Cheap flights from Panama City to Madrid, Spain from £386
This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
20 Nov — 27 Nov1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in February or May, booked 55 days in advance, depart on a Monday or Wednesday and return on a Wednesday
Cheap flight deals from Panama City to Madrid
Enter your travel dates to find the best prices.
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Best
Direct
Last-minute
One-way
Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 21 October 2026.
Sun 27/1202:30 -
1 stop23h 40m
Sat 23/108:10 -
1 stop23h 10m
Deal found 19/10£561
Wed 30/1210:05 -
1 stop21h 20m
Fri 22/110:10 -
1 stop21h 10m
Deal found 19/10£564
Tue 17/1110:00 -
1 stop17h 30m
Thu 26/1111:15 -
2 stops38h 23m
Deal found 20/10£575
Mon 28/1223:55 -
2 stops26h 05m
Sun 7/211:15 -
2 stops33h 30m
Deal found 21/10£577
Mon 28/1223:55 -
2 stops26h 05m
Tue 26/113:25 -
2 stops36h 37m
Deal found 19/10£579
Wed 18/1110:00 -
1 stop17h 30m
Tue 8/1213:25 -
2 stops36h 37m
Deal found 19/10£580
Wed 18/1110:00 -
1 stop17h 30m
Mon 7/1211:15 -
2 stops33h 30m
Deal found 20/10£582
Mon 28/1223:55 -
2 stops26h 05m
Wed 20/113:25 -
2 stops31h 20m
Deal found 20/10£583
Wed 30/1216:41 -
2 stops33h 04m
Thu 4/213:25 -
2 stops36h 37m
Deal found 20/10£584
Sun 22/1116:41 -
2 stops34h 49m
Mon 7/1206:25 -
2 stops19h 37m
Deal found 19/10£589
Tue 17/1110:00 -
1 stop17h 30m
Wed 2/1206:25 -
2 stops19h 37m
Deal found 20/10£593
Best flights from Panama City to Madrid
Discover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 21 October 2026.
Fri 27/1108:55 -
2 stops18h 35m
Sun 13/1211:00 -
2 stops33h 45m
Deal found 16/10£575
Tue 16/321:30 -
Nonstop9h 35m
Tue 30/315:05 -
Nonstop10h 35m
Deal found 19/10£630
Mon 1/210:00 -
1 stop17h 30m
Sun 21/211:00 -
2 stops39h 02m
Deal found 19/10£579
Wed 27/116:41 -
2 stops34h 49m
Thu 11/211:15 -
2 stops33h 30m
Deal found 19/10£579
Mon 18/116:41 -
2 stops34h 49m
Sat 6/211:15 -
2 stops35h 57m
Deal found 17/10£579
Tue 9/210:00 -
1 stop17h 30m
Sun 28/211:15 -
2 stops38h 23m
Deal found 18/10£579
Mon 18/116:41 -
2 stops34h 49m
Thu 28/111:15 -
2 stops33h 30m
Deal found 19/10£579
Sun 24/110:00 -
1 stop17h 30m
Sun 14/213:25 -
2 stops36h 37m
Deal found 16/10£581
Wed 30/1216:41 -
2 stops33h 04m
Thu 4/213:25 -
2 stops36h 37m
Deal found 19/10£584
Wed 27/110:00 -
1 stop17h 30m
Fri 12/211:15 -
2 stops35h 57m
Deal found 17/10£619
Wed 3/210:00 -
1 stop17h 30m
Mon 15/211:15 -
2 stops35h 57m
Deal found 21/10£619
Mon 18/110:00 -
2 stops25h 50m
Mon 25/111:15 -
2 stops33h 30m
Deal found 18/10£636
Direct flights from Panama City to Madrid
Explore direct flight options from Panama City to Madrid based on user searches, and compare prices and availability for your desired travel dates. Data last updated 21 October 2026.
