Cheap flights from Panama City to Madrid, Spain from £489
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 31/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
18 Jul — 25 Jul1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in February or October, booked 35 days in advance, depart on a Wednesday or Friday and return on a Wednesday
Cheap flight deals from Panama City to Madrid
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Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 18 June 2026.
Wed 19/822:55
PTY
-
MAD
1 stop27h 05m
United Airlines
Sun 13/911:15
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 15/6£583
Tue 1/922:55
PTY
-
MAD
2 stops24h 55m
United Airlines
Sat 12/912:45
MAD
-
PTY
2 stops37h 46m
United Airlines
Deal found 16/6£584
Mon 14/909:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Sun 4/1013:30
MAD
-
PTY
2 stops36h 07m
United Airlines
Deal found 15/6£585
Fri 23/1009:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Fri 6/1111:00
MAD
-
PTY
2 stops33h 45m
United Airlines
Deal found 16/6£586
Thu 1/1009:45
PTY
-
MAD
2 stops38h 05m
United Airlines
Sat 24/1013:30
MAD
-
PTY
2 stops36h 08m
United Airlines
Deal found 16/6£588
Wed 30/909:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Sat 17/1013:30
MAD
-
PTY
2 stops31h 44m
United Airlines
Deal found 16/6£588
Sun 6/915:30
PTY
-
MAD
2 stops34h 30m
United Airlines
Sun 27/913:30
MAD
-
PTY
2 stops36h 07m
United Airlines
Deal found 15/6£592
Fri 17/722:55
PTY
-
MAD
2 stops26h 10m
United Airlines
Thu 30/706:20
MAD
-
PTY
2 stops20h 11m
United Airlines
Deal found 14/6£595
Tue 28/714:24
PTY
-
MAD
2 stops19h 21m
Multiple Airlines
Tue 25/806:00
MAD
-
PTY
2 stops20h 45m
Multiple Airlines
Deal found 15/6£595
Sun 30/822:55
PTY
-
MAD
2 stops24h 55m
United Airlines
Fri 18/906:20
MAD
-
PTY
2 stops20h 11m
United Airlines
Deal found 17/6£597
Best flights from Panama City to Madrid
Discover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 18 June 2026.
Tue 18/815:30
PTY
-
MAD
2 stops34h 30m
United Airlines
Wed 31/310:50
MAD
-
PTY
1 stop15h 41m
United Airlines
Deal found 15/6£586
Tue 6/1015:30
PTY
-
MAD
2 stops34h 30m
United Airlines
Wed 14/1011:15
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 15/6£589
Sun 30/822:55
PTY
-
MAD
2 stops29h 55m
United Airlines
Mon 21/910:50
MAD
-
PTY
1 stop15h 41m
United Airlines
Deal found 17/6£600
Fri 4/909:45
PTY
-
MAD
2 stops19h 05m
United Airlines
Mon 28/911:15
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 15/6£607
Fri 7/807:55
PTY
-
MAD
2 stops21h 25m
United Airlines
Sun 30/810:50
MAD
-
PTY
1 stop15h 41m
United Airlines
Deal found 14/6£613
Thu 17/909:45
PTY
-
MAD
2 stops23h 25m
United Airlines
Thu 24/911:15
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 16/6£620
Wed 7/1009:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Sat 17/1010:50
MAD
-
PTY
1 stop15h 41m
United Airlines
Deal found 18/6£623
Sat 11/709:45
PTY
-
MAD
2 stops39h 20m
United Airlines
Mon 20/710:50
MAD
-
PTY
1 stop15h 41m
United Airlines
Deal found 17/6£660
Fri 3/709:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Sat 11/711:15
MAD
-
PTY
2 stops38h 22m
United Airlines
Deal found 15/6£660
Sun 12/709:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Wed 29/710:50
MAD
-
PTY
1 stop24h 14m
United Airlines
Deal found 14/6£660
Sat 4/709:45
PTY
-
MAD
2 stops39h 20m
United Airlines
Mon 28/911:15
MAD
-
PTY
2 stops38h 22m
United Airlines
Deal found 16/6£660
Fri 17/709:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Wed 29/710:50
MAD
-
PTY
1 stop24h 14m
United Airlines
Deal found 14/6£660
Direct flights from Panama City to Madrid
Explore direct flight options from Panama City to Madrid based on user searches, and compare prices and availability for your desired travel dates. Data last updated 18 June 2026.
