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Cheap flights from Panama City to Madrid, Spain from £320

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
18 Jun — 25 Jun1
1 adult

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in March or February, booked 58 days in advance, depart on a Saturday or Tuesday and return on a Monday

Cheap flight deals from Panama City to Madrid

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 13 June 2025.

Round-trip from

£526

One-way from

£320

Popular in

July

Cheapest in

March

Average price

£580

Good round-trip deal

£637 or less

Good one-way deal

£459 or less
KLM
  • KLM
  • 5/7-26/9
  • 2 total stops
  • 51h 10m total
  • Panama City to Madrid
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Turkish Airlines
  • Turkish Airlines
  • 21/9
  • 1 total stop
  • 32h 40m total
  • Panama City to Madrid
Search Deals
Highest demand for flights based on searches. 9% potential increase in price (£41 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£7 potential savings vs. average return price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Madrid Barajas.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Madrid Barajas.
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Find flight deals from Panama City to Madrid

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 13 June 2025.

Sat 5/719:55PTY - MAD
1 stop16h 25mMultiple Airlines
Fri 26/913:05MAD - PTY
1 stop34h 45mMultiple Airlines
Deal found 11/6£526
Sun 12/1020:25PTY - MAD
Nonstop9h 50mAir Europa
Mon 27/1015:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 11/6£533
Wed 17/921:55PTY - MAD
1 stop29h 30mTurkish Airlines
Tue 7/1012:00MAD - PTY
1 stop39h 00mTurkish Airlines
Deal found 12/6£545
Tue 4/1118:45PTY - MAD
1 stop15h 20mKLM
Tue 18/1120:35MAD - PTY
1 stop25h 50mKLM
Deal found 11/6£552
Thu 30/1003:19PTY - MAD
1 stop13h 16mAvianca
Wed 5/1110:55MAD - PTY
1 stop16h 05mAvianca
Deal found 11/6£588
Sun 5/1009:45PTY - MAD
1 stop16h 15mUnited Airlines
Wed 15/1011:15MAD - PTY
2 stops38h 22mUnited Airlines
Deal found 12/6£622

Cheapflights Fare Finder

Customise your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 13 June 2025.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Panama City

Fly to

Madrid

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 5/7

19:55-19:20

1 stop16h 25m

Madrid Barajas

Fri 26/9

13:05-16:50

1 stop34h 45m

£526

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 12/10

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Mon 27/10

15:10-19:45

Nonstop10h 35m

£533

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 17/9

21:55-10:25

1 stop29h 30m

Madrid Barajas

Tue 7/10

12:00-20:00

1 stop39h 00m

£545

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 4/11

18:45-16:05

1 stop15h 20m

Madrid Barajas

Tue 18/11

20:35-16:25

1 stop25h 50m

£552

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 30/10

03:19-22:35

1 stop13h 16m

Madrid Barajas

Wed 5/11

10:55-21:00

1 stop16h 05m

£588

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 5/10

09:45-09:00

1 stop16h 15m

Madrid Barajas

Wed 15/10

11:15-18:37

2 stops38h 22m

£622

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 21/9

21:55-13:35

1 stop32h 40m

£320

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 13/10

13:30-14:05

2 stops17h 35m

£354

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 8/7

18:50-12:05

1 stop34h 15m

£373

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 3/7

20:25-13:15

Nonstop9h 50m

£388

Flights are sorted by cheapest return flights first.

Deals found on 13/6

Showing 1-10 of 13 results
1
2

Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

Use this chart to determine the optimal time to book a return flight from Panama City to Madrid. Price data was last updated on 9 June 2025.

To ensure you get the cheapest price possible for a flight from Panama City to Madrid, you should look to book at least 58 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, January is the cheapest month in which you can book a flight from Panama City to Madrid (average of £94). Flying from Panama City to Madrid in August is currently the most expensive (average of £266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 13 June 2025.

It’s optimal to fly from Panama City to Madrid in the morning. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight at midday.

Weekly flight availability from Panama City to Madrid

Explore weekly flight availability from Panama City to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 13 June 2025.

The most flights from PTY to MAD are scheduled on a Saturday (9 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (3 on average).