Thu 15/420:25 -
Nonstop9h 50m
Sat 1/515:05 -
Nonstop10h 35m
Deal found 16/10£604
Wed 14/420:25 -
Nonstop9h 50m
Sun 2/515:05 -
Nonstop10h 35m
Deal found 17/10£606
Mon 8/321:30 -
Nonstop9h 35m
Sun 30/515:05 -
Nonstop10h 35m
Deal found 16/10£607
Wed 27/118:35 -
Nonstop10h 05m
Wed 10/212:00 -
Nonstop11h 05m
Deal found 16/10£623
Tue 16/321:30 -
Nonstop9h 35m
Tue 30/315:05 -
Nonstop10h 35m
Deal found 18/10£630
Wed 24/318:35 -
Nonstop10h 05m
Wed 7/415:55 -
Nonstop11h 05m
Deal found 16/10£647
Fri 22/118:35 -
Nonstop10h 05m
Wed 3/212:00 -
Nonstop11h 05m
Deal found 20/10£651
Wed 3/221:30 -
Nonstop9h 35m
Fri 26/215:10 -
Nonstop10h 35m
Deal found 18/10£654
Tue 2/221:30 -
Nonstop9h 35m
Thu 25/215:10 -
Nonstop10h 35m
Deal found 18/10£678
Wed 4/1121:30 -
Nonstop9h 35m
Wed 18/1115:10 -
Nonstop10h 35m
Deal found 20/10£684
Mon 1/221:30 -
Nonstop9h 35m
Wed 24/215:10 -
Nonstop10h 35m
Deal found 18/10£702
Last-minute flights from Panama City to Madrid
Discover last-minute flight deals from Panama City to Madrid. Data last updated 21 October 2026 and is based on user searches.
Mon 16/1110:00 -
2 stops19h 45m
Mon 23/1111:00 -
2 stops38h 38m
Deal found 19/10£594
Tue 17/1110:00 -
1 stop17h 30m
Thu 26/1111:15 -
2 stops38h 23m
Deal found 20/10£575
Tue 17/1108:55 -
2 stops18h 35m
Tue 24/1113:25 -
2 stops60h 37m
Deal found 17/10£577
Tue 17/1110:00 -
1 stop17h 30m
Wed 2/1206:25 -
2 stops19h 37m
Deal found 20/10£593
Wed 18/1110:00 -
1 stop17h 30m
Tue 8/1213:25 -
2 stops36h 37m
Deal found 19/10£580
Wed 18/1110:00 -
1 stop17h 30m
Mon 7/1211:15 -
2 stops33h 30m
Deal found 20/10£582
Wed 18/1110:00 -
2 stops28h 15m
Wed 25/1111:00 -
2 stops39h 02m
Deal found 16/10£607
Sun 22/1116:41 -
2 stops34h 49m
Mon 7/1206:25 -
2 stops19h 37m
Deal found 19/10£589
Tue 24/1116:41 -
2 stops33h 04m
Thu 10/1213:25 -
2 stops36h 37m
Deal found 20/10£584
One-way flights from Panama City to Madrid
Search for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated 21 October 2026.
Tue 10/1121:31 -
2 stops37h 39m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 19/10£386
Fri 25/1221:55 -
1 stop15h 40m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 21/10£461
Wed 4/1118:45 -
1 stop15h 20m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 19/10£462
Mon 30/1118:45 -
1 stop22h 50m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 20/10£463
Fri 4/1218:45 -
1 stop15h 20m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 20/10£463
Wed 3/210:05 -
1 stop14h 05m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 18/10£482
Fri 27/1118:35 -
Nonstop10h 05m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 20/10£487
Mon 19/421:55 -
2 stops18h 30m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 17/10£514
Mon 22/218:10 -
1 stop23h 15m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 17/10£516
Find flight deals from Panama City to Madrid
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 21 October 2026.
