Cheap flights from Panama City to Madrid, Spain from £479
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
16 Sep — 23 Sep1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in February or October, booked 35 days in advance, depart on a Wednesday or Monday and return on a Wednesday
Cheap flight deals from Panama City to Madrid
Enter your travel dates to find the best prices.
Cheapest
Best
Direct
Last-minute
One-way
Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 17 August 2026.
Fri 11/914:23 -
1 stop14h 52m
Fri 18/906:00 -
1 stop17h 50m
Deal found 14/8£560
Sun 18/1015:30 -
2 stops34h 30m
Sat 21/1111:00 -
2 stops33h 45m
Deal found 16/8£564
Mon 5/1021:55 -
2 stops18h 30m
Tue 13/1010:05 -
1 stop16h 40m
Deal found 13/8£566
Wed 7/1009:45 -
2 stops39h 20m
Sat 17/1011:15 -
2 stops39h 16m
Deal found 16/8£567
Wed 30/909:45 -
1 stop16h 15m
Wed 7/1010:50 -
1 stop15h 41m
Deal found 16/8£569
Thu 29/1009:30 -
1 stop17h 45m
Tue 10/1113:25 -
2 stops60h 37m
Deal found 17/8£570
Sun 11/1009:45 -
1 stop16h 15m
Wed 21/1010:50 -
1 stop15h 41m
Deal found 12/8£570
Thu 22/1009:45 -
1 stop16h 15m
Tue 24/1113:25 -
2 stops36h 37m
Deal found 17/8£573
Fri 23/1009:45 -
1 stop16h 15m
Mon 2/1111:00 -
2 stops33h 45m
Deal found 17/8£574
Thu 15/1009:45 -
2 stops38h 05m
Thu 29/1012:25 -
2 stops31h 20m
Deal found 14/8£575
Sat 17/1015:30 -
2 stops33h 35m
Thu 5/1113:25 -
2 stops31h 20m
Deal found 17/8£576
Best flights from Panama City to Madrid
Discover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 17 August 2026.
Wed 28/1009:30 -
1 stop17h 45m
Thu 5/1111:15 -
2 stops38h 23m
Deal found 14/8£567
Tue 22/915:30 -
2 stops57h 35m
Thu 8/1011:15 -
2 stops33h 59m
Deal found 15/8£567
Fri 25/909:45 -
1 stop16h 15m
Thu 10/1211:00 -
2 stops39h 02m
Deal found 12/8£567
Wed 30/909:45 -
1 stop16h 15m
Wed 7/1011:15 -
2 stops33h 59m
Deal found 16/8£567
Fri 2/1009:45 -
1 stop16h 15m
Fri 16/1011:15 -
2 stops39h 16m
Deal found 15/8£567
Sun 24/110:00 -
1 stop17h 15m
Wed 24/211:00 -
2 stops38h 38m
Deal found 14/8£567
Wed 28/1007:55 -
2 stops19h 20m
Thu 12/1111:00 -
2 stops39h 02m
Deal found 13/8£567
Wed 30/909:45 -
1 stop16h 15m
Thu 15/1010:50 -
2 stops38h 47m
Deal found 16/8£567
Wed 28/1009:30 -
1 stop17h 45m
Sat 7/1111:15 -
2 stops38h 23m
Deal found 13/8£567
Fri 2/1009:45 -
1 stop16h 15m
Wed 14/1010:50 -
1 stop15h 41m
Deal found 16/8£567
Sun 11/1015:30 -
2 stops33h 35m
Wed 21/1012:45 -
2 stops37h 46m
Deal found 12/8£576
Direct flights from Panama City to Madrid
Explore direct flight options from Panama City to Madrid based on user searches, and compare prices and availability for your desired travel dates. Data last updated 17 August 2026.
