Cheap flights from Mexico City to Panama City from £126
This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 31/12. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
8 Oct — 15 Oct1
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in February or January, booked 90 days in advance, depart on a Thursday or Monday and return on a Monday
Cheap flight deals from Mexico City to Panama City
Enter your travel dates to find the best prices.
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Direct
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One-way
Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 8 September 2026.
Fri 25/1215:30 -
Nonstop3h 50m
Wed 30/1211:44 -
Nonstop3h 46m
Deal found 7/9£282
Wed 7/1001:20 -
Nonstop3h 41m
Sat 17/1016:12 -
Nonstop3h 53m
Deal found 3/9£292
Wed 4/1101:20 -
Nonstop3h 44m
Sat 21/1121:31 -
Nonstop3h 44m
Deal found 7/9£300
Thu 24/902:10 -
Nonstop3h 41m
Mon 5/1019:12 -
Nonstop3h 53m
Deal found 7/9£321
Fri 18/1215:30 -
Nonstop3h 50m
Wed 23/1209:19 -
Nonstop3h 51m
Deal found 7/9£329
Thu 24/1201:20 -
Nonstop3h 42m
Fri 25/1211:44 -
Nonstop3h 46m
Deal found 5/9£335
Tue 27/1002:00 -
Nonstop3h 41m
Sun 1/1119:18 -
Nonstop4h 07m
Deal found 8/9£367
Mon 21/1209:10 -
Nonstop3h 51m
Mon 4/109:21 -
Nonstop3h 49m
Deal found 6/9£386
Tue 20/1002:10 -
Nonstop3h 41m
Wed 28/1014:50 -
Nonstop3h 50m
Deal found 6/9£392
Sun 11/1009:50 -
Nonstop3h 48m
Sun 11/1021:28 -
Nonstop3h 47m
Deal found 7/9£397
Thu 17/1209:10 -
Nonstop3h 51m
Mon 4/109:21 -
Nonstop3h 49m
Deal found 7/9£412
Best flights from Mexico City to Panama City
Discover carefully curated flight deals from Mexico City to Panama City that have cost, travel time, and stopovers in mind to ensure you get the best travel experience. Data last updated 8 September 2026.
Wed 7/1001:20 -
Nonstop3h 41m
Sat 17/1016:12 -
Nonstop3h 53m
Deal found 3/9£292
Sat 19/1209:10 -
Nonstop3h 51m
Sat 26/1211:44 -
Nonstop3h 46m
Deal found 5/9£292
Thu 24/902:10 -
Nonstop3h 41m
Mon 5/1019:12 -
Nonstop3h 53m
Deal found 8/9£292
Mon 1/209:10 -
Nonstop3h 48m
Mon 8/216:20 -
Nonstop4h 00m
Deal found 7/9£292
Sat 10/1013:10 -
Nonstop3h 44m
Sat 17/1009:29 -
Nonstop3h 41m
Deal found 4/9£292
Thu 12/1109:10 -
Nonstop3h 53m
Thu 26/1119:18 -
Nonstop4h 07m
Deal found 5/9£292
Sat 16/115:30 -
Nonstop3h 47m
Wed 17/211:44 -
Nonstop3h 46m
Deal found 4/9£292
Sat 19/1209:10 -
Nonstop3h 51m
Sun 27/1211:44 -
Nonstop3h 46m
Deal found 3/9£292
Fri 30/1005:55 -
Nonstop3h 51m
Wed 11/1121:31 -
Nonstop3h 44m
Deal found 7/9£292
Fri 8/105:55 -
Nonstop3h 43m
Fri 15/121:27 -
Nonstop3h 48m
Deal found 4/9£292
Wed 4/1101:20 -
Nonstop3h 44m
Sat 21/1121:31 -
Nonstop3h 44m
Deal found 7/9£300
Direct flights from Mexico City to Panama City
Explore direct flight options from Mexico City to Panama City based on user searches, and compare prices and availability for your desired travel dates. Data last updated 8 September 2026.
