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Cheap flights from Manchester to Missouri from £353

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
MAN — STL
21 Apr — 28 Apr1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Manchester to Missouri

Enter your travel dates to find the best prices.

Cheapest flights from Manchester to Missouri
Explore the most affordable flight options available from Manchester to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 22 March 2026.

Tue 10/1106:15
MAN
-
STL
2 stops19h 12m
British Airways
Tue 17/1118:13
STL
-
MAN
2 stops16h 17m
British Airways
Deal found 17/3£642
Tue 10/1108:55
MAN
-
STL
2 stops19h 34m
British Airways
Tue 24/1118:13
STL
-
MAN
2 stops16h 17m
British Airways
Deal found 17/3£643
Tue 22/912:20
MAN
-
STL
1 stop13h 10m
British Airways
Tue 6/1015:33
STL
-
MAN
2 stops17h 37m
British Airways
Deal found 20/3£672
Thu 12/1111:40
MAN
-
STL
2 stops16h 49m
British Airways
Thu 26/1111:51
STL
-
MAN
2 stops15h 19m
British Airways
Deal found 18/3£673
Tue 10/1113:30
MAN
-
STL
1 stop16h 09m
Virgin Atlantic
Tue 17/1111:51
STL
-
MAN
2 stops12h 49m
Virgin Atlantic
Deal found 17/3£677
Tue 10/1113:30
MAN
-
STL
1 stop13h 19m
Multiple Airlines
Tue 17/1111:51
STL
-
MAN
2 stops14h 59m
Multiple Airlines
Deal found 17/3£686
Wed 13/510:40
MAN
-
STL
1 stop19h 19m
Virgin Atlantic
Wed 20/510:49
STL
-
MAN
2 stops15h 36m
Virgin Atlantic
Deal found 18/3£689
Thu 30/410:35
MAN
-
MCI
2 stops17h 29m
Lufthansa
Thu 7/506:17
MCI
-
MAN
2 stops22h 08m
Lufthansa
Deal found 21/3£923
Mon 4/510:35
MAN
-
MCI
2 stops33h 51m
United Airlines
Mon 11/512:50
MCI
-
MAN
2 stops15h 00m
United Airlines
Deal found 20/3£943
Wed 16/909:00
MAN
-
SGF
2 stops37h 21m
United Airlines
Sun 20/917:05
SGF
-
MAN
2 stops42h 05m
United Airlines
Deal found 18/3£946
Wed 16/906:05
MAN
-
COU
2 stops17h 40m
United Airlines
Sun 20/915:05
COU
-
MAN
2 stops36h 45m
United Airlines
Deal found 20/3£947
Tue 5/505:55
MAN
-
MCI
2 stops20h 46m
United Airlines
Tue 12/512:50
MCI
-
MAN
2 stops15h 00m
United Airlines
Deal found 21/3£947

Find flight deals from Manchester to Missouri

Keep the following information in mind while searching for Manchester to Missouri flight deals. Data was last updated 22 March 2026.

Round-trip from

£689

One-way from

£353

Popular in

August

Cheapest in

December

Average price

£785
Virgin Atlantic
  • Virgin Atlantic
  • 13/5-20/5
  • 3 total stops
  • 34h 55m total
  • Manchester to Missouri
Search Deals
5/5
  • 5/5
  • 3 total stops
  • 51h 14m total
  • Manchester to Missouri
Search Deals
Highest demand for flights based on searches. 11% potential increase in price (£87 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£15 potential savings vs. average return price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Manchester to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 22 March 2026.
Use the filters below to find and compare flights from Manchester to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Thu 3/9

10:50-23:51

2 stops19h 01m

Lambert-St Louis

Wed 9/9

12:47-09:50

2 stops15h 03m

£711

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Wed 6/5

08:00-23:46

2 stops21h 46m

Lambert-St Louis

Sun 10/5

11:45-22:35

2 stops28h 50m

£720

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Fri 17/4

13:00-23:36

1 stop16h 36m

Lambert-St Louis

Fri 24/4

18:50-08:50

1 stop32h 00m

£728

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Sat 18/4

13:15-23:36

1 stop16h 21m

Lambert-St Louis

Sat 25/4

17:00-08:15

2 stops57h 15m

£742

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Fri 17/4

06:55-19:30

2 stops18h 35m

Lambert-St Louis

Fri 24/4

12:27-21:05

2 stops26h 38m

£746

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Thu 7/5

05:55-17:56

2 stops18h 01m

Lambert-St Louis

Tue 12/5

10:19-08:25

2 stops16h 06m

£752

ManchesterSt. Louis

MAN - STL

MANSTL

Manchester

Thu 3/9

13:00-08:06

1 stop25h 06m

Lambert-St Louis

Wed 9/9

17:30-16:55

2 stops17h 25m

£764

ManchesterKansas City

MAN - MCI

MANMCI

Manchester

Thu 30/4

10:35-22:04

2 stops17h 29m

Kansas City

Thu 7/5

06:17-10:25

2 stops22h 08m

£923

ManchesterSpringfield

MAN - SGF

MANSGF

Manchester

Wed 16/9

09:00-16:21

2 stops37h 21m

Springfield-Branson

Sun 20/9

17:05-17:10

2 stops42h 05m

£946

ManchesterColumbia

MAN - COU

MANCOU

Manchester

Wed 16/9

06:05-17:45

2 stops17h 40m

Columbia Regional

Sun 20/9

15:05-09:50

2 stops36h 45m

£947

Flights are sorted by cheapest return flights first.

