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Cheap flights from Southampton to Santiago from £1,015

SOU — SCL
9 Dec — 16 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Southampton to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Southampton to Santiago

Mon 23/1108:40 -
2 stops50h 00m
Sun 6/1223:10 -
2 stops38h 55m
Deal found 7/11£1,134
Tue 22/1217:35 -
2 stops21h 05m
Tue 29/1223:10 -
2 stops38h 55m
Deal found 7/11£1,542
Tue 22/1217:35 -
3 stops34h 30m
Tue 29/1207:30 -
3 stops30h 35m
Deal found 7/11£1,795

Find flight deals from Southampton to Santiago

Round-trip from

£915

Popular in

December

Cheapest in

January

Average price

£917
KLM
  • KLM
  • 11/1-2/3
  • 4 total stops
  • 56h 15m total
  • Southampton to Santiago
Search Deals
Highest demand for flights based on searches. 3% potential increase in price (£26 potential increase over avg. return price).
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Cheapest flight prices on average. 2% potential price decrease (£19 potential savings vs. average return price).
Search Deals
Average for round-trip flights in November 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Southampton to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Tue 12/1

08:40-09:45

2 stops28h 05m

Santiago Arturo Merino Benitez

Wed 3/3

13:10-17:00

2 stops24h 50m

£1,015

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Wed 13/1

08:40-11:40

2 stops30h 00m

Santiago Arturo Merino Benitez

Tue 2/3

12:05-17:00

2 stops25h 55m

£1,031

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Tue 12/1

08:40-09:45

2 stops28h 05m

Santiago Arturo Merino Benitez

Thu 4/3

13:10-17:00

2 stops24h 50m

£1,058

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Mon 11/1

08:40-09:45

2 stops28h 05m

Santiago Arturo Merino Benitez

Thu 4/3

13:10-17:00

2 stops24h 50m

£1,058

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Mon 23/11

08:40-07:40

2 stops50h 00m

Santiago Arturo Merino Benitez

Sun 6/12

23:10-17:05

2 stops38h 55m

£1,134
Fastest return journey

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Wed 13/1

15:20-10:05

2 stops21h 45m

Santiago Arturo Merino Benitez

Thu 4/3

11:50-14:10

1 stop23h 20m

£1,254

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Thu 14/1

09:20-22:20

2 stops40h 00m

Santiago Arturo Merino Benitez

Wed 3/3

12:05-15:45

1 stop24h 40m

£1,527

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Tue 22/12

17:35-11:40

2 stops21h 05m

Santiago Arturo Merino Benitez

Tue 29/12

23:10-17:05

2 stops38h 55m

£1,542

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Tue 22/12

17:35-01:05

3 stops34h 30m

Santiago Arturo Merino Benitez

Tue 29/12

07:30-17:05

3 stops30h 35m

£1,795

Flights are sorted by cheapest return flights first.

Deals found on 6/11

Sorted by cheapest first

Best time to book a flight from Southampton to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Southampton with our price prediction graph.
Estimated return price

Reviews of airlines servicing Santiago

See what other customers who have flown with KLM from Southampton to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,595 reviews
Check prices

Overall

7.8

Entertainment

7.2

Food

7.4

Boarding

7.8

Crew

8.4

Comfort

7.7

Reviews

1 / 20
4.0
Okay

Abhisek,Aug 2026

JFK - AMS

They didn’t offer any options for breakfast and had only one option which was cold meat and cheese. I would expect at least one more option in premium economy
KLM
7.8
Good
1,595 reviews
KLM
7.8
Good
1,595 reviews
Check prices

Overall

7.8

Entertainment

7.2

Food

7.4

Boarding

7.8

Crew

8.4

Comfort

7.7

Reviews

1 / 20
4.0
Okay

Abhisek,Aug 2026

JFK - AMS

They didn’t offer any options for breakfast and had only one option which was cold meat and cheese. I would expect at least one more option in premium economy

Related info for your journey

  • How long is the flight from Southampton to Santiago?

    For as low as £1,015, KLM can have you in Santiago from Southampton in 28h 05m. The distance from Southampton to Santiago is about 7183 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Southampton to Santiago that include hotel bookings?

    Yes. In addition to deals on Southampton to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Southampton to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Southampton to Santiago.

  • Can I find deals for business class flights from Southampton to Santiago?

    Yes. Cheapflights offers flight deals from Southampton to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Southampton to Santiago

AirlineCheapestAverageFlexibilityOn-time
KLMCheapest£1,199Average£1,332FlexibilityNo cancel feeOn-time75%
Search KLM flights

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Cheapflights does show flights with no change fees to all users. To see these options for flights from Southampton to Santiago, users can toggle the no change fees filter when performing a flight search.

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