Rainfall in Madrid by month

Plan your trip to Madrid by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Madrid ranges from 10.0 - 60.0 inches per month. November is typically the wettest month, when rainfall can reach 60.0 mm. July is typically the driest time to visit Madrid when rainfall is around 10.0 mm.

Temperature in Madrid by month

Plan your trip to Madrid by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Madrid, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 25.0 C. Travellers hoping to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 5.0 C).

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated 13 June 2025.
See what other customers who have flown with KLM, United Airlines and Turkish Airlines from Panama City to Madrid have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,358 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.2

Overall

7.8

Boarding

7.8

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
KLM
7.8
Good
1,358 reviews
KLM
7.8
Good
1,358 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.2

Overall

7.8

Boarding

7.8

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
United Airlines
7.4
Good
8,790 reviews
KLM
7.8
Good
1,358 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.2

Overall

7.8

Boarding

7.8

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
Turkish Airlines
7.3
Good
3,849 reviews
KLM
7.8
Good
1,358 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.2

Overall

7.8

Boarding

7.8

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
Iberia
7.0
Good
2,776 reviews
KLM
7.8
Good
1,358 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.2

Overall

7.8

Boarding

7.8

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.
Air Europa
6.9
Okay
529 reviews
KLM
7.8
Good
1,358 reviews
Check prices

Comfort

7.7

Entertainment

7.1

Crew

8.4

Food

7.2

Overall

7.8

Boarding

7.8

Reviews

1 / 20
8.0
Excellent

Allan,Jun 2025

YYZ - AMS

I always enjoy flying KLM. Service is attentive, friendly and professional. The seat, when fully reclined is a little hard; some kind of mattress or topper would be helpful here. The dinner was really not very good …. “Meatless meatballs” tasted quite peculiar. Breakfast which consisted of an egg white omelette in flour tortilla was also rather tasteless.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Madrid?

    If you book a flight from Panama City to Madrid, you will be flying from Tocumen Intl to Barajas. Flights to Madrid Barajas (MAD) from Panama City Tocumen Intl (PTY) take 9h 50m for a nonstop flight. There are 4 flights from Tocumen Intl to Madrid per day from 2 airlines.

  • How popular is this Panama City to Madrid flight route?

    Flights from Panama City Tocumen Intl to Madrid Barajas have been viewed 4 times in the past calendar month.

  • What are the cheapest airlines flying from Panama City to Madrid round-trip?

    According to our current data, Air Europa (£533), Turkish Airlines (£545), and KLM (£552) offers the cheapest pricing from Panama City to Madrid. Air Europa is 6% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City to Madrid one-way?

    £320 is the cheapest one-way deal found within the past few days, from Turkish Airlines. You may also be able to find cheap deals on Avianca and KLM, with prices starting from £354 and £373, respectively.

  • What are the most reliable airlines from Panama City to Madrid?

    The top 3 most reliable airlines when flying from Panama City to Madrid are Air Europa (88%), Etihad Airways (88%) and China Eastern (88%).

  • What are the cheapest flights from Panama City to Madrid?

    Looking at all options, your cheapest flight can be booked for £383. While the most popular route (Panama City Tocumen Intl - Madrid Barajas) can be booked for £731 on average our data indicates £605 when flying from Panama City to Madrid.

  • Can I find deals for flights from Panama City to Madrid that include hotel bookings?

    Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Madrid?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

  • Can I find deals for business class flights from Panama City to Madrid?

    Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Madrid?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Madrid (average of £94). Flying from Panama City to Madrid in August is currently the most expensive (average of £266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Guadalajara
Getafe

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Top 2 airlines flying from Panama City to Madrid

Discover the top 2 airlines that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 13 June 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest£478Average£622FlexibilityNo cancel feeOn-time83%
Search Air Europa flights
IberiaCheapest£489Average£679FlexibilityNo cancel feeOn-time77%
Search Iberia flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City to Madrid?

Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama City to Madrid. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.

Why should you use Cheapflights to find cheap flight tickets from Panama City to Madrid?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City to Madrid for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Panama City to Madrid with no change fees?

Certainly. Search results for flights to Madrid from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?

Of course! You can now track prices for flights from Panama City to Madrid and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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