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Cheap flights from Panama City to Brussels Bruxelles-National Airport from £406

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 24/12. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BRU
11 Jan — 18 Jan1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Bruxelles-National

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Bruxelles-National
Explore the most affordable flight options available from Panama City to Bruxelles-National. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 December 2025.

Mon 15/1210:25PTY - BRU
2 stops22h 05mMultiple Airlines
Sat 10/110:20BRU - PTY
2 stops27h 16mMultiple Airlines
Deal found 12/12£915
Mon 15/1218:45PTY - BRU
1 stop13h 30mKLM
Sat 10/106:15BRU - PTY
1 stop16h 15mKLM
Deal found 11/12£963
Wed 17/1218:45PTY - BRU
1 stop13h 30mKLM
Sun 28/1214:45BRU - PTY
1 stop31h 45mKLM
Deal found 10/12£1,063
Mon 15/1222:29PTY - BRU
2 stops27h 21mUnited Airlines
Sat 10/110:00BRU - PTY
2 stops26h 13mUnited Airlines
Deal found 11/12£1,206
Thu 11/1223:55PTY - BRU
2 stops27h 00mUnited Airlines
Thu 18/1210:30BRU - PTY
2 stops39h 57mUnited Airlines
Deal found 10/12£1,222
Wed 17/1218:41PTY - BRU
2 stops31h 09mUnited Airlines
Sun 28/1211:55BRU - PTY
2 stops32h 00mUnited Airlines
Deal found 10/12£1,476

Find flight deals from Panama City to Bruxelles-National

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Bruxelles-National (BRU). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 December 2025.

Round-trip from

£636

One-way from

£406

Popular in

December

Cheapest in

January

Average price

£789
KLM
  • KLM
  • 13/4-25/4
  • 2 total stops
  • 30h 20m total
  • Panama City to Brussels
Search Deals
KLM
  • KLM
  • 24/12
  • 1 total stop
  • 33h 25m total
  • Panama City to Brussels
Search Deals
Highest demand for flights based on searches. 6% potential increase in price (£31 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£10 potential savings vs. average return price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama City to Bruxelles-National that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 December 2025.
Use the filters below to find and compare flights from Panama City to Brussels Bruxelles-National Airport that are best for you.

Fly from

Panama City

Fly to

Bruxelles-National

Route

Depart

Return

Price

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 13/4

18:50-14:40

1 stop12h 50m

Brussels Bruxelles-National

Sat 25/4

06:20-16:50

1 stop17h 30m

£636

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 14/2

18:45-22:20

1 stop21h 35m

Brussels Bruxelles-National

Thu 26/2

08:05-16:30

1 stop14h 25m

£656

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 4/5

13:55-19:35

2 stops22h 40m

Brussels Bruxelles-National

Wed 27/5

12:05-20:00

1 stop14h 55m

£679

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 14/2

07:55-14:30

2 stops24h 35m

Brussels Bruxelles-National

Thu 26/2

10:20-06:35

2 stops26h 15m

£711

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Thu 19/3

21:30-17:45

1 stop14h 15m

Brussels Bruxelles-National

Wed 1/4

18:55-18:40

1 stop30h 45m

£718

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 13/4

22:15-21:25

1 stop40h 10m

Brussels Bruxelles-National

Sat 25/4

14:25-18:30

2 stops35h 05m

£734

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 14/2

16:41-07:15

2 stops32h 34m

Brussels Bruxelles-National

Thu 26/2

10:10-20:02

2 stops39h 52m

£790

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Fri 30/1

11:35-07:15

2 stops37h 40m

Brussels Bruxelles-National

Sun 15/2

10:10-20:02

2 stops39h 52m

£790

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Fri 26/12

18:45-14:15

1 stop13h 30m

£406

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 27/12

18:45-22:20

1 stop21h 35m

£406

Flights are sorted by cheapest return flights first.

Deals found on 11/12

Showing 1-10 of 14 results
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Best time to book a flight from Panama City to Bruxelles-National

Have a flexible travel schedule? Discover the best time to fly to Bruxelles-National from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Brussels Bruxelles-National Airport

How far ahead should I book a flight from Panama City to Brussels Bruxelles-National Airport?

Use this chart to determine the optimal time to book a return flight from Panama City to Bruxelles-National. Price data was last updated on 5 December 2025.

To ensure you get the cheapest price possible for a flight from Panama City to Brussels Bruxelles-National Airport, you should look to book at least 42 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Brussels Bruxelles-National Airport?

Currently, January is the cheapest month in which you can book a flight from Panama City to Brussels Bruxelles-National Airport (average of £512). Flying from Panama City to Brussels Bruxelles-National Airport in December is currently the most expensive (average of £633). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Bruxelles-National. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Brussels Bruxelles-National?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly out of when you book flights from Panama City to Brussels Bruxelles-National. 0 airlines have flights from Tocumen Intl to Brussels Bruxelles-National on a regular basis. Booking flights from Panama City Tocumen Intl to Brussels Bruxelles-National should not be difficult; the airport handles an average of 0 outbound flights to Brussels Bruxelles-National per day.

  • How long is the flight from Panama City to Brussels Bruxelles-National Airport?

    For as low as £636, KLM can have you in Brussels Bruxelles-National Airport from Panama City in 12h 50m. Panama City and Brussels Bruxelles-National Airport are separated by a distance of 5462 mi.

  • Can I find deals for flights from Panama City to Bruxelles-National that include hotel bookings?

    Yes. In addition to deals on Panama City to Bruxelles-National flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Bruxelles-National?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Bruxelles-National.

  • Can I find deals for business class flights from Panama City to Bruxelles-National?

    Yes. Cheapflights offers flight deals from Panama City to Bruxelles-National by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Brussels Bruxelles-National Airport?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Brussels Bruxelles-National Airport (average of £512). Flying from Panama City to Brussels Bruxelles-National Airport in December is currently the most expensive (average of £633). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Brussels Bruxelles-National Airport?

Book flights to Brussels Bruxelles-National Airport if you plan to visit one of these locations
Ypres
Leuven
Mons
Spa
Charleroi
Hasselt
Mechelen
Zaventem

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Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City to Bruxelles-National?

Deals for Panama City to Bruxelles-National flights are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose better, like price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Panama City to Bruxelles-National?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Panama City to Bruxelles-National for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Panama City to Bruxelles-National with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Panama City to Bruxelles-National flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Panama City to Bruxelles-National become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Bruxelles-National from Panama City today and book when prices fit your budget.

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