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Cheap flights from Frankfurt am Main Airport to Panama City from £306

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/9. Fares are subject to change and may not be available on all flights or dates of travel.
FRA — PTY
12 Oct — 19 Oct1
1 adult
1 adult, Economy

Cheap flight deals from Frankfurt to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Frankfurt (FRA) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 12 September 2025.

Round-trip from

£478

One-way from

£306

Popular in

December

Cheapest in

May

Average price

£538
Air Europa
  • Air Europa
  • 21/11-28/11
  • 2 total stops
  • 60h 55m total
  • Frankfurt am Main to Panama City
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Air Europa
  • Air Europa
  • 17/9
  • 1 total stop
  • 30h 30m total
  • Frankfurt am Main to Panama City
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Highest demand for flights based on searches. 13% potential increase in price (£65 potential increase over avg. return price).
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Cheapest flight prices on average. 4% potential price decrease (£17 potential savings vs. average return price).
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Average for round-trip flights in September 2025
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Find flight deals from Frankfurt to Panama City

Cheapest flights from Frankfurt to Panama City
Explore the most affordable flight options available from Frankfurt to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 12 September 2025.

Thu 18/909:45FRA - PTY
1 stop15h 00mMultiple Airlines
Sun 19/1018:50PTY - FRA
1 stop20h 10mMultiple Airlines
Deal found 10/9£475
Fri 21/1119:05FRA - PTY
1 stop30h 40mAir Europa
Fri 28/1121:30PTY - FRA
1 stop30h 15mAir Europa
Deal found 11/9£478
Wed 5/1119:05FRA - PTY
1 stop30h 40mAir Europa
Fri 28/1121:30PTY - FRA
1 stop30h 15mAir Europa
Deal found 10/9£479
Sun 12/1021:50FRA - PTY
Nonstop11h 50mCondor
Thu 23/1011:05PTY - FRA
Nonstop11h 10mCondor
Deal found 10/9£486
Sat 8/1110:45FRA - PTY
1 stop15h 00mAir Europa
Sun 23/1121:30PTY - FRA
1 stop14h 20mAir Europa
Deal found 11/9£490
Sat 8/1110:45FRA - PTY
1 stop15h 00mAir Europa
Fri 5/1221:30PTY - FRA
1 stop14h 20mAir Europa
Deal found 10/9£492
Sat 8/1110:45FRA - PTY
1 stop15h 00mAir Europa
Sat 29/1121:30PTY - FRA
1 stop30h 15mAir Europa
Deal found 10/9£498
Fri 31/1019:05FRA - PTY
1 stop30h 40mAir Europa
Thu 15/121:30PTY - FRA
1 stop14h 20mAir Europa
Deal found 10/9£499
Fri 17/1017:10FRA - PTY
2 stops32h 27mUnited Airlines
Sun 19/1015:35PTY - FRA
1 stop40h 40mUnited Airlines
Deal found 10/9£503
Thu 25/913:35FRA - PTY
1 stop37h 35mUnited Airlines
Sat 27/915:30PTY - FRA
2 stops32h 00mUnited Airlines
Deal found 10/9£504
Wed 24/1213:20FRA - PTY
1 stop35h 29mUnited Airlines
Wed 31/1211:35PTY - FRA
1 stop18h 05mUnited Airlines
Deal found 12/9£509

Cheapflights Fare Finder

 
Customise your flight search to find flights from Frankfurt to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 12 September 2025.
Use the filters below to find and compare flights from Frankfurt am Main Airport to Panama City that are best for you.

Fly from

Frankfurt

Fly to

Panama City

Route

Depart

Return

Price

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 25/9

13:35-20:10

1 stop37h 35m

Panama City Tocumen Intl

Sat 27/9

15:30-06:30

2 stops32h 00m

£504

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sat 7/3

17:25-17:49

1 stop30h 24m

Panama City Tocumen Intl

Sat 28/3

15:00-14:15

1 stop41h 15m

£509

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Mon 17/11

17:25-18:49

1 stop31h 24m

Panama City Tocumen Intl

Wed 10/12

10:00-07:25

1 stop15h 25m

£509

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Wed 31/12

11:30-13:55

2 stops32h 25m

Panama City Tocumen Intl

Wed 21/1

16:41-06:35

2 stops31h 54m

£509

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 1/1

11:30-13:55

2 stops32h 25m

Panama City Tocumen Intl

Thu 22/1

08:55-09:20

1 stop18h 25m

£509

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 1/1

11:30-13:55

2 stops32h 25m

Panama City Tocumen Intl

Sun 18/1

16:41-06:35

2 stops31h 54m

£509

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sat 22/11

17:10-13:55

2 stops26h 45m

Panama City Tocumen Intl

Wed 26/11

08:55-09:20

1 stop18h 25m

£509

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Wed 24/12

13:20-18:49

1 stop35h 29m

Panama City Tocumen Intl

Wed 31/12

11:35-11:40

1 stop18h 05m

£509

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Mon 9/2

13:20-14:45

2 stops31h 25m

Panama City Tocumen Intl

Sun 22/2

08:55-11:40

1 stop20h 45m

£509

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 8/1

13:20-18:49

1 stop35h 29m

Panama City Tocumen Intl

Thu 29/1

11:35-09:20

1 stop15h 45m

£509

Flights are sorted by cheapest return flights first.

Deals found on 10/9

Showing 1-10 of 22 results
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Best time to book a flight from Frankfurt to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Frankfurt with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Frankfurt am Main Airport to Panama City

How far ahead should I book a flight from Frankfurt am Main Airport to Panama City?

Use this chart to determine the optimal time to book a return flight from Frankfurt to Panama City. Price data was last updated on 29 August 2025.

To ensure you get the cheapest price possible for a flight from Frankfurt am Main Airport to Panama City, you should look to book at least 59 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Frankfurt am Main Airport to Panama City?

Currently, April is the cheapest month in which you can book a flight from Frankfurt am Main Airport to Panama City (average of £763). Flying from Frankfurt am Main Airport to Panama City in December is currently the most expensive (average of £1,051). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from FRA to PTY?

Find hourly flight availability from Frankfurt to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated 12 September 2025.

When flying from Frankfurt am Main Airport to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Frankfurt to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Frankfurt am Main?

    For a flight from Frankfurt am Main to Panama City, you will be flying into Tocumen Intl. Panama City Tocumen Intl (PTY) is just 11.4 mi from the center of the city. Tocumen Intl is the only Panama City airport and it handles 0 inbound flights from Frankfurt am Main per day. 0 airlines have flights to Panama City Tocumen Intl from Frankfurt am Main on a regular basis.

  • How long is the flight from Frankfurt am Main Airport to Panama City?

    Departing from Frankfurt am Main Airport to Panama City will take you 37h 35m. Airlines will cover a distance of 5644 mi.

  • Can I find deals for flights from Frankfurt to Panama City that include hotel bookings?

    Yes. In addition to deals on Frankfurt to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Frankfurt to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Frankfurt to Panama City.

  • Can I find deals for business class flights from Frankfurt to Panama City?

    Yes. Cheapflights offers flight deals from Frankfurt to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Frankfurt am Main Airport to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Frankfurt am Main Airport to Panama City (average of £763). Flying from Frankfurt am Main Airport to Panama City in December is currently the most expensive (average of £1,051). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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