Cheap flights from Panama City to Madrid, Spain from £431
This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 30/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
19 Oct — 26 Oct1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in February or May, booked 35 days in advance, depart on a Wednesday or Monday and return on a Wednesday
Cheap flight deals from Panama City to Madrid
Enter your travel dates to find the best prices.
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One-way
Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 19 September 2026.
Thu 5/1121:30 -
Nonstop9h 35m
Tue 24/1115:10 -
Nonstop10h 35m
Deal found 16/9£544
Mon 26/1021:30 -
Nonstop9h 35m
Sat 21/1115:10 -
Nonstop10h 35m
Deal found 14/9£545
Fri 18/914:23 -
1 stop14h 52m
Sat 26/906:00 -
2 stops21h 42m
Deal found 16/9£551
Thu 22/1004:25 -
1 stop12h 55m
Fri 6/1108:10 -
1 stop15h 05m
Deal found 16/9£560
Wed 30/1210:05 -
1 stop21h 20m
Wed 27/110:10 -
1 stop21h 10m
Deal found 18/9£561
Wed 16/914:23 -
1 stop14h 52m
Thu 24/912:20 -
1 stop14h 25m
Deal found 16/9£564
Wed 21/1020:25 -
Nonstop9h 50m
Wed 4/1115:10 -
Nonstop10h 35m
Deal found 16/9£568
Mon 19/1020:25 -
Nonstop9h 50m
Wed 28/1015:10 -
Nonstop10h 35m
Deal found 14/9£569
Fri 23/1020:25 -
Nonstop9h 50m
Mon 2/1115:10 -
Nonstop10h 35m
Deal found 17/9£570
Tue 20/1020:25 -
Nonstop9h 50m
Sun 25/1015:10 -
Nonstop10h 35m
Deal found 18/9£571
Mon 23/1110:00 -
1 stop17h 30m
Sat 12/1211:15 -
2 stops33h 30m
Deal found 14/9£573
Tue 17/1110:00 -
2 stops39h 45m
Thu 26/1111:00 -
2 stops38h 38m
Deal found 16/9£574
Best flights from Panama City to Madrid
Discover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 19 September 2026.
Tue 10/1121:30 -
Nonstop9h 35m
Tue 24/1115:10 -
Nonstop10h 35m
Deal found 16/9£544
Sat 31/1009:30 -
1 stop18h 00m
Sat 7/1111:00 -
2 stops39h 02m
Deal found 16/9£574
Wed 4/1121:30 -
Nonstop9h 35m
Wed 18/1115:10 -
Nonstop10h 35m
Deal found 18/9£544
Fri 23/1015:30 -
2 stops58h 15m
Mon 2/1111:00 -
2 stops38h 38m
Deal found 17/9£574
Wed 14/1009:45 -
1 stop16h 15m
Fri 23/1011:15 -
2 stops33h 59m
Deal found 16/9£574
Thu 29/1015:41 -
2 stops34h 04m
Sun 8/1111:00 -
2 stops38h 38m
Deal found 18/9£574
Mon 1/216:41 -
2 stops34h 49m
Mon 15/211:15 -
2 stops35h 57m
Deal found 18/9£578
Mon 18/116:41 -
2 stops34h 49m
Sat 6/211:15 -
2 stops33h 30m
Deal found 18/9£578
Direct flights from Panama City to Madrid
Explore direct flight options from Panama City to Madrid based on user searches, and compare prices and availability for your desired travel dates. Data last updated 19 September 2026.
