sun 13/1218:45 -
1 stop7h 35m
Sat 19/1202:30 -
1 stop14h 20m
Deal found 29/10£444
Sat 21/1108:55 -
Nonstop2h 35m
Thu 3/1212:44 -
Nonstop2h 29m
Deal found 28/10£454
Thu 24/1219:03 -
Nonstop2h 37m
Mon 28/1222:41 -
Nonstop2h 27m
Deal found 26/10£459
Wed 4/1118:45 -
1 stop15h 25m
Thu 26/1102:30 -
1 stop14h 20m
Deal found 28/10£461

Find flight deals from Santo Domingo to Panama City

Round-trip from

£361

One-way from

£253

Popular in

August

Cheapest in

January

Average price

£426
Avianca
  • Avianca
  • 17/1-25/1
  • 2 total stops
  • 19h 50m total
  • Santo Domingo to Panama City
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Avianca
  • Avianca
  • 7/11-31/12
  • 1 total stop
  • 5h 30m total
  • Santo Domingo to Panama City
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£14 potential increase over avg. return price).
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Cheapest flight prices on average. 0% potential price decrease (£3 potential savings vs. average return price).
Search Deals
Average for round-trip flights in October 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Wed 11/11

12:45-17:15

1 stop5h 30m

Panama City Tocumen Intl

Wed 31/12

00:00-00:30

Nonstop0h 00m

£253

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Fri 12/2

14:19-15:58

Nonstop2h 39m

Panama City Tocumen Intl

Mon 22/2

22:41-02:04

Nonstop2h 23m

£370

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Fri 29/1

14:19-15:58

Nonstop2h 39m

Panama City Tocumen Intl

Sun 31/1

09:42-13:08

Nonstop2h 26m

£370

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Mon 23/11

19:06-20:40

Nonstop2h 34m

Panama City Tocumen Intl

Fri 27/11

08:15-11:45

Nonstop2h 30m

£370

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Fri 13/11

19:06-20:40

Nonstop2h 34m

Panama City Tocumen Intl

Fri 20/11

09:42-13:10

Nonstop2h 28m

£370

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Tue 22/12

12:09-13:45

Nonstop2h 36m

Panama City Tocumen Intl

Fri 15/1

12:44-16:08

Nonstop2h 24m

£370

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Sat 16/1

12:42-14:21

Nonstop2h 39m

Panama City Tocumen Intl

Sat 23/1

12:44-16:08

Nonstop2h 24m

£370

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Thu 28/1

12:06-13:45

Nonstop2h 39m

Panama City Tocumen Intl

Sun 31/1

12:44-16:08

Nonstop2h 24m

£370

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Sun 14/2

19:02-20:40

Nonstop2h 38m

Panama City Tocumen Intl

Sat 20/2

07:39-11:02

Nonstop2h 23m

£370

Santo DomingoPanama City

SDQ Santo Domingo Las Americas - PTY Panama City Tocumen Intl

SDQPTY

Santo Domingo Las Americas

Fri 5/3

14:37-16:15

Nonstop2h 38m

Panama City Tocumen Intl

Mon 8/3

10:05-13:29

Nonstop2h 24m

£370

Flights are sorted by cheapest return flights first.

Deals found on 28/10

Showing 1-10 of 17 resultsSorted by cheapest first
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Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

To ensure you get the cheapest price possible for a flight from Santo Domingo to Panama City, you should look to book at least 89 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of £395). Flying from Santo Domingo to Panama City in August is currently the most expensive (average of £463). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santo Domingo to Panama City as you normally would.

How much does it cost for a return flight from Santo Domingo to Panama City?

Airfare is below average for this route at the moment.

Santo Domingo to Panama City flights typically cost between £370 and £472 in January.
The cheapest return price found within the last 5 days was £361 on Avianca (17 Jan–25 Jan).

Related info for your journey

  • How popular is this Santo Domingo to Panama City flight route?

    Within the past month, 1 users have taken a look at flights from Santo Domingo Las Americas to Panama City Tocumen Intl.

  • How long is the flight from Santo Domingo to Panama City?

    Departing from Santo Domingo to Panama City will take you 2h 35m. The distance from Santo Domingo to Panama City is about 917 mi. Generally, flights for this route are direct.

  • What are the most reliable airlines from Santo Domingo to Panama City?

    The top 3 most reliable airlines when flying from Santo Domingo to Panama City are Air France (85%), Copa Airlines (84%) and KLM (80%).

  • Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

  • Can I find deals for business class flights from Santo Domingo to Panama City?

    Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Panama City?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of £395). Flying from Santo Domingo to Panama City in August is currently the most expensive (average of £463). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Need flexible booking options for your flight to Panama City from Santo Domingo? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

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