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Cheap flights from Panama City to San Francisco from £295

PTY — SFO
3 Dec — 10 Dec1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to San Francisco

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to San Francisco

Tue 3/1118:31 -
Nonstop7h 41m
Sun 8/1100:33 -
Nonstop7h 13m
Deal found 30/10£544
Tue 3/1116:41 -
1 stop22h 38m
Mon 9/1105:00 -
1 stop11h 38m
Deal found 30/10£548
Mon 23/1108:55 -
1 stop18h 09m
Fri 27/1123:59 -
1 stop16h 39m
Deal found 29/10£555
Tue 3/1112:44 -
Nonstop7h 41m
Wed 11/1119:36 -
Nonstop7h 10m
Deal found 2/11£603
Fri 6/1115:24 -
1 stop11h 32m
Tue 10/1123:59 -
1 stop11h 03m
Deal found 3/11£606
Wed 11/1112:44 -
Nonstop7h 41m
Fri 27/1100:33 -
Nonstop7h 13m
Deal found 3/11£620
Thu 17/1210:05 -
2 stops14h 35m
Thu 31/1213:15 -
1 stop9h 55m
Deal found 31/10£623
Wed 4/1115:24 -
1 stop11h 32m
Mon 9/1122:59 -
1 stop12h 03m
Deal found 3/11£663
Mon 9/1118:31 -
Nonstop7h 41m
Wed 11/1100:33 -
Nonstop7h 13m
Deal found 30/10£677
Fri 11/1218:31 -
Nonstop7h 46m
Sat 16/119:36 -
Nonstop7h 03m
Deal found 1/11£678
Thu 17/1216:41 -
1 stop24h 54m
Fri 8/107:15 -
1 stop9h 23m
Deal found 2/11£682

Find flight deals from Panama City to San Francisco

Round-trip from

£544

One-way from

£295

Popular in

December

Cheapest in

April

Average price

£611
Copa Airlines
  • Copa Airlines
  • 20/11-22/11
  • Nonstop
  • 14h 54m total
  • Panama City to San Francisco
Search Deals
Copa Airlines
  • Copa Airlines
  • 1/12-31/12
  • Nonstop
  • 7h 46m total
  • Panama City to San Francisco
Search Deals
Highest demand for flights based on searches. 5% potential increase in price (£24 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£9 potential savings vs. average return price).
Search Deals
Average for round-trip flights in November 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Tue 1/12

18:31-23:17

Nonstop7h 46m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£295

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Sat 5/12

16:41-15:04

1 stop25h 23m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£299

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Fri 20/11

18:31-23:12

Nonstop7h 41m

San Francisco

Sun 22/11

00:33-10:46

Nonstop7h 13m

£544

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Fri 20/11

16:41-07:28

1 stop17h 47m

San Francisco

Mon 23/11

18:35-19:38

1 stop22h 03m

£548

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Mon 23/11

16:41-00:04

1 stop10h 23m

San Francisco

Fri 27/11

23:15-19:38

1 stop17h 23m

£555

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Wed 7/4

17:56-23:40

Nonstop7h 44m

San Francisco

Tue 20/4

01:22-10:21

Nonstop6h 59m

£673

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Fri 15/1

12:40-17:25

Nonstop7h 45m

San Francisco

Tue 26/1

00:40-10:46

Nonstop7h 06m

£673

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Thu 24/12

16:41-11:58

1 stop22h 17m

San Francisco

Mon 28/12

23:59-17:12

1 stop14h 13m

£677

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Thu 17/12

16:41-14:35

1 stop24h 54m

San Francisco

Fri 8/1

07:15-19:38

1 stop9h 23m

£682

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Tue 19/1

18:31-23:15

Nonstop7h 44m

San Francisco

Thu 28/1

00:40-10:46

Nonstop7h 06m

£685

Flights are sorted by cheapest return flights first.

Deals found on 29/10

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 36 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of £465). Flying from Panama City to San Francisco in December is currently the most expensive (average of £687). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

When flying from Panama City to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Panama City to San Francisco?

Airfare is typical for this route at the moment.

Panama City to San Francisco flights typically cost between £544 and £635 in November.
The cheapest return price found within the last 5 days was £544 on Copa Airlines (20 Nov–22 Nov).

Related info for your journey

  • How long is the flight from Panama City to San Francisco?

    Copa Airlines and United Airlines can get you from Panama City to San Francisco in just under 7h 41m. Your travel time can differ by up to 10h 06m. There are 3318 mi between Panama City and San Francisco. Both multi-stop and direct flights can be found to your destination and back.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Francisco?

    Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of £465). Flying from Panama City to San Francisco in December is currently the most expensive (average of £687). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
San Bruno
Santa Cruz
Roseville
Newark
Sunnyvale
Bodega Bay

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Panama City to San Francisco

Panama City to Los Angeles flights

Fly with Cheapflights

How does Cheapflights help users find flights from Panama City to San Francisco?

When you search for this flight from Panama City to San Francisco, Cheapflights searches on 900+ travel sites to save you time finding great flight deals online. Additionally, we offer filter features so you can choose a preferred cabin class or airline, see different price ranges, and much more so you can book the flight for you.

Why should you use Cheapflights to find cheap flight tickets from Panama City to San Francisco?

Cheapflights helps you find that perfect flight to San Francisco from Panama City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Panama City to San Francisco with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Panama City to San Francisco, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Panama City to San Francisco become cheaper?

Yes! Start tracking prices for Panama City to San Francisco flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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