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Cheap flights from Panama City to San Francisco from £263

PTY — SFO
6 Oct — 13 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to San Francisco

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to San Francisco

Thu 22/1012:38 -
Nonstop7h 32m
Wed 28/1020:36 -
Nonstop7h 14m
Deal found 2/9£490
Thu 22/1015:50 -
1 stop10h 05m
Wed 28/1014:15 -
1 stop18h 20m
Deal found 2/9£513
Sat 19/905:30 -
1 stop9h 20m
Wed 23/914:15 -
2 stops17h 00m
Deal found 3/9£514
Sun 25/1005:30 -
1 stop19h 10m
Fri 30/1000:00 -
2 stops13h 15m
Deal found 5/9£521
Sat 19/1212:40 -
Nonstop7h 45m
Fri 1/100:40 -
Nonstop7h 06m
Deal found 3/9£559
Thu 22/1012:38 -
Nonstop7h 32m
Fri 30/1001:31 -
Nonstop7h 15m
Deal found 2/9£563
Sun 18/1018:08 -
Nonstop7h 32m
Sun 25/1020:36 -
Nonstop7h 14m
Deal found 2/9£568
Fri 30/1018:08 -
Nonstop7h 32m
Sun 8/1100:33 -
Nonstop7h 13m
Deal found 6/9£635
Sat 19/1215:25 -
1 stop11h 33m
Sat 2/106:00 -
1 stop12h 43m
Deal found 5/9£639
Mon 12/1018:08 -
Nonstop7h 32m
Fri 23/1001:12 -
Nonstop7h 15m
Deal found 3/9£641

Find flight deals from Panama City to San Francisco

Round-trip from

£482

One-way from

£263

Popular in

February

Cheapest in

April

Average price

£513
Copa Airlines
  • Copa Airlines
  • 3/2-17/2
  • Nonstop
  • 14h 48m total
  • Panama City to San Francisco
Search Deals
Copa Airlines
  • Copa Airlines
  • 19/11-31/12
  • Nonstop
  • 7h 41m total
  • Panama City to San Francisco
Search Deals
Highest demand for flights based on searches. 2% potential increase in price (£8 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease (£4 potential savings vs. average return price).
Search Deals
Average for round-trip flights in September 2026
Search Deals

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Thu 19/11

12:44-17:25

Nonstop7h 41m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£263

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Thu 17/12

18:31-23:17

Nonstop7h 46m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£263

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Mon 14/12

12:40-17:25

Nonstop7h 45m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£263

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Thu 3/12

12:40-17:25

Nonstop7h 45m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£268
Fastest return journey

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Wed 28/10

18:08-23:40

Nonstop7h 32m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£387

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Tue 27/10

18:08-23:40

Nonstop7h 32m

San Francisco

Wed 31/12

00:00-03:00

Nonstop0h 00m

£387

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Thu 22/10

15:50-23:55

1 stop10h 05m

San Francisco

Wed 28/10

14:15-10:35

1 stop18h 20m

£513

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Wed 3/2

12:38-17:25

Nonstop7h 47m

San Francisco

Tue 16/2

00:42-10:46

Nonstop7h 04m

£563

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Thu 21/1

18:31-23:15

Nonstop7h 44m

San Francisco

Wed 27/1

00:40-10:46

Nonstop7h 06m

£635

Panama CitySan Francisco

PTY Panama City Tocumen Intl - SFO San Francisco

PTYSFO

Panama City Tocumen Intl

Tue 19/1

18:31-23:15

Nonstop7h 44m

San Francisco

Wed 27/1

00:40-10:46

Nonstop7h 06m

£635

Flights are sorted by cheapest return flights first.

Deals found on 3/9

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 36 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of £453). Flying from Panama City to San Francisco in February is currently the most expensive (average of £587). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

When flying from Panama City to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Panama City to San Francisco?

Airfare is typical for this route at the moment.

Panama City to San Francisco flights typically cost between £450 and £648 in February.
The cheapest return price found within the last 5 days was £482 on Copa Airlines (3 Feb–17 Feb).

Related info for your journey

  • How long is the flight from Panama City to San Francisco?

    Avianca and Copa Airlines can get you from Panama City to San Francisco in just under 7h 32m. Your travel time can differ by up to 2h 33m. There are 3318 mi between Panama City and San Francisco. Both multi-stop and direct flights can be found to your destination and back.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Francisco?

    Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of £453). Flying from Panama City to San Francisco in February is currently the most expensive (average of £587). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
San Bruno
Roseville
Newark
Bodega Bay
Sunnyvale
South San Francisco

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Panama City to San Francisco

Panama City to Los Angeles flights

Fly with Cheapflights

How does Cheapflights help users find flights from Panama City to San Francisco?

When you search for this flight from Panama City to San Francisco, Cheapflights searches on 900+ travel sites to save you time finding great flight deals online. Additionally, we offer filter features so you can choose a preferred cabin class or airline, see different price ranges, and much more so you can book the flight for you.

Why should you use Cheapflights to find cheap flight tickets from Panama City to San Francisco?

Cheapflights helps you find that perfect flight to San Francisco from Panama City by searching from hundreds of airlines and agencies you know and love. We are also free to use, in case you were wondering!

Can Cheapflights find flights from Panama City to San Francisco with no change fees?

Cheapflights does show flights with no change fees to all users. To see these options for flights from Panama City to San Francisco, users can toggle the no change fees filter when performing a flight search.

Can Cheapflights notify me if prices for flights from Panama City to San Francisco become cheaper?

Yes! Start tracking prices for Panama City to San Francisco flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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