Thu 5/1121:30 -
Nonstop9h 35m
Tue 24/1115:10 -
Nonstop10h 35m
Deal found 16/9£544
Tue 9/221:30 -
Nonstop9h 35m
Tue 23/215:10 -
Nonstop10h 35m
Deal found 14/9£545
Sat 6/221:30 -
Nonstop9h 35m
Tue 16/215:10 -
Nonstop10h 35m
Deal found 15/9£568
Wed 21/1020:25 -
Nonstop9h 50m
Wed 4/1115:10 -
Nonstop10h 35m
Deal found 17/9£568
Mon 19/1020:25 -
Nonstop9h 50m
Wed 28/1015:10 -
Nonstop10h 35m
Deal found 14/9£569
Fri 23/1020:25 -
Nonstop9h 50m
Mon 2/1115:10 -
Nonstop10h 35m
Deal found 17/9£570
Tue 20/1020:25 -
Nonstop9h 50m
Sun 25/1015:10 -
Nonstop10h 35m
Deal found 18/9£571
Fri 19/218:35 -
Nonstop10h 05m
Wed 24/212:00 -
Nonstop11h 05m
Deal found 18/9£575
Thu 12/1121:30 -
Nonstop9h 35m
Thu 26/1115:10 -
Nonstop10h 35m
Deal found 15/9£591
Thu 19/1121:30 -
Nonstop9h 35m
Wed 25/1115:10 -
Nonstop10h 35m
Deal found 18/9£592
Sun 1/1121:30 -
Nonstop9h 35m
Sun 15/1115:10 -
Nonstop10h 35m
Deal found 19/9£592
Fri 23/1020:25 -
Nonstop9h 50m
Mon 26/1015:10 -
Nonstop10h 35m
Deal found 17/9£593
Last-minute flights from Panama City to Madrid
Discover last-minute flight deals from Panama City to Madrid. Data last updated 19 September 2026 and is based on user searches.
Fri 18/914:23 -
1 stop14h 52m
Sat 26/906:00 -
2 stops21h 42m
Deal found 16/9£551
Tue 13/1015:30 -
2 stops34h 30m
Mon 16/1111:00 -
2 stops33h 45m
Deal found 15/9£573
Wed 14/1009:45 -
1 stop16h 15m
Fri 23/1010:50 -
1 stop15h 41m
Deal found 16/9£577
Thu 15/1009:45 -
2 stops38h 05m
Fri 30/1011:00 -
2 stops38h 02m
Deal found 14/9£577
Mon 19/1020:25 -
Nonstop9h 50m
Wed 28/1015:10 -
Nonstop10h 35m
Deal found 14/9£569
Tue 20/1020:25 -
Nonstop9h 50m
Sun 25/1015:10 -
Nonstop10h 35m
Deal found 18/9£571
Wed 21/1020:25 -
Nonstop9h 50m
Wed 4/1115:10 -
Nonstop10h 35m
Deal found 17/9£568
Thu 22/1020:25 -
Nonstop9h 50m
Tue 24/1115:10 -
Nonstop10h 35m
Deal found 16/9£544
Thu 22/1004:25 -
1 stop12h 55m
Fri 6/1108:10 -
1 stop15h 05m
Deal found 16/9£560
Fri 23/1020:25 -
Nonstop9h 50m
Mon 2/1115:10 -
Nonstop10h 35m
Deal found 17/9£570
Mon 26/1021:30 -
Nonstop9h 35m
Sat 21/1115:10 -
Nonstop10h 35m
Deal found 14/9£545
Sat 31/1009:30 -
1 stop18h 00m
Sat 7/1111:00 -
2 stops39h 02m
Deal found 16/9£574
One-way flights from Panama City to Madrid
Search for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated 19 September 2026.
Fri 30/1021:30 -
Nonstop9h 35m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 14/9£431
Sun 8/1118:45 -
1 stop22h 50m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 15/9£452
Thu 5/1118:45 -
1 stop22h 50m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 15/9£452
Tue 13/1018:50 -
1 stop21h 35m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 17/9£454
Tue 1/1221:55 -
1 stop15h 40m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 16/9£455
Sat 7/1118:45 -
1 stop22h 50m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 18/9£456
Wed 14/1018:50 -
1 stop17h 45m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 15/9£464
Tue 6/1006:46 -
2 stops26h 39m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 14/9£470
Mon 2/1122:30 -
2 stops19h 05m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 15/9£477
Find flight deals from Panama City to Madrid
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 19 September 2026.
