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Cheap flights from Panama City to Brussels Bruxelles-National Airport from £628

This is the cheapest retur flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BRU
23 Jul — 30 Jul1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama City to Bruxelles-National

Enter your travel dates to find the best prices.

Cheapest flights from Panama City to Bruxelles-National
Explore the most affordable flight options available from Panama City to Bruxelles-National. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 23 June 2026.

Sun 4/1018:50
PTY
-
BRU
1 stop12h 50m
KLM
Sun 11/1010:35
BRU
-
PTY
2 stops16h 10m
KLM
Deal found 20/6£628
Fri 4/1221:45
PTY
-
BRU
1 stop30h 50m
Turkish Airlines
Thu 10/1211:35
BRU
-
PTY
1 stop38h 30m
Turkish Airlines
Deal found 18/6£647
Mon 5/1018:50
PTY
-
BRU
1 stop20h 25m
KLM
Mon 12/1010:25
BRU
-
PTY
2 stops16h 20m
KLM
Deal found 23/6£722

Find flight deals from Panama City to Bruxelles-National

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Bruxelles-National (BRU). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 23 June 2026.

Round-trip from

£628

Popular in

December

Cheapest in

February

Average price

£796
KLM
  • KLM
  • 4/10-11/10
  • 3 total stops
  • 29h 00m total
  • Panama City to Brussels
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (£28 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (£11 potential savings vs. average return price).
Search Deals
Average for round-trip flights in June 2026
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Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama City to Bruxelles-National that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 23 June 2026.
Use the filters below to find and compare flights from Panama City to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Fri 4/12

21:45-10:35

1 stop30h 50m

Brussels Bruxelles-National

Thu 10/12

11:35-20:05

1 stop38h 30m

£647

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 5/10

18:50-22:15

1 stop20h 25m

Brussels Bruxelles-National

Mon 12/10

10:25-19:45

2 stops16h 20m

£722

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 20/7

22:55-07:45

1 stop25h 50m

Brussels Bruxelles-National

Sun 2/8

12:00-04:04

2 stops47h 04m

£811

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Thu 6/8

09:45-07:45

1 stop15h 00m

Brussels Bruxelles-National

Thu 13/8

11:10-04:04

1 stop23h 54m

£811
Fastest return journey

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Thu 30/7

09:45-07:45

1 stop15h 00m

Brussels Bruxelles-National

Fri 7/8

11:10-19:31

1 stop15h 21m

£812

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Wed 22/7

09:45-07:45

1 stop15h 00m

Brussels Bruxelles-National

Wed 29/7

11:10-04:04

1 stop23h 54m

£812

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sun 6/9

22:55-09:00

2 stops27h 05m

Brussels Bruxelles-National

Wed 16/9

11:10-19:31

1 stop15h 21m

£812

Flights are sorted by cheapest return flights first.

Deals found on 18/6

Sorted by cheapest first

Best time to book a flight from Panama City to Bruxelles-National

Have a flexible travel schedule? Discover the best time to fly to Bruxelles-National from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Brussels Bruxelles-National Airport

How far ahead should I book a flight from Panama City to Brussels Bruxelles-National Airport?

To ensure you get the cheapest price possible for a flight from Panama City to Brussels Bruxelles-National Airport, you should look to book at least 18 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Panama City to Brussels Bruxelles-National Airport?

Currently, February is the cheapest month in which you can book a flight from Panama City to Brussels Bruxelles-National Airport (average of £611). Flying from Panama City to Brussels Bruxelles-National Airport in December is currently the most expensive (average of £895). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Panama City to Brussels Bruxelles-National Airport?

Related info for your journey

Find useful and relevant information for your journey from Panama City to Bruxelles-National. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Brussels Bruxelles-National?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly out of when you book flights from Panama City to Brussels Bruxelles-National. 0 airlines have flights from Tocumen Intl to Brussels Bruxelles-National on a regular basis. Booking flights from Panama City Tocumen Intl to Brussels Bruxelles-National should not be difficult; the airport handles an average of 0 outbound flights to Brussels Bruxelles-National per day.

  • How long is the flight from Panama City to Brussels Bruxelles-National Airport?

    For as low as £722, Turkish Airlines can have you in Brussels Bruxelles-National Airport from Panama City in 20h 25m. Panama City and Brussels Bruxelles-National Airport are separated by a distance of 5462 mi. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Panama City to Bruxelles-National that include hotel bookings?

    Yes. In addition to deals on Panama City to Bruxelles-National flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Bruxelles-National?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Bruxelles-National.

  • Can I find deals for business class flights from Panama City to Bruxelles-National?

    Yes. Cheapflights offers flight deals from Panama City to Bruxelles-National by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Brussels Bruxelles-National Airport?

    Currently, February is the cheapest month in which you can book a flight from Panama City to Brussels Bruxelles-National Airport (average of £611). Flying from Panama City to Brussels Bruxelles-National Airport in December is currently the most expensive (average of £895). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Brussels Bruxelles-National Airport?

Book flights to Brussels Bruxelles-National Airport if you plan to visit one of these locations
Leuven
Charleroi
Mechelen
Ypres
Mons
Hasselt
Dinant
Zaventem

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Can Cheapflights find flights from Panama City to Bruxelles-National with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Panama City to Bruxelles-National flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Panama City to Bruxelles-National become cheaper?

Yes, Cheapflights has a feature called Price Alert, which notifies users when flight prices change. Track prices for your flight to Bruxelles-National from Panama City today and book when prices fit your budget.

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