Wed 7/1020:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Thu 22/1015:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 16/6£613
Wed 16/921:05
PTY
-
MAD
Nonstop10h 05m
Iberia
Mon 28/915:55
MAD
-
PTY
Nonstop10h 40m
Iberia
Deal found 16/6£618
Sun 12/721:05
PTY
-
MAD
Nonstop10h 05m
Iberia
Sun 23/815:55
MAD
-
PTY
Nonstop10h 40m
Iberia
Deal found 18/6£622
Mon 19/1020:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Fri 20/1115:10
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 16/6£625
Fri 24/720:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Fri 21/815:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 16/6£637
Sun 18/1020:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Thu 19/1115:10
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 16/6£653
Wed 29/720:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Wed 19/815:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 16/6£661
Sun 20/920:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 3/1015:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 14/6£665
Thu 15/1020:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Mon 16/1115:10
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 16/6£665
Sat 25/720:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 22/815:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 16/6£685
Thu 30/720:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Thu 27/815:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 16/6£690
Mon 7/921:05
PTY
-
MAD
Nonstop10h 05m
Iberia
Fri 11/915:55
MAD
-
PTY
Nonstop10h 40m
Iberia
Deal found 16/6£693
Last-minute flights from Panama City to Madrid
Discover last-minute flight deals from Panama City to Madrid. Data last updated 18 June 2026 and is based on user searches.
Sun 12/709:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Tue 28/705:55
MAD
-
PTY
2 stops29h 09m
United Airlines
Deal found 14/6£600
Tue 14/709:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Thu 13/810:50
MAD
-
PTY
1 stop15h 41m
United Airlines
Deal found 14/6£583
Wed 15/722:55
PTY
-
MAD
2 stops26h 10m
United Airlines
Thu 30/706:05
MAD
-
PTY
2 stops28h 59m
United Airlines
Deal found 17/6£592
Wed 15/715:30
PTY
-
MAD
2 stops33h 35m
Multiple Airlines
Wed 22/718:25
MAD
-
PTY
2 stops40h 39m
Multiple Airlines
Deal found 15/6£601
Thu 16/722:55
PTY
-
MAD
2 stops26h 10m
United Airlines
Wed 29/705:55
MAD
-
PTY
2 stops29h 09m
United Airlines
Deal found 15/6£598
Fri 17/709:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Thu 30/706:20
MAD
-
PTY
2 stops28h 44m
United Airlines
Deal found 14/6£595
Tue 28/714:24
PTY
-
MAD
2 stops19h 21m
Multiple Airlines
Tue 25/806:00
MAD
-
PTY
2 stops20h 45m
Multiple Airlines
Deal found 15/6£595
Fri 31/709:45
PTY
-
MAD
1 stop16h 15m
United Airlines
Fri 21/811:15
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 16/6£586
One-way flights from Panama City to Madrid
Search for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated 18 June 2026.
Fri 31/722:20
PTY
-
MAD
1 stop32h 15m
Turkish Airlines
Deal found 18/6£489
Mon 21/921:05
PTY
-
MAD
Nonstop10h 05m
Iberia
Deal found 15/6£502
Sun 19/721:05
PTY
-
MAD
Nonstop10h 05m
Iberia
Deal found 17/6£502
Mon 3/821:05
PTY
-
MAD
Nonstop10h 05m
Iberia
Deal found 16/6£503
Sun 20/921:05
PTY
-
MAD
Nonstop10h 05m
Iberia
Deal found 14/6£505
Sat 8/820:25
PTY
-
MAD
Nonstop9h 50m
Copa Airlines
Deal found 16/6£508
Sun 9/814:20
PTY
-
MAD
2 stops19h 25m
Air France
Deal found 18/6£509
Mon 3/814:20
PTY
-
MAD
2 stops19h 25m
Air France
Deal found 16/6£509
Mon 21/921:55
PTY
-
MAD
2 stops18h 30m
KLM
Deal found 15/6£510
Mon 12/1021:55
PTY
-
MAD
2 stops18h 30m
KLM
Deal found 16/6£512
Mon 6/722:20
PTY
-
MAD
1 stop41h 15m
Turkish Airlines
Deal found 15/6£514
Find flight deals from Panama City to Madrid
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 18 June 2026.
