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Cheap flights from Manchester to St. Louis from £352

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
MAN — STL
20 Apr — 27 Apr1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Manchester to St. Louis

Enter your travel dates to find the best prices.

Cheapest flights from Manchester to St. Louis
Explore the most affordable flight options available from Manchester to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 21 March 2026.

Tue 10/1106:15
MAN
-
STL
2 stops19h 12m
British Airways
Tue 17/1118:13
STL
-
MAN
2 stops16h 17m
British Airways
Deal found 17/3£641
Tue 10/1108:55
MAN
-
STL
2 stops19h 34m
British Airways
Tue 24/1118:13
STL
-
MAN
2 stops16h 17m
British Airways
Deal found 17/3£641
Mon 5/1006:55
MAN
-
STL
2 stops19h 13m
British Airways
Sun 11/1021:40
STL
-
MAN
1 stop12h 25m
British Airways
Deal found 17/3£657
Mon 5/1006:00
MAN
-
STL
1 stop13h 25m
Multiple Airlines
Sun 11/1021:40
STL
-
MAN
1 stop12h 25m
Multiple Airlines
Deal found 17/3£667
Tue 22/912:20
MAN
-
STL
1 stop13h 10m
British Airways
Tue 6/1015:33
STL
-
MAN
2 stops17h 37m
British Airways
Deal found 20/3£670
Thu 12/1111:40
MAN
-
STL
2 stops16h 49m
British Airways
Thu 26/1111:51
STL
-
MAN
2 stops15h 19m
British Airways
Deal found 18/3£671
Tue 10/1113:30
MAN
-
STL
1 stop16h 09m
Virgin Atlantic
Tue 17/1111:51
STL
-
MAN
2 stops12h 49m
Virgin Atlantic
Deal found 17/3£675
Tue 10/1113:30
MAN
-
STL
1 stop13h 19m
Multiple Airlines
Tue 17/1111:51
STL
-
MAN
2 stops14h 59m
Multiple Airlines
Deal found 17/3£684

Find flight deals from Manchester to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MAN) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 21 March 2026.

Round-trip from

£686

One-way from

£352

Popular in

August

Cheapest in

December

Average price

£783
Finnair
  • Finnair
  • 30/4-7/5
  • 4 total stops
  • 47h 49m total
  • Manchester to St. Louis
Search Deals
5/5
  • 5/5
  • 3 total stops
  • 51h 14m total
  • Manchester to St. Louis
Search Deals
Highest demand for flights based on searches. 11% potential increase in price (£87 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£15 potential savings vs. average return price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Manchester to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 21 March 2026.
Use the filters below to find and compare flights from Manchester to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Thu 3/9

07:45-20:19

2 stops18h 34m

Lambert-St Louis

Wed 9/9

12:47-09:50

2 stops15h 03m

£707

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Wed 6/5

07:55-22:17

2 stops20h 22m

Lambert-St Louis

Sun 10/5

11:45-07:45

2 stops38h 00m

£715

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Thu 30/4

08:50-22:59

2 stops20h 09m

Lambert-St Louis

Thu 7/5

12:27-09:45

2 stops15h 18m

£720

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Thu 30/4

20:00-19:30

1 stop29h 30m

Lambert-St Louis

Thu 7/5

11:45-21:55

2 stops28h 10m

£723

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Fri 17/4

13:00-23:36

1 stop16h 36m

Lambert-St Louis

Fri 24/4

18:50-08:50

1 stop32h 00m

£726

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Sat 18/4

13:15-23:36

1 stop16h 21m

Lambert-St Louis

Sat 25/4

17:00-08:15

2 stops57h 15m

£740

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Fri 17/4

06:55-19:30

2 stops18h 35m

Lambert-St Louis

Fri 24/4

12:27-21:05

2 stops26h 38m

£744
Cheapest one-way

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Fri 15/5

06:15-00:21

3 stops24h 06m

£402

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Tue 5/5

05:55-21:13

2 stops21h 18m

£457
Fastest single journey

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Fri 15/5

05:55-13:25

1 stop13h 30m

£491

Flights are sorted by cheapest return flights first.

Deals found on 16/3

Sorted by cheapest first

Best time to book a flight from Manchester to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Manchester with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Manchester to St. Louis

How far ahead should I book a flight from Manchester to St. Louis?

Use this chart to determine the optimal time to book a return flight from Manchester to St. Louis. Price data was last updated on 13 March 2026.

Booking 46 days in advance of your planned departure date is, on average, the best time to get cheap flights from Manchester to St. Louis. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Manchester to St. Louis?

