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Cheap flights from Mexico City to Panama City from £143

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 16/2. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
26 Feb — 5 Mar1
1 adult
1 adult, Economy, 0 bags
Cheapflights Tip: The best prices from Mexico City Benito Juarez to Panama City Tocumen Intl are usually found in July or August, booked 72 days in advance, depart on a Wednesday or Monday and return on a Monday

Cheap flight deals from Mexico City to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Mexico City to Panama City
Explore the most affordable flight options available from Mexico City to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 27 January 2026.

Mon 23/205:00
MEX
-
PTY
1 stop8h 00m
Avianca
Thu 26/214:55
PTY
-
MEX
1 stop9h 00m
Avianca
Deal found 25/1£236
Thu 12/213:10
MEX
-
PTY
Nonstop3h 38m
Copa Airlines
Thu 19/219:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Deal found 26/1£266
Thu 29/113:10
MEX
-
PTY
Nonstop3h 38m
Copa Airlines
Thu 5/221:25
PTY
-
MEX
Nonstop3h 50m
Copa Airlines
Deal found 26/1£282
Wed 25/205:00
MEX
-
PTY
2 stops10h 55m
Avianca
Sun 1/319:50
PTY
-
MEX
1 stop6h 25m
Avianca
Deal found 26/1£289
Thu 29/109:25
MEX
-
PTY
Nonstop3h 41m
Copa Airlines
Sun 1/209:21
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 26/1£297
Sun 22/305:55
MEX
-
PTY
Nonstop3h 39m
Copa Airlines
Thu 26/311:41
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 26/1£332
Tue 31/302:10
MEX
-
PTY
Nonstop3h 40m
Copa Airlines
Mon 6/422:11
PTY
-
MEX
Nonstop3h 49m
Copa Airlines
Deal found 25/1£366
Fri 4/913:10
MEX
-
PTY
Nonstop3h 44m
Copa Airlines
Sat 12/919:12
PTY
-
MEX
Nonstop3h 53m
Copa Airlines
Deal found 26/1£380
Wed 11/305:00
MEX
-
PTY
2 stops10h 55m
Avianca
Tue 17/317:50
PTY
-
MEX
1 stop10h 10m
Avianca
Deal found 25/1£395
Wed 8/705:50
MEX
-
PTY
Nonstop3h 43m
Copa Airlines
Sat 18/716:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Deal found 25/1£407
Tue 10/215:30
MEX
-
PTY
Nonstop3h 37m
Copa Airlines
Fri 13/219:02
PTY
-
MEX
Nonstop4h 03m
Copa Airlines
Deal found 27/1£423

Find flight deals from Mexico City to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 27 January 2026.

Round-trip from

£236

One-way from

£172

Popular in

April

Cheapest in

July

Average price

£294

Good one-way deal

£156 or less
Avianca
  • Avianca
  • 23/2-26/2
  • 2 total stops
  • 17h 00m total
  • Mexico City to Panama City
Search Deals
Avianca
  • Avianca
  • 17/2
  • 1 total stop
  • 13h 50m total
  • Mexico City to Panama City
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (£16 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£3 potential savings vs. average return price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 27 January 2026.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Mexico City

Fly to

Panama City

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 23/2

05:00-14:00

1 stop8h 00m

Panama City Tocumen Intl

Thu 26/2

14:55-22:55

1 stop9h 00m

£236

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 25/2

15:30-20:07

Nonstop3h 37m

Panama City Tocumen Intl

Wed 4/3

11:41-14:30

Nonstop3h 49m

£266

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 2/5

09:50-14:30

Nonstop3h 40m

Panama City Tocumen Intl

Sun 10/5

11:45-14:30

Nonstop3h 45m

£266

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 12/2

05:55-10:35

Nonstop3h 40m

Panama City Tocumen Intl

Thu 19/2

21:25-00:15

Nonstop3h 50m

£266

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 11/2

13:10-17:48

Nonstop3h 38m

Panama City Tocumen Intl

Fri 20/2

19:02-22:05

Nonstop4h 03m

£266

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 4/3

13:10-17:49

Nonstop3h 39m

Panama City Tocumen Intl

Wed 11/3

09:22-12:10

Nonstop3h 48m

£266

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 17/2

19:55-08:50

2 stops35h 55m

£159

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 16/2

00:40-14:00

1 stop12h 20m

£169

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 16/2

13:50-00:40

1 stop9h 50m

£169

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 16/2

15:30-20:07

Nonstop3h 37m

£268

Flights are sorted by cheapest return flights first.

Deals found on 27/1

Showing 1-10 of 12 results
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Best time to book a flight from Mexico City to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mexico City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Panama City

How far ahead should I book a flight from Mexico City to Panama City?

Use this chart to determine the optimal time to book a return flight from Mexico City to Panama City. Price data was last updated on 23 January 2026.

The best time to book flights from Mexico City to Panama City is 72 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Panama City?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £128). Flying from Mexico City to Panama City in April is currently the most expensive (average of £227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PTY?

Find hourly flight availability from Mexico City to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 27 January 2026.

One of the essential ways to save on airfare from Mexico City to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at midday could potentially save you up to 45% on airfare.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Mexico City to Panama City flight route?

    The Mexico City Benito Juarez to Panama City Tocumen Intl flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Mexico City to Panama City?

    For as low as £266, Copa Airlines can have you in Panama City from Mexico City in 3h 37m. The distance between Mexico City and Panama City is about 1497 mi. All flights are typically direct.

  • What are the most reliable airlines from Mexico City to Panama City?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mexico City to Panama City on time: Copa Airlines (94%), Emirates (93%), AeroMexico Connect (91%).

  • What are the cheapest flights from Mexico City to Panama City?

    Looking for the cheapest flight from Mexico City to Panama City? While on average our users pay £192, our data indicates the cheapest price to be £136. The most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl), is priced around £246.

  • Can I find deals for flights from Mexico City to Panama City that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama City.

  • Can I find deals for business class flights from Mexico City to Panama City?

    Yes. Cheapflights offers flight deals from Mexico City to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama City?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Panama City (average of £128). Flying from Mexico City to Panama City in April is currently the most expensive (average of £227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

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Why should you use Cheapflights to find cheap flight tickets from Mexico City to Panama City?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Panama City from Mexico City.

Can Cheapflights find flights from Mexico City to Panama City with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Mexico City to Panama City flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Mexico City to Panama City become cheaper?

Yes! Start tracking prices for Mexico City to Panama City flights today and get alerted whenever prices for these flights change. To access this feature, click the bell icon next to the flight deals above, which will prompt you for a valid email address to receive your alerts.

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