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Cheap flights from Southampton to Santiago from £1,224

SOU — SCL
13 Oct — 20 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Southampton to Santiago

Enter your travel dates to find the best prices.

Cheapest flights from Southampton to Santiago

Mon 26/1012:25 -
3 stops25h 50m
Sun 1/1104:45 -
3 stops35h 45m
Deal found 11/9£1,224
Tue 27/1008:40 -
2 stops28h 10m
Tue 3/1112:05 -
2 stops26h 00m
Deal found 12/9£1,312
Tue 27/1009:20 -
3 stops44h 35m
Tue 3/1111:30 -
3 stops29h 00m
Deal found 12/9£1,322

Find flight deals from Southampton to Santiago

Round-trip from

£1,224

Popular in

December

Cheapest in

January

Average price

£877
26/10-1/11
  • 26/10-1/11
  • 6 total stops
  • 61h 35m total
  • Southampton to Santiago
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Highest demand for flights based on searches. 1% potential increase in price (£11 potential increase over avg. return price).
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Cheapest flight prices on average. 2% potential price decrease (£15 potential savings vs. average return price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Southampton to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Mon 26/10

12:25-11:15

3 stops25h 50m

Santiago Arturo Merino Benitez

Sun 1/11

04:45-19:30

3 stops35h 45m

£1,224
Fastest return journey

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Tue 27/10

08:40-09:50

2 stops28h 10m

Santiago Arturo Merino Benitez

Tue 3/11

12:05-17:05

2 stops26h 00m

£1,312

SouthamptonSantiago

SOU Southampton Eastleigh - SCL Santiago Arturo Merino Benitez

SOUSCL

Southampton Eastleigh

Tue 27/10

09:20-02:55

3 stops44h 35m

Santiago Arturo Merino Benitez

Tue 3/11

11:30-19:30

3 stops29h 00m

£1,322

Flights are sorted by cheapest return flights first.

Deals found on 11/9

Sorted by cheapest first

Best time to book a flight from Southampton to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Southampton with our price prediction graph.
Estimated return price

Reviews of airlines servicing Santiago

See what other customers who have flown with KLM from Southampton to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,577 reviews
Check prices

Comfort

7.7

Boarding

7.8

Food

7.3

Entertainment

7.2

Overall

7.8

Crew

8.4

Reviews

1 / 20
4.0
Okay

Abhisek,Aug 2026

JFK - AMS

They didn’t offer any options for breakfast and had only one option which was cold meat and cheese. I would expect at least one more option in premium economy
KLM
7.8
Good
1,577 reviews
KLM
7.8
Good
1,577 reviews
Check prices

Comfort

7.7

Boarding

7.8

Food

7.3

Entertainment

7.2

Overall

7.8

Crew

8.4

Reviews

1 / 20
4.0
Okay

Abhisek,Aug 2026

JFK - AMS

They didn’t offer any options for breakfast and had only one option which was cold meat and cheese. I would expect at least one more option in premium economy

Related info for your journey

  • How long is the flight from Southampton to Santiago?

    For as low as £1,312, KLM can have you in Santiago from Southampton in 28h 10m. The distance from Southampton to Santiago is about 7183 mi.

  • Can I find deals for flights from Southampton to Santiago that include hotel bookings?

    Yes. In addition to deals on Southampton to Santiago flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Southampton to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Southampton to Santiago.

  • Can I find deals for business class flights from Southampton to Santiago?

    Yes. Cheapflights offers flight deals from Southampton to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar

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Top airline flying from Southampton to Santiago

AirlineCheapestAverageFlexibilityOn-time
KLMCheapest£1,188Average£1,320FlexibilityNo cancel feeOn-time75%
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