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Cheap flights from Santiago to Guayaquil from £145

SCL — GYE
17 Oct — 24 Oct1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Santiago to Guayaquil

Enter your travel dates to find the best prices.

Cheapest flights from Santiago to Guayaquil

Mon 28/907:40 -
1 stop11h 55m
Tue 6/1009:10 -
1 stop13h 10m
Deal found 16/9£293
Thu 29/1003:28 -
1 stop9h 47m
Sun 15/1118:38 -
1 stop27h 41m
Deal found 14/9£299
Fri 25/901:43 -
1 stop11h 38m
Tue 29/918:28 -
1 stop24h 04m
Deal found 15/9£321
Tue 15/912:22 -
1 stop24h 59m
Sat 19/908:28 -
1 stop17h 28m
Deal found 14/9£449
Sun 20/1201:27 -
1 stop24h 29m
Sun 27/1218:34 -
1 stop27h 01m
Deal found 16/9£456
Fri 18/905:14 -
1 stop10h 20m
Fri 18/918:28 -
1 stop9h 42m
Deal found 16/9£470
Mon 28/1206:00 -
1 stop22h 15m
Fri 5/203:18 -
1 stop21h 32m
Deal found 16/9£724
Thu 5/1122:45 -
2 stops44h 50m
Tue 1/1214:45 -
2 stops40h 05m
Deal found 15/9£1,736
Sun 8/1122:45 -
2 stops26h 55m
Wed 2/1212:22 -
2 stops42h 28m
Deal found 15/9£1,747
Fri 6/1122:45 -
2 stops44h 50m
Wed 2/1212:22 -
2 stops42h 28m
Deal found 15/9£1,765
Mon 9/1122:45 -
2 stops48h 11m
Wed 2/1212:22 -
2 stops42h 28m
Deal found 15/9£1,847

Find flight deals from Santiago to Guayaquil

Round-trip from

£293

One-way from

£145

Popular in

January

Cheapest in

August

Average price

£347
Avianca
  • Avianca
  • 28/9-6/10
  • 2 total stops
  • 25h 05m total
  • Santiago to Guayaquil
Search Deals
Copa Airlines
  • Copa Airlines
  • 28/9-31/12
  • 1 total stop
  • 10h 07m total
  • Santiago to Guayaquil
Search Deals
Highest demand for flights based on searches. 7% potential increase in price (£21 potential increase over avg. return price).
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Cheapest flight prices on average. 1% potential price decrease (£4 potential savings vs. average return price).
Search Deals
Average for round-trip flights in September 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

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Cheapest return flight
Fastest return journey

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Tue 13/10

03:15-11:21

1 stop10h 06m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£180

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Wed 23/9

01:43-11:21

1 stop11h 38m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£189

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Thu 24/9

01:06-11:21

1 stop12h 15m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£189

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Fri 2/10

01:07-11:21

1 stop12h 14m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£201

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Thu 1/10

01:30-14:50

2 stops15h 20m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£206

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Wed 16/12

03:19-20:57

1 stop19h 38m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£294

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Mon 28/9

03:14-11:21

1 stop10h 07m

Guayaquil Jose Joaquin de Olmedo

Tue 29/9

18:28-23:39

1 stop27h 11m

£299

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Mon 12/10

06:00-02:15

1 stop22h 15m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£301

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Sun 20/12

01:27-23:56

1 stop24h 29m

Guayaquil Jose Joaquin de Olmedo

Sun 27/12

18:34-23:35

1 stop27h 01m

£456

SantiagoGuayaquil

SCL Santiago Arturo Merino Benitez - GYE Guayaquil Jose Joaquin de Olmedo

SCLGYE

Santiago Arturo Merino Benitez

Mon 19/10

06:00-02:15

1 stop22h 15m

Guayaquil Jose Joaquin de Olmedo

Wed 31/12

00:00-02:00

Nonstop0h 00m

£524

Flights are sorted by cheapest return flights first.

Deals found on 15/9

Showing 1-10 of 19 resultsSorted by cheapest first
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Best time to book a flight from Santiago to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Santiago with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Santiago to Guayaquil

How far ahead should I book a flight from Santiago to Guayaquil?

The price you pay for your flight from Santiago to Guayaquil may vary depending on when you book. For the best chance of a lower fare, look to book 58 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santiago to Guayaquil?

Currently, August is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of £313). Flying from Santiago to Guayaquil in January is currently the most expensive (average of £405). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to GYE?

When flying from Santiago to Guayaquil, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost for a return flight from Santiago to Guayaquil?

Airfare is below average for this route at the moment.

Santiago to Guayaquil flights typically cost between £315 and £383 in September.
The cheapest return price found within the last 5 days was £293 on Avianca (28 Sept–6 Oct).

Related info for your journey

  • How long is the flight from Santiago to Guayaquil?

    For as low as £299, Copa Airlines can have you in Guayaquil from Santiago in 10h 07m. Airlines will cover a distance of 2235 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Santiago to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Santiago to Guayaquil flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Guayaquil.

  • Can I find deals for business class flights from Santiago to Guayaquil?

    Yes. Cheapflights offers flight deals from Santiago to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Guayaquil?

    Currently, August is the cheapest month in which you can book a flight from Santiago to Guayaquil (average of £313). Flying from Santiago to Guayaquil in January is currently the most expensive (average of £405). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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