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Cheap flights from Manchester to Panama City from £305

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/3. Fares are subject to change and may not be available on all flights or dates of travel.
MAN — PTY
21 Mar — 28 Mar1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Manchester to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Manchester to Panama City
Explore the most affordable flight options available from Manchester to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 19 February 2026.

Wed 15/409:30
MAN
-
PTY
1 stop15h 10m
Multiple Airlines
Sat 25/421:33
PTY
-
MAN
2 stops32h 07m
Multiple Airlines
Deal found 18/2£651
Wed 15/406:05
MAN
-
PTY
2 stops38h 09m
United Airlines
Sat 25/415:30
PTY
-
MAN
2 stops36h 55m
United Airlines
Deal found 18/2£655
Mon 16/306:15
MAN
-
PTY
1 stop18h 30m
Multiple Airlines
Mon 23/321:30
PTY
-
MAN
1 stop15h 10m
Multiple Airlines
Deal found 16/2£656
Sat 4/406:05
MAN
-
PTY
2 stops38h 09m
United Airlines
Sat 18/415:30
PTY
-
MAN
2 stops36h 55m
United Airlines
Deal found 17/2£659
Thu 7/505:55
MAN
-
PTY
2 stops40h 17m
United Airlines
Mon 11/509:45
PTY
-
MAN
2 stops25h 25m
United Airlines
Deal found 18/2£662
Sun 21/605:50
MAN
-
PTY
1 stop19h 55m
Multiple Airlines
Sat 27/618:50
PTY
-
MAN
1 stop19h 15m
Multiple Airlines
Deal found 15/2£665
Mon 16/322:25
MAN
-
PTY
2 stops23h 40m
Turkish Airlines
Mon 23/321:45
PTY
-
MAN
1 stop31h 05m
Turkish Airlines
Deal found 16/2£670
Sun 21/605:50
MAN
-
PTY
1 stop19h 55m
Multiple Airlines
Sun 28/621:55
PTY
-
MAN
2 stops18h 05m
Multiple Airlines
Deal found 15/2£680
Sun 1/313:00
MAN
-
PTY
2 stops35h 45m
Multiple Airlines
Thu 12/321:30
PTY
-
MAN
3 stops33h 20m
Multiple Airlines
Deal found 16/2£684

Find flight deals from Manchester to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MAN) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 19 February 2026.

Round-trip from

£651

One-way from

£305

Popular in

December

Cheapest in

September

Average price

£777
15/4-25/4
  • 15/4-25/4
  • 3 total stops
  • 47h 17m total
  • Manchester to Panama City
Search Deals
15/3
  • 15/3
  • 1 total stop
  • 18h 35m total
  • Manchester to Panama City
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£28 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£8 potential savings vs. average return price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Manchester to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 19 February 2026.
Use the filters below to find and compare flights from Manchester to Panama City that are best for you.

Fly from

Manchester

Fly to

Panama City

Route

Depart

Return

Price

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Wed 15/4

09:30-18:40

1 stop15h 10m

Panama City Tocumen Intl

Sat 25/4

21:33-11:40

2 stops32h 07m

£651

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Wed 15/4

06:05-14:14

2 stops38h 09m

Panama City Tocumen Intl

Sat 25/4

15:30-10:25

2 stops36h 55m

£655

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Sun 21/6

05:50-19:45

1 stop19h 55m

Panama City Tocumen Intl

Sun 28/6

18:50-10:20

1 stop33h 30m

£655

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Sat 4/4

06:05-14:14

2 stops38h 09m

Panama City Tocumen Intl

Sat 18/4

15:30-10:25

2 stops36h 55m

£659

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Thu 7/5

05:55-16:12

2 stops40h 17m

Panama City Tocumen Intl

Mon 11/5

09:45-17:10

2 stops25h 25m

£662

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Mon 16/3

22:25-17:05

2 stops23h 40m

Panama City Tocumen Intl

Mon 23/3

21:45-09:50

1 stop31h 05m

£670

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Sun 15/3

06:10-19:45

1 stop18h 35m

£305

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Wed 22/4

14:55-19:45

1 stop34h 50m

£654

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Wed 22/4

20:50-19:45

2 stops28h 55m

£690

ManchesterPanama City

MAN - PTY

MANPTY

Manchester

Sun 15/3

12:50-16:07

2 stops56h 17m

£867

Flights are sorted by cheapest return flights first.

