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Cheap flights from Panama City to Santo Domingo from £209

PTY — SDQ
15 Oct — 22 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Santo Domingo

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Santo Domingo

Sun 11/1004:25 -
1 stop6h 25m
Sun 18/1018:50 -
1 stop6h 45m
Deal found 13/9£364
Fri 25/909:42 -
Nonstop2h 31m
Wed 30/914:16 -
Nonstop2h 33m
Deal found 11/9£364
Mon 30/1108:15 -
Nonstop2h 30m
Mon 11/114:19 -
Nonstop2h 39m
Deal found 11/9£393
Sat 19/1222:41 -
Nonstop2h 27m
Sat 16/114:19 -
Nonstop2h 39m
Deal found 11/9£423
Sun 20/908:11 -
Nonstop2h 31m
Wed 6/112:06 -
Nonstop2h 39m
Deal found 11/9£425
Fri 18/907:24 -
Nonstop2h 31m
Sat 17/1018:41 -
Nonstop2h 33m
Deal found 14/9£534
Tue 15/919:26 -
Nonstop2h 30m
Sat 19/908:47 -
Nonstop2h 33m
Deal found 13/9£621
Sun 1/1110:00 -
1 stop12h 46m
Thu 5/1114:53 -
2 stops24h 52m
Deal found 10/9£750
Sun 6/1205:30 -
2 stops11h 20m
Sat 19/1212:45 -
2 stops14h 25m
Deal found 13/9£819
Sun 13/919:26 -
Nonstop2h 30m
Sun 20/906:06 -
Nonstop2h 33m
Deal found 13/9£925
Mon 28/910:00 -
2 stops27h 10m
Thu 1/1015:20 -
2 stops28h 17m
Deal found 10/9£1,080

Find flight deals from Panama City to Santo Domingo

Round-trip from

£364

One-way from

£209

Popular in

July

Cheapest in

January

Average price

£364
Avianca
  • Avianca
  • 5/12-6/12
  • 2 total stops
  • 23h 45m total
  • Panama City to Santo Domingo
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Copa Airlines
  • Copa Airlines
  • 8/11-31/12
  • Nonstop
  • 2h 32m total
  • Panama City to Santo Domingo
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£13 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£4 potential savings vs. average return price).
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Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to Santo Domingo that are best for you.

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Cheapest return flight

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Sun 8/11

19:26-22:58

Nonstop2h 32m

Santo Domingo Las Americas

Wed 31/12

00:00-23:30

Nonstop0h 00m

£209

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Wed 11/11

19:26-22:58

Nonstop2h 32m

Santo Domingo Las Americas

Wed 31/12

00:00-23:30

Nonstop0h 00m

£209

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Mon 9/11

09:42-13:10

Nonstop2h 28m

Santo Domingo Las Americas

Wed 31/12

00:00-23:30

Nonstop0h 00m

£209

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Fri 6/11

08:15-11:45

Nonstop2h 30m

Santo Domingo Las Americas

Wed 31/12

00:00-23:30

Nonstop0h 00m

£209

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Mon 28/9

08:11-11:42

Nonstop2h 31m

Santo Domingo Las Americas

Thu 1/10

08:47-10:20

Nonstop2h 33m

£364

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Mon 2/11

12:44-16:12

Nonstop2h 28m

Santo Domingo Las Americas

Tue 10/11

19:06-20:40

Nonstop2h 34m

£364

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Sat 31/10

09:42-13:12

Nonstop2h 30m

Santo Domingo Las Americas

Thu 5/11

12:45-14:21

Nonstop2h 36m

£364

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Tue 17/11

12:44-16:12

Nonstop2h 28m

Santo Domingo Las Americas

Tue 24/11

19:06-20:40

Nonstop2h 34m

£364

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Sat 3/10

07:24-10:54

Nonstop2h 30m

Santo Domingo Las Americas

Mon 12/10

12:42-14:15

Nonstop2h 33m

£364

Panama CitySanto Domingo

PTY Panama City Tocumen Intl - SDQ Santo Domingo Las Americas

PTYSDQ

Panama City Tocumen Intl

Sun 1/11

09:42-13:10

Nonstop2h 28m

Santo Domingo Las Americas

Thu 5/11

05:55-07:28

Nonstop2h 33m

£364

Flights are sorted by cheapest return flights first.

Deals found on 10/9

Showing 1-10 of 17 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Panama City with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santo Domingo

How far ahead should I book a flight from Panama City to Santo Domingo?

To ensure you get the cheapest price possible for a flight from Panama City to Santo Domingo, you should look to book at least 69 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of £335). Flying from Panama City to Santo Domingo in July is currently the most expensive (average of £407). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SDQ?

When flying from Panama City to Santo Domingo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Panama City to Santo Domingo?

Airfare is typical for this route at the moment.

Panama City to Santo Domingo flights typically cost between £357 and £407 in October.
The cheapest return price found within the last 5 days was £364 on Avianca (11 Oct–18 Oct).

Related info for your journey

  • How long is the flight from Panama City to Santo Domingo?

    Departing from Panama City to Santo Domingo will take you 2h 31m. The distance between Panama City and Santo Domingo is about 917 mi. Most flights are nonstop.

  • What are the most reliable airlines from Panama City to Santo Domingo?

    The top 3 most reliable airlines when flying from Panama City to Santo Domingo are KLM (88%), Air France (88%) and Turkish Airlines (88%).

  • Can I find deals for flights from Panama City to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Panama City to Santo Domingo flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santo Domingo.

  • Can I find deals for business class flights from Panama City to Santo Domingo?

    Yes. Cheapflights offers flight deals from Panama City to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Santo Domingo (average of £335). Flying from Panama City to Santo Domingo in July is currently the most expensive (average of £407). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Panama City to Santo Domingo

Panama City to Punta Cana flights

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By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Santo Domingo from Panama City.

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Cheapflights does show flights with no change fees to all users. To see these options for flights from Panama City to Santo Domingo, users can toggle the no change fees filter when performing a flight search.

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