Currently, March is the cheapest month in which you can book a flight from Manchester to St. Louis (average of £518). Flying from Manchester to St. Louis in August is currently the most expensive (average of £813). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated 21 March 2026.
Get a feel of what it's like to fly with Virgin Atlantic,United Airlines, andAer Lingus from Manchester to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Virgin Atlantic
7.5
Good
682 reviews
Check prices

Boarding

7.7

Crew

8.2

Food

6.9

Entertainment

7.6

Overall

7.5

Comfort

7.3

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
Virgin Atlantic
7.5
Good
682 reviews
Virgin Atlantic
7.5
Good
682 reviews
Check prices

Boarding

7.7

Crew

8.2

Food

6.9

Entertainment

7.6

Overall

7.5

Comfort

7.3

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
United Airlines
7.4
Good
9,453 reviews
Virgin Atlantic
7.5
Good
682 reviews
Check prices

Boarding

7.7

Crew

8.2

Food

6.9

Entertainment

7.6

Overall

7.5

Comfort

7.3

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
Aer Lingus
7.2
Good
1,481 reviews
Virgin Atlantic
7.5
Good
682 reviews
Check prices

Boarding

7.7

Crew

8.2

Food

6.9

Entertainment

7.6

Overall

7.5

Comfort

7.3

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
Lufthansa
6.8
Okay
7,861 reviews
Virgin Atlantic
7.5
Good
682 reviews
Check prices

Boarding

7.7

Crew

8.2

Food

6.9

Entertainment

7.6

Overall

7.5

Comfort

7.3

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!
British Airways
6.7
Okay
7,806 reviews
Virgin Atlantic
7.5
Good
682 reviews
Check prices

Boarding

7.7

Crew

8.2

Food

6.9

Entertainment

7.6

Overall

7.5

Comfort

7.3

Reviews

1 / 20
6.0
Good

Pratap,Aug 2025

JFK - LHR

The flight is clean, food good and the staff are excellent! Very professional, polite and accommodating. The seat itself is really mediocre. Can’t believe there is not inch of storage space. Believe it or not it there is not place even to put away your phone or pen!! Very very surprising and terribly inconvenient. No coat hanger hook either. Had to give it away. ALL IN ALL VERY INCONVENIENT business class seat compared to their peers. What is even more surprising is that this on their relatively new fleet of Airbus A350-1000. I was having com platelets different expectations of Virgin and this has disappointed me. Everything else is just as good and as you would expect from Virgin!

Related info for your journey

Find useful and relevant information for your journey from Manchester to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Manchester to St. Louis?

    Airlines like British Airways fly from Manchester to St. Louis in about 18h 34m. The time it takes to get you to your destination can typically vary by up to . There are 4061 mi between Manchester and St. Louis.

  • What are the cheapest airlines flying from Manchester to St. Louis round-trip?

    British Airways, at £556, was found to be the cheapest airline from Manchester to St. Louis.Alternate airlines flying return to your destination include Delta and Virgin Atlantic. British Airways is currently priced 35% below the average price you’ll pay for this route.

  • Can I find deals for flights from Manchester to St. Louis that include hotel bookings?

    Yes. In addition to deals on Manchester to St. Louis flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Manchester to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to St. Louis.

  • Can I find deals for business class flights from Manchester to St. Louis?

    Yes. Cheapflights offers flight deals from Manchester to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Manchester to St. Louis?

    Currently, March is the cheapest month in which you can book a flight from Manchester to St. Louis (average of £518). Flying from Manchester to St. Louis in August is currently the most expensive (average of £813). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 7 airlines flying from Manchester to St. Louis

Discover the top 7 airlines that operate flights from Manchester to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 21 March 2026.
AirlineCheapestAverageFlexibilityOn-time
British AirwaysCheapest£556Average£787FlexibilityNo cancel feeOn-time70%
Search British Airways flights
DeltaCheapest£609Average£861FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
Virgin AtlanticCheapest£643Average£884FlexibilityNo cancel feeOn-time72%
Search Virgin Atlantic flights
United AirlinesCheapest£718Average£825FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
LufthansaCheapest£724Average£1,013FlexibilityNo cancel feeOn-time76%
Search Lufthansa flights
KLMCheapest£750Average£878FlexibilityNo cancel feeOn-time75%
Search KLM flights
Aer LingusCheapest£846Average£1,034FlexibilityNo cancel feeOn-timeN/A
Search Aer Lingus flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Manchester to St. Louis?

Cheapflights makes it easy to find Manchester to St. Louis flights by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Manchester to St. Louis?

Millions of users choose and trust Cheapflights to book the best flight deals from Manchester to St. Louis for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Manchester to St. Louis with no change fees?

Certainly. Search results for flights to St. Louis from Manchester shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Manchester to St. Louis become cheaper?

Yes, Cheapflights offers price alerts on Manchester to St. Louis flights so you can book your travel at the perfect time. Price Alerts can be enabled by clicking the bell icon next to the flight deals above and providing your email address where you want to receive the alerts.

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