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Cheap flights from Knoxville to Manchester from £469

This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAN
12 Oct — 19 Oct1
1 adult
1 adult, Economy

Cheap flight deals from Knoxville to Manchester

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Manchester (MAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 September 2025.

Round-trip from

£469

Popular in

June

Cheapest in

November

Average price

£647
Virgin Atlantic
  • Virgin Atlantic
  • 7/10-14/10
  • 2 total stops
  • 28h 12m total
  • Knoxville to Manchester
Search Deals
Highest demand for flights based on searches. 14% potential increase in price (£87 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease (£24 potential savings vs. average return price).
Search Deals
Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Manchester

Cheapest flights from Knoxville to Manchester
Explore the most affordable flight options available from Knoxville to Manchester. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 September 2025.

Tue 7/1014:55TYS - MAN
1 stop12h 40mVirgin Atlantic
Tue 14/1012:35MAN - TYS
1 stop15h 32mVirgin Atlantic
Deal found 9/9£469
Tue 7/1007:11TYS - MAN
2 stops19h 24mDelta
Tue 14/1014:15MAN - TYS
2 stops23h 45mDelta
Deal found 9/9£472
Sat 4/1017:52TYS - MAN
2 stops33h 33mUnited Airlines
Sat 11/1011:35MAN - TYS
2 stops51h 35mUnited Airlines
Deal found 10/9£568
Fri 10/1014:00TYS - MAN
2 stops22h 20mUnited Airlines
Sat 25/1009:10MAN - TYS
2 stops19h 42mUnited Airlines
Deal found 11/9£582
Tue 25/1108:26TYS - MAN
2 stops27h 34mUnited Airlines
Sun 30/1112:50MAN - TYS
2 stops54h 53mUnited Airlines
Deal found 9/9£605
Tue 25/1105:25TYS - MAN
1 stop24h 05mDelta
Sun 30/1109:05MAN - TYS
1 stop16h 01mDelta
Deal found 9/9£632
Fri 10/1014:27TYS - MAN
1 stop13h 08mDelta
Sat 25/1005:55MAN - TYS
2 stops20h 18mDelta
Deal found 10/9£649
Mon 1/1220:04TYS - MAN
2 stops15h 26mAmerican Airlines
Wed 31/1208:55MAN - TYS
2 stops17h 19mAmerican Airlines
Deal found 10/9£692

Cheapflights Fare Finder

 
Customise your flight search to find flights from Knoxville to Manchester that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 September 2025.
Use the filters below to find and compare flights from Knoxville to Manchester that are best for you.

Fly from

Knoxville

Fly to

Manchester

Route

Depart

Return

Price

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Tue 7/10

14:55-08:35

1 stop12h 40m

Manchester

Tue 14/10

12:35-23:07

1 stop15h 32m

£469

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Tue 7/10

07:11-07:35

2 stops19h 24m

Manchester

Tue 14/10

14:15-09:00

2 stops23h 45m

£472

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Wed 4/3

14:55-12:20

2 stops16h 25m

Manchester

Sun 8/3

06:00-22:53

2 stops21h 53m

£538

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Sat 4/10

17:52-08:25

2 stops33h 33m

Manchester

Sat 11/10

11:35-10:10

2 stops51h 35m

£568

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Fri 10/10

10:51-08:25

2 stops16h 34m

Manchester

Sat 25/10

09:10-23:52

2 stops19h 42m

£582

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Tue 25/11

08:26-17:00

2 stops27h 34m

Manchester

Sun 30/11

12:50-14:43

2 stops54h 53m

£605

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Wed 4/3

14:30-10:30

1 stop15h 00m

Manchester

Sun 8/3

06:00-19:38

2 stops18h 38m

£623

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Tue 25/11

05:25-10:30

1 stop24h 05m

Manchester

Sun 30/11

09:05-20:06

1 stop16h 01m

£632

KnoxvilleManchester

TYS - MAN

TYSMAN

Knoxville McGhee Tyson

Fri 10/10

14:27-08:35

1 stop13h 08m

Manchester

Sat 25/10

05:55-21:13

2 stops20h 18m

£649

Flights are sorted by cheapest return flights first.

Deals found on 9/9

Best time to book a flight from Knoxville to Manchester

Have a flexible travel schedule? Discover the best time to fly to Manchester from Knoxville with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Manchester

What is the cheapest month to book a flight from Knoxville to Manchester?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Manchester (average of £117). Flying from Knoxville to Manchester in September is currently the most expensive (average of £143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Manchester. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Manchester?

    A quick flight from Knoxville to Manchester can take about 12h 40m. Virgin Atlantic provides one of the quickest options available for as low as £469. There are 3961 mi between Knoxville and Manchester. This flight may include one or multiple stops.

  • Can I find deals for flights from Knoxville to Manchester that include hotel bookings?

    Yes. In addition to deals on Knoxville to Manchester flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Manchester?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Manchester.

  • Can I find deals for business class flights from Knoxville to Manchester?

    Yes. Cheapflights offers flight deals from Knoxville to Manchester by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Manchester?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Manchester (average of £117). Flying from Knoxville to Manchester in September is currently the most expensive (average of £143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Manchester?

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Southport
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