Deals found on 18/2

Showing 1-10 of 13 results
1
2

Best time to book a flight from Manchester to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Manchester with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Manchester to Panama City

How far ahead should I book a flight from Manchester to Panama City?

Use this chart to determine the optimal time to book a return flight from Manchester to Panama City. Price data was last updated on 13 February 2026.

Booking 86 days in advance of your planned departure date is, on average, the best time to get cheap flights from Manchester to Panama City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Manchester to Panama City?

Currently, November is the cheapest month in which you can book a flight from Manchester to Panama City (average of £557). Flying from Manchester to Panama City in December is currently the most expensive (average of £688). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated 19 February 2026.
Get a feel of what it's like to fly with KLM, Air France, andUnited Airlines from Manchester to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.7
Good
1,459 reviews
Check prices

Entertainment

7.1

Comfort

7.6

Boarding

7.8

Food

7.3

Crew

8.4

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
KLM
7.7
Good
1,459 reviews
KLM
7.7
Good
1,459 reviews
Check prices

Entertainment

7.1

Comfort

7.6

Boarding

7.8

Food

7.3

Crew

8.4

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Air France
7.4
Good
1,533 reviews
KLM
7.7
Good
1,459 reviews
Check prices

Entertainment

7.1

Comfort

7.6

Boarding

7.8

Food

7.3

Crew

8.4

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
United Airlines
7.4
Good
9,323 reviews
KLM
7.7
Good
1,459 reviews
Check prices

Entertainment

7.1

Comfort

7.6

Boarding

7.8

Food

7.3

Crew

8.4

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Turkish Airlines
7.3
Good
4,222 reviews
KLM
7.7
Good
1,459 reviews
Check prices

Entertainment

7.1

Comfort

7.6

Boarding

7.8

Food

7.3

Crew

8.4

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Lufthansa
6.8
Okay
7,789 reviews
KLM
7.7
Good
1,459 reviews
Check prices

Entertainment

7.1

Comfort

7.6

Boarding

7.8

Food

7.3

Crew

8.4

Overall

7.7

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas

Related info for your journey

Find useful and relevant information for your journey from Manchester to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Manchester to Panama City?

    A quick flight from Manchester to Panama City can take about 38h 09m. United Airlines provides one of the quickest options available for as low as £655. The distance from Manchester to Panama City is about 5182 mi.

  • What are the cheapest airlines flying from Manchester to Panama City round-trip?

    According to our current data, Air France (£557), KLM (£584), and United Airlines (£600) offers the cheapest pricing from Manchester to Panama City. Air France is currently priced 24% below the average price you’ll pay for this route.

  • Can I find deals for flights from Manchester to Panama City that include hotel bookings?

    Yes. In addition to deals on Manchester to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Manchester to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to Panama City.

  • Can I find deals for business class flights from Manchester to Panama City?

    Yes. Cheapflights offers flight deals from Manchester to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Manchester to Panama City?

    Currently, November is the cheapest month in which you can book a flight from Manchester to Panama City (average of £557). Flying from Manchester to Panama City in December is currently the most expensive (average of £688). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Manchester to Panama City

Discover the top 5 airlines that operate flights from Manchester to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 19 February 2026.
AirlineCheapestAverageFlexibilityOn-time
Air FranceCheapest£557Average£700FlexibilityNo cancel feeOn-time77%
Search Air France flights
KLMCheapest£584Average£818FlexibilityNo cancel feeOn-time75%
Search KLM flights
United AirlinesCheapest£600Average£688FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
LufthansaCheapest£623Average£669FlexibilityNo cancel feeOn-time76%
Search Lufthansa flights
Turkish AirlinesCheapest£650Average£712FlexibilityNo cancel feeOn-time77%
Search Turkish Airlines flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Manchester to Panama City?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to Panama City from Manchester today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Manchester to Panama City?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Panama City from Manchester.

Can Cheapflights find flights from Manchester to Panama City with no change fees?

Certainly. Search results for flights to Panama City from Manchester shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Manchester to Panama City become cheaper?

Of course! You can now track prices for flights from Manchester to Panama City and get an alert from Cheapflights when they change. Have a valid email address ready and click the bell icon next to the flight deals above to set up your price alerts.

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