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Cheap flights from Mexico City to Santiago from £221

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 24/3. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
14 Apr — 21 Apr1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 15 March 2026.

Wed 29/405:50
MEX
-
SCL
1 stop11h 33m
Copa Airlines
Tue 5/500:01
SCL
-
MEX
1 stop16h 29m
Copa Airlines
Deal found 15/3£482
Wed 29/416:55
MEX
-
SCL
3 stops25h 39m
Multiple Airlines
Wed 6/515:20
SCL
-
MEX
2 stops20h 40m
Multiple Airlines
Deal found 15/3£488
Wed 6/502:10
MEX
-
SCL
1 stop15h 13m
Copa Airlines
Mon 11/504:09
SCL
-
MEX
1 stop19h 56m
Copa Airlines
Deal found 13/3£494
Fri 15/501:20
MEX
-
SCL
1 stop20h 06m
Copa Airlines
Sat 6/611:17
SCL
-
MEX
1 stop12h 43m
Copa Airlines
Deal found 13/3£505
Wed 8/402:10
MEX
-
SCL
1 stop15h 13m
Copa Airlines
Sat 25/411:25
SCL
-
MEX
1 stop14h 50m
Copa Airlines
Deal found 10/3£509
Sat 2/501:20
MEX
-
SCL
1 stop19h 23m
Copa Airlines
Wed 13/504:09
SCL
-
MEX
1 stop16h 56m
Copa Airlines
Deal found 14/3£517
Mon 25/501:20
MEX
-
SCL
1 stop16h 03m
Copa Airlines
Tue 2/602:51
SCL
-
MEX
1 stop21h 14m
Copa Airlines
Deal found 12/3£525
Thu 19/301:20
MEX
-
SCL
1 stop19h 29m
Copa Airlines
Sun 29/305:19
SCL
-
MEX
1 stop12h 11m
Copa Airlines
Deal found 14/3£533
Mon 30/301:20
MEX
-
SCL
1 stop19h 19m
Copa Airlines
Fri 3/702:56
SCL
-
MEX
1 stop21h 04m
Copa Airlines
Deal found 11/3£540
Mon 6/405:50
MEX
-
SCL
1 stop11h 33m
Copa Airlines
Sat 18/400:46
SCL
-
MEX
1 stop20h 19m
Copa Airlines
Deal found 12/3£548
Thu 4/601:20
MEX
-
SCL
1 stop16h 03m
Copa Airlines
Mon 22/611:17
SCL
-
MEX
1 stop12h 48m
Copa Airlines
Deal found 12/3£553

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 15 March 2026.

Round-trip from

£482

One-way from

£221

Popular in

December

Cheapest in

May

Average price

£473

Good one-way deal

£378 or less
Copa Airlines
  • Copa Airlines
  • 29/4-5/5
  • 2 total stops
  • 28h 02m total
  • Mexico City to Santiago
Search Deals
Copa Airlines
  • Copa Airlines
  • 24/3
  • 1 total stop
  • 14h 52m total
  • Mexico City to Santiago
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£4 potential savings vs. average return price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 15 March 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 10/5

01:20-23:26

1 stop20h 06m

Santiago Arturo Merino Benitez

Wed 20/5

11:17-01:00

1 stop15h 43m

£494

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 18/5

05:50-22:43

1 stop14h 53m

Santiago Arturo Merino Benitez

Mon 25/5

04:09-22:05

1 stop19h 56m

£494

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 17/4

01:20-19:23

1 stop16h 03m

Santiago Arturo Merino Benitez

Sat 2/5

04:09-00:15

1 stop22h 06m

£494
Fastest return journey

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 26/5

05:50-23:26

1 stop15h 36m

Santiago Arturo Merino Benitez

Tue 2/6

02:22-12:10

1 stop11h 48m

£505

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 12/5

05:50-05:10

1 stop21h 20m

Santiago Arturo Merino Benitez

Wed 20/5

04:09-14:30

1 stop12h 21m

£517

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 11/4

05:50-23:26

1 stop15h 36m

Santiago Arturo Merino Benitez

Sun 19/4

02:30-22:05

1 stop21h 35m

£517

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 20/5

01:20-19:23

1 stop16h 03m

Santiago Arturo Merino Benitez

Tue 26/5

04:41-00:15

1 stop21h 34m

£517

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 7/5

09:50-23:26

1 stop11h 36m

Santiago Arturo Merino Benitez

Tue 19/5

04:09-22:05

1 stop19h 56m

£517

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 27/5

01:20-22:43

1 stop19h 23m

Santiago Arturo Merino Benitez

Thu 4/6

00:38-14:30

1 stop15h 52m

£525
Cheapest one-way

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 14/4

13:10-03:00

1 stop11h 50m

£246

Flights are sorted by cheapest return flights first.

Deals found on 10/3

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a return flight from Mexico City to Santiago. Price data was last updated on 13 March 2026.

Booking 90 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £200). Flying from Mexico City to Santiago in June is currently the most expensive (average of £322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 15 March 2026.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 1 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • How long is the flight from Mexico City to Santiago?

    Airlines like Copa Airlines fly from Mexico City to Santiago in about 20h 06m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 4096 mi.

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider LATAM Airlines (92%), Wamos Air (92%) or WestJet (80%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • What are the cheapest flights from Mexico City to Santiago?

    Looking for the cheapest flight from Mexico City to Santiago? While on average our users pay £562, our data indicates the cheapest price to be £378. The most popular route (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), is priced around £391.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £200). Flying from Mexico City to Santiago in June is currently the most expensive (average of £322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Balmaceda car hire
Lastarria car hire

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Mexico City to Santiago?

Cheapflights helps you search for flights from Mexico City to Santiago via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights helps you find that perfect flight to Santiago from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Need flexible booking options for your flight to Santiago from Mexico City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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