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Cheap flights from Mexico City to Santiago from £202

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
12 Oct — 19 Oct1
1 adult
1 adult, Economy

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 September 2025.

Round-trip from

£394

One-way from

£202

Popular in

December

Cheapest in

May

Average price

£467
LATAM Airlines
  • LATAM Airlines
  • 7/10-13/10
  • 3 total stops
  • 38h 40m total
  • Mexico City to Santiago
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Avianca
  • Avianca
  • 4/10
  • 1 total stop
  • 15h 35m total
  • Mexico City to Santiago
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Highest demand for flights based on searches. 7% potential increase in price (£25 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
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Average for round-trip flights in September 2025
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 September 2025.

Tue 7/1019:05MEX - SCL
2 stops15h 15mMultiple Airlines
Mon 13/1018:30SCL - MEX
1 stop23h 25mMultiple Airlines
Deal found 10/9£394
Tue 7/1014:00MEX - SCL
1 stop12h 15mAvianca
Tue 14/1007:10SCL - MEX
1 stop13h 55mAvianca
Deal found 10/9£398
Thu 30/1020:00MEX - SCL
1 stop23h 00mMultiple Airlines
Tue 4/1121:30SCL - MEX
2 stops43h 20mMultiple Airlines
Deal found 10/9£400
Wed 24/905:50MEX - SCL
1 stop15h 14mCopa Airlines
Tue 7/1003:35SCL - MEX
1 stop21h 30mCopa Airlines
Deal found 12/9£403
Sat 22/1120:55MEX - SCL
1 stop21h 55mMultiple Airlines
Sun 30/1118:30SCL - MEX
1 stop22h 20mMultiple Airlines
Deal found 10/9£404
Tue 2/1201:20MEX - SCL
1 stop16h 01mCopa Airlines
Thu 11/1212:20SCL - MEX
1 stop15h 40mCopa Airlines
Deal found 12/9£409
Mon 17/1101:20MEX - SCL
1 stop19h 21mCopa Airlines
Thu 27/1101:12SCL - MEX
1 stop21h 08mCopa Airlines
Deal found 10/9£410
Mon 17/1113:10MEX - SCL
1 stop11h 14mCopa Airlines
Sun 23/1101:29SCL - MEX
1 stop16h 01mCopa Airlines
Deal found 12/9£410
Sun 14/1202:00MEX - SCL
1 stop19h 24mCopa Airlines
Thu 5/305:21SCL - MEX
1 stop19h 44mCopa Airlines
Deal found 10/9£416
Tue 7/1015:10MEX - SCL
1 stop20h 50mLATAM Airlines
Tue 14/1009:40SCL - MEX
Nonstop8h 55mLATAM Airlines
Deal found 10/9£416
Sun 7/1201:20MEX - SCL
1 stop19h 21mCopa Airlines
Tue 16/1205:12SCL - MEX
1 stop19h 53mCopa Airlines
Deal found 10/9£417

Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 September 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 5/3

15:00-22:00

1 stop28h 00m

Santiago Arturo Merino Benitez

Tue 10/3

22:15-13:50

1 stop18h 35m

£395

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 2/10

05:50-23:40

1 stop14h 50m

Santiago Arturo Merino Benitez

Sun 5/10

04:47-22:05

1 stop20h 18m

£403

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 11/11

02:00-00:06

1 stop19h 06m

Santiago Arturo Merino Benitez

Tue 2/12

12:20-01:00

1 stop15h 40m

£403

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 23/10

01:40-20:20

1 stop15h 40m

Santiago Arturo Merino Benitez

Thu 27/11

12:20-22:05

1 stop12h 45m

£403

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 12/10

02:00-20:20

1 stop15h 20m

Santiago Arturo Merino Benitez

Mon 10/11

05:12-19:20

1 stop17h 08m

£403

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 6/10

01:40-20:20

1 stop15h 40m

Santiago Arturo Merino Benitez

Tue 14/10

12:29-22:05

1 stop12h 36m

£403

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 8/10

02:00-00:04

1 stop19h 04m

Santiago Arturo Merino Benitez

Mon 13/10

04:47-22:05

1 stop20h 18m

£403

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 25/9

09:50-03:42

1 stop14h 52m

Santiago Arturo Merino Benitez

Mon 6/10

03:35-22:05

1 stop21h 30m

£403

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 4/10

04:55-23:30

1 stop15h 35m

£202

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 28/12

01:20-20:21

1 stop16h 01m

£242

Flights are sorted by cheapest return flights first.

Deals found on 11/9

Showing 1-10 of 17 results
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a return flight from Mexico City to Santiago. Price data was last updated on 29 August 2025.

Booking 90 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £1,031). Flying from Mexico City to Santiago in December is currently the most expensive (average of £1,468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 12 September 2025.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Mexico City to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 2 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • How long is the flight from Mexico City to Santiago?

    Airlines like Copa Airlines fly from Mexico City to Santiago in about 14h 50m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 4096 mi.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £1,031). Flying from Mexico City to Santiago in December is currently the most expensive (average of £1,468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Balmaceda car hire
Puerto Montt car hire
Lastarria car hire

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Santiago?

Cheapflights helps you search for flights from Mexico City to Santiago via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights helps you find that perfect flight to Santiago from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Need flexible booking options for your flight to Santiago from Mexico City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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