Fri 25/1215:30 -
Nonstop3h 50m
Wed 30/1211:44 -
Nonstop3h 46m
Deal found 7/9£282
Fri 15/108:55 -
Nonstop3h 51m
Wed 17/214:46 -
Nonstop3h 59m
Deal found 4/9£283
Wed 7/1001:20 -
Nonstop3h 41m
Sat 17/1016:12 -
Nonstop3h 53m
Deal found 3/9£292
Wed 13/108:55 -
Nonstop3h 51m
Sat 20/214:46 -
Nonstop3h 59m
Deal found 4/9£293
Wed 4/1101:20 -
Nonstop3h 44m
Sat 21/1121:31 -
Nonstop3h 44m
Deal found 7/9£300
Thu 24/902:10 -
Nonstop3h 41m
Mon 5/1019:12 -
Nonstop3h 53m
Deal found 7/9£321
Fri 18/1215:30 -
Nonstop3h 50m
Wed 23/1209:19 -
Nonstop3h 51m
Deal found 7/9£329
Mon 1/209:10 -
Nonstop3h 48m
Mon 15/309:13 -
Nonstop3h 57m
Deal found 7/9£330
Thu 24/1201:20 -
Nonstop3h 42m
Fri 25/1211:44 -
Nonstop3h 46m
Deal found 5/9£335
Tue 27/1002:00 -
Nonstop3h 41m
Sun 1/1119:18 -
Nonstop4h 07m
Deal found 8/9£367
Fri 1/109:10 -
Nonstop3h 44m
Tue 5/109:21 -
Nonstop3h 49m
Deal found 7/9£378
Last-minute flights from Mexico City to Panama City
Discover last-minute flight deals from Mexico City to Panama City. Data last updated 8 September 2026 and is based on user searches.
Thu 10/905:50 -
Nonstop3h 51m
Wed 23/921:27 -
Nonstop3h 48m
Deal found 6/9£460
Fri 11/905:50 -
Nonstop3h 51m
Sat 19/921:27 -
Nonstop3h 48m
Deal found 3/9£446
Mon 14/901:20 -
Nonstop3h 41m
Sun 20/921:27 -
Nonstop3h 48m
Deal found 6/9£487
Tue 15/923:20 -
1 stop13h 55m
Sun 20/904:25 -
1 stop8h 45m
Deal found 6/9£424
Thu 17/902:10 -
Nonstop3h 41m
Sun 20/922:12 -
Nonstop3h 48m
Deal found 4/9£497
Thu 24/902:10 -
Nonstop3h 41m
Mon 5/1019:12 -
Nonstop3h 53m
Deal found 7/9£321
Mon 5/1002:10 -
Nonstop3h 41m
Mon 19/1019:12 -
Nonstop3h 53m
Deal found 5/9£300
Wed 7/1001:20 -
Nonstop3h 41m
Sat 17/1016:12 -
Nonstop3h 53m
Deal found 3/9£292
Sun 11/1009:50 -
Nonstop3h 48m
Sun 11/1021:28 -
Nonstop3h 47m
Deal found 7/9£397
Tue 20/1002:10 -
Nonstop3h 41m
Wed 28/1014:50 -
Nonstop3h 50m
Deal found 6/9£392
Tue 27/1002:00 -
Nonstop3h 41m
Sun 1/1119:18 -
Nonstop4h 07m
Deal found 8/9£367
One-way flights from Mexico City to Panama City
Search for one-way flight options from Mexico City to Panama City. Find affordable one-way fares based on user searches. Data last updated 8 September 2026.
Thu 31/1203:25 -
Nonstop3h 40m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 4/9£126
Wed 6/113:10 -
Nonstop3h 48m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 8/9£187
Fri 6/1115:30 -
Nonstop3h 48m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 8/9£195
Mon 14/922:00 -
2 stops25h 35m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 4/9£237
Mon 14/909:05 -
Nonstop3h 55m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 4/9£358
Sun 24/105:00 -
2 stops11h 15m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 8/9£371
Tue 26/116:55 -
2 stops15h 15m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 6/9£382
Sun 13/909:05 -
Nonstop3h 55m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 3/9£404
Sat 23/105:00 -
2 stops27h 10m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 8/9£405
Sun 24/100:30 -
2 stops33h 05m
Wed 31/1200:00 -
Nonstop0h 00m
Deal found 6/9£417
Find flight deals from Mexico City to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 8 September 2026.