Customise your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 21 October 2026.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 4/11
18:45-16:05
1 stop15h 20m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£462
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Sun 8/11
18:45-19:35
1 stop18h 50m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£462
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 4/12
18:45-16:05
1 stop15h 20m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£463
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 30/11
18:45-19:35
1 stop18h 50m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£469
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 27/11
18:35-10:40
Nonstop10h 05m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£487
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Thu 5/11
22:30-23:35
2 stops19h 05m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£487
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 8/3
16:10-08:10
1 stop34h 00m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£516
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 18/1
22:00-10:25
1 stop30h 25m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£538
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 27/11
08:55-09:30
2 stops18h 35m
Madrid Barajas
Sun 13/12
11:00-14:45
2 stops33h 45m
£575
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 1/2
10:00-09:30
1 stop17h 30m
Madrid Barajas
Sun 21/2
11:00-20:02
2 stops39h 02m
£579
Flights are sorted by cheapest return flights first.
Deals found on 18/10
Showing 1-10 of 22 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Madrid
Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
PTY-MAD
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Madrid
Prices
Delays
How far ahead should I book a flight from Panama City to Madrid?
To ensure you get the cheapest price possible for a flight from Panama City to Madrid, you should look to book at least 90 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of £567). Flying from Panama City to Madrid in July is currently the most expensive (average of £725). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to MAD?
Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 21 October 2026.
When flying from Panama City to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost for a return flight from Panama City to Madrid?
Airfare is typical for this route at the moment.
Panama City to Madrid flights typically cost between £547 and £689 in December.The cheapest return price found within the last 5 days was £561 on Avianca (27 Dec–23 Jan).
How often are flights from Panama City to Madrid delayed?
About 13% of weekly flights between Panama City and Madrid have experienced delays in the past year, with the average delay time being 153 minutes.
What is the most punctual flight time for Panama City to Madrid flights?
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Tuesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Madrid flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 10% of flights being delayed.
Reviews of airlines servicing Madrid
Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated 21 October 2026.
See what other customers who have flown with Air Europa from Panama City to Madrid have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew was good, food could be better, moovie selection poor
Related info for your journey
Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Panama City to Madrid?
If you book a flight from Panama City to Madrid, you will be flying from Tocumen Intl to Barajas. Flights to Madrid Barajas (MAD) from Panama City Tocumen Intl (PTY) take 9h 35m for a nonstop flight. There are 3 flights from Tocumen Intl to Madrid per day from 1 airline.
How popular is this Panama City to Madrid flight route?
Flights from Panama City Tocumen Intl to Madrid Barajas have been viewed 10 times in the past calendar month.
How long is the flight from Panama City to Madrid?
A quick flight from Panama City to Madrid can take about 18h 35m. United Airlines provides one of the quickest options available for as low as £575. Airlines will cover a distance of 5065 mi.
What is the cheapest airline to fly from Panama City to Madrid round-trip?
According to our current data, Air Europa (£527), offers the cheapest pricing from Panama City to Madrid. Air Europa is 17% cheaper than the average price of flights available within the next 90 days to this destination.
What are the most reliable airlines from Panama City to Madrid?
The top 3 most reliable airlines when flying from Panama City to Madrid are Air Europa (80%), Etihad Airways (80%) and China Eastern (80%).
What are the cheapest flights from Panama City to Madrid?
Looking at all options, your cheapest flight can be booked for £527. While the most popular route (Panama City Tocumen Intl - Madrid Barajas) can be booked for £621 on average, our data indicates £579 when flying from Panama City to Madrid.
Can I find deals for business class flights from Panama City to Madrid?
Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of £567). Flying from Panama City to Madrid in July is currently the most expensive (average of £725). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Explore flights to Madrid departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 21 October 2026.
Discover the top airline that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 21 October 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Panama City to Madrid?
Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama City to Madrid. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.
Why should you use Cheapflights to find cheap flight tickets from Panama City to Madrid?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City to Madrid for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Panama City to Madrid with no change fees?
Certainly. Search results for flights to Madrid from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.
Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?
Of course! You can now track prices for flights from Panama City to Madrid and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
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