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Cheap flights from Mexico City to Panama City from £125

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
9 Nov — 16 Nov1
1 adult
1 adult, Economy

Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in July or August, booked 83 days in advance, depart on a Monday or Wednesday and return on a Monday

Cheap flight deals from Mexico City to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 10 October 2025.

Round-trip from

£205

One-way from

£125

Popular in

December

Cheapest in

July

Average price

£295

Good one-way deal

£195 or less
Copa Airlines
  • Copa Airlines
  • 31/12-13/1
  • Nonstop
  • 7h 32m total
  • Mexico City to Panama City
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Avianca
  • Avianca
  • 5/2
  • 1 total stop
  • 36h 20m total
  • Mexico City to Panama City
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Highest demand for flights based on searches. 9% potential increase in price (£23 potential increase over avg. return price).
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Cheapest flight prices on average. 2% potential price decrease (£5 potential savings vs. average return price).
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Average for round-trip flights in October 2025
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Price to beat on a one-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
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Find flight deals from Mexico City to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 10 October 2025.

Wed 26/1108:40MEX - PTY
Nonstop3h 52mAeromexico
Tue 9/1214:36PTY - MEX
Nonstop3h 59mAeromexico
Deal found 9/10£218
Thu 16/1001:40MEX - PTY
Nonstop3h 40mCopa Airlines
Mon 20/1022:21PTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 9/10£248
Tue 9/1215:30MEX - PTY
Nonstop3h 45mCopa Airlines
Sun 21/1222:14PTY - MEX
Nonstop3h 46mCopa Airlines
Deal found 9/10£258
Thu 13/1101:20MEX - PTY
Nonstop3h 39mCopa Airlines
Tue 18/1122:13PTY - MEX
Nonstop3h 47mCopa Airlines
Deal found 10/10£269
Tue 25/1101:20MEX - PTY
Nonstop3h 39mCopa Airlines
Tue 9/1209:18PTY - MEX
Nonstop3h 52mCopa Airlines
Deal found 9/10£279
Sat 22/1101:20MEX - PTY
Nonstop3h 39mCopa Airlines
Sun 30/1111:44PTY - MEX
Nonstop3h 46mCopa Airlines
Deal found 9/10£282
Tue 9/1201:20MEX - PTY
Nonstop3h 40mCopa Airlines
Sun 14/1222:14PTY - MEX
Nonstop3h 46mCopa Airlines
Deal found 10/10£287
Fri 17/1005:50MEX - PTY
Nonstop3h 44mCopa Airlines
Sun 19/1022:21PTY - MEX
Nonstop3h 39mCopa Airlines
Deal found 9/10£288
Thu 30/1001:20MEX - PTY
Nonstop3h 40mCopa Airlines
Sun 2/1119:02PTY - MEX
Nonstop4h 03mCopa Airlines
Deal found 9/10£291
Tue 14/1015:30MEX - PTY
Nonstop3h 43mCopa Airlines
Tue 21/1019:04PTY - MEX
Nonstop4h 01mCopa Airlines
Deal found 9/10£300
Wed 31/1215:30MEX - PTY
Nonstop3h 45mCopa Airlines
Mon 5/122:13PTY - MEX
Nonstop3h 47mCopa Airlines
Deal found 9/10£303

Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 10 October 2025.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Mexico City