Deals found on 19/3

Showing 1-10 of 34 resultsSorted by cheapest first
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2
3
4

Best time to book a flight from Manchester to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Manchester with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Manchester to Missouri

What is the cheapest month to book a flight from Manchester to Missouri?

Currently, January is the cheapest month in which you can book a flight from Manchester to Missouri (average of £501). Flying from Manchester to Missouri in August is currently the most expensive (average of £781). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated 22 March 2026.
Get a feel of what it's like to fly with KLM,Virgin Atlantic, andUnited Airlines from Manchester to Missouri by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,475 reviews
Check prices

Boarding

7.8

Crew

8.4

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
KLM
7.8
Good
1,475 reviews
KLM
7.8
Good
1,475 reviews
Check prices

Boarding

7.8

Crew

8.4

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Virgin Atlantic
7.5
Good
682 reviews
KLM
7.8
Good
1,475 reviews
Check prices

Boarding

7.8

Crew

8.4

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
United Airlines
7.4
Good
9,453 reviews
KLM
7.8
Good
1,475 reviews
Check prices

Boarding

7.8

Crew

8.4

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Aer Lingus
7.2
Good
1,481 reviews
KLM
7.8
Good
1,475 reviews
Check prices

Boarding

7.8

Crew

8.4

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
British Airways
6.7
Okay
7,806 reviews
KLM
7.8
Good
1,475 reviews
Check prices

Boarding

7.8

Crew

8.4

Comfort

7.6

Food

7.3

Overall

7.8

Entertainment

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas

Related info for your journey

Find useful and relevant information for your journey from Manchester to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Manchester to Missouri?

    If you book a flight to Missouri from Manchester, you will be flying from Manchester, which is the city’s only airport. Manchester (MAN) is located 8.9 mi from the center of Manchester.

  • How long is the flight from Manchester to Missouri?

    Airlines like Virgin Atlantic, British Airways, and Lufthansa fly from Manchester to Missouri in about 17h 29m. The time it takes to get you to your destination can typically vary by up to 9h 07m. The distance between Manchester and Missouri is about 4195 mi. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • What are the most popular routes from Manchester to Missouri?

    While some choose either Manchester - Lambert-St Louis or Manchester - Columbia Regional, Manchester - Kansas City is the most popular route from Manchester to Missouri.

  • Can I find deals for flights from Manchester to Missouri that include hotel bookings?

    Yes. In addition to deals on Manchester to Missouri flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Manchester to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to Missouri.

  • Can I find deals for business class flights from Manchester to Missouri?

    Yes. Cheapflights offers flight deals from Manchester to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Manchester to Missouri?

    Currently, January is the cheapest month in which you can book a flight from Manchester to Missouri (average of £501). Flying from Manchester to Missouri in August is currently the most expensive (average of £781). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Manchester to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 9 airlines flying from Manchester to Missouri

Discover the top 9 airlines that operate flights from Manchester to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 22 March 2026.
AirlineCheapestAverageFlexibilityOn-time
British AirwaysCheapest£557Average£832FlexibilityNo cancel feeOn-time70%
Search British Airways flights
Virgin AtlanticCheapest£572Average£948FlexibilityNo cancel feeOn-time72%
Search Virgin Atlantic flights
Scandinavian AirlinesCheapest£584Average£729FlexibilityNo cancel feeOn-time77%
Search Scandinavian Airlines flights
DeltaCheapest£611Average£863FlexibilityNo cancel feeOn-timeN/A
Search Delta flights
KLMCheapest£672Average£1,009FlexibilityNo cancel feeOn-time75%
Search KLM flights
United AirlinesCheapest£681Average£838FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
LufthansaCheapest£726Average£1,015FlexibilityNo cancel feeOn-time76%
Search Lufthansa flights
American AirlinesCheapest£844Average£1,044FlexibilityNo cancel feeOn-time71%
Search American Airlines flights
Aer LingusCheapest£848Average£1,005FlexibilityNo cancel feeOn-timeN/A
Search Aer Lingus flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Manchester to Missouri?

Deals for Manchester to Missouri flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Manchester to Missouri?

By finding flights from multiple airlines and providers at completely no cost, Cheapflights helps millions of users like you annually find the best flights to Missouri from Manchester.

Can Cheapflights find flights from Manchester to Missouri with no change fees?

Yes! Cheapflights helps users easily find flights from Manchester to Missouri with no change fees.

Can Cheapflights notify me if prices for flights from Manchester to Missouri become cheaper?

Not ready to book yet? You can track prices for flights from Manchester to Missouri on Cheapflights with our Price Alert feature and get notified when better prices are available.

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