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Cheap flights from Frankfurt am Main Airport to Panama City from £354

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 18/3. Fares are subject to change and may not be available on all flights or dates of travel.
FRA — PTY
14 Jan — 21 Jan1
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Frankfurt to Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Frankfurt to Panama City
Explore the most affordable flight options available from Frankfurt to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 15 December 2025.

Fri 26/1217:25FRA - PTY
1 stop31h 24mUnited Airlines
Sun 28/1211:35PTY - FRA
1 stop18h 05mUnited Airlines
Deal found 14/12£547
Fri 26/1217:25FRA - PTY
1 stop31h 24mUnited Airlines
Wed 31/1208:55PTY - FRA
1 stop20h 45mUnited Airlines
Deal found 14/12£552
Fri 26/1217:25FRA - PTY
1 stop31h 24mUnited Airlines
Sat 17/110:00PTY - FRA
2 stops22h 05mUnited Airlines
Deal found 14/12£553
Thu 25/1213:50FRA - PTY
1 stop35h 48mUnited Airlines
Wed 31/1208:55PTY - FRA
1 stop20h 45mUnited Airlines
Deal found 14/12£587
Thu 25/1213:50FRA - PTY
1 stop35h 48mUnited Airlines
Wed 25/309:30PTY - FRA
2 stops18h 35mUnited Airlines
Deal found 14/12£590
Fri 26/1217:25FRA - PTY
1 stop31h 24mUnited Airlines
Thu 15/110:00PTY - FRA
2 stops18h 00mUnited Airlines
Deal found 14/12£611
Fri 26/1213:50FRA - PTY
1 stop30h 55mUnited Airlines
Wed 14/111:35PTY - FRA
1 stop18h 05mUnited Airlines
Deal found 14/12£631
Fri 26/1217:25FRA - PTY
1 stop31h 24mUnited Airlines
Thu 8/111:35PTY - FRA
2 stops20h 30mUnited Airlines
Deal found 13/12£632
Thu 25/1213:50FRA - PTY
1 stop35h 48mUnited Airlines
Mon 29/1223:55PTY - FRA
2 stops24h 45mUnited Airlines
Deal found 14/12£636

Find flight deals from Frankfurt to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Frankfurt (FRA) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated 15 December 2025.

Round-trip from

£514

One-way from

£354

Popular in

December

Cheapest in

May

Average price

£690
Air Europa
  • Air Europa
  • 22/2-12/3
  • 2 total stops
  • 60h 55m total
  • Frankfurt am Main to Panama City
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KLM
  • KLM
  • 18/3
  • 1 total stop
  • 15h 35m total
  • Frankfurt am Main to Panama City
Search Deals
Highest demand for flights based on searches. 10% potential increase in price (£50 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease (£10 potential savings vs. average return price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Frankfurt to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 858,174 searches. Data last updated 15 December 2025.
Use the filters below to find and compare flights from Frankfurt am Main Airport to Panama City that are best for you.

Fly from

Frankfurt

Fly to

Panama City

Route

Depart

Return

Price

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 26/2

19:05-19:45

1 stop30h 40m

Panama City Tocumen Intl

Thu 12/3

21:30-09:45

1 stop30h 15m

£514

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Fri 27/2

10:45-19:45

1 stop15h 00m

Panama City Tocumen Intl

Sat 21/3

21:30-09:45

1 stop30h 15m

£537

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sat 28/2

19:05-19:45

1 stop30h 40m

Panama City Tocumen Intl

Sun 15/3

21:30-09:45

1 stop30h 15m

£545

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sat 7/3

09:50-05:10

2 stops25h 20m

Panama City Tocumen Intl

Sat 28/3

15:41-07:15

1 stop33h 34m

£547

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Wed 8/4

09:45-04:04

2 stops25h 19m

Panama City Tocumen Intl

Tue 28/4

10:00-14:05

2 stops21h 05m

£547

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 7/5

06:35-19:31

2 stops19h 56m

Panama City Tocumen Intl

Mon 11/5

10:00-14:05

2 stops21h 05m

£547

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Mon 13/4

09:45-04:04

2 stops25h 19m

Panama City Tocumen Intl

Tue 12/5

09:45-14:05

2 stops21h 20m

£548

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 25/12

13:50-14:45

1 stop30h 55m

Panama City Tocumen Intl

Thu 15/1

16:41-06:35

2 stops31h 54m

£552

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Thu 25/12

13:50-19:38

1 stop35h 48m

Panama City Tocumen Intl

Sun 28/12

11:35-11:40

1 stop18h 05m

£552

Frankfurt am MainPanama City

FRA - PTY

FRAPTY

Frankfurt am Main

Sun 1/3

10:25-14:45

2 stops34h 20m

Panama City Tocumen Intl

Thu 19/3

07:55-09:00

1 stop19h 05m

£552

Flights are sorted by cheapest return flights first.

Deals found on 13/12

Showing 1-10 of 16 results
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Best time to book a flight from Frankfurt to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Frankfurt with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Frankfurt am Main Airport to Panama City

How far ahead should I book a flight from Frankfurt am Main Airport to Panama City?

Use this chart to determine the optimal time to book a return flight from Frankfurt to Panama City. Price data was last updated on 12 December 2025.

To ensure you get the cheapest price possible for a flight from Frankfurt am Main Airport to Panama City, you should look to book at least 12 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Frankfurt am Main Airport to Panama City?

Currently, June is the cheapest month in which you can book a flight from Frankfurt am Main Airport to Panama City (average of £292). Flying from Frankfurt am Main Airport to Panama City in July is currently the most expensive (average of £492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost for a return flight from Frankfurt am Main Airport to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Frankfurt to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Frankfurt am Main?

    For a flight from Frankfurt am Main to Panama City, you will be flying into Tocumen Intl. Panama City Tocumen Intl (PTY) is just 11.4 mi from the center of the city. Tocumen Intl is the only Panama City airport and it handles 0 inbound flights from Frankfurt am Main per day. 0 airlines have flights to Panama City Tocumen Intl from Frankfurt am Main on a regular basis.

  • How long is the flight from Frankfurt am Main Airport to Panama City?

    Departing from Frankfurt am Main Airport to Panama City will take you 15h. Airlines will cover a distance of 5644 mi. Both multi-stop and direct flights can be found to your destination and back.

  • Can I find deals for flights from Frankfurt to Panama City that include hotel bookings?

    Yes. In addition to deals on Frankfurt to Panama City flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Frankfurt to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Frankfurt to Panama City.

  • Can I find deals for business class flights from Frankfurt to Panama City?

    Yes. Cheapflights offers flight deals from Frankfurt to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Frankfurt am Main Airport to Panama City?

    Currently, June is the cheapest month in which you can book a flight from Frankfurt am Main Airport to Panama City (average of £292). Flying from Frankfurt am Main Airport to Panama City in July is currently the most expensive (average of £492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

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Why should you use Cheapflights to find cheap flight tickets from Frankfurt to Panama City?

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Yes! Cheapflights helps users easily find flights from Frankfurt to Panama City with no change fees.

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Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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