Sun 24/118:35 -
Nonstop10h 05m
Wed 24/212:00 -
Nonstop11h 05m
Deal found 14/8£558
Wed 10/218:35 -
Nonstop10h 05m
Fri 19/212:00 -
Nonstop11h 05m
Deal found 14/8£568
Fri 12/218:35 -
Nonstop10h 05m
Fri 26/212:00 -
Nonstop11h 05m
Deal found 14/8£592
Sun 11/1020:25 -
Nonstop9h 50m
Thu 22/1015:05 -
Nonstop10h 35m
Deal found 17/8£600
Wed 30/920:25 -
Nonstop9h 50m
Wed 7/1015:05 -
Nonstop10h 35m
Deal found 16/8£618
Mon 28/920:25 -
Nonstop9h 50m
Tue 13/1015:05 -
Nonstop10h 35m
Deal found 14/8£623
Wed 30/920:25 -
Nonstop9h 50m
Tue 13/1015:05 -
Nonstop10h 35m
Deal found 17/8£623
Fri 25/920:25 -
Nonstop9h 50m
Tue 13/1015:05 -
Nonstop10h 35m
Deal found 14/8£646
Fri 2/1020:25 -
Nonstop9h 50m
Mon 19/1015:05 -
Nonstop10h 35m
Deal found 17/8£647
Sat 26/920:25 -
Nonstop9h 50m
Sat 3/1015:05 -
Nonstop10h 35m
Deal found 16/8£650
Thu 24/920:25 -
Nonstop9h 50m
Sat 10/1015:05 -
Nonstop10h 35m
Deal found 13/8£668
Last-minute flights from Panama City to Madrid
Discover last-minute flight deals from Panama City to Madrid. Data last updated 17 August 2026 and is based on user searches.
Fri 11/914:23 -
1 stop14h 52m
Fri 18/906:00 -
1 stop17h 50m
Deal found 14/8£560
Mon 14/915:30 -
2 stops34h 30m
Mon 28/910:50 -
1 stop15h 41m
Deal found 17/8£570
Mon 14/909:45 -
2 stops24h 00m
Mon 21/910:50 -
1 stop15h 41m
Deal found 14/8£587
Tue 15/915:30 -
2 stops33h 35m
Wed 23/910:50 -
1 stop15h 41m
Deal found 17/8£574
Thu 17/909:45 -
1 stop16h 15m
Thu 24/910:50 -
1 stop15h 41m
Deal found 17/8£570
Tue 22/909:45 -
1 stop16h 15m
Wed 7/1005:55 -
2 stops20h 36m
Deal found 15/8£586
Wed 23/910:00 -
2 stops39h 05m
Sat 3/1006:20 -
2 stops20h 11m
Deal found 14/8£582
Thu 24/909:45 -
1 stop16h 15m
Thu 8/1013:30 -
2 stops37h 01m
Deal found 14/8£573
Fri 25/909:45 -
1 stop16h 15m
Fri 9/1010:50 -
1 stop15h 41m
Deal found 16/8£567
Wed 30/909:45 -
1 stop16h 15m
Wed 7/1010:50 -
1 stop15h 41m
Deal found 16/8£569
One-way flights from Panama City to Madrid
Search for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated 17 August 2026.
Mon 21/921:05 -
Nonstop10h 05m
Deal found 17/8£479
Sun 29/1118:35 -
Nonstop10h 05m
Deal found 17/8£480
Mon 12/1020:25 -
Nonstop9h 50m
Deal found 14/8£497
Sat 26/920:25 -
Nonstop9h 50m
Deal found 12/8£498
Tue 29/921:55 -
2 stops18h 30m
Deal found 13/8£501
Sun 20/920:25 -
Nonstop9h 50m
Deal found 12/8£509
Mon 21/922:20 -
1 stop29h 05m
Deal found 16/8£530
Fri 22/122:00 -
1 stop33h 15m
Deal found 17/8£531
Find flight deals from Panama City to Madrid
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 17 August 2026.
Customise your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 17 August 2026.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 28/10
09:30-09:15
1 stop17h 45m
Madrid Barajas
Thu 5/11
11:15-19:38
2 stops38h 23m
£567
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Tue 22/9
15:30-08:05
2 stops57h 35m
Madrid Barajas
Thu 8/10
11:15-14:14
2 stops33h 59m
£567
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 25/9
09:45-09:00
1 stop16h 15m
Madrid Barajas
Thu 10/12
11:00-20:02
2 stops39h 02m
£567
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 30/9
09:45-09:00
1 stop16h 15m
Madrid Barajas
Wed 7/10
11:15-14:14
2 stops33h 59m
£567
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 2/10
09:45-09:00
1 stop16h 15m
Madrid Barajas
Fri 16/10
11:15-19:31
2 stops39h 16m
£567
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Sun 24/1
10:00-09:15
1 stop17h 15m
Madrid Barajas
Wed 24/2
11:00-19:38
2 stops38h 38m
£567
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 28/10
07:55-09:15
2 stops19h 20m
Madrid Barajas
Thu 12/11
11:00-20:02
2 stops39h 02m
£567
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 30/9
09:45-09:00
1 stop16h 15m
Madrid Barajas
Thu 15/10
10:50-18:37
2 stops38h 47m
£567
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 28/10
09:30-09:15
1 stop17h 45m
Madrid Barajas
Sat 7/11
11:15-19:38
2 stops38h 23m
£567
Fastest return journey
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 2/10
09:45-09:00
1 stop16h 15m
Madrid Barajas
Wed 14/10
10:50-19:31
1 stop15h 41m
£567
Flights are sorted by cheapest return flights first.