Fly to

Panama City

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 31/10

13:10-17:55

Nonstop3h 45m

Panama City Tocumen Intl

Wed 5/11

22:13-01:00

Nonstop3h 47m

£248

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 10/1

02:00-06:41

Nonstop3h 41m

Panama City Tocumen Intl

Mon 19/1

16:13-19:20

Nonstop4h 07m

£267

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 31/1

01:20-06:00

Nonstop3h 40m

Panama City Tocumen Intl

Sun 15/2

21:25-00:15

Nonstop3h 50m

£267

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 4/2

01:20-06:00

Nonstop3h 40m

Panama City Tocumen Intl

Mon 16/2

21:25-00:15

Nonstop3h 50m

£267

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 2/2

05:55-10:35

Nonstop3h 40m

Panama City Tocumen Intl

Mon 9/2

21:25-00:15

Nonstop3h 50m

£267

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 14/11

09:25-14:14

Nonstop3h 49m

Panama City Tocumen Intl

Mon 17/11

22:13-01:00

Nonstop3h 47m

£269

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 11/11

01:20-05:59

Nonstop3h 39m

Panama City Tocumen Intl

Wed 19/11

22:13-01:00

Nonstop3h 47m

£269

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 31/10

15:30-20:13

Nonstop3h 43m

Panama City Tocumen Intl

Sat 8/11

19:02-22:05

Nonstop4h 03m

£269

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 13/11

15:30-20:14

Nonstop3h 44m

Panama City Tocumen Intl

Sat 22/11

19:02-22:05

Nonstop4h 03m

£269

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 5/2

00:40-14:00

1 stop36h 20m

£125

Flights are sorted by cheapest return flights first.

Deals found on 9/10

Showing 1-10 of 19 results
1
2

Best time to book a flight from Mexico City to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama City

How far ahead should I book a flight from Mexico City to Panama City?

Use this chart to determine the optimal time to book a return flight from Mexico City to Panama City. Price data was last updated on 3 October 2025.

The best time to book flights from Mexico City to Panama City is 83 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Panama City?

Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £132). Flying from Mexico City to Panama City in April is currently the most expensive (average of £277). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PTY?

Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 10 October 2025.

One of the essential ways to save on airfare from Mexico City to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at midday could potentially save you up to 39% on airfare.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated 10 October 2025.
Get a feel of what it's like to fly with Copa Airlines from Mexico City to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,545 reviews
Check prices

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Food

6.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sept 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,545 reviews
Copa Airlines
7.6
Good
1,545 reviews
Check prices

Comfort

7.4

Entertainment

6.8

Boarding

7.8

Food

6.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sept 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mexico City to Panama City?

    If you book a flight from Mexico City to Panama City, you will be flying from Benito Juarez to Tocumen Intl. Flights to Panama City Tocumen Intl (PTY) from Mexico City Benito Juarez (MEX) take 3h 46m for a nonstop flight. There are 8 flights from Benito Juarez to Panama City per day from 1 airline.

  • How popular is this Mexico City to Panama City flight route?

    The Mexico City Benito Juarez to Panama City Tocumen Intl flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Panama City?

    For as low as £248, Copa Airlines can have you in Panama City from Mexico City in 3h 45m. The distance between Mexico City and Panama City is about 1497 mi. All flights are typically direct.

  • What is the cheapest airline to fly from Mexico City to Panama City round-trip?

    Currently priced at £265, Copa Airlines will fly you from Mexico City to Panama City and back. In addition to Copa Airlines, many other airlines offer competitively priced options for your trip. Copa Airlines is currently priced 13% below the average price you’ll pay for this route.

  • What are the most reliable airlines from Mexico City to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: AeroMexico Connect (96%), Emirates (96%), Copa Airlines (89%).

  • What are the cheapest flights from Mexico City to Panama City?

    Looking for the cheapest flight from Mexico City to Panama City? While on average our users pay £197, our data indicates the cheapest price to be £175. The most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl), is priced around £257.

  • Can I find deals for flights from Mexico City to Panama City that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.

  • Can I find deals for business class flights from Mexico City to Panama City?

    Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama City?

    Currently, September is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £132). Flying from Mexico City to Panama City in April is currently the most expensive (average of £277). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

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Top airline flying from Mexico City to Panama City

Discover the top airline that operate flights from Mexico City to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 10 October 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest£265Average£320FlexibilityNo cancel feeOn-time70%
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Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Mexico City to Panama City?

Cheapflights makes it easy to find Mexico City to Panama City flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Mexico City to Panama City?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Panama City from Mexico City.

Can Cheapflights find flights from Mexico City to Panama City with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Mexico City to Panama City flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Mexico City to Panama City become cheaper?

Yes! Start tracking prices for Mexico City to Panama City flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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