Customise your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 19 September 2026.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Tue 13/10
18:50-23:25
1 stop21h 35m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£454
Fastest return journey
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 30/10
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£455
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Sat 7/11
18:45-23:35
1 stop22h 50m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£456
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 14/10
18:50-19:35
1 stop17h 45m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£464
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Thu 5/11
22:30-23:35
2 stops19h 05m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£476
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 12/10
18:50-19:35
1 stop17h 45m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£478
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 2/11
22:30-23:35
2 stops19h 05m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£479
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 4/11
22:30-23:35
2 stops19h 05m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£485
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Tue 20/10
21:55-23:25
2 stops18h 30m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£499
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Sat 6/2
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Wed 31/12
00:00-18:00
Nonstop0h 00m
£503
Flights are sorted by cheapest return flights first.
Deals found on 17/9
Showing 1-10 of 19 resultsSorted by cheapest first
1
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Best time to book a flight from Panama City to Madrid
Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
PTY-MAD
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Madrid
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Madrid?
To ensure you get the cheapest price possible for a flight from Panama City to Madrid, you should look to book at least 90 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of £562). Flying from Panama City to Madrid in July is currently the most expensive (average of £725). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to MAD?
Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 19 September 2026.
When flying from Panama City to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost for a return flight from Panama City to Madrid?
Airfare is below average for this route at the moment.
Panama City to Madrid flights typically cost between £554 and £720 in November.The cheapest return price found within the last 5 days was £544 on Air Europa (5 Nov–24 Nov).
Weekly flight availability from Panama City to Madrid
Explore weekly flight availability from Panama City to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 19 September 2026.
The most flights from PTY to MAD are scheduled on a Friday (10 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (4 on average).
How often are flights from Panama City to Madrid delayed?
About 13% of weekly flights between Panama City and Madrid have experienced delays in the past year, with the average delay time being 152 minutes.
What is the most punctual flight time for Panama City to Madrid flights?
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Tuesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Madrid flights?
Over the past year, Air Europa have had the lowest number of delays on this route, with just 10% of flights being delayed.
Reviews of airlines servicing Madrid
Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated 19 September 2026.
See what other customers who have flown with Air Europa from Panama City to Madrid have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
The food was below average for a business class flight
Related info for your journey
Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
What airports do I use to fly from Panama City to Madrid?
If you book a flight from Panama City to Madrid, you will be flying from Tocumen Intl to Barajas. Flights to Madrid Barajas (MAD) from Panama City Tocumen Intl (PTY) take 9h 35m for a nonstop flight. There are 6 flights from Tocumen Intl to Madrid per day from 1 airline.
How popular is this Panama City to Madrid flight route?
Flights from Panama City Tocumen Intl to Madrid Barajas have been viewed 10 times in the past calendar month.
How long is the flight from Panama City to Madrid?
A quick flight from Panama City to Madrid can take about 9h 35m. Air Europa provides one of the quickest options available for as low as £544. Airlines will cover a distance of 5065 mi. This flight may include one or multiple stops.
What is the cheapest airline to fly from Panama City to Madrid round-trip?
According to our current data, Air Europa (£526), offers the cheapest pricing from Panama City to Madrid. Air Europa is 16% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for business class flights from Panama City to Madrid?
Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of £562). Flying from Panama City to Madrid in July is currently the most expensive (average of £725). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Explore flights to Madrid departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 19 September 2026.
Discover the top airline that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 19 September 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Panama City to Madrid?
Cheapflights goes through 900+ travel sites to look for the best flight deals for flights from Panama City to Madrid. Too many options? Cheapflights also provides filters for things like airlines, price ranges, and number of stops to help you make a decision easily.
Why should you use Cheapflights to find cheap flight tickets from Panama City to Madrid?
Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City to Madrid for you. Better yet — we are completely free to use.
Can Cheapflights find flights from Panama City to Madrid with no change fees?
Certainly. Search results for flights to Madrid from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.
Can Cheapflights notify me if prices for flights from Panama City to Madrid become cheaper?
Of course! You can now track prices for flights from Panama City to Madrid and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.
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