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Cheap flights from Mexico City to Santiago from £193

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/3. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
2 Mar — 9 Mar1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Mexico City to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 31 January 2026.

Wed 18/305:55
MEX
-
SCL
1 stop15h 39m
Copa Airlines
Thu 2/405:17
SCL
-
MEX
1 stop16h 48m
Copa Airlines
Deal found 30/1£402
Sat 21/311:00
MEX
-
SCL
1 stop32h 00m
Multiple Airlines
Mon 30/315:33
SCL
-
MEX
2 stops25h 17m
Multiple Airlines
Deal found 28/1£425
Fri 6/319:50
MEX
-
SCL
Nonstop8h 40m
Multiple Airlines
Fri 13/309:30
SCL
-
MEX
1 stop25h 05m
Multiple Airlines
Deal found 29/1£435
Mon 6/405:50
MEX
-
SCL
1 stop15h 36m
Copa Airlines
Sun 19/411:25
SCL
-
MEX
1 stop14h 50m
Copa Airlines
Deal found 30/1£438
Thu 12/213:10
MEX
-
SCL
1 stop12h 04m
Copa Airlines
Thu 28/504:41
SCL
-
MEX
1 stop16h 24m
Copa Airlines
Deal found 30/1£468
Sun 9/823:20
MEX
-
SCL
1 stop12h 55m
Avianca
Wed 26/806:40
SCL
-
MEX
1 stop13h 25m
Avianca
Deal found 30/1£477
Sat 31/101:20
MEX
-
SCL
1 stop20h 12m
Copa Airlines
Fri 27/312:28
SCL
-
MEX
1 stop12h 37m
Copa Airlines
Deal found 30/1£483
Fri 14/823:20
MEX
-
SCL
1 stop21h 10m
Avianca
Mon 17/806:10
SCL
-
MEX
1 stop13h 55m
Avianca
Deal found 29/1£491
Tue 3/209:25
MEX
-
SCL
1 stop14h 52m
Copa Airlines
Tue 10/203:34
SCL
-
MEX
1 stop21h 31m
Copa Airlines
Deal found 29/1£499
Sun 1/316:00
MEX
-
SCL
1 stop19h 05m
Multiple Airlines
Sun 8/309:30
SCL
-
MEX
1 stop31h 50m
Multiple Airlines
Deal found 30/1£510
Wed 29/705:50
MEX
-
SCL
1 stop19h 10m
Copa Airlines
Tue 4/802:27
SCL
-
MEX
1 stop14h 03m
Copa Airlines
Deal found 30/1£518

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 31 January 2026.

Round-trip from

£402

One-way from

£193

Popular in

February

Cheapest in

May

Average price

£447
Copa Airlines
  • Copa Airlines
  • 18/3-2/4
  • 2 total stops
  • 32h 27m total
  • Mexico City to Santiago
Search Deals
Copa Airlines
  • Copa Airlines
  • 22/3
  • 1 total stop
  • 14h 54m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 6% potential increase in price (£22 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£7 potential savings vs. average return price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 31 January 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 18/3

05:55-00:34

1 stop15h 39m

Santiago Arturo Merino Benitez

Thu 2/4

05:17-19:05

1 stop16h 48m

£402

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 20/3

01:20-00:34

1 stop20h 14m

Santiago Arturo Merino Benitez

Mon 30/3

12:28-00:15

1 stop14h 47m

£402

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 21/3

11:00-22:00

1 stop32h 00m

Santiago Arturo Merino Benitez

Mon 30/3

15:33-13:50

2 stops25h 17m

£425

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 6/3

19:50-07:30

Nonstop8h 40m

Santiago Arturo Merino Benitez

Fri 13/3

09:30-07:35

1 stop25h 05m

£435

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 26/4

05:50-22:43

1 stop14h 53m

Santiago Arturo Merino Benitez

Sun 3/5

04:09-22:05

1 stop19h 56m

£438

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 7/5

15:30-05:10

1 stop11h 40m

Santiago Arturo Merino Benitez

Sun 10/5

02:22-22:05

1 stop21h 43m

£438

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 6/4

05:50-23:26

1 stop15h 36m

Santiago Arturo Merino Benitez

Sun 19/4

11:25-00:15

1 stop14h 50m

£438

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 28/4

01:20-19:23

1 stop16h 03m

Santiago Arturo Merino Benitez

Tue 12/5

04:09-19:05

1 stop16h 56m

£438

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 2/5

00:25-19:23

1 stop16h 58m

Santiago Arturo Merino Benitez

Tue 12/5

04:09-19:05

1 stop16h 56m

£438

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 12/2

13:10-04:14

1 stop12h 04m

Santiago Arturo Merino Benitez

Thu 28/5

04:41-19:05

1 stop16h 24m

£468

Flights are sorted by cheapest return flights first.

Deals found on 29/1

Showing 1-10 of 16 results
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Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a return flight from Mexico City to Santiago. Price data was last updated on 23 January 2026.

Booking 90 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £224). Flying from Mexico City to Santiago in June is currently the most expensive (average of £314). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 31 January 2026.

When flying from Mexico City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 1 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • How long is the flight from Mexico City to Santiago?

    Airlines like Copa Airlines fly from Mexico City to Santiago in about 15h 39m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 4096 mi.

  • What are the most reliable airlines from Mexico City to Santiago?

    Consider LATAM Airlines (95%), Wamos Air (95%) or Aeromexico (86%) when booking your flight. These represent the most reliable airlines when flying from Mexico City to Santiago.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £224). Flying from Mexico City to Santiago in June is currently the most expensive (average of £314). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Balmaceda car hire
Puerto Montt car hire
Lastarria car hire

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Mexico City to Santiago?

Cheapflights helps you search for flights from Mexico City to Santiago via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights helps you find that perfect flight to Santiago from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Need flexible booking options for your flight to Santiago from Mexico City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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