Customise your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 18 June 2026.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Tue 18/8
15:30-09:00
2 stops34h 30m
Madrid Barajas
Wed 31/3
10:50-19:31
1 stop15h 41m
£586
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Tue 6/10
15:30-09:00
2 stops34h 30m
Madrid Barajas
Wed 14/10
11:15-14:14
2 stops33h 59m
£589
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Sun 30/8
22:55-11:50
2 stops29h 55m
Madrid Barajas
Mon 21/9
10:50-19:31
1 stop15h 41m
£600
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Fri 4/9
09:45-11:50
2 stops19h 05m
Madrid Barajas
Mon 28/9
11:15-14:14
2 stops33h 59m
£607
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Fri 7/8
07:55-12:20
2 stops21h 25m
Madrid Barajas
Sun 30/8
10:50-19:31
1 stop15h 41m
£613
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Thu 17/9
09:45-16:10
2 stops23h 25m
Madrid Barajas
Thu 24/9
11:15-14:14
2 stops33h 59m
£620
Fastest return journey
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Wed 7/10
09:45-09:00
1 stop16h 15m
Madrid Barajas
Sat 17/10
10:50-19:31
1 stop15h 41m
£623
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Sat 11/7
09:45-08:05
2 stops39h 20m
Madrid Barajas
Mon 20/7
10:50-19:31
1 stop15h 41m
£660
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Fri 3/7
09:45-09:00
1 stop16h 15m
Madrid Barajas
Sat 11/7
11:15-18:37
2 stops38h 22m
£660
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Sun 12/7
09:45-09:00
1 stop16h 15m
Madrid Barajas
Wed 29/7
10:50-04:04
1 stop24h 14m
£660
Flights are sorted by cheapest return flights first.
Deals found on 18/6
Showing 1-10 of 20 resultsSorted by cheapest first
1
2
Best time to book a flight from Panama City to Madrid
Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
PTY-MAD
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Madrid
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Madrid?
To ensure you get the cheapest price possible for a flight from Panama City to Madrid, you should look to book at least 90 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of £554). Flying from Panama City to Madrid in December is currently the most expensive (average of £730). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to MAD?
Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 18 June 2026.
When flying from Panama City to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost for a return flight from Panama City to Madrid?
Weekly flight availability from Panama City to Madrid
Explore weekly flight availability from Panama City to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 18 June 2026.
The most flights from PTY to MAD are scheduled on a Wednesday (10 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (5 on average).
How often are flights from Panama City to Madrid delayed?
About 12% of weekly flights between Panama City and Madrid have experienced delays in the past year, with the average delay time being 144 minutes.
What is the most punctual flight time for Panama City to Madrid flights?
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Sunday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Madrid flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 10% of flights being delayed.
Reviews of airlines servicing Madrid
Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated 18 June 2026.
See what other customers who have flown with Air Europa from Panama City to Madrid have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Everything went well. We had a baggage issue but it was taken care of. Staff was very friendly.
Related info for your journey
Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Panama City to Madrid?
If you book a flight from Panama City to Madrid, you will be flying from Tocumen Intl to Barajas. Flights to Madrid Barajas (MAD) from Panama City Tocumen Intl (PTY) take 9h 50m for a nonstop flight. There are 6 flights from Tocumen Intl to Madrid per day from 1 airline.
How popular is this Panama City to Madrid flight route?
Flights from Panama City Tocumen Intl to Madrid Barajas have been viewed 16 times in the past calendar month.
How long is the flight from Panama City to Madrid?
A quick flight from Panama City to Madrid can take about 34h 30m. United Airlines provides one of the quickest options available for as low as £589. Airlines will cover a distance of 5065 mi.
What is the cheapest airline to fly from Panama City to Madrid round-trip?
According to our current data, Air Europa (£531), offers the cheapest pricing from Panama City to Madrid. Air Europa is 15% cheaper than the average price of flights available within the next 90 days to this destination.
What are the most reliable airlines from Panama City to Madrid?
The top 3 most reliable airlines when flying from Panama City to Madrid are Air Europa (90%), Etihad Airways (90%) and China Eastern (90%).
What are the cheapest flights from Panama City to Madrid?
Looking at all options, your cheapest flight can be booked for £500. While the most popular route (Panama City Tocumen Intl - Madrid Barajas) can be booked for £784 on average, our data indicates £698 when flying from Panama City to Madrid.
Can I find deals for business class flights from Panama City to Madrid?
Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of £554). Flying from Panama City to Madrid in December is currently the most expensive (average of £730). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Discover the top airline that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 18 June 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Panama City to Madrid?
Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama City to Madrid. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.
Why should you use Cheapflights to find cheap flight tickets from Panama City to Madrid?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City to Madrid for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Panama City to Madrid with no change fees?
Certainly. Search results for flights to Madrid from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.
Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?
Of course! You can now track prices for flights from Panama City to Madrid and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
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