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Cheap flights from Panama City to Brussels Bruxelles-National Airport from £528

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 14/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BRU
21 Apr — 28 Apr1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Bruxelles-National

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Bruxelles-National
Explore the most affordable flight options available from Panama City to Bruxelles-National. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 22 March 2026.

Wed 8/422:20
PTY
-
BRU
1 stop33h 55m
Turkish Airlines
Mon 20/411:10
BRU
-
PTY
2 stops38h 15m
Turkish Airlines
Deal found 18/3£549
Mon 6/422:20
PTY
-
BRU
1 stop28h 50m
Turkish Airlines
Fri 10/414:25
BRU
-
PTY
1 stop37h 00m
Turkish Airlines
Deal found 20/3£567
Wed 3/620:25
PTY
-
BRU
1 stop14h 15m
Air Europa
Sun 7/610:45
BRU
-
PTY
1 stop14h 55m
Air Europa
Deal found 17/3£645
Mon 13/422:20
PTY
-
BRU
1 stop33h 55m
Turkish Airlines
Sat 25/407:20
BRU
-
PTY
2 stops42h 05m
Turkish Airlines
Deal found 17/3£648
Thu 19/315:10
PTY
-
BRU
2 stops19h 55m
Multiple Airlines
Wed 1/407:05
BRU
-
PTY
1 stop19h 55m
Multiple Airlines
Deal found 17/3£778
Fri 4/910:00
PTY
-
BRU
2 stops38h 15m
United Airlines
Sun 13/910:15
BRU
-
PTY
2 stops40h 16m
United Airlines
Deal found 19/3£792
Sat 18/410:00
PTY
-
BRU
2 stops20h 15m
United Airlines
Sat 25/410:15
BRU
-
PTY
2 stops24h 49m
United Airlines
Deal found 19/3£807

Find flight deals from Panama City to Bruxelles-National

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Bruxelles-National (BRU). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 22 March 2026.

Round-trip from

£549

One-way from

£528

Popular in

April

Cheapest in

February

Average price

£627
Turkish Airlines
  • Turkish Airlines
  • 8/4-20/4
  • 3 total stops
  • 72h 10m total
  • Panama City to Brussels
Search Deals
Turkish Airlines
  • Turkish Airlines
  • 14/7
  • 1 total stop
  • 18h 20m total
  • Panama City to Brussels
Search Deals
Highest demand for flights based on searches. 0% potential increase in price (£2 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£12 potential savings vs. average return price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama City to Bruxelles-National that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 22 March 2026.
Use the filters below to find and compare flights from Panama City to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Wed 8/4

22:20-15:15

1 stop33h 55m

Brussels Bruxelles-National

Mon 20/4

11:10-18:25

2 stops38h 15m

£549

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 6/4

22:20-10:10

1 stop28h 50m

Brussels Bruxelles-National

Fri 10/4

14:25-20:25

1 stop37h 00m

£567
Fastest return journey

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Wed 3/6

20:25-17:40

1 stop14h 15m

Brussels Bruxelles-National

Sun 7/6

10:45-18:40

1 stop14h 55m

£645

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 13/4

22:20-15:15

1 stop33h 55m

Brussels Bruxelles-National

Sat 25/4

07:20-18:25

2 stops42h 05m

£648

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 24/8

15:30-07:15

2 stops56h 45m

Brussels Bruxelles-National

Wed 9/9

11:10-19:31

1 stop15h 21m

£839

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 20/7

15:30-07:15

2 stops32h 45m

Brussels Bruxelles-National

Sun 2/8

09:55-04:04

2 stops25h 09m

£863

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 13/4

10:00-07:15

2 stops38h 15m

Brussels Bruxelles-National

Sat 25/4

10:15-04:04

2 stops24h 49m

£872
Cheapest one-way

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Tue 14/7

20:05-10:10

1 stop31h 05m

£528
Fastest single journey

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 28/3

22:55-07:15

2 stops25h 20m

£714

Flights are sorted by cheapest return flights first.

Deals found on 19/3

Sorted by cheapest first

Best time to book a flight from Panama City to Bruxelles-National

Have a flexible travel schedule? Discover the best time to fly to Bruxelles-National from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Brussels Bruxelles-National Airport

How far ahead should I book a flight from Panama City to Brussels Bruxelles-National Airport?

Use this chart to determine the optimal time to book a return flight from Panama City to Bruxelles-National. Price data was last updated on 13 March 2026.

To ensure you get the cheapest price possible for a flight from Panama City to Brussels Bruxelles-National Airport, you should look to book at least 49 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Brussels Bruxelles-National Airport?

Currently, May is the cheapest month in which you can book a flight from Panama City to Brussels Bruxelles-National Airport (average of £513). Flying from Panama City to Brussels Bruxelles-National Airport in December is currently the most expensive (average of £718). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Bruxelles-National. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Brussels Bruxelles-National?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly out of when you book flights from Panama City to Brussels Bruxelles-National. 0 airlines have flights from Tocumen Intl to Brussels Bruxelles-National on a regular basis. Booking flights from Panama City Tocumen Intl to Brussels Bruxelles-National should not be difficult; the airport handles an average of 0 outbound flights to Brussels Bruxelles-National per day.

  • How long is the flight from Panama City to Brussels Bruxelles-National Airport?

    For as low as £645, Turkish Airlines can have you in Brussels Bruxelles-National Airport from Panama City in 14h 15m. Panama City and Brussels Bruxelles-National Airport are separated by a distance of 5462 mi. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Panama City to Bruxelles-National that include hotel bookings?

    Yes. In addition to deals on Panama City to Bruxelles-National flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Bruxelles-National?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Bruxelles-National.

  • Can I find deals for business class flights from Panama City to Bruxelles-National?

    Yes. Cheapflights offers flight deals from Panama City to Bruxelles-National by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Brussels Bruxelles-National Airport?

    Currently, May is the cheapest month in which you can book a flight from Panama City to Brussels Bruxelles-National Airport (average of £513). Flying from Panama City to Brussels Bruxelles-National Airport in December is currently the most expensive (average of £718). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Brussels Bruxelles-National Airport?

Book flights to Brussels Bruxelles-National Airport if you plan to visit one of these locations
Leuven
Ypres
Mechelen
Mons
Spa
Charleroi
Hasselt
Dinant
Zaventem

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Why should you use Cheapflights to find cheap flight tickets from Panama City to Bruxelles-National?

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Can Cheapflights find flights from Panama City to Bruxelles-National with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Panama City to Bruxelles-National flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Panama City to Bruxelles-National become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Bruxelles-National from Panama City today and book when prices fit your budget.

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