Customise your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated 8 September 2026.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Cheapest return flight
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Thu 31/12
03:25-08:05
Nonstop3h 40m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£126
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Sun 8/11
09:10-14:03
Nonstop3h 53m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Fri 1/1
03:25-08:05
Nonstop3h 40m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Wed 6/1
03:25-08:05
Nonstop3h 40m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Sun 15/11
01:20-06:04
Nonstop3h 44m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Tue 26/1
15:30-20:17
Nonstop3h 47m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Fastest return journey
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Fri 5/3
02:00-06:34
Nonstop3h 34m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Sat 31/10
02:00-06:41
Nonstop3h 41m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Wed 6/1
13:10-17:58
Nonstop3h 48m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Mexico CityPanama City
MEX Mexico City Benito Juarez - PTY Panama City Tocumen Intl
MEXPTY
Mexico City Benito Juarez
Thu 24/9
15:30-20:14
Nonstop3h 44m
Panama City Tocumen Intl
Wed 31/12
00:00-23:00
Nonstop0h 00m
£187
Flights are sorted by cheapest return flights first.
Deals found on 4/9
Showing 1-10 of 23 resultsSorted by cheapest first
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Best time to book a flight from Mexico City to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
MEX-PTY
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mexico City to Panama City
Prices
Airlines
Delays
How far ahead should I book a flight from Mexico City to Panama City?
The best time to book flights from Mexico City to Panama City is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Mexico City to Panama City?
Currently, February is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £270). Flying from Mexico City to Panama City in July is currently the most expensive (average of £330). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MEX to PTY?
Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 8 September 2026.
One of the essential ways to save on airfare from Mexico City to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 35% on airfare.
How much does it cost for a return flight from Mexico City to Panama City?
Airfare is typical for this route at the moment.
Mexico City to Panama City flights typically cost between £277 and £427 in December.The cheapest return price found within the last 5 days was £282 on Copa Airlines (25 Dec–30 Dec).
Weekly flight availability from Mexico City to Panama City
Explore weekly flight availability from Mexico City to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated 8 September 2026.
The most flights from MEX to PTY are scheduled on a Monday (9 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (8 on average).
How often are flights from Mexico City to Panama City delayed?
About 4% of weekly flights between Mexico City and Panama City have experienced delays in the past year, with the average delay time being 119 minutes.
What is the most punctual flight time for Mexico City to Panama City flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Wednesday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Mexico City to Panama City flights?
Over the past year, Copa Airlines have had the lowest number of delays on this route, with just 4% of flights being delayed.
Related info for your journey
Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
How popular is this Mexico City to Panama City flight route?
The Mexico City Benito Juarez to Panama City Tocumen Intl flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Mexico City to Panama City?
For as low as £292, Copa Airlines can have you in Panama City from Mexico City in 3h 41m. The distance between Mexico City and Panama City is about 1497 mi. All flights are typically direct.
What are the most reliable airlines from Mexico City to Panama City?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: Emirates (95%), Aeromexico (95%), AeroMexico Connect (95%).
What are the cheapest flights from Mexico City to Panama City?
Looking for the cheapest flight from Mexico City to Panama City? While on average our users pay £187, our data indicates the cheapest price to be £187. The most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl), is priced around £392.
Can I find deals for flights from Mexico City to Panama City that include hotel bookings?
Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.
How can I find direct flights from Mexico City to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.
Can I find deals for business class flights from Mexico City to Panama City?
Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Mexico City to Panama City?
Currently, February is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £270). Flying from Mexico City to Panama City in July is currently the most expensive (average of £330). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Browse through other flights departing from Mexico City. Flights are based on user searches made on Cheapflights and were last updated on 8 September 2026.
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on 8 September 2026.
Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.
How does Cheapflights help users find flights from Mexico City to Panama City?
Cheapflights makes it easy to find Mexico City to Panama City flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.
Why should you use Cheapflights to find cheap flight tickets from Mexico City to Panama City?
By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Panama City from Mexico City.
Can Cheapflights find flights from Mexico City to Panama City with no change fees?
Users can book flights with no change fees policies with our dedicated filters. Book flights from Mexico City to Panama City flexibly with Cheapflights today.
Can Cheapflights notify me if prices for flights from Mexico City to Panama City become cheaper?
Yes! Start tracking prices for Mexico City to Panama City flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.
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