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Cheap flights from Mexico City to Santiago from £217

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/12. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
4 Aug — 11 Aug1
1 adult

Cheap flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 30 July 2025.

Round-trip from

£424

One-way from

£217

Popular in

December

Cheapest in

May

Average price

£463
Copa Airlines
  • Copa Airlines
  • 13/8-22/8
  • 2 total stops
  • 38h 58m total
  • Mexico City to Santiago
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Avianca
  • Avianca
  • 8/12
  • 1 total stop
  • 44h 00m total
  • Mexico City to Santiago
Search Deals
Highest demand for flights based on searches. 6% potential increase in price (£26 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£6 potential savings vs. average return price).
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Average for round-trip flights in July 2025
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Find flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 30 July 2025.

Wed 13/801:40MEX - SCL
1 stop19h 04mCopa Airlines
Fri 22/804:11SCL - MEX
1 stop19h 54mCopa Airlines
Deal found 27/7£424
Wed 29/1000:40MEX - SCL
1 stop25h 45mAvianca
Sun 2/1100:45SCL - MEX
1 stop14h 25mAvianca
Deal found 28/7£431
Tue 7/1017:05MEX - SCL
2 stops17h 15mLATAM Airlines
Tue 14/1016:10SCL - MEX
1 stop25h 45mLATAM Airlines
Deal found 27/7£451

Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 30 July 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Mexico City

Fly to

Santiago

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 13/8

01:40-23:08

1 stop19h 28m

Santiago Arturo Merino Benitez

Thu 21/8

02:26-22:05

1 stop21h 39m

£424

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 29/10

00:40-05:25

1 stop25h 45m

Santiago Arturo Merino Benitez

Sun 2/11

00:45-12:10

1 stop14h 25m

£431

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 7/10

17:05-13:20

2 stops17h 15m

Santiago Arturo Merino Benitez

Tue 14/10

16:10-14:55

1 stop25h 45m

£451

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 8/12

00:40-23:40

1 stop44h 00m

£217

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 5/8

14:00-19:24

3 stops27h 24m

£319

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 10/8

01:40-23:08

1 stop19h 28m

£328

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 5/8

20:00-06:40

Nonstop8h 40m

£507

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 10/10

15:00-15:05

3 stops45h 05m

£2,191

Flights are sorted by cheapest return flights first.

Deals found on 30/7

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

Use this chart to determine the optimal time to book a return flight from Mexico City to Santiago. Price data was last updated on 25 July 2025.

Booking 90 days in advance of your planned departure date is, on average, the best time to get cheap flights from Mexico City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £1,031). Flying from Mexico City to Santiago in December is currently the most expensive (average of £1,468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 30 July 2025.

It’s typically best to fly out from Mexico City to Santiago at midday. Doing so could potentially save you 58% on the flight price compared to flying in the morning, which is usually more expensive.

How much does it cost for a return flight from Mexico City to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated 30 July 2025.
Read reviews from past customers who have flown with LATAM Airlines, Qantas Airways, andCopa Airlines from Mexico City to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Comfort

7.4

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,822 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Comfort

7.4

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Qantas Airways
7.5
Good
883 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Comfort

7.4

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Copa Airlines
7.5
Good
1,493 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Comfort

7.4

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
Avianca
6.7
Okay
2,386 reviews
LATAM Airlines
7.5
Good
1,822 reviews
Check prices

Comfort

7.4

Boarding

7.6

Crew

8.1

Entertainment

7.0

Food

6.7

Overall

7.5

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 2 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from £424. Other airlines that can offer you cheap pricing are Avianca, from £431, and LATAM Airlines, from £451. Users have found that Copa Airlines is 10% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    The cheapet airlines for a one-way flight from Mexico City to Santiago are Avianca (£217), Copa Airlines (£328), and LATAM Airlines (£507).

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, May is the cheapest month in which you can book a flight from Mexico City to Santiago (average of £1,031). Flying from Mexico City to Santiago in December is currently the most expensive (average of £1,468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Complete your trip

Complete your trip to Santiago by adding a car hire and/or hotel booking to your travel itinerary.
Santiago car hire
Santiago Arturo Merino Benitez Airport car hire
Punta Arenas car hire
Puerto Montt car hire
Balmaceda car hire
Lastarria car hire

Fly with Cheapflights

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How does Cheapflights help users find flights from Mexico City to Santiago?

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Santiago?

Cheapflights helps you find that perfect flight to Santiago from Mexico City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Mexico City to Santiago with no change fees?

Need flexible booking options for your flight to Santiago from Mexico City? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from Mexico City to Santiago become cheaper?

Yes! Start tracking prices for Mexico City to Santiago flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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