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Cheap flights from Mexico City to Panama City from £121

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
12 Apr — 19 Apr1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in August or July, booked 72 days in advance, depart on a Wednesday or Monday and return on a Monday

Cheap flight deals from Mexico City to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 13 March 2026.

Fri 3/413:10
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Mon 6/422:11
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 12/3£248
Wed 8/404:55
MEX
-
PTY
1 stop8h 20m
Avianca
Fri 24/415:10
PTY
-
MEX
1 stop8h 50m
Avianca
Deal found 9/3£250
Wed 8/408:40
MEX
-
PTY
Nonstop3h 50m
Aeromexico
Fri 24/415:00
PTY
-
MEX
Nonstop4h 00m
Aeromexico
Deal found 9/3£257
Sat 25/413:10
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Sat 2/511:45
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Deal found 11/3£262
Sat 25/423:20
MEX
-
PTY
1 stop13h 55m
Avianca
Sat 2/515:10
PTY
-
MEX
1 stop8h 50m
Avianca
Deal found 11/3£267
Wed 8/408:40
MEX
-
PTY
Nonstop3h 50m
Multiple Airlines
Fri 24/415:10
PTY
-
MEX
1 stop8h 50m
Multiple Airlines
Deal found 9/3£269
Wed 8/715:30
MEX
-
PTY
Nonstop3h 46m
Copa Airlines
Sat 18/709:25
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Deal found 11/3£275
Mon 6/415:30
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Sat 11/422:11
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 12/3£278
Mon 20/409:50
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Fri 1/511:45
PTY
-
MEX
Nonstop3h 45m
Copa Airlines
Deal found 10/3£283
Sat 20/600:25
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Sun 28/619:05
PTY
-
MEX
Nonstop4h 00m
Copa Airlines
Deal found 10/3£290
Thu 16/415:30
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Sun 26/409:19
PTY
-
MEX
Nonstop3h 51m
Copa Airlines
Deal found 10/3£298

Find flight deals from Mexico City to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 13 March 2026.

Round-trip from

£248

One-way from

£121

Popular in

April

Cheapest in

August

Average price

£302
Copa Airlines
  • Copa Airlines
  • 3/4-6/4
  • Nonstop
  • 7h 32m total
  • Mexico City to Panama City
Search Deals
Copa Airlines
  • Copa Airlines
  • 7/4
  • Nonstop
  • 3h 43m total
  • Mexico City to Panama City
Search Deals
Highest demand for flights based on searches. 9% potential increase in price (£22 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£4 potential savings vs. average return price).
Search Deals
Average for round-trip flights in March 2026
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Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 13 March 2026.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 4/9

15:30-20:14

Nonstop3h 44m

Panama City Tocumen Intl

Sun 13/9

11:47-14:30

Nonstop3h 43m

£275

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 16/4

09:50-14:30

Nonstop3h 40m

Panama City Tocumen Intl

Sun 26/4

09:19-12:10

Nonstop3h 51m

£298

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 20/6

00:25-05:08

Nonstop3h 43m

Panama City Tocumen Intl

Sun 28/6

21:28-00:15

Nonstop3h 47m

£298

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 24/6

05:50-10:33

Nonstop3h 43m

Panama City Tocumen Intl

Sun 28/6

09:24-12:10

Nonstop3h 46m

£314

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 3/7

05:50-10:33

Nonstop3h 43m

Panama City Tocumen Intl

Tue 7/7

22:05-01:00

Nonstop3h 55m

£314
Fastest return journey

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 12/5

13:10-17:50

Nonstop3h 40m

Panama City Tocumen Intl

Sat 16/5

11:45-14:30

Nonstop3h 45m

£314
Cheapest one-way

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 11/4

13:10-17:53

Nonstop3h 43m

£121
Fastest single journey

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 13/4

09:50-14:30

Nonstop3h 40m

£121

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 8/4

15:30-20:10

Nonstop3h 40m

£121

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 3/4

13:10-17:53

Nonstop3h 43m

£125

Flights are sorted by cheapest return flights first.

Deals found on 12/3

Showing 1-10 of 18 resultsSorted by cheapest first
1
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Best time to book a flight from Mexico City to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama City

How far ahead should I book a flight from Mexico City to Panama City?

Use this chart to determine the optimal time to book a return flight from Mexico City to Panama City. Price data was last updated on 6 March 2026.

The best time to book flights from Mexico City to Panama City is 72 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Panama City?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £130). Flying from Mexico City to Panama City in April is currently the most expensive (average of £231). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PTY?

Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 13 March 2026.

One of the essential ways to save on airfare from Mexico City to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at midday could potentially save you up to 45% on airfare.

How much does it cost for a return flight from Mexico City to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Panama City flight route?

    The Mexico City Benito Juarez to Panama City Tocumen Intl flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Panama City?

    For as low as £275, Copa Airlines can have you in Panama City from Mexico City in 3h 46m. The distance between Mexico City and Panama City is about 1497 mi. All flights are typically direct.

  • What are the most reliable airlines from Mexico City to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: Copa Airlines (90%), Emirates (89%), AeroMexico Connect (82%).

  • Can I find deals for flights from Mexico City to Panama City that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.

  • Can I find deals for business class flights from Mexico City to Panama City?

    Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama City?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £130). Flying from Mexico City to Panama City in April is currently the most expensive (average of £231). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Panama City?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Panama City from Mexico City.

Can Cheapflights find flights from Mexico City to Panama City with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Mexico City to Panama City flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Mexico City to Panama City become cheaper?

Yes! Start tracking prices for Mexico City to Panama City flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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