Deals found on 16/8
Showing 1-10 of 19 resultsSorted by cheapest first
1
2
Best time to book a flight from Panama City to Madrid
Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
PTY-MAD
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Madrid
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Madrid?
To ensure you get the cheapest price possible for a flight from Panama City to Madrid, you should look to book at least 34 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of £553). Flying from Panama City to Madrid in December is currently the most expensive (average of £721). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to MAD?
Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 17 August 2026.
When flying from Panama City to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost for a return flight from Panama City to Madrid?
Airfare is below average for this route at the moment.
Panama City to Madrid flights typically cost between £603 and £844 in January.The cheapest return price found within the last 5 days was £558 on Iberia (24 Jan–24 Feb).
Weekly flight availability from Panama City to Madrid
Explore weekly flight availability from Panama City to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 17 August 2026.
The most flights from PTY to MAD are scheduled on a Monday (10 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (4 on average).
How often are flights from Panama City to Madrid delayed?
About 12% of weekly flights between Panama City and Madrid have experienced delays in the past year, with the average delay time being 146 minutes.
What is the most punctual flight time for Panama City to Madrid flights?
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Tuesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Madrid flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 9% of flights being delayed.
Reviews of airlines servicing Madrid
Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated 17 August 2026.
See what other customers who have flown with Air Europa from Panama City to Madrid have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
The food was below average for a business class flight
Related info for your journey
Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Panama City to Madrid?
If you book a flight from Panama City to Madrid, you will be flying from Tocumen Intl to Barajas. Flights to Madrid Barajas (MAD) from Panama City Tocumen Intl (PTY) take 9h 35m for a nonstop flight. There are 6 flights from Tocumen Intl to Madrid per day from 1 airline.
How popular is this Panama City to Madrid flight route?
Flights from Panama City Tocumen Intl to Madrid Barajas have been viewed 12 times in the past calendar month.
How long is the flight from Panama City to Madrid?
A quick flight from Panama City to Madrid can take about 17h 45m. United Airlines provides one of the quickest options available for as low as £567. Airlines will cover a distance of 5065 mi.
What is the cheapest airline to fly from Panama City to Madrid round-trip?
According to our current data, Air Europa (£517), offers the cheapest pricing from Panama City to Madrid. Air Europa is 17% cheaper than the average price of flights available within the next 90 days to this destination.
What are the most reliable airlines from Panama City to Madrid?
The top 3 most reliable airlines when flying from Panama City to Madrid are Qatar Airways (77%), Air Europa (77%) and Etihad Airways (77%).
What are the cheapest flights from Panama City to Madrid?
Looking at all options, your cheapest flight can be booked for £487. While the most popular route (Panama City Tocumen Intl - Madrid Barajas) can be booked for £567 on average, our data indicates £495 when flying from Panama City to Madrid.
Can I find deals for business class flights from Panama City to Madrid?
Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of £553). Flying from Panama City to Madrid in December is currently the most expensive (average of £721). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Explore flights to Madrid departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 17 August 2026.
Discover the top airline that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 17 August 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Panama City to Madrid?
Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama City to Madrid. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.
Why should you use Cheapflights to find cheap flight tickets from Panama City to Madrid?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City to Madrid for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Panama City to Madrid with no change fees?
Certainly. Search results for flights to Madrid from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.
Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?
Of course! You can now track prices for flights from Panama City to Madrid and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
We value your privacy
Cheapflights and its partners wish to use cookies or similar technologies to store and/or access information on and about your device and process personal data such as your IP address, device identifiers etc., in order to improve your experience on the site, to analyse navigation, to offer and measure personalised advertising, and to facilitate sharing on social networks. We also allow the use of third-party cookies (including those from our advertising partners) on our sites.
By clicking 'Accept', you consent to your data being processed by 0 vendors on this web site for the purposes described in this notice. You can review the vendors and their individual processing purposes on the .
To review individual processing purposes and cookie categories, please click ’Select individual purposes’. You can review your choices and withdraw your consent at any time by clicking the ’Privacy Preferences